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Search Results for " racemate "

93

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11178L	ELN318463 racemate ELN318463 (racemate),ELN 318463 racemate	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	ELN318463 racemate (ELN 318463 racemate) 是 ELN318463 的外消旋体，ELN318463 是一种淀粉样前体蛋白 (APP) 选择性 γ-分泌酶抑制剂。
T10591	BPO-27 racemate BPO-27 (racemate)	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	BPO-27 racemate (BPO-27(racemate)) 是一种CFTR 抑制剂，IC50为8 nM。
T10464L	Atuveciclib Racemate BAY-1143572 Racemate,阿维西利	CDK	Cell Cycle/Checkpoint
	Atuveciclib Racemate (BAY-1143572 Racemate) 是 Atuveciclib 的外消旋混合物。 Atuveciclib 是口服有效的 P-TEFb/CDK9高选择性抑制剂，CDK9/CycT1的 IC50为13 nM。
T16731	Rentiapril racemate (Rac)-SA-446,SA-446 racemate,(Rac)-Rentiapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Rentiapril racemate (SA-446 racemate) 是 Rentiapril 的外消旋体。Rentiapril racemate 具有抗炎活性，可用于研究青光眼。
T12400	Peliglitazar racemate (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate	PPAR	DNA Damage/DNA Repair; Metabolism
	Peliglitazar racemate(BMS 426707-01 racemate) 是 Peliglitazar 的外消旋体。Peliglitazar racemate 可作为潜在的抗糖尿病和抗肥胖剂。
T7359	CAY10471 Racemate TM30089 Racemate,3-[[(4-氟苯基)磺酰基]甲基氨基]-1,2,3,4-四氢-9H-咔唑-9-乙酸	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	CAY10471 Racemate (TM30089 Racemate) 是一种高选择性的 CRTH2/DP 2 受体拮抗剂，对 hCRTH2 的Ki 值为 0.6 nM，对其选择性远高于人血栓素 A2 受体 TP 或 PGD2 受体 DP。它对大小鼠的同源 CRTH2 也具有拮抗作用。
T3534	Tetrabenazine Racemate Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Racemate (Rubigen) 是一种选择性和可逆的囊泡单胺转运蛋白 2(VMAT-2) 抑制剂。它阻断神经递质吸收到肾上腺素能储存囊泡中，并已被用作囊泡运输系统的高亲和力标记。
T7504	Necrostatin 2 racemate 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate	RIP kinase	Apoptosis; NF-κB
	Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂，是一种稳定型 Nec-1。
T22988	MK-4827 Racemate Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	MK-4827 Racemate (Niraparib Racemate) 是一种选择性 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 nM 和 2.1 nM，对 PARP3、V-PARP 和 Tank1 的选择性超过 330 倍。
T13331	WAY127093B racemate	PDE	Metabolism
	WAY127093B racemate 是WAY127093 B 的外消旋体。WAY127093B 是一种磷酸二酯酶IV 抑制剂，在大鼠和豚鼠中具有口服活性。
T2344L	LY 344864 racemate	5-HT Receptor	GPCR/G Protein; Neuroscience
	LY 344864 racemate 是一种 5-HT1F 受体激动剂。
T12215	Nexopamil racemate (Rac)-Nexopamil	Calcium Channel; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nexopamil racemate（(Rac)-Nexopamil）是 Nexopamil 的外消旋体。Nexopamil racemate 具有潜在的抗哮喘和抗溃疡活性。
T6425	BTZ043 Racemate BTZ044,BTZ10526038,Benzothiazinone 10526038	Antibacterial; DprE1	Microbiology/Virology; Others
	BTZ043 Racemate (Benzothiazinone 10526038) 是一种癸二烯基磷酰-β-D-核糖 2'-差向异构酶(DprE1) 抑制剂，用作新的抗分枝杆菌剂。
T5054	GSK963 GSK963 (Racemate)	RIP kinase	Apoptosis; NF-κB
	GSK963 是手性的选择性受体相互作用蛋白 1 酶抑制剂，其IC50值为 29 nM。它在体外强效选择性抑制小鼠和人细胞的坏死。
T6809	CPI-169 racemate CPI 169,CPI-169,CPI169	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	CPI-169 racemate (CPI 169) 是CPI-169的消旋体。CPI-169 是一种有效的选择性 EZH2 抑制剂，对 EZH2 WT、EZH2 Y641N 和 EZH1 的 IC50 分别为 0.24、0.51 和 6.1 nM。
T9005	VPC-80051 racemate	Others	Others
	VPC-80051 是一种有效的 hnRNP A1 剪接活性抑制剂，靶向 hnRNP A1 RBD 并降低 22Rv1 CRPC 细胞系中的 AR-V7 信使水平。
T3449	Bay 41-4109 racemate	HBV	Microbiology/Virology
	BAY 41-4109 racemate 是BAY 41-4109的消旋体。BAY 41-4109有效抑制人乙型肝炎病毒，IC50值为53 nM。
T72753	RSV604 racemate A-60444 racemate
	RSV604 (A-60444) racemate 是一种外消旋混合物，与 S-异构体相比，RSV604 racemate 对呼吸道合胞病毒(RSV)菌株的作用效果弱很多。
T11951	Mavoglurant racemate AFQ-056 racemate	Others	Others
	Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.
T13313	Seviteronel racemate VT-464 (racemate)	Others	Others
	Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.
T10997	Derazantinib Racemate ARQ-087 Racemate	Others	Others
	Derazantinib Racemate (ARQ-087 Racemate) 是 Derazantinib 的外消旋体。Derazantinib 是一种有效的，ATP 竞争型的，具有口服活性的酪氨酸激酶抑制剂，能够抑制软骨细胞 FGFR1 (IC50:4.5 nM)、FGFR2 (IC50:1.8 nM)、FGFR3 (IC50:4.5nM)。
T11859	Litronesib Racemate LY-2523355 Racemate,KF-89617 Racemate	Others	Others
	Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.
T13293	Veledimex racemate RG-115932 racemate,INXN-1001 racemate	Others	Others
	Veledimex racemate, the racemic form of veledimex, is an orally available, small-molecule ligand that activates the RheoSwitch Therapeutic System.
T13814	Pemafibrate (racemate) K13675 (racemate)	Others	Others
	Pemafibrate racemate is the racemate of pemafibrate
T13081	Taranabant racemate MK-0364 racemate	Cannabinoid Receptor	GPCR/G Protein
	Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
T16440	Ibrutinib Racemate PCI-32765 (Racemate)	Others	Others
	Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib.
T24822	SPM-242 racemate SPM 242 racemate,SPM242 racemate
	SPM-242 racemate is an antagonist of S1P(3)-selective.
T11786	KUL-7211 racemate KUL 7211 racemate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	KUL 7211 is a selective β-adrenoceptor agonist. KUL 7211 racemate is the racemate of KUL 7211.
T12245	Nosantine racemate 诺次黄嘌呤外消旋体,NPT-15392 racemate	IL Receptor	Immunology/Inflammation
	Nosantine racemate is the racemate of Nosantine which is a IL-2 inducer or enhancer of IL-2 induction by phytohemagglutinin (PHA).
T12866	SCH 42495 racemate SCH 42495 (racemate)	Others	Others
	SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.
T12583	PX20606 trans racemate PX-102 trans racemate	Others	Others
	PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).
T13700	GDC-0927 Racemate SRN-927 Racemate	Others	Others
	GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.
T13450L	GNE-140 racemate GNE-140 (racemate)	Others	Others
	GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.
T22677	Cobimetinib racemate Cobimetinib (racemate),考比替尼 (外消旋体)	MEK	MAPK
	Cobimetinib racemate (Cobimetinib (racemate)) 是 Cobimetinib 的外消旋体，是一种选择性 MEK 抑制剂。
T12185	Naveglitazar racemate	Others	Others
	Naveglitazar racemate is the racemate of Naveglitazar.
T10504	Implitapide Racemate	Others	Others
	Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T11649	INCB054329 Racemate	Others	Others
	INCB054329 Racemate is an inhibitor of BET protein.
T11018	DHMEQ racemate rel-DHMEQ	NF-κB	NF-κB
	DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
T19202	BAY-678 racemate	Others	Others
	BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, selective and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM).
T71483	Streptonigrin (racemate)
	Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.
T12768	RP 73163 Racemate	Others	Others
	RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent inhibitor of ACAT, shows cholesterol lowering activity.
T10660L2	CAL-130 Racemate	PI3K	PI3K/Akt/mTOR signaling
	CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T12136	N-0861 racemate	AChR	Neuroscience
	N-0861 racemate is the racemate of N-0861.
T11378L	GDC-0834 Racemate	Others	Others
	GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor
T12722	Ribocil-C Racemate	Others	Others
	Ribocil-C Racemate 是 Ribocil-C 的外消旋体。Ribocil-C 是具有高度选择性的，细菌核黄素核糖开关 (bacterial riboflavin riboswitches) 抑制剂。
T15829	L 888607 Racemate	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	L 888607 Racemate is a selective antagonist of prostaglandin D2 receptor subtype 1 (DP1) (Kis: 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively).
T70953	AZ5576 racemate
	AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage a...
T10481	BAY 73-6691 racemate	Others	Others
	BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor.
T22258	(S)-AMG-510	Ras	GPCR/G Protein; MAPK
	(S)-AMG-510 是 AMG-510 的 S型化合物，是 KRAS G12C 的强效共价抑制剂，具有潜在的抗肿瘤活性。
T72707	(Rac)-Lonafarnib Sch66336 racemate
	(Rac)-Lonafarnib (Sch66336外消旋体) 作为Lonafarnib的外消旋体，属于一种口服有效的法尼基蛋白转移酶 (FPTase) 抑制剂，针对H-ras、K-ras及N-ras展现出杰出的抑制效能，其IC50值分别为1.9 nM、5.2 nM和2.8 nM。此外，Lonafarnib还显示出对抗肝炎三角洲病毒 (HDV) 的潜在活性。

化合物

ELN318463 racemate

Cat.No: T11178L

Synonym: ELN318463 (racemate),ELN 318463 racemate

Target: Gamma-secretase

BPO-27 racemate

Cat.No: T10591

Synonym: BPO-27 (racemate)

Target: CFTR, Autophagy

Atuveciclib Racemate

Cat.No: T10464L

Synonym: BAY-1143572 Racemate,阿维西利

Target: CDK

Rentiapril racemate

Cat.No: T16731

Synonym: (Rac)-SA-446,SA-446 racemate,(Rac)-Rentiapril

Target: Angiotensin-converting Enzyme (ACE)

Peliglitazar racemate

Cat.No: T12400

Synonym: (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate

Target: PPAR

CAY10471 Racemate

Cat.No: T7359

Synonym: TM30089 Racemate,3-[[(4-氟苯基)磺酰基]甲基氨基]-1,2,3,4-四氢-9H-咔唑-9-乙酸

Target: GPR, Prostaglandin Receptor

Tetrabenazine Racemate

Cat.No: T3534

Synonym: Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE

Target: Monoamine Transporter

Necrostatin 2 racemate

Cat.No: T7504

Synonym: 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate

Target: RIP kinase

MK-4827 Racemate

Cat.No: T22988

Synonym: Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide

Target: PARP

WAY127093B racemate

Cat.No: T13331

Target: PDE

LY 344864 racemate

Cat.No: T2344L

Target: 5-HT Receptor

Nexopamil racemate

Cat.No: T12215

Synonym: (Rac)-Nexopamil

Target: Calcium Channel, 5-HT Receptor

BTZ043 Racemate

Cat.No: T6425

Synonym: BTZ044,BTZ10526038,Benzothiazinone 10526038

Target: Antibacterial, DprE1

Cat.No: T5054

Synonym: GSK963 (Racemate)

Target: RIP kinase

CPI-169 racemate

Cat.No: T6809

Synonym: CPI 169,CPI-169,CPI169

Target: Epigenetic Reader Domain, Histone Methyltransferase

VPC-80051 racemate

Cat.No: T9005

Target: Others

Bay 41-4109 racemate

Cat.No: T3449

Target: HBV

RSV604 racemate

Cat.No: T72753

Synonym: A-60444 racemate

Mavoglurant racemate

Cat.No: T11951

Synonym: AFQ-056 racemate

Target: Others

Seviteronel racemate

Cat.No: T13313

Synonym: VT-464 (racemate)

Target: Others

Derazantinib Racemate

Cat.No: T10997

Synonym: ARQ-087 Racemate

Target: Others

Litronesib Racemate

Cat.No: T11859

Synonym: LY-2523355 Racemate,KF-89617 Racemate

Target: Others

Veledimex racemate

Cat.No: T13293

Synonym: RG-115932 racemate,INXN-1001 racemate

Target: Others

Pemafibrate (racemate)

Cat.No: T13814

Synonym: K13675 (racemate)

Target: Others

Taranabant racemate

Cat.No: T13081

Synonym: MK-0364 racemate

Target: Cannabinoid Receptor

Ibrutinib Racemate

Cat.No: T16440

Synonym: PCI-32765 (Racemate)

Target: Others

SPM-242 racemate

Cat.No: T24822

Synonym: SPM 242 racemate,SPM242 racemate

KUL-7211 racemate

Cat.No: T11786

Synonym: KUL 7211 racemate

Target: Adrenergic Receptor

Nosantine racemate

Cat.No: T12245

Synonym: 诺次黄嘌呤外消旋体,NPT-15392 racemate

Target: IL Receptor

SCH 42495 racemate

Cat.No: T12866

Synonym: SCH 42495 (racemate)

Target: Others

PX20606 trans racemate

Cat.No: T12583

Synonym: PX-102 trans racemate

Target: Others

GDC-0927 Racemate

Cat.No: T13700

Synonym: SRN-927 Racemate

Target: Others

GNE-140 racemate

Cat.No: T13450L

Synonym: GNE-140 (racemate)

Target: Others

Cobimetinib racemate

Cat.No: T22677

Synonym: Cobimetinib (racemate),考比替尼 (外消旋体)

Target: MEK

Naveglitazar racemate

Cat.No: T12185

Target: Others

Implitapide Racemate

Cat.No: T10504

Target: Others

INCB054329 Racemate

Cat.No: T11649

Target: Others

DHMEQ racemate

Cat.No: T11018

Synonym: rel-DHMEQ

Target: NF-κB

BAY-678 racemate

Cat.No: T19202

Target: Others

Streptonigrin (racemate)

Cat.No: T71483

RP 73163 Racemate

Cat.No: T12768

Target: Others

CAL-130 Racemate

Cat.No: T10660L2

Target: PI3K

N-0861 racemate

Cat.No: T12136

Target: AChR

GDC-0834 Racemate

Cat.No: T11378L

Target: Others

Ribocil-C Racemate

Cat.No: T12722

Target: Others

L 888607 Racemate

Cat.No: T15829

Target: Aurora Kinase

AZ5576 racemate

Cat.No: T70953

BAY 73-6691 racemate

Cat.No: T10481

Target: Others

Cat.No: T22258

Target: Ras

(Rac)-Lonafarnib

Cat.No: T72707

Synonym: Sch66336 racemate

Cat. No.	Product Name	Target	Signaling Pathways
T7220	Prohydrojasmon racemate Propyl dihydrojasmonate,茉莉酮,Prohydrojasmon	Others	Others
	Prohydrojasmon racemate (Propyl dihydrojasmonate) 是 Prohydrojasmon 的外消旋体。其中Prohydrojasmon 是合成的植物生长调节剂。
T3801	(Rac)-Byakangelicin 白当归素,Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin	Others	Others
	(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) 是一种 Byakangelicin 的外消旋体，主要分离自 Angelica 属中。其中 Byakangelicin 是醛糖还原酶抑制剂(IC50:6.2 μM)，可用作抗肿瘤剂。
T40080	(±)-Taxifolin (±)-Dihydroquercetin	Antioxidant; Tyrosinase	oxidation-reduction; Proteases/Proteasome
	(±)-Taxifolin ((±)-Dihydroquercetin) 是 Taxifolin 的外消旋体。Taxifolin 是一种常见于洋葱，水飞蓟，法国海洋松树皮和道格拉斯冷杉树皮中的类黄酮，具有抗酪氨酸酶和抗纤维化活性。Taxifolin 对胶原酶具有抑制作用，IC 50 值为 193.3 μM。Taxifolin是一种具有抗氧化能力的自由基清除剂。
T12681	(±)-Vasicine (±)-Peganine	Others	Others
	(±)-Vasicine is the racemate of Vasicine. Vasicine isolated from Peganum harmala seeds, with anti-ulcer activity.
T40803	Isoanthricin (Rac)-Deoxypodophyllotoxin
	Isoanthricin, also known as (Rac)-Deoxypodophyllotoxin, is the racemate form of Deoxypodophyllotoxin, a powerful compound with noteworthy antitumor and anti-inflammatory properties.
T12667	(Rac)-Hesperetin	Others	Others
	(Rac)-Hesperetin is the racemate form of of Hesperetin. Hesperetin is a natural flavanone compound, and it exhibits potent inhibitory effects against human UGT activity, making it a broad-spectrum inhibitor. Furthermore, Hesperetin induces apoptosis through the activation of p38 MAPK.

天然产物

Prohydrojasmon racemate

Cat.No: T7220

Synonym: Propyl dihydrojasmonate,茉莉酮,Prohydrojasmon

Target: Others

(Rac)-Byakangelicin

Cat.No: T3801

Synonym: 白当归素,Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin

Target: Others

Cat.No: T40080

Synonym: (±)-Dihydroquercetin

Target: Antioxidant, Tyrosinase

Cat.No: T12681

Synonym: (±)-Peganine

Target: Others

Cat.No: T40803

Synonym: (Rac)-Deoxypodophyllotoxin

(Rac)-Hesperetin

Cat.No: T12667

Target: Others

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