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59

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40588	Acifluorfen	Others	Others
	Acifluorfen 是一种除草剂。Acifluorfen 是一种原卟啉原氧化酶抑制剂，可促进原卟啉 IX 的积累，并诱导啮齿动物肝脏发生肿瘤。它会引起敏感植物物种中的色素和脂质强烈的光氧化破坏。
T0840	Methimazole Tapazole,Thiamazole,甲巯咪唑	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Methimazole (Thiamazole) 是抗甲状腺化合物，具有显著的肝毒性，常用于研究甲亢。
T9054	RO6889678	HBV	Microbiology/Virology
	RO6889678 是高效的 HBV 衣壳结构抑制剂，其吸收、分布、代谢和排泄特征较为复杂。它可通过 CYP3A4 介导的氧化作用进行代谢，以及通过 UDP-葡萄糖醛酸基转移酶 UGT1A3 和 UGT1A1 介导的直接葡萄糖醛酸化作用进行代谢。它是一种诱导剂，可作用于人肝细胞中 CYP3A4 和共调节蛋白。
T2102	FH1 BRD-K4477,NSC 12407	Others	Others
	FH1 (NSC-12407) 可提高肝细胞功能，促进诱导多能干 (iPS) 衍生的肝细胞向更成熟的表型分化，并促使分化良好的肝细胞样细胞 (iHeps) 培养物的成熟。
T27061	CP-24879 hydrochloride CP-24879 HCl	Others	Others
	CP-24879 hydrochloride (CP-24879 HCl) 是选择性的 delta5D/delta6D 联合抑制剂。它能显著降低肝细胞内脂质积聚和炎症损伤。它在脂肪-1 和 ω-3 处理的肝细胞中表现出优越的抗脂肪变性和抗炎作用，可用于非酒精性脂肪性肝炎的研究。
T2292	FPH2 BRD-9424	Others	Others
	FPH2 (BRD-9424) 是促进 iPS 衍生肝细胞分化的小分子。它诱导原代人肝细胞的功能性增殖，有潜质用于研究肝脏疾病的新疗法。
T20887	Atorvastatin Sodium Lipitor	LDL; Aquaporin; HMG-CoA Reductase	Membrane transporter/Ion channel; Metabolism
	Atorvastatin Sodium (Lipitor) 是一种HMG-CoA 还原酶的竞争性抑制剂，增加肝细胞上低密度脂蛋白（LDL）受体的表达。Atorvastatin sodium 处理抑制水汽蛋白4来减轻缺血性脑水肿。
T6506	FPH1 BRD-6125	Others	Others
	FPH1 (BRD-6125) 在体外能够提高人肝原代细胞的活性及数量，并促进 iPS 细胞向肝系分化。
T78791	AMPK activator 12	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	AMPK activator 12 是一种 AMPK 激活剂和 GDF15 诱导剂，能提升人肝细胞内GDF15蛋白的表达水平，可用于研究癌症。
T2172	SQ22536 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536	AChR	Neuroscience
	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) 是一种腺苷酸环化酶抑制剂。
T4353	SR-18292 SR 18292	Autophagy	Autophagy; Metabolism
	SR-18292 是一种 PPARγ 共激活因子-1α (PGC-1α) 抑制剂，可增加 PGC-1α 乙酰化，抑制糖异生基因表达并减少肝细胞中的葡萄糖生成。
T19675	SM360320 CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR	Immunology/Inflammation
	SM360320 (CL-087) 是一种有效的特异性 TLR7 激动剂。 SM360320 除了其 IFN 介导的活性外，还通过 I 型 IFN 非依赖性机制抑制肝细胞中的 HCV 复制。 SM360320 可用于研究作为治疗性 DNA 疫苗的免疫佐剂。
T16510	PF-915275	Dehydrogenase	Metabolism
	PF-915275 是口服有效的人 11β-羟基类固醇脱氢酶1型选择性抑制剂，Ki 为 2.3 nM，在 HEK293 细胞中的EC50为 15 nM 。它对人和猴原代肝细胞中可的松向皮质醇的转化具有剂量依赖性，EC50分别为 20 nM 和 100 nM。
T22891	KL001 KL 001,KL-001	Others	Others
	KL001 是一流的隐花色素蛋白 (CRY)稳定剂，可与 CRY1 和 CRY2 特异性相互作用。其中CRY 是一种对蓝光敏感的黄素蛋白，参与调节动植物的昼夜节律。KL001能够防止泛素依赖性 CRY 降解，从而延长了昼夜节律周期，具有控制空腹激素诱导的糖异生的潜力。
T15367	Gadoxetate Disodium Gd-EOB-DTPA Disodium,钆塞酸二钠,ZK 139834	Others	Others
	Gadoxetate Disodium 是一种肝胆系统中磁共振成像 (MRI) 中的造影剂，能够在正常的功能性肝细胞中累积，可用于局灶性肝脏病变（如肝细胞癌或 T1 加权成像的肝转移）的研究。
T67509	Cholesteryl Hemisuccinate Cholesterol hydrogen succinate	Apoptosis; DNA/RNA Synthesis; Topoisomerase	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) 是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物，具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚的肝毒性，并防止 AAP 诱导的肝细胞凋亡和坏死。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶和 DNA 拓扑异构酶，从而抑制 DNA 复制和修复以及细胞分裂。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T28239	Ono 1082 Ono-1082,Ono1082
	Ono 1082 could increase cAMP levels in rat hepatocytes.
T24628	PF-739
	PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.
T34757	Symphytine
	Symphytine is a natural inducer of hepatic tumors. Symphytine interacts with DNA in liver endothelial cells and hepatocytes, resulting in DNA damage, mutation induction, and cancer development.
T36663	Decanoyl-L-carnitine (chloride)
	Decanoyl-L-carnitine is an ester derivative of L-carnitine . It increases the formation of C24 fatty acid intermediates, as well as docosapentaenoic and docosahexaenoic acid in rat hepatocytes.
T16992	Taribavirin hydrochloride	Others	Others
	Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and
T68884	Aplysin
	Aplysin is an antineoplastic agent. Aplysin has been shown to suppress breast cancer cell activity via inhibition of the PI3K/AKT/FOXO3a pathway. Aplysin has also been shown to protect hepatocytes against oxidative damage.
T26005	Pyroglutamylleucine Pglu-leu
	Pyroglutamylleucine is a peptide from wheat gluten hydrolysate which suppresses the induction of inducible nitric oxide synthase in interleukin-1β-stimulated primary cultured rat hepatocytes.
T16993	Taribavirin	Others	Others
	Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he
T19848	Cyclosporin B 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2
	Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also
T36668	Geranylgeranoic Acid
	Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also...
T35448	10-Thiastearic Acid
	Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 μM. This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.
T78783	HBV-IN-35	HBV	Microbiology/Virology
	HBV-IN-35（Compound 88）是具有对小鼠和人肝细胞中HBV抗病毒活性的抑制剂，其EC50值分别为100 nM和400 nM。
T37223	Glucagon Receptor Antagonist I
	Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
TP1520	Hepatitis B Virus Core (128-140) Hepatitis B Virus Core 128-140
	The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during the cell cycle.
T79874	CHK-336
	CHK-336（Example 1）为口服活性LDHA抑制剂（IC50＜1 nM），有效抑制小鼠肝细胞产生乳酸。该化合物适用于高草酸尿症相关研究。
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T73148	ACT-777991
	ACT-777991为一种选择性、口服生效的CXCR3拮抗剂，于动物模型中展现出微粒体及肝细胞稳定性，能抑制活化T细胞向CXCL11迁移。
T83044	Antimalarial agent 33	Parasite	Microbiology/Virology
	Antimalarial agent 33 (compound 5g) 显示针对红细胞期和肝期疟原虫的抗活性，特别是对 K1 恶性疟原虫株，其EC50为1.1 μM。Antimalarial agent 33 还展示出提升的微粒体稳定性（T1/2=29分钟），并且对原代肝细胞未表现出明显的细胞毒效应。
T60294	FBPase-IN-2
	FBPase-IN-2 (HS36) 是一种有效的果糖-1,6-二磷酸酶 (FBPase) 共价抑制剂，IC50值为 0.15 μM。FBPase-IN-2 可减少肝细胞内葡萄糖的产生，可用于二型糖尿病的研究。
T60510	Perhexiline
	Perhexiline 是一种口服活性的 CPT1和 CPT2抑制剂，可降低脂肪酸的代谢。Perhexiline 可以穿过血脑屏障 (BBB)具有抗癌活性。Perhexiline 诱导肝细胞中的线粒体功能障碍和细胞凋亡。因此，Perhexiline 可用于研究癌症和心绞痛等心血管疾病。
T73993	Fazirsiran
	Fazirsiran (ARO-AAT) 是第二代 RNA 干扰 (RNAi) 活性分子。Fazirsiran 由胆固醇偶联的 RNAi 触发器 (chol-RNAi) 组成，通过 RNAi 选择性降解 AAT mRNA，以及与 N-乙酰半乳糖胺 (NAG) 偶联的蜂毒肽衍生肽配制成赋形剂 EX1，促进肝细胞内 chol RNAi 的内体逃逸。
T11606	ICA-105665 PF-04895162	Others	Others
	ICA-105665 (PF-04895162) 是一种有效的口服活性的神经元 Kv7.2/7.3和 Kv7.3/7.5钾通道激动剂。ICA-105665 在人肝细胞中具有低细胞毒性潜力，但抑制肝线粒体功能和胆盐输出蛋白 (BSEP) 转运 (IC50为 311 μM)。ICA-105665 可穿透中枢神经系统 (CNS)并具有抗癫痫作用。
T82289	Glycolate oxidase-IN-1
	Glycolate oxidase-IN-1（化合物26），一种水杨酸衍生物，作为乙醇酸氧化酶 (GO) 抑制剂，展现出38.2 μM的IC50。该化合物能有效降低原发性高草酸尿症 1 型 (PH1) 患者肝细胞中的草酸盐生成，有助于相关疾病的研究。
T61949	Evogliptin
	Evogliptin (DA-1229) 是具有口服活性的DPP4抑制剂。Evogliptin 在小鼠模型中具有显著而持久的降糖效果。Evogliptin 通过诱导自噬抑制肝细胞的纤维化和炎症信号的产生。Evogliptin 可用于 2 型糖尿病、慢性肝脏炎症，骨质疏松症及肾功能损害的研究。
T60629	PF-06649298
	PF-06649298 是一种钠偶联柠檬酸盐转运蛋白抑制剂，可用于调节糖代谢以及脂代谢的研究。PF-06649298 在人类肝细胞中与 NaCT 特异性结合从而抑制柠檬酸盐的转运，IC50值为 16.2 μM。
T68790	Shinorine
	Shinorine, a mycosporine-like amino acid (MAA), is a small molecule sunscreen produced in some bacteria. Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway. Shinorine is also an analogue of porphyra-344. Both porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding. Shinorine may be a useful agent to prevent or retard the progression of multiple degenerative disorders of ageing. S...
T36098	Isovaleryl-L-carnitine (chloride)
	Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated wit...
T83767	4-Hydroxyphenylglyoxylic Acid UK 22486
	4-Hydroxyphenylglyoxylic acid 是一种抑制剂，针对 carnitine palmitoyltransferase 1 (CPT1)，同时也是前药 oxfenicine 的活性代谢物。在 200 至 1,000 µM 的浓度范围内，该化合物能够抑制离体大鼠肝线粒体中的 CPT1，并能够抑制离体大鼠肝细胞中的油酸氧化。
T73616	Glutamate dehydrogenase (NAD(P))
	Glutamate dehydrogenase NAD(P) (GLDH)（谷氨酸脱氢酶 NAD(P)）是一种存在于肝细胞、肾组织、脑、肌肉和肠细胞的线粒体酶，主要应用于生化研究。作为尿素循环的一环，该酶催化谷氨酸的逆向氧化脱氨反应，生成α-酮戊二酸（α-KG）。
T76628	(Met(O)27)-Glucagon (1-29) (human, rat, porcine)
	'(Met(O)27)-Glucagon (1-29) (human, rat, porcine) 为修饰版胰高血糖素。在大鼠肝细胞内，其促进葡萄糖合成的活性虽与天然胰高血糖素相似，但呈现出较低效率，暗示蛋氨酸对于胰高血糖素与其肝脏受体绑定具有关键性作用。'
T74301	PSI-353661
	PSI-353661 (GS-558093) 是一种嘌呤核苷酸类NS5B 聚合酶抑制剂，可抵抗HCV 感染。PSI-353661抑制野生型和 S282T 抵抗性复制子HCV 的EC90s 分别为 8 nM 和 11 nM。PSI-353661 可在人原代肝细胞中产生高浓度的活性三磷酸。
T63866	GSK-3β inhibitor 7
	GSK-3β inhibitor 7 是一种 GSK-3β 抑制剂 (IC50: 5.25 μM)。GSK-3β inhibitor 7 通过插入 GSK-3β 的 ATP-binding binding 口袋并形成氢键发挥作用。GSK-3β inhibitor 7 具有较高的肝细胞葡萄糖摄取率 (83.5%)，能够用于研究癌症、糖尿病、炎症、阿尔茨海默病和双相情感障碍等多种疾病。
T70661	Azalanstat mesylate
	Azalanstat is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low densi...

化合物

Cat.No: T40588

Target: Others

Cat.No: T0840

Synonym: Tapazole,Thiamazole,甲巯咪唑

Target: Thyroid hormone receptor(THR)

Cat.No: T9054

Target: HBV

Cat.No: T2102

Synonym: BRD-K4477,NSC 12407

Target: Others

CP-24879 hydrochloride

Cat.No: T27061

Synonym: CP-24879 HCl

Target: Others

Cat.No: T2292

Synonym: BRD-9424

Target: Others

Atorvastatin Sodium

Cat.No: T20887

Synonym: Lipitor

Target: LDL, Aquaporin, HMG-CoA Reductase

Cat.No: T6506

Synonym: BRD-6125

Target: Others

AMPK activator 12

Cat.No: T78791

Target: AMPK

Cat.No: T2172

Synonym: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536

Target: AChR

Cat.No: T4353

Synonym: SR 18292

Target: Autophagy

Cat.No: T19675

Synonym: CL-087,SM 360320,CL 087,1V136,SM-360320,CL087

Target: TLR

Cat.No: T16510

Target: Dehydrogenase

Cat.No: T22891

Synonym: KL 001,KL-001

Target: Others

Gadoxetate Disodium

Cat.No: T15367

Synonym: Gd-EOB-DTPA Disodium,钆塞酸二钠,ZK 139834

Target: Others

Cholesteryl Hemisuccinate

Cat.No: T67509

Synonym: Cholesterol hydrogen succinate

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

Cat.No: T28239

Synonym: Ono-1082,Ono1082

Cat.No: T24628

Cat.No: T34757

Decanoyl-L-carnitine (chloride)

Cat.No: T36663

Taribavirin hydrochloride

Cat.No: T16992

Target: Others

Cat.No: T68884

Pyroglutamylleucine

Cat.No: T26005

Synonym: Pglu-leu

Cat.No: T16993

Target: Others

Cat.No: T19848

Synonym: 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2

Geranylgeranoic Acid

Cat.No: T36668

10-Thiastearic Acid

Cat.No: T35448

Cat.No: T78783

Target: HBV

Glucagon Receptor Antagonist I

Cat.No: T37223

Hepatitis B Virus Core (128-140)

Cat.No: TP1520

Synonym: Hepatitis B Virus Core 128-140

Cat.No: T79874

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

Cat.No: T73148

Antimalarial agent 33

Cat.No: T83044

Target: Parasite

Cat.No: T60294

Cat.No: T60510

Cat.No: T73993

Cat.No: T11606

Synonym: PF-04895162

Target: Others

Glycolate oxidase-IN-1

Cat.No: T82289

Cat.No: T61949

Cat.No: T60629

Cat.No: T68790

Isovaleryl-L-carnitine (chloride)

Cat.No: T36098

4-Hydroxyphenylglyoxylic Acid

Cat.No: T83767

Synonym: UK 22486

Glutamate dehydrogenase (NAD(P))

Cat.No: T73616

(Met(O)27)-Glucagon (1-29) (human, rat, porcine)

Cat.No: T76628

Cat.No: T74301

GSK-3β inhibitor 7

Cat.No: T63866

Azalanstat mesylate

Cat.No: T70661

Cat. No.	Product Name	Target	Signaling Pathways
T4S0779	D-tetrahydropalmatine	Others; Dopamine Receptor	GPCR/G Protein; Neuroscience; Others
	D-Tetrahydropalmatine 是一种主要存在于延胡索类植物中的异喹啉生物碱。它是有机阳离子转运蛋白 1 抑制剂。它是多巴胺受体拮抗剂，对 D1 受体具有优先亲和力。
T8288	14-Deoxyandrographolide 去氧穿心莲内酯,14-去氧穿心莲内酯	Apoptosis; Others	Apoptosis; Others
	14-Deoxyandrographolide 是穿心莲中的一种天然产物，是一种钙通道阻断剂，具有保肝功效。它通过诱导 TNFRSF1A 的释放，使肝细胞对 TNF-α 介导的凋亡脱敏。
T5254	Glycodeoxycholate Sodium Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt,脱氧甘胆酸钠	Others; Endogenous Metabolite	Metabolism; Others
	Glycodeoxycholate Sodium (Glycodeoxycholic acid sodium salt) 诱导肝细胞凋亡的机制与内切酶的DNA裂解有关。它是一种次级胆汁酸，由结肠环境中微生物菌群中存在的酶的作用产生。
T5S0281	Tubuloside A	NOS	Immunology/Inflammation
	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
T5234	Glycoursodeoxycholic acid Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA	Others; Endogenous Metabolite	Metabolism; Others
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物，是熊去氧胆酸的代谢物。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
TN4388	Kielcorin	Antifection	Microbiology/Virology
	Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
TN3872	Diosbulbin D 山药	ROS	Immunology/Inflammation
	Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.
TN2224	Soyasapogenol A 大豆甾醇A,大豆甾醇 A	TNF	Apoptosis
	Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.
TN2876	3,4-Dihydroxy-2-methoxyxanthone	Antibacterial; Antifection	Microbiology/Virology
	3,4-Dihydroxy-2-methoxyxanthone 显示出抗菌和保肝活性，它能防止叔丁基过氧化氢诱导的新鲜离体大鼠肝细胞的脂质过氧化和细胞死亡，并在一定程度上有效防止细胞谷胱甘肽平衡的扰乱。
TMA0627	Taxiresinol	TNF	Apoptosis
	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...
TN1080	Kaji-ichigoside F1 蔷薇苷
	Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibite
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

D-tetrahydropalmatine

Cat.No: T4S0779

Target: Others, Dopamine Receptor

14-Deoxyandrographolide

Cat.No: T8288

Synonym: 去氧穿心莲内酯,14-去氧穿心莲内酯

Target: Apoptosis, Others

Glycodeoxycholate Sodium

Cat.No: T5254

Synonym: Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt,脱氧甘胆酸钠

Target: Others, Endogenous Metabolite

Cat.No: T5S0281

Target: NOS

Glycoursodeoxycholic acid

Cat.No: T5234

Synonym: Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA

Target: Others, Endogenous Metabolite

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Cat.No: TN4388

Target: Antifection

Cat.No: TN3872

Synonym: 山药

Target: ROS

Soyasapogenol A

Cat.No: TN2224

Synonym: 大豆甾醇A,大豆甾醇 A

Target: TNF

3,4-Dihydroxy-2-methoxyxanthone

Cat.No: TN2876

Target: Antibacterial, Antifection

Cat.No: TMA0627

Target: TNF

Cylindrospermopsin

Cat.No: T35770

Kaji-ichigoside F1

Cat.No: TN1080

Synonym: 蔷薇苷

Norbixin hydrate

Cat.No: T83915

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

(E)-Guggulsterone

Cat.No: T36563

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