53
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8676 |
FOY 251
|
Others; Serine/threonin kinase; SARS-CoV | Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Others |
FOY 251 是一种蛋白酶抑制剂,是具有抗蛋白水解活性的 Camostate 代谢物,能抑制 SARS-CoV-2 的感染。 | |||
T2154 |
MG-132
Z-LLL-al,Z-Leu-Leu-Leu-CHO |
Apoptosis; Proteasome; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM),具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂,可诱导凋亡。 | |||
T20490 |
Z-Arg(Z)2-OH
NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine |
Others | Others |
Z-Arg(Z)2-OH 可用于检测螨匀浆中的蛋白水解活性的实验中。 | |||
T6941 |
PI-1840
PI 1840 |
PARP; Proteasome | Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination |
PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂,IC50=27nM。 | |||
T2122 |
Ixazomib
艾沙佐米,MLN2238 |
Proteasome; Caspase; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
Ixazomib (MLN2238) 含硼肽蛋白酶体抑制剂(PI),可抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点,IC50为 3.4 nM,Ki 为 0.93 nM。它还抑制半胱天冬酶样 (β1) 和胰蛋白酶样 (β2) 蛋白水解位点,IC50值为 31和3500 nM。 | |||
T2016 |
MLN9708
Ixazomib Citrate |
Proteasome | Proteases/Proteasome; Ubiquitination |
MLN9708 (Ixazomib Citrate) 抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点 (Ki50=0.93 nM, IC50=3.4 nM/)。 MLN9708 的生物活性形式是水溶液或血浆中的 MLN2238。 | |||
T7675 |
Substance P (1-7) 2TFA(68060-49-1(free base))
|
Others | Others |
Substance P (1-7) 2TFA(68060-49-1(free base)) 是速激肽P(SP)蛋白水解降解后形成的主要生物活性代谢物,具有抗炎、抗伤害和抗痛觉过敏作用。 | |||
TP1266 |
γ-Glu-Phe TFA(7432-24-8 free base)
γ-Glu-Phe TFA(7432-24-8,FREE) |
Endogenous Metabolite | Metabolism |
γ-Glu-Phe TFA(7432-24-8 free base) 是由γ-谷氨酸和苯丙氨酸组成的二肽,是较大蛋白质的蛋白水解分解产物。它可能是由谷胱甘肽与相应氨基酸之间的转肽作用形成的,由γ-谷氨酰转肽酶催化。 | |||
T13665 |
DT2216
|
Apoptosis; Ligand for E3 Ligase; PROTACs | Apoptosis; PROTAC |
DT2216 抑制各种 Bcl-XL 依赖性白血病和癌细胞,但对血小板的毒性显着降低。DT2216 是一种选择性 B 细胞淋巴瘤,极大 (BCL-XL),蛋白水解靶向嵌合体 (PROTAC)。DT2216 靶向 bcl-XL 到 Von Hippel-Lindau (VHL) E3 连接酶进行降解。 | |||
TP1597L |
Secretoneurin, rat acetate
Secretoneurin, rat acetate(149146-12-3 Free base) |
Others | Others |
Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽,由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放,它对单核细胞和嗜酸性粒细胞有很强的趋化作用,但对粒细胞没有。 | |||
T63790 |
Cbl-b-IN-3
|
E1/E2/E3 Enzyme | Ubiquitination |
Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。 | |||
T3226 |
Paritaprevir
ABT-450,Veruprevir,帕利瑞韦 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Paritaprevir (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂,可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物,由非结构蛋白 3 和 4A (NS3/NS4A) 组成,对 HCV 基因型 1 具有潜在活性。 给药后,paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点,并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成,从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶,对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要,并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒,感染与肝细胞癌 (HCC) 的发展有关。 | |||
T32677 |
Leucylproline
Leu-pro |
||
Leucylproline is a peptide that proteolytic breakdown product by larger proteins. | |||
T37011 |
Boc-LRR-AMC
|
||
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | |||
T69640 |
MI-1851
|
||
MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells. | |||
TP1597 |
Secretoneurin, rat
|
||
Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII). | |||
T11316 | FOY 251 free base | Others | Others |
FOY 251 free base acts as a proteinase inhibitor. FOY 251 free base is an anti-proteolytic active metabolite camostate. | |||
T78194 |
Skp2 inhibitor 2
|
E1/E2/E3 Enzyme | Ubiquitination |
Skp2 inhibitor 2 (14f)为F-box蛋白S期激酶相关蛋白2(Skp2)的抑制剂,其IC50值为10.2 μM(针对Skp2-Cks1复合体)。该化合物是cullin-RING 连接酶的组成部分,负责招募并使底物泛素化,从而涉及蛋白质的水解和非水解相关过程。 | |||
T70280 |
KB-R7785
|
||
KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production. | |||
T38116 |
Fmoc-Ala-Glu-Asn-Lys-NH2
Fmoc-Ala-Glu-Asn-Lys-NH2 |
||
Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1]. | |||
T76155 | Glutamic acid protease | ||
谷氨酸蛋白酶仅存在于真菌中,为一种含谷氨酸残基的蛋白水解酶。 | |||
T37697 |
D-GsMTx4
D-GsMTx4 |
||
TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion. | |||
T78402 |
Boc-Gln-Ala-Arg-AMC acetate
|
||
Boc-Gln-Ala-Arg-AMC醋酸盐是trypsin的一种荧光底物,主要用于检测TMPRSS2的蛋白水解活性。 | |||
T75124 | BTK-IN-24 | ||
BTK-IN-24 (compound 195) 是一种有效的BTK 抑制剂,通过泛素蛋白水解途径降解BTK。 | |||
TP1664 |
Proinsulin C-Peptide (55-89), human
|
||
Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-peptide. | |||
T76145 | Clostripain | ||
Clostripain(Clostridiopeptidase B)为源自Clostridium histolyticum的蛋白质水解酶,展现酯酶、酰胺酶及蛋白酶活性,特异性高,针对精氨酸羧基肽键。 | |||
TP1514 |
α-Neoendorphin (1-8)
α-Neoendorphin 1-8 |
||
α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide and is a part for the neoendorphins which are a group of endogenous opioid peptides derived from the proteolytic c | |||
T7396 |
Substance P(1-7)
Substance P 1-7 |
Others; Neurokinin receptor | GPCR/G Protein; Neuroscience; Others |
Substance P(1-7) (Substance P 1-7) 是神经肽P 物质的片段,可对孤束核产生抑制和缓和作用,具有抗炎、抗伤害和抗痛觉过敏的作用。 | |||
TP1864 |
[Glu1]-Fibrinopeptide B
[Glu1]-纤维蛋白肽B |
||
[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts. | |||
T74173 |
PROTAC PARP/EGFR ligand 1
|
||
PROTACPARP/EGFR ligand 1 是一种活性化合物,可通过蛋白水解靶向嵌合体(PROTAC)技术用于合成双 PARPEGFR 降解剂的合成。 | |||
T37418 |
Z-LLL-AMC
|
||
Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment. | |||
T80076 |
Ac-ESMD-CHO
|
Casein Kinase | Metabolism; Stem Cells |
Ac-ESMD-CHO是一种抑制caspase-3和caspase-7的化合物。该化合物能有效阻止caspase-3前体肽(CPP32)在Glu-Ser-Met-Asp(ESMD)位点发生的蛋白水解切割作用。 | |||
TP1725 |
Bradykinin (1-5)
|
||
Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. Bradykinin (1-5) m | |||
T71420 | RO314724 | ||
RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants. | |||
T77014 | Frovocimab | ||
Frovocimab (LY 3015014)为一种人源化IgG4单克隆抗体(mAb),其功能为中和PCSK9,通过抑制PCSK9与LDL受体(LDLR)的结合,促使已结合的PCSK9正常进行蛋白水解切割。 | |||
T81372 |
Proteasome-activating peptide 1
|
||
Proteasome-activating peptide 1 是一种肽,其作用是提升胰凝乳蛋白酶样蛋白酶体(proteasome)的催化活性,有效增强体外及细胞培养环境下的蛋白质降解效率。此外,该肽能阻止肌萎缩侧索硬化症(Amyotrophic Lateral Sclerosis, ALS)细胞模型中蛋白质的过度聚集。 | |||
T37417 |
Z-LLE-AMC
|
||
Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment. | |||
T36942 |
SSAA09E1
SSAA09E1 |
||
SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50= 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50= 5.33 μM) but not cathepsin B when used at a concentration of 20 μM. 1.() | |||
T75993 | Pepsin A | ||
Pepsin A 是人和猪胃中的主要蛋白酶,是一种类似胃蛋白酶的胃小蛋白水解酶。Pepsin A 有助于脊椎动物胃中食物蛋白质的蛋白质水解。 | |||
T36189 |
CAY10406
|
||
CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are 'effector caspases' that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is currently a... | |||
T81838 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
|
||
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物,通过其裂解引起的荧光强度变化来评估其活性。 | |||
T83689 |
Histatin 8 TFA
Hst-8 |
||
Histatin 8是一种唾液抗微生物肽,是histatin 3和histatin 5的蛋白水解片段。针对A. baumannii(包括对colistin敏感或耐药的菌株)在32 µg/ml浓度下显示活性。Histatin 8也对C. albicans和C. tropicalis显示活性(MICs分别为1和5 mg/ml)。 | |||
T80239 |
TFLLRNPNDK-NH2
|
Thrombin | Proteases/Proteasome |
TFLLRNPNDK-NH2 是具备生物活性的肽类化合物,作为凝血酶受体激活肽(PAR-1 激动剂肽)能够可逆地与 PAR-1 结合,模拟凝血酶对底物蛋白通过水解作用产生的“束缚配体”。同凝血酶的作用相似,此肽能够增加液体与蛋白质的渗透性。 | |||
TP1580 |
Activated Protein C (390-404), human TFA
|
||
The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg | |||
T73701 | Urokinase (peptidolytic) | ||
Urokinase peptidolytic (Urokinase-type plasminogen activator) 是一种丝氨酸蛋白酶,是丝氨酸蛋白酶纤溶酶的一种非活性形式(酶原)。纤溶酶的激活可触发蛋白水解级联反应,进而参与血栓溶解或细胞外基质降解,涉及血管疾病和癌症相关研究。 | |||
T76243 |
Proteasome-activating peptide 1 TFA
|
||
Proteasome-activating peptide 1 TFA 是一种肽类蛋白酶体激活剂,能显著增强胰凝乳蛋白酶样蛋白酶体的催化活性,进而提升体外及培养环境中的蛋白质水解效率。此外,Proteasome-activating peptide 1 TFA 还能有效阻止肌萎缩侧索硬化症细胞模型内的蛋白质聚集现象。 | |||
T78805 |
AD4
|
Others | Others |
AD4是一种青蒿素衍生的PROTACs,具有针对PCLAF的高效降解能力,在RS4;11细胞中的IC50仅为0.6 nM。通过激活p21/Rb轴,AD4展现出明显的抗肿瘤活性。此外,AD4在NOD/SCID小鼠移植的RS4;11模型中显著延长了生存时间,证实了其体内疗效。 | |||
T76119 | Rennin | ||
Rennin(亦称Chymosin)是一种蛋白水解酶,与胃蛋白酶有关,其由部分动物胃细胞合成。该酶特异性针对其天然底物K-酪蛋白,在氨基酸残基105和106、苯丙氨酸与甲硫氨酸间的肽键处进行切割,使液态奶转化为半固体状,以便在胃中停留更久,广泛应用于奶酪生产中。 | |||
T82252 |
GTPγS tetralithium
|
||
GTPγS (tetralithium) 是一种G蛋白激活剂,能够通过酪氨酸激酶依赖性机制刺激GLUT4的转位,并促进磷脂酶活化和肌动蛋白的聚合,从而可以作为蛋白质抑制蛋白酶介导降解的保护剂。此外,GTPγS (tetralithium) 在研究G蛋白α亚单位功能和激酶活性时可以与其结合使用,并可用作裂解缓冲液中的一个组分。 | |||
T75775 |
Compstatin TFA
|
||
Compstatin TFA是一种含有13个残基的环肽,作为补体系统C3的高效抑制剂,显示出物种特异性。该化合物能够结合到狒狒的C3上,并抵抗狒狒血液中的蛋白质水解裂解(与人类相似)。Compstatin TFA专一性地抑制灵长类动物的补体系统激活。其对补体经典途径和旁路途径的IC50值分别为63μM和12μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13827 |
Pronase E (Activity ≥ 7000 U/g)
Pronase,Pronase E |
Others | Others |
Pronase E 是一种蛋白水解酶混合物,从灰色链霉菌 (Streptomyces griseus) 中获得,能够将蛋白质消化成单个氨基酸。 | |||
T1614 |
Hydrocortisone
氢化可的松,Cortisol |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Hydrocortisone (Cortisol) 是一种糖皮质激素,由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体,可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄,并抑制免疫和炎症反应。 | |||
T64812 |
Collagenase Type I
Collagenase I,Collagenase Type I (From microorganisms) |
Others | Others |
Collagenase Type I 是一种蛋白水解酶,能分解胶原蛋白中的肽键(胶原蛋白是结缔组织的主要结构蛋白)。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质,从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组,潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。 | |||
TN4046 | Excisanin A | MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ... |