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53

抑制剂 & 化合物

4

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Cat. No. Product Name Target Signaling Pathways
T8676 FOY 251

Others; Serine/threonin kinase; SARS-CoV Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Others
FOY 251 是一种蛋白酶抑制剂,是具有抗蛋白水解活性的 Camostate 代谢物,能抑制 SARS-CoV-2 的感染。
T2154 MG-132

Z-LLL-al,Z-Leu-Leu-Leu-CHO

Apoptosis; Proteasome; Autophagy Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM),具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂,可诱导凋亡。
T20490 Z-Arg(Z)2-OH

NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine

Others Others
Z-Arg(Z)2-OH 可用于检测螨匀浆中的蛋白水解活性的实验中。
T6941 PI-1840

PI 1840

PARP; Proteasome Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination
PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂,IC50=27nM。
T2122 Ixazomib

艾沙佐米,MLN2238

Proteasome; Caspase; Autophagy Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
Ixazomib (MLN2238) 含硼肽蛋白酶体抑制剂(PI),可抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点,IC50为 3.4 nM,Ki 为 0.93 nM。它还抑制半胱天冬酶样 (β1) 和胰蛋白酶样 (β2) 蛋白水解位点,IC50值为 31和3500 nM。
T2016 MLN9708

Ixazomib Citrate

Proteasome Proteases/Proteasome; Ubiquitination
MLN9708 (Ixazomib Citrate) 抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点 (Ki50=0.93 nM, IC50=3.4 nM/)。 MLN9708 的生物活性形式是水溶液或血浆中的 MLN2238。
T7675 Substance P (1-7) 2TFA(68060-49-1(free base))

Others Others
Substance P (1-7) 2TFA(68060-49-1(free base)) 是速激肽P(SP)蛋白水解降解后形成的主要生物活性代谢物,具有抗炎、抗伤害和抗痛觉过敏作用。
TP1266 γ-Glu-Phe TFA(7432-24-8 free base)

γ-Glu-Phe TFA(7432-24-8,FREE)

Endogenous Metabolite Metabolism
γ-Glu-Phe TFA(7432-24-8 free base) 是由γ-谷氨酸和苯丙氨酸组成的二肽,是较大蛋白质的蛋白水解分解产物。它可能是由谷胱甘肽与相应氨基酸之间的转肽作用形成的,由γ-谷氨酰转肽酶催化。
T13665 DT2216

Apoptosis; Ligand for E3 Ligase; PROTACs Apoptosis; PROTAC
DT2216 抑制各种 Bcl-XL 依赖性白血病和癌细胞,但对血小板的毒性显着降低。DT2216 是一种选择性 B 细胞淋巴瘤,极大 (BCL-XL),蛋白水解靶向嵌合体 (PROTAC)。DT2216 靶向 bcl-XL 到 Von Hippel-Lindau (VHL) E3 连接酶进行降解。
TP1597L Secretoneurin, rat acetate

Secretoneurin, rat acetate(149146-12-3 Free base)

Others Others
Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽,由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放,它对单核细胞和嗜酸性粒细胞有很强的趋化作用,但对粒细胞没有。
T63790 Cbl-b-IN-3

E1/E2/E3 Enzyme Ubiquitination
Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T3226 Paritaprevir

ABT-450,Veruprevir,帕利瑞韦

HCV Protease Microbiology/Virology; Proteases/Proteasome
Paritaprevir (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂,可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物,由非结构蛋白 3 和 4A (NS3/NS4A) 组成,对 HCV 基因型 1 具有潜在活性。 给药后,paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点,并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成,从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶,对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要,并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒,感染与肝细胞癌 (HCC) 的发展有关。
T32677 Leucylproline

Leu-pro

Leucylproline is a peptide that proteolytic breakdown product by larger proteins.
T37011 Boc-LRR-AMC

Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T69640 MI-1851

MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.
TP1597 Secretoneurin, rat

Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).
T11316 FOY 251 free base

Others Others
FOY 251 free base acts as a proteinase inhibitor. FOY 251 free base is an anti-proteolytic active metabolite camostate.
T78194 Skp2 inhibitor 2

E1/E2/E3 Enzyme Ubiquitination
Skp2 inhibitor 2 (14f)为F-box蛋白S期激酶相关蛋白2(Skp2)的抑制剂,其IC50值为10.2 μM(针对Skp2-Cks1复合体)。该化合物是cullin-RING 连接酶的组成部分,负责招募并使底物泛素化,从而涉及蛋白质的水解和非水解相关过程。
T70280 KB-R7785

KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production.
T38116 Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T76155 Glutamic acid protease

谷氨酸蛋白酶仅存在于真菌中,为一种含谷氨酸残基的蛋白水解酶。
T37697 D-GsMTx4

D-GsMTx4

TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.
T78402 Boc-Gln-Ala-Arg-AMC acetate

Boc-Gln-Ala-Arg-AMC醋酸盐是trypsin的一种荧光底物,主要用于检测TMPRSS2的蛋白水解活性。
T75124 BTK-IN-24

BTK-IN-24 (compound 195) 是一种有效的BTK 抑制剂,通过泛素蛋白水解途径降解BTK。
TP1664 Proinsulin C-Peptide (55-89), human

Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-peptide.
T76145 Clostripain

Clostripain(Clostridiopeptidase B)为源自Clostridium histolyticum的蛋白质水解酶,展现酯酶、酰胺酶及蛋白酶活性,特异性高,针对精氨酸羧基肽键。
TP1514 α-Neoendorphin (1-8)

α-Neoendorphin 1-8

α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide and is a part for the neoendorphins which are a group of endogenous opioid peptides derived from the proteolytic c
T7396 Substance P(1-7)

Substance P 1-7

Others; Neurokinin receptor GPCR/G Protein; Neuroscience; Others
Substance P(1-7) (Substance P 1-7) 是神经肽P 物质的片段,可对孤束核产生抑制和缓和作用,具有抗炎、抗伤害和抗痛觉过敏的作用。
TP1864 [Glu1]-Fibrinopeptide B

[Glu1]-纤维蛋白肽B

[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts.
T74173 PROTAC PARP/EGFR ligand 1

PROTACPARP/EGFR ligand 1 是一种活性化合物,可通过蛋白水解靶向嵌合体(PROTAC)技术用于合成双 PARPEGFR 降解剂的合成。
T37418 Z-LLL-AMC

Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment.
T80076 Ac-ESMD-CHO

Casein Kinase Metabolism; Stem Cells
Ac-ESMD-CHO是一种抑制caspase-3和caspase-7的化合物。该化合物能有效阻止caspase-3前体肽(CPP32)在Glu-Ser-Met-Asp(ESMD)位点发生的蛋白水解切割作用。
TP1725 Bradykinin (1-5)

Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. Bradykinin (1-5) m
T71420 RO314724

RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.
T77014 Frovocimab

Frovocimab (LY 3015014)为一种人源化IgG4单克隆抗体(mAb),其功能为中和PCSK9,通过抑制PCSK9与LDL受体(LDLR)的结合,促使已结合的PCSK9正常进行蛋白水解切割。
T81372 Proteasome-activating peptide 1

Proteasome-activating peptide 1 是一种肽,其作用是提升胰凝乳蛋白酶样蛋白酶体(proteasome)的催化活性,有效增强体外及细胞培养环境下的蛋白质降解效率。此外,该肽能阻止肌萎缩侧索硬化症(Amyotrophic Lateral Sclerosis, ALS)细胞模型中蛋白质的过度聚集。
T37417 Z-LLE-AMC

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.
T36942 SSAA09E1

SSAA09E1

SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50= 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50= 5.33 μM) but not cathepsin B when used at a concentration of 20 μM. 1.()
T75993 Pepsin A

Pepsin A 是人和猪胃中的主要蛋白酶,是一种类似胃蛋白酶的胃小蛋白水解酶。Pepsin A 有助于脊椎动物胃中食物蛋白质的蛋白质水解。
T36189 CAY10406

CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are 'effector caspases' that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is currently a...
T81838 Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物,通过其裂解引起的荧光强度变化来评估其活性。
T83689 Histatin 8 TFA

Hst-8

Histatin 8是一种唾液抗微生物肽,是histatin 3和histatin 5的蛋白水解片段。针对A. baumannii(包括对colistin敏感或耐药的菌株)在32 µg/ml浓度下显示活性。Histatin 8也对C. albicans和C. tropicalis显示活性(MICs分别为1和5 mg/ml)。
T80239 TFLLRNPNDK-NH2

Thrombin Proteases/Proteasome
TFLLRNPNDK-NH2 是具备生物活性的肽类化合物,作为凝血酶受体激活肽(PAR-1 激动剂肽)能够可逆地与 PAR-1 结合,模拟凝血酶对底物蛋白通过水解作用产生的“束缚配体”。同凝血酶的作用相似,此肽能够增加液体与蛋白质的渗透性。
TP1580 Activated Protein C (390-404), human TFA

The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg
T73701 Urokinase (peptidolytic)

Urokinase peptidolytic (Urokinase-type plasminogen activator) 是一种丝氨酸蛋白酶,是丝氨酸蛋白酶纤溶酶的一种非活性形式(酶原)。纤溶酶的激活可触发蛋白水解级联反应,进而参与血栓溶解或细胞外基质降解,涉及血管疾病和癌症相关研究。
T76243 Proteasome-activating peptide 1 TFA

Proteasome-activating peptide 1 TFA 是一种肽类蛋白酶体激活剂,能显著增强胰凝乳蛋白酶样蛋白酶体的催化活性,进而提升体外及培养环境中的蛋白质水解效率。此外,Proteasome-activating peptide 1 TFA 还能有效阻止肌萎缩侧索硬化症细胞模型内的蛋白质聚集现象。
T78805 AD4

Others Others
AD4是一种青蒿素衍生的PROTACs,具有针对PCLAF的高效降解能力,在RS4;11细胞中的IC50仅为0.6 nM。通过激活p21/Rb轴,AD4展现出明显的抗肿瘤活性。此外,AD4在NOD/SCID小鼠移植的RS4;11模型中显著延长了生存时间,证实了其体内疗效。
T76119 Rennin

Rennin(亦称Chymosin)是一种蛋白水解酶,与胃蛋白酶有关,其由部分动物胃细胞合成。该酶特异性针对其天然底物K-酪蛋白,在氨基酸残基105和106、苯丙氨酸与甲硫氨酸间的肽键处进行切割,使液态奶转化为半固体状,以便在胃中停留更久,广泛应用于奶酪生产中。
T82252 GTPγS tetralithium

GTPγS (tetralithium) 是一种G蛋白激活剂,能够通过酪氨酸激酶依赖性机制刺激GLUT4的转位,并促进磷脂酶活化和肌动蛋白的聚合,从而可以作为蛋白质抑制蛋白酶介导降解的保护剂。此外,GTPγS (tetralithium) 在研究G蛋白α亚单位功能和激酶活性时可以与其结合使用,并可用作裂解缓冲液中的一个组分。
T75775 Compstatin TFA

Compstatin TFA是一种含有13个残基的环肽,作为补体系统C3的高效抑制剂,显示出物种特异性。该化合物能够结合到狒狒的C3上,并抵抗狒狒血液中的蛋白质水解裂解(与人类相似)。Compstatin TFA专一性地抑制灵长类动物的补体系统激活。其对补体经典途径和旁路途径的IC50值分别为63μM和12μM。

化合物

FOY 251
Cat.No: T8676
Synonym:
Target: Others, Serine/threonin kinase, SARS-CoV
MG-132
Cat.No: T2154
Synonym: Z-LLL-al,Z-Leu-Leu-Leu-CHO
Target: Apoptosis, Proteasome, Autophagy
Z-Arg(Z)2-OH
Cat.No: T20490
Synonym: NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine
Target: Others
PI-1840
Cat.No: T6941
Synonym: PI 1840
Target: PARP, Proteasome
Ixazomib
Cat.No: T2122
Synonym: 艾沙佐米,MLN2238
Target: Proteasome, Caspase, Autophagy
MLN9708
Cat.No: T2016
Synonym: Ixazomib Citrate
Target: Proteasome
Substance P (1-7) 2TFA(68060-49-1(free base))
Cat.No: T7675
Synonym:
Target: Others
γ-Glu-Phe TFA(7432-24-8 free base)
Cat.No: TP1266
Synonym: γ-Glu-Phe TFA(7432-24-8,FREE)
Target: Endogenous Metabolite
DT2216
Cat.No: T13665
Synonym:
Target: Apoptosis, Ligand for E3 Ligase, PROTACs
Secretoneurin, rat acetate
Cat.No: TP1597L
Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)
Target: Others
Cbl-b-IN-3
Cat.No: T63790
Synonym:
Target: E1/E2/E3 Enzyme
Paritaprevir
Cat.No: T3226
Synonym: ABT-450,Veruprevir,帕利瑞韦
Target: HCV Protease
Leucylproline
Cat.No: T32677
Synonym: Leu-pro
Target:
Boc-LRR-AMC
Cat.No: T37011
Synonym:
Target:
MI-1851
Cat.No: T69640
Synonym:
Target:
Secretoneurin, rat
Cat.No: TP1597
Synonym:
Target:
FOY 251 free base
Cat.No: T11316
Synonym:
Target: Others
Skp2 inhibitor 2
Cat.No: T78194
Synonym:
Target: E1/E2/E3 Enzyme
KB-R7785
Cat.No: T70280
Synonym:
Target:
Fmoc-Ala-Glu-Asn-Lys-NH2
Cat.No: T38116
Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2
Target:
Glutamic acid protease
Cat.No: T76155
Synonym:
Target:
D-GsMTx4
Cat.No: T37697
Synonym: D-GsMTx4
Target:
Boc-Gln-Ala-Arg-AMC acetate
Cat.No: T78402
Synonym:
Target:
BTK-IN-24
Cat.No: T75124
Synonym:
Target:
Proinsulin C-Peptide (55-89), human
Cat.No: TP1664
Synonym:
Target:
Clostripain
Cat.No: T76145
Synonym:
Target:
α-Neoendorphin (1-8)
Cat.No: TP1514
Synonym: α-Neoendorphin 1-8
Target:
Substance P(1-7)
Cat.No: T7396
Synonym: Substance P 1-7
Target: Others, Neurokinin receptor
[Glu1]-Fibrinopeptide B
Cat.No: TP1864
Synonym: [Glu1]-纤维蛋白肽B
Target:
PROTAC PARP/EGFR ligand 1
Cat.No: T74173
Synonym:
Target:
Z-LLL-AMC
Cat.No: T37418
Synonym:
Target:
Ac-ESMD-CHO
Cat.No: T80076
Synonym:
Target: Casein Kinase
Bradykinin (1-5)
Cat.No: TP1725
Synonym:
Target:
RO314724
Cat.No: T71420
Synonym:
Target:
Frovocimab
Cat.No: T77014
Synonym:
Target:
Proteasome-activating peptide 1
Cat.No: T81372
Synonym:
Target:
Z-LLE-AMC
Cat.No: T37417
Synonym:
Target:
SSAA09E1
Cat.No: T36942
Synonym: SSAA09E1
Target:
Pepsin A
Cat.No: T75993
Synonym:
Target:
CAY10406
Cat.No: T36189
Synonym:
Target:
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
Cat.No: T81838
Synonym:
Target:
Histatin 8 TFA
Cat.No: T83689
Synonym: Hst-8
Target:
TFLLRNPNDK-NH2
Cat.No: T80239
Synonym:
Target: Thrombin
Activated Protein C (390-404), human TFA
Cat.No: TP1580
Synonym:
Target:
Urokinase (peptidolytic)
Cat.No: T73701
Synonym:
Target:
Proteasome-activating peptide 1 TFA
Cat.No: T76243
Synonym:
Target:
AD4
Cat.No: T78805
Synonym:
Target: Others
Rennin
Cat.No: T76119
Synonym:
Target:
GTPγS tetralithium
Cat.No: T82252
Synonym:
Target:
Compstatin TFA
Cat.No: T75775
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T13827 Pronase E (Activity ≥ 7000 U/g)

Pronase,Pronase E

Others Others
Pronase E 是一种蛋白水解酶混合物,从灰色链霉菌 (Streptomyces griseus) 中获得,能够将蛋白质消化成单个氨基酸。
T1614 Hydrocortisone

氢化可的松,Cortisol

Glucocorticoid Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Hydrocortisone (Cortisol) 是一种糖皮质激素,由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体,可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄,并抑制免疫和炎症反应。
T64812 Collagenase Type I

Collagenase I,Collagenase Type I (From microorganisms)

Others Others
Collagenase Type I 是一种蛋白水解酶,能分解胶原蛋白中的肽键(胶原蛋白是结缔组织的主要结构蛋白)。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质,从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组,潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。
TN4046 Excisanin A

MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...

天然产物

Pronase E (Activity ≥ 7000 U/g)
Cat.No: T13827
Synonym: Pronase,Pronase E
Target: Others
Hydrocortisone
Cat.No: T1614
Synonym: 氢化可的松,Cortisol
Target: Glucocorticoid Receptor, Endogenous Metabolite
Collagenase Type I
Cat.No: T64812
Synonym: Collagenase I,Collagenase Type I (From microorganisms)
Target: Others
Excisanin A
Cat.No: TN4046
Synonym:
Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK
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