36
16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24557 |
NSC756093
NSC-756093,NSC 756093 |
Others | Others |
NSC756093 可能抑制 GBP1:PIM1 相互作用。 NSC756093 可用于卵巢癌研究。 | |||
T6207 |
SC144
|
Apoptosis; Interleukin | Apoptosis; Immunology/Inflammation |
SC144 是一种口服活性 gp130 抑制剂。它结合 gp130,诱导 gp130 磷酸化(S782) 和去糖基化,消除 Stat3 磷酸化和核易位,进一步抑制下游靶基因的表达。它对 gp130 配体触发的信号转导有明显的抑制作用,可诱导人卵巢癌细胞凋亡。 | |||
T2679 |
BMS-265246
BMS265246 |
CDK | Cell Cycle/Checkpoint |
BMS-265246 是一种有效的选择性 CDK1/2 抑制剂,对 CDK1/cyclin B 和 CDK2/cyclin E 的 IC50分别为6 nM 和9 nM。 | |||
T2617 |
SNS-314 Mesylate
SNS-314 |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
SNS-314 Mesylate (SNS-314) 是一种有效且特异性的极光激酶抑制剂,对极光激酶 A、B、C 的 IC50值分别为 9,31 和 3 nM。 | |||
T34262 |
RAPTA-C
|
Apoptosis | Apoptosis |
RAPTA-C 可通过线粒体和 p53-JNK 途径诱导 EAC 细胞周期停滞和凋亡,可用于研究乳腺癌和卵巢癌。 | |||
T12238 |
NNC 55-0396
NNC 55-0396 dihydrochloride |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
NNC 55-0396 是一种高特异性的 T 型钙通道阻滞剂,IC50 为 6.8 μM。 NNC 55-0396 可用于预防人类卵巢癌细胞增殖的研究。 | |||
T67741 |
SU056
|
Others | Others |
SU056 是一种 YB-1 抑制剂,可以抑制与其相关的下游蛋白质和通路。SU056 可以诱导卵巢癌细胞周期停滞、凋亡 (apoptosis),并抑制癌细胞迁移。SU056 可增强紫杉醇的细胞毒性。 | |||
T16680 |
PTC-028
|
Apoptosis; BMI-1 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
PTC-028 是一种口服有效的干细胞因子 BMI-1的抑制剂,可下调 BMI-1,诱导 caspase 介导的细胞凋亡。它选择性地抑制癌细胞,可用于治疗卵巢癌。 | |||
T60039 |
KSQ-4279
USP1-IN-1 |
PARP; DUB | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination |
KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性,可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。 | |||
T8464 |
RA-9
|
Apoptosis; DUB | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
RA-9 是一种高选择性蛋白酶体相关的 DUBs 抑制剂,具有良好的毒性和抗癌活性。它阻断泛素依赖性蛋白降解而不影响 20S 蛋白酶体蛋白水解活性。它诱导卵巢癌细胞内质网应激反应,选择性诱导卵巢癌细胞株和供体原代培养细胞凋亡。 | |||
T16328 |
Nitroaspirin
2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物,与 Aspirin 结合可抑制环氧合酶=,可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白,显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡,具有抗血栓和抗血小板特性。 | |||
T36674 |
DMU-212
|
Apoptosis; ERK | Apoptosis; MAPK |
DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物,表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。 | |||
T71998 |
673-A
|
||
673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). 673-A also overcomes chemotherapy resistance in vivo. | |||
T24879 |
Thioxodihydroquinazolinone-19
Thioxodihydroquinazolinone19 |
||
In platinum-resistant A2780cis human ovarian cancer cells, thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisplatin. | |||
T36700 | CKD 602 | ||
Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo. | |||
TP1427 |
ReACp53
|
||
ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). | |||
T41070 |
LP-184
|
||
LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, and pancreatic. | |||
T21324 |
R306465
R-306465,JNJ 16241199,R 306465,JNJ-16241199,JNJ16241199 |
||
R306465 is a potent inhibitor of HDAC1 and -8 (class I) in vitro. It potently inhibited cell proliferation of all main solid tumour indications, including colon, ovarian, breast, lung and prostate cancer cell lines with IC50 values ranging from 30 to 300 | |||
T15723 | LBW242 | Others | Others |
LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells. LBW242 displays effec | |||
T79315 |
PROTAC TG2 degrader-2
|
PROTACs | PROTAC |
PROTACTG2 degrader-2(compound 7)是一种针对Transglutaminase 2(TG2)的选择性竞争性降解剂,其Kd值大于100 μM。该化合物能有效抑制卵巢癌细胞的迁移,并降低其TG2表达水平,因此可作为卵巢癌研究的工具。 | |||
T36449 |
(S)-α-Methylbenzyl Ricinoleamide
|
||
(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 μM. | |||
T71549 |
RKS-262
|
||
RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50): ~ 10 nM) while several... | |||
T71099 |
LLL12
|
||
LLL12 是一种 STAT3小分子抑制剂,抑制 STAT3磷酸化。LLL12 增强顺铂 和紫杉醇 对卵巢癌症细胞生成、迁徙、和生长的抑制作用。 | |||
T71218 | AEZS-112 | ||
AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cytotoxic effect was least pronounced in G2 phase of the cell cycle, indicating cell death during mitosis, as detd. by FACS anal. AEZS 112 showed anti-tumor activity in human ovarian and endometrial cancer cell lines at low micromolar concns., which could not be abrogated by caspase ... | |||
T78296 |
IMAB027
ASP1650 |
||
IMAB027 (ASP1650)是针对CLDN6 (Claudin 6)的特异性单克隆抗体,CLDN6作为一种紧密连接蛋白,其在多种人类癌症中异常高表达,尤其显著于卵巢癌。IMAB027展现出抗肿瘤特性,并能诱导表达CLDN6的卵巢癌和睾丸癌细胞走向凋亡。 | |||
T71287 |
CDKI-83
|
||
CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be devel... | |||
T82605 |
DB21, Galectin-1 Antagonist
|
Galectin | Immunology/Inflammation |
DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中,该化合物能增强血管生成和肿瘤生长的抑制效果。 | |||
T69055 |
PD153035 nitrate
|
||
PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also... | |||
T83938 |
TAT-PDHPS1
|
||
TAT-PDHPS1是一种针对Yes-associated protein (YAP) 信号的肽抑制剂。它由内源性肽PDHPS1和能穿透细胞的肽序列TAT组成。PDHPS1与蛋白磷酸酶2磷酸酶激活因子(PTPA)结合, 激活蛋白磷酸酶2A (PP2A)。该激活促进YAP的磷酸化和抑制YAP靶向基因的表达。TAT-PDHPS1能够抑制体外卵巢癌细胞的增殖和小鼠皮下异种移植肿瘤模型中的卵巢肿瘤生长。 | |||
T36846 |
Chromomycin A2
|
||
Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It also inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs; IC50s = 4, 0.5, 3, 5, 5, and 8 nM, respective... | |||
T36404 |
PRLX-93936
|
||
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM... | |||
T72630 | BRD4 Inhibitor-25 | ||
BRD4Inhibitor-25 是一种BRD4抑制剂,对BRD4的BD1和BD2结构域的IC50为 0.82 μM,1.94 μM。BRD4Inhibitor-25 在卵巢癌细胞中诱导凋亡和自噬细胞死亡。BRD4Inhibitor-25 可用于癌症、心血管、神经肌肉和炎症性疾病的研究。 | |||
T71811 |
Lobaric acid
|
||
Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the h... | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... | |||
T83921 |
IMCTA-C14 TFA
|
||
IMCTA-C14是一种洗涤剂且是微生物代谢产物4-糖腺苷的衍生物。其临界胶束浓度(CMC)为0.11 mM,亲水亲油平衡(HLB)值为9.72。IMCTA-C14(0.05%和0.5%)能从OVK18卵巢癌细胞提取蛋白质,包括膜蛋白。它对几种不同菌株具有活性(MICs = 8-128 µg/ml),并对52种癌细胞系具有细胞毒性(IC50s = 2.9-29.2 µg/ml)。IMCTA-C14(50 µM)诱导OVK18细胞的自噬。 | |||
T63351 | MS8511 | ||
MS8511 是一种选择性的G9a/GLP 共价的不可逆抑制剂,可靶向底物结合位点的半胱氨酸残基,IC50值为 100 nM ( G9a) 和 140 nM (GLP),Kd 值44 nM (G9a) 和 46 nM (GLP)。 MS8511 可降低细胞内 H3K9me2 水平并提高抗增殖活性。MS8511 可用于研究多种癌症 (包括脑癌、乳腺癌、卵巢癌、肺癌、膀胱癌、黑色素瘤、结肠直肠癌) 和其他疾病,如阿尔茨海默病 (AD)、镰状细胞病、Prader-Willi 综合征 (PWS). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1839 |
Kumatakenin
Jaranol,华良姜素,熊竹素,Kaempferol 3,7-O-dimethyl ether |
Apoptosis; Anti-infection | Apoptosis; Microbiology/Virology |
Kumatakenin 是一种从丁香中分离得到的黄酮类天然产物,可诱导卵巢癌细胞凋亡。 | |||
T5780 |
HYPOCRELLIN B
|
Apoptosis; Parasite; Antifungal | Apoptosis; Microbiology/Virology |
Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料,可用于癌症光动力研究。它是一个凋亡诱导剂,还拥有抗菌和抗利什曼活性。 | |||
T21883 |
Gedunin
|
HSP | Cytoskeletal Signaling; Metabolism |
Gedunin 是从印楝种子中提取的一种重要柠檬苦素,具有抗癌、抗病毒、抗炎和杀虫活性。它可阻断 SARS-CoV-2 病毒进入人宿主细胞,用于 COVID-19 研究。它是Hsp90抑制剂,诱导 Hsp90 依赖的蛋白降解,抑制卵巢癌细胞增殖。 | |||
T35749 |
Thymohydroquinone
Thymoquinol |
Antioxidant; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应,在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml),在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中,它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用,体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
T17155 |
Trabectedin
Ecteinascidin 743,曲贝替定,ET-743 |
Apoptosis; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱,有抗肿瘤的活性, 通过与 DNA 的小沟结合,阻断应激诱导的蛋白质的转录,诱导 DNA 骨架裂解和癌细胞凋亡,并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。 | |||
TN5156 |
Totaradiol
|
NADPH-oxidase | Immunology/Inflammation |
Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line. | |||
TN3383 |
α-Amyrin palmitate
alpha-Amyrin palmitate |
PKA | Tyrosine Kinase/Adaptors |
alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki=6 microM), it also shows weak cytotoxicity against the A2780 human ovarian cancer cell line. | |||
TN3447 |
Arjunglucoside I
|
||
Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM. | |||
TN2913 | 3-Acetoxy-11-ursen-28,13-olide | Phosphatase | Metabolism |
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. | |||
TN2529 |
1-Decarboxy-3-oxo-ceanothic acid
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. It shows cytotoxic against OVCAR-3 and HeLa cancer cell line | |||
TN4168 | Grifolin | Others | Others |
Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs | |||
TN2936 |
3-Hydroxy-11-ursen-28,13-olide
|
Others | Others |
3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-moderate antiproliferative activity ag | |||
TN6524 |
Irilone
|
||
Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiat | |||
TN5474 |
Bonducellin
|
||
Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac | |||
TN3364 |
Agrimonolide
|
Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells |
Agrimonolide 是一种来自异香豆素的化合物,主要存在于草药Agrimonia pilosa Ledeb 中,具有显著的生物活性。Agrimonolide 通过抑制脂多糖(LPS)诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平,可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1,对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是,Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制,同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡,同时增加活性氧(ROS)和总铁的水平。Agrimonolide 很容易穿过血脑屏障,表明其在神经系统疾病的治疗应用方面具有潜力。 |