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371

抑制剂 & 化合物

77

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T80528	Ssm spooky toxin SsTx Toxin	Potassium Channel	Membrane transporter/Ion channel
	Ssm Spooky Toxin是从Scolopendra mutilans中分离出的化合物，其特点是有效抑制KCNQ（电压门控钾通道家族7）通道，表现出对血液和呼吸系统的致命毒性。Ssm Spooky Toxin对Kv7.4、Kv1.3和Shal通道的IC50值分别为2.8 μM、5.26 μM和0.1-0.3 M，且能够通过针对T细胞中的KV1.3通道抑制细胞因子的产生，在蜈蚣的循环系统中起着关键作用。
T82700	Cn2 toxin β-Mammal toxin Cn2
	Cn2 toxin为一β类毒素，具有与电压门控钠通道（Nav）的电压感应域结合的能力。
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...
TP1588	Tetanus toxin (830-843) Tetanus toxin 830-843
	Tetanus toxin (830-843) from tetanus toxoid is a universal human tetanus toxin T cell epitope. It induces T-cell activation and is used as a helper peptide in vaccinations.
T35774	HC Toxin
	HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.
T9541	CTB Cholera Toxin B subunit	Epigenetic Reader Domain	Chromatin/Epigenetic
	CTB (Cholera Toxin B subunit) 是一种 p300 组蛋白乙酰转移酶的激活剂，可诱导 MCF-7 细胞凋亡。
TP1588L	Tetanus toxin 830-843 acetate Tetanus toxin 830-843 acetate(119260-99-0 free base)	Others	Others
	Tetanus toxin 830-843 acetate (Tetanus toxin 830-843 acetate (119260-99-0 free base)) 来自破伤风类毒素的醋酸破伤风毒素(830-843) 是一种通用的人类破伤风毒素 T 细胞表位。它诱导 T 细胞活化并在疫苗接种中用作辅助肽。
T19509	Pertussis Toxin	Others	Others
	Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis.
T34906	Toxin IIc
	Toxin IIc is a biochemical.
T29927	AM Toxin III
	AM Toxin III is a phytotoxic peptide.
T29926	AM Toxin II
	AM Toxin II is a Cyclic tetradepsipeptide isolated from Alternaria mali.
T29804	AK-Toxin II
	AK-Toxin II is a host-specific toxin to Japanese white pear.
T80066	ShK toxin	Potassium Channel	Membrane transporter/Ion channel
	ShK toxin 是从加勒比海葵（Stichodactylu helianthus）的全身提取物中分离出的一种蛋白，能够阻断电压依赖性钾通道(Kv1.3 通道)。在竞争实验中，ShK toxin 与树突毒素 I 及α-树突毒素相互竞争，以与大鼠脑突触体膜结合，从而促进乙酰胆碱的释放。此外，ShK toxin 抑制培养的大鼠背根神经节神经元中的K+ 电流，并且能够抑制T淋巴细胞的增殖。
T80484	Aa1 toxin	Potassium Channel	Membrane transporter/Ion channel
	Aa1 toxin 是从 Androctonus australis Garzoni 毒液中提取的神经毒性肽，特异性阻断钾通道（potassium channel）。它在神经系统疾病研究中有应用。
TP1063	Psalmotoxin 1 PcTx1,Psalmopoeus cambridgei toxin-1
	Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.
T80524	Vm24-toxin Vaejovis mexicanus peptide 24	Potassium Channel	Membrane transporter/Ion channel
	Vm24-toxin，源自墨西哥蝎Vaejovis mexicanus smithy，属于毒素肽类，其作用机制为抑制Kv1.3钾通道。
T80487	MmTx2 toxin Micrurotoxin 2	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	MmTx2 toxin作为一种GABAA受体调节剂，具有提升GABAA受体对激动剂反应敏感性的作用。该毒素来源于珊瑚蛇的毒液，并在神经系统相关疾病（例如癫痫、精神分裂症及慢性疼痛）的研究中发挥重要用途。
T80489	MmTx1 toxin Micrurotoxin 1	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	MmTx1毒素是一种调节变构性GABAA受体活性的化合物，它能够提升GABAA受体对激动剂的反应性。
T23759	Aspergillomarasmine A Toxin C (Pyrenophora teres)
	Aspergillomarasmine A is a polyamine acid naturally produced by the mold Aspergillus Versicolor.
T80843	Wasabi Receptor Toxin WaTx
	Wasabi Receptor Toxin通过延长TRPA1通道的开放时间并降低其Ca2+渗透性，从而激活该通道。该化合物被应用于急性与持续性疼痛研究领域。
T124258	NT 2 Toxin
	NT 2 Toxin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124258，CAS号为 76348-84-0。
T80477	Muscarinic toxin 3 MT3	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Muscarinic toxin 3 (MT3) 是高效的非竞争性mAChR及adrenoceptors拮抗剂，对M1、M4、α1A、α1B、α1D、α2A、α2B、α2C受体展示出不同程度的选择性，其pIC50值分别为6.71、8.79、8.86、7.57、8.13、8.49、6.5、7.29。该化合物具有显著的肾上腺素受体抑制活性。
T125787	AAL Toxin TB2
	AAL Toxin TB2 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125787。
T80168	Scorpion toxin Tf2	Sodium Channel	Membrane transporter/Ion channel
	Scorpion toxin Tf2为一种在Tityus fasciolatus的毒液中首次发现的β-蝎毒素。作为Nav1.3激活剂，该毒素与神经元的电压门控钠（Nav）亚型相关，此亚型与癫痫和伤害感受密切相关。Scorpion toxin Tf2作用于hNav1.3，能够增强其激活电压，并且能够在静息膜电位下开启该通道。
T125565	AAL Toxin TD1
	AAL Toxin TD1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125565。
T80183	Muscarinic toxin 7
	Muscarinic toxin 7，一种肽类毒素，特异性地针对毒蕈碱M1受体表现出选择性和非竞争性的拮抗活性。
T125567	AAL Toxin TC1
	AAL Toxin TC1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125567。
T125563	AAL Toxin TE1
	AAL Toxin TE1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125563。
T125562	AAL Toxin TE2
	AAL Toxin TE2 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125562。
T124207	AAL Toxin TA1
	AAL Toxin TA1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124207。
T125566	AAL Toxin TC2
	AAL Toxin TC2 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125566。
T124208	AAL Toxin TA2
	AAL Toxin TA2 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124208。
T125564	AAL Toxin TD2
	AAL Toxin TD2 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125564。
T125788	AAL Toxin TB1
	AAL Toxin TB1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125788。
T81011	Tetanus Toxin (830–844)
	Tetanus Toxin (830–844) 是具有生物活性的肽类化合物。它是破伤风毒素衍生的 TT830–844 CD4+ T 细胞表位，能与多种 HLA-DRB 分子结合。该 CD4+ T 细胞表位由于与广泛的 HLA-DRB 分子具有亲和力，有潜力在大范围人群中诱发 CD4+ T 细胞应答。
T73804	Botulinum toxin type B
	Botulinum toxin type B是用于颈部肌张力障碍研究的抗原特异性肉毒毒素。该毒素为厌氧细菌肉毒梭菌产生的外毒素，其机制是通过抑制乙酰胆碱在神经肌肉接头的释放，从而导致注射部位肌肉的松弛性麻痹或减弱。
T80431	δ-Theraphotoxin-Hm1a toxin	Sodium Channel	Membrane transporter/Ion channel
	δ-Theraphotoxin-Hm1a毒素是一种针对Nav1.1通道的选择性激活剂，能够诱发疼痛反应和增强触觉敏感度，常用于研究肠易激综合征。
T80530	Spinoxin SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13	Potassium Channel	Membrane transporter/Ion channel
	Spinoxin是一种从Heterometrus spinifer蝎子毒液中提取的神经毒素，由34个氨基酸残基组成，通过4个二硫桥交联。它能有效抑制Kv1.3钾通道（IC50= 63 nM），是研发诊断及治疗自身免疫性疾病和癌症策略时的潜在分子靶点。
T80851	VSTx-3 Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3是KV通道阻断剂，同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言，其对hNaV1.3通道的IC50为0.19 μM，对hNaV1.7通道的IC50为0.43 μM，对hNaV1.8通道的IC50为0.77 μM。
T80964	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)为T细胞增殖激活剂，以剂量依赖性方式增强人外周血单核细胞(PBMC)的体外增殖，适用于癌症与炎症免疫研究。
T16557	PNU-159682	Topoisomerase	DNA Damage/DNA Repair
	PNU-159682 是蒽环类新霉素的代谢产物，是一种 DNA 拓扑异构酶 II 抑制剂，具有出色的细胞毒性。
TP2325L	Endotoxin Inhibitor acetate(147396-10-9 free base)	Others	Others
	Endotoxin Inhibitor acetate(147396-10-9 free base) 对细菌生理活性有很强的阻断作用，从而产生具有二硫键和大量赖氨酸的抗菌毒素抑制剂序列。内毒素抑制剂醋酸盐在酸性条件下更可能发挥生理活性
T35325L	α-Conotoxin GI acetate α-Conotoxin GI acetate (76862-65-2 Free base)	Others	Others
	α-Conotoxin GI acetate 是肌肉型烟碱乙酰胆碱受体 (nAChR) 的竞争性拮抗剂。
TP1745L	Ceratotoxin A acetate Ceratotoxin A acetate(150671-04-8 Free base)	Antibacterial	Microbiology/Virology
	Ceratotoxin A acetate 是从副腺分泌液中分离出来的，具有抗菌作用。
TP2063L	α-Conotoxin MII acetate α-Conotoxin MII acetate (175735-93-0 Free base)	AChR	Neuroscience
	α-Conotoxin MII acetate 是一种来自海洋蜗牛 Conus magus 毒液的 16 个氨基酸肽。它有效阻断由 α3β2 亚基组成的烟碱型乙酰胆碱受体，IC50 为 0.5 nM。它可有效阻断含 β3 的神经元烟碱乙酰胆碱受体。
T124797	Ochratoxin B	Endogenous Metabolite	Metabolism
	Ochratoxin B 由多种曲霉和青霉菌产生的，是霉菌毒素 Ochratoxin A 的类似物，会对农产品造成污染。
TP2063	α-Conotoxin MII	AChR	Neuroscience
	α-Conotoxin MII 是可从僧袍芋螺中分离得到的一种天然产物，有效抑制 nAChR 受体的α3β2亚基，IC50值为 0.5 nM。它还可有效抑制 β3-containing 神经尼古丁受体。
T21769L	β-Pompilidotoxin Acetate β-Pompilidotoxin Acetate(216064-36-7 Free base)	Sodium Channel	Membrane transporter/Ion channel
	β-Pompilidotoxin Acetate 是一种黄蜂毒肽。它可以减缓钠通道的失活并增加细胞中的稳态钠电流。
TP2065L	α-Conotoxin PIA acetate	AChR	Neuroscience
	α-Conotoxin PIA acetate 是烟碱型乙酰胆碱受体 (nAChR) 的拮抗剂，主要针对 α6 和 α3 亚基。
T78108	µ-Conotoxin-CnIIIC acetate	Sodium Channel	Membrane transporter/Ion channel
	µ-Conotoxin-CnIIIC acetate 是一种高效的 NaV1.4 钠通道拮抗剂，是由22个氨基酸组成的芋螺肽，可用于肌肉松弛和缓解疼痛。

化合物

Ssm spooky toxin

Cat.No: T80528

Synonym: SsTx Toxin

Target: Potassium Channel

Cat.No: T82700

Synonym: β-Mammal toxin Cn2

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

Tetanus toxin (830-843)

Cat.No: TP1588

Synonym: Tetanus toxin 830-843

Cat.No: T35774

Cat.No: T9541

Synonym: Cholera Toxin B subunit

Target: Epigenetic Reader Domain

Tetanus toxin 830-843 acetate

Cat.No: TP1588L

Synonym: Tetanus toxin 830-843 acetate(119260-99-0 free base)

Target: Others

Pertussis Toxin

Cat.No: T19509

Target: Others

Cat.No: T34906

Cat.No: T29927

Cat.No: T29926

Cat.No: T29804

Cat.No: T80066

Target: Potassium Channel

Cat.No: T80484

Target: Potassium Channel

Cat.No: TP1063

Synonym: PcTx1,Psalmopoeus cambridgei toxin-1

Cat.No: T80524

Synonym: Vaejovis mexicanus peptide 24

Target: Potassium Channel

Cat.No: T80487

Synonym: Micrurotoxin 2

Target: GABA Receptor

Cat.No: T80489

Synonym: Micrurotoxin 1

Target: GABA Receptor

Aspergillomarasmine A

Cat.No: T23759

Synonym: Toxin C (Pyrenophora teres)

Wasabi Receptor Toxin

Cat.No: T80843

Synonym: WaTx

Cat.No: T124258

Muscarinic toxin 3

Cat.No: T80477

Synonym: MT3

Target: Adrenergic Receptor

AAL Toxin TB2

Cat.No: T125787

Scorpion toxin Tf2

Cat.No: T80168

Target: Sodium Channel

AAL Toxin TD1

Cat.No: T125565

Muscarinic toxin 7

Cat.No: T80183

AAL Toxin TC1

Cat.No: T125567

AAL Toxin TE1

Cat.No: T125563

AAL Toxin TE2

Cat.No: T125562

AAL Toxin TA1

Cat.No: T124207

AAL Toxin TC2

Cat.No: T125566

AAL Toxin TA2

Cat.No: T124208

AAL Toxin TD2

Cat.No: T125564

AAL Toxin TB1

Cat.No: T125788

Tetanus Toxin (830–844)

Cat.No: T81011

Botulinum toxin type B

Cat.No: T73804

δ-Theraphotoxin-Hm1a toxin

Cat.No: T80431

Target: Sodium Channel

Cat.No: T80530

Synonym: SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13

Target: Potassium Channel

Cat.No: T80851

Synonym: Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F

Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)

Cat.No: T80964

Cat.No: T16557

Target: Topoisomerase

Endotoxin Inhibitor acetate(147396-10-9 free base)

Cat.No: TP2325L

Target: Others

α-Conotoxin GI acetate

Cat.No: T35325L

Synonym: α-Conotoxin GI acetate (76862-65-2 Free base)

Target: Others

Ceratotoxin A acetate

Cat.No: TP1745L

Synonym: Ceratotoxin A acetate(150671-04-8 Free base)

Target: Antibacterial

α-Conotoxin MII acetate

Cat.No: TP2063L

Synonym: α-Conotoxin MII acetate (175735-93-0 Free base)

Target: AChR

Cat.No: T124797

Target: Endogenous Metabolite

α-Conotoxin MII

Cat.No: TP2063

Target: AChR

β-Pompilidotoxin Acetate

Cat.No: T21769L

Synonym: β-Pompilidotoxin Acetate(216064-36-7 Free base)

Target: Sodium Channel

α-Conotoxin PIA acetate

Cat.No: TP2065L

Target: AChR

µ-Conotoxin-CnIIIC acetate

Cat.No: T78108

Target: Sodium Channel

Cat. No.	Product Name	Target	Signaling Pathways
T5625	Zearalenone 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2	Others	Others
	Zearalenone (F2 toxin) 是真菌毒素，主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性，急性毒性低。
T13726	HT-2 Toxin	Others	Others
	HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.
T13053	T-2 Toxin T-2 Mycotoxin	Others	Others
	T- 2 Toxin is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains,( LD50 are 5.2 and 1.5 mg/kg BWa in mice and rats,respectively ).
T3381	Lysionotin 岩豆素	Others	Others
	Lysionotin (Nevadensin) 是一种类黄酮，分离自黄花草药中。它可抑制 α-Toxin (一种成孔蛋白) 的表达，并在体内和体外针对金黄色葡萄球菌显示出显著的保护作用。它可用于研究由金黄色葡萄球菌引起的肺炎。
T7438	3,5-Dimethoxyphenol Phloroglucinol dimethyl ether,3,5-二甲氧基苯酚	Tyrosinase	Proteases/Proteasome
	3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) 是一种存在于人类食用红豆杉的叶子中的毒素代谢物。
Fr13883	3-Methoxyphenylacetic acid	Others	Others
	3-Methoxyphenylacetic acid 是 m-hydroxyphenylacetic (m-OHPAA) 的衍生物，茄形假丝酵母中的一种植物毒素。它可用于针对介氧菌根腐烂的毒素介导的生物测定法的开发。
T3999	D(+)-Galactosamine hydrochloride D-半乳糖胺盐酸盐,D-氨基半乳糖盐酸盐,D-Galactosamine HCl	Others	Others
	D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) 是一种被证实的实验毒素，它能够产生自由基及UTP 核苷酸的消耗导致肝损伤，中毒剂量会造成肾功能不全，而肾功能衰竭通常和终末期肝损伤有关。脂多糖/D-Galactosamine 诱导的急性肝损伤是一种已知的暴发性肝衰竭动物模型。
T8150	Nudifloramide 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺	PARP; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) 是烟酰胺-腺嘌呤二核苷酸(NAD) 降解的一种最终产物，可显著抑制PARP-1活性。
T19866	Indican NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside	OAT; MRP	Immunology/Inflammation; Membrane transporter/Ion channel
	Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷，染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中 IS 是尿毒症毒素，是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。
TMS0418	Dihydroergotoxine mesylate 甲磺酸二氢麦角碱,Ergoloid mesylates,甲磺酸双氢麦角毒碱	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Dihydroergotoxine mesylate (Ergoloid mesylates) 是系列生物碱盐混合物，对GABAA 受体高结合活性。它主要用于改善与衰老相关的精神退化的症状和身体症状。
TN1525	Convallatoxin K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷	NF-κB; P-gp; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Convallatoxin 是从铃兰分离得到的一种强心苷。它是 P-糖蛋白底物，并识别 Val982 是参与其转运的重要氨基酸。它是配体诱导的 MOR 胞吞作用的增强剂，通过激活PPARγ和抑制NF-κB 改善结肠炎，具有抗炎和抗增殖特性。
TN7041	(-)-Epipodophyllotoxin	Apoptosis	Apoptosis
	(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂，在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。
T2937	4'-Demethylepipodophyllotoxin 4'-DMEP,4-Demethylepipodophyllotoxin,4'-脱甲基表鬼臼毒素,4'-去甲基表鬼臼毒素,DMEP,4'-O-demethylepipodophyllotoxin	Microtubule Associated	Cytoskeletal Signaling
	4'-Demethylepipodophyllotoxin (DMEP) 是一种有效的微管组装抑制剂。
T27012	Chrysotoxine Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol,鼓槌石斛素	NF-κB	NF-κB
	Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) 通过 NF-κB 调节和线粒体保护抑制 SH-SY5Y 细胞中 6-羟基多巴胺诱导的细胞凋亡。
T2S0029	4'-Demethylpodophyllotoxin 4'-去甲鬼臼毒素,4'-去甲基鬼臼毒素	Others	Others
	4'-Demethylpodophyllotoxin 是一种木脂素类化合物，存在于Podophyllum hexandrum 根和P. peltatum 中，对多种癌细胞系具有潜在的细胞毒性。
T34295	Resiniferatoxin RTX,[3H]resiniferatoxin,树脂毒素	IL Receptor	Immunology/Inflammation
	Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生，有助于防御 T.spiralis 感染，并可用于免疫反应调节剂的研究。
T16535	Picrotoxinin	Chloride channel; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Picrotoxinin 是一种氯离子通道阻断剂和 GABAA 的非竞争性拮抗剂，对 α1β2γ2L GABAA 的 IC50 为 1.15 μM。 Picrotoxinin 具有惊厥作用。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。
TN1087	Deoxypodophyllotoxin 脱氧鬼臼毒素,去氧鬼臼毒素	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Deoxypodophyllotoxin 是从桃儿七根茎分离的一种木酚素，是鬼臼毒素衍生物，具有抗有丝分裂和抗病毒特性。它是血管生成抑制剂，作为靶向微管药物，在肿瘤学中具有重大影响。它引起 DRG 神经元细胞内 Ca2+浓度增加，诱导细胞自噬和凋亡。
T83321	4-Demethyldeoxypodophyllotoxin	Chk	Cell Cycle/Checkpoint
	4-Demethyldeoxypodophyllotoxin 是一种来自 Podophyllum peltatum 根部的芳基四氢萘木酚素类化合物，具有抗癌活性，可调节 MCF-7乳腺癌细胞中的Chk-2信号通路。
T0295	Digitoxin Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄	ATPase; Others	Membrane transporter/Ion channel; Others
	Digitoxin (Digitoxinum) 是Na+/K+-ATPase 有效抑制剂, EC50 值为0.78 μM。
TN2356	Tetradehydropodophyllotoxin 去氢鬼臼毒素,Dehydropodophyllotoxin	Others; Antifungal	Microbiology/Virology; Others
	Tetradehydropodophyllotoxin (Dehydropodophyllotoxin) 具有抗真菌和抗肿瘤活性。
TN3520	Bisdethiobis(methylthio)gliotoxin	PAFR	GPCR/G Protein
	Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
T75722	Chlorotoxin TFA
	Chlorotoxin TFA，一种从蝎子毒液中分离出的多肽，作为氯离子通道 (chloride channel) 的阻断剂，具备抗癌活性。
T29599	Acetyldigitoxin Acylanide
	Acetyldigitoxin is a derivative of lanatoside A or of DIGITOXIN and can be used for fast digitalization in congestive heart failure.
T41238	Viridicatumtoxin

T36068	Brevetoxin B
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
T34885	Tinyatoxin TNX,TTN,TTX
	Tinyatoxin is a neurotoxin that works through vanillin receptors on sensory nerves.
T75539	Nereistoxin
	Nereistoxin (Nereistoxine) 是一种神经毒素，从海洋环节动物 Lumbriconereis heteropoda 中分离出来，可以通过阻断烟碱乙酰胆碱受体发挥作用。
T13123	Tentoxin	Endogenous Metabolite	Metabolism
	Tentoxin 是一种由植物致病真菌产生的环状肽，在敏感植物中，当其浓度在纳摩尔到微摩尔之间时，会使 F1马达失活，而更高的浓度会超过该酶的天然活性
TN4134	Gitoxin 洋地黄	Others	Others
	Gitoxin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4134，CAS号为 4562-36-1。
T31993	Grayanotoxin II G-II,Deacetylanhydroandromedotoxin,delta(sup 10 (18))-Andromedenol
	Grayanotoxins are a group of closely related neurotoxins named after Leucothoe grayana. Extract from leaves of Ericaceae.
TN4165	Grayanotoxin I	Others	Others
	Grayanotoxin I 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4165，CAS号为 4720-09-6。
TN4813	Podophyllotoxin 4-O-glucoside	Others	Others
	Podophyllotoxin 4-O-glucoside是一种天然产物，属于小檗科八角莲属，其产品编号为 TN4813，CAS号为 16481-54-2。Podophyllotoxin 4-O-glucoside可用作对照参考。
TN1359	Aflatoxin G1 黄曲霉毒素G1,黄曲霉毒素 G1	TNF; NF-κB	Apoptosis; NF-κB
	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.
TN5232	Victoxinine	Others	Others
	Victoxinine, the toxic metabolite, considered previously to be a unique product of Helminthosporium victoriae.
T13534	Aflatoxin M1 黄曲霉毒素 M1	Others	Others
	Aflatoxin M1, a significant metabolite of Aflatoxin B1, is a mycotoxin synthesized by Aspergillus flavus and Aspergillus parasiticus fungi. Toxicity levels of Aflatoxins follow the order: Aflatoxin B1 > Aflatoxin M1 > Aflatoxin G1 > Aflatoxin B2 > Aflatoxin M2 > Aflatoxin G2.
T83322	4'-Demethyldehydropodophyllotoxin
	4'-Demethyldehydropodophyllotoxin 是从 Podophyllum hexandrum 叶片中提取的芳基四氢萘类化合物，显示出细胞毒性和抗肿瘤活性。
T10609	Brevetoxin-3 PbTx-3	Others	Others
	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
T33775	Ochratoxin C HSDB 3439
	Ochratoxin C is a toxic metabolite from Aspergillus orchraceus.
T34536	Satratoxin H Satratoxin-H
	Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage.
T13544	Altertoxin I Dihydroalterperylenol	Others	Others
	Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi. It is mutagenic and cytotoxic and can weakly disrupt metabolic communication.
T30156	Asebotoxin III
	Asebotoxin III is a diterpenoid obtained from the leaves of Asebi, Pieris japonica.
T33033	Lyngbyatoxin A
	Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.
T13533	Aflatoxin G2 黄曲霉毒素 G2	Others	Others
	Aflatoxin G2 is a major naturally produced aflatoxin. It is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.
TN1694	Gliotoxin	Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Gliotoxin 是一种次生代谢产物，由A. fumigatus 分泌，可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性，从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度，调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。
T13535	Aflatoxin M2 黄曲霉毒素 M2	Others	Others
	Aflatoxin M2 is a major metabolite of Aflatoxin B1. It is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.
TN4496	Marginatoxin	Caspase; Fas/FasL	Apoptosis; Proteases/Proteasome
	Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.
TN1357	Acetylepipodophyllotoxin	Others	Others
	Acetylepipodophyllotoxin has insecticidal activity.
TN4937	Sambutoxin	Others	Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were
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天然产物

Cat.No: T5625

Synonym: 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2

Target: Others

Cat.No: T13726

Target: Others

Cat.No: T13053

Synonym: T-2 Mycotoxin

Target: Others

Cat.No: T3381

Synonym: 岩豆素

Target: Others

3,5-Dimethoxyphenol

Cat.No: T7438

Synonym: Phloroglucinol dimethyl ether,3,5-二甲氧基苯酚

Target: Tyrosinase

3-Methoxyphenylacetic acid

Cat.No: Fr13883

Target: Others

D(+)-Galactosamine hydrochloride

Cat.No: T3999

Synonym: D-半乳糖胺盐酸盐,D-氨基半乳糖盐酸盐,D-Galactosamine HCl

Target: Others

Cat.No: T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺

Target: PARP, Endogenous Metabolite

Cat.No: T19866

Synonym: NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside

Target: OAT, MRP

Dihydroergotoxine mesylate

Cat.No: TMS0418

Synonym: 甲磺酸二氢麦角碱,Ergoloid mesylates,甲磺酸双氢麦角毒碱

Target: GABA Receptor

Cat.No: TN1525

Synonym: K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷

Target: NF-κB, P-gp, PPAR

(-)-Epipodophyllotoxin

Cat.No: TN7041

Target: Apoptosis

4'-Demethylepipodophyllotoxin

Cat.No: T2937

Synonym: 4'-DMEP,4-Demethylepipodophyllotoxin,4'-脱甲基表鬼臼毒素,4'-去甲基表鬼臼毒素,DMEP,4'-O-demethylepipodophyllotoxin

Target: Microtubule Associated

Cat.No: T27012

Synonym: Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol,鼓槌石斛素

Target: NF-κB

4'-Demethylpodophyllotoxin

Cat.No: T2S0029

Synonym: 4'-去甲鬼臼毒素,4'-去甲基鬼臼毒素

Target: Others

Resiniferatoxin

Cat.No: T34295

Synonym: RTX,[3H]resiniferatoxin,树脂毒素

Target: IL Receptor

Cat.No: T16535

Target: Chloride channel, GABA Receptor

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Deoxypodophyllotoxin

Cat.No: TN1087

Synonym: 脱氧鬼臼毒素,去氧鬼臼毒素

Target: Apoptosis, Microtubule Associated, Autophagy

4-Demethyldeoxypodophyllotoxin

Cat.No: T83321

Target: Chk

Cat.No: T0295

Synonym: Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄

Target: ATPase, Others

Tetradehydropodophyllotoxin

Cat.No: TN2356

Synonym: 去氢鬼臼毒素,Dehydropodophyllotoxin

Target: Others, Antifungal

Bisdethiobis(methylthio)gliotoxin

Cat.No: TN3520

Target: PAFR

Chlorotoxin TFA

Cat.No: T75722

Acetyldigitoxin

Cat.No: T29599

Synonym: Acylanide

Viridicatumtoxin

Cat.No: T41238

Cat.No: T36068

Cat.No: T34885

Synonym: TNX,TTN,TTX

Cat.No: T75539

Cat.No: T13123

Target: Endogenous Metabolite

Cat.No: TN4134

Synonym: 洋地黄

Target: Others

Grayanotoxin II

Cat.No: T31993

Synonym: G-II,Deacetylanhydroandromedotoxin,delta(sup 10 (18))-Andromedenol

Cat.No: TN4165

Target: Others

Podophyllotoxin 4-O-glucoside

Cat.No: TN4813

Target: Others

Cat.No: TN1359

Synonym: 黄曲霉毒素G1,黄曲霉毒素 G1

Target: TNF, NF-κB

Cat.No: TN5232

Target: Others

Cat.No: T13534

Synonym: 黄曲霉毒素 M1

Target: Others

4'-Demethyldehydropodophyllotoxin

Cat.No: T83322

Cat.No: T10609

Synonym: PbTx-3

Target: Others

Cat.No: T33775

Synonym: HSDB 3439

Cat.No: T34536

Synonym: Satratoxin-H

Cat.No: T13544

Synonym: Dihydroalterperylenol

Target: Others

Cat.No: T30156

Cat.No: T33033

Cat.No: T13533

Synonym: 黄曲霉毒素 G2

Target: Others

Cat.No: TN1694

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Cat.No: T13535

Synonym: 黄曲霉毒素 M2

Target: Others

Cat.No: TN4496

Target: Caspase, Fas/FasL

Acetylepipodophyllotoxin

Cat.No: TN1357

Target: Others

Cat.No: TN4937

Target: Others

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