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53

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21687	Conoidin A	Parasite	Microbiology/Virology
	Conoidin A 是刚地弓形虫过氧化物酶 II 的细胞通透性抑制剂，有杀线虫特性。它共价结合 TgPrxII 的过氧化物催化位点 Cys47，不可逆地抑制其过氧化物活性，IC50为 23 µM。它也抑制哺乳动物 PrxI 和 PrxII 的氧化。它具有抗氧化、神经保护作用，可研究缺血性心脏病。
T9022	AZD9977 AZD 9977	Glucocorticoid Receptor	Endocrinology/Hormones
	AZD9977 是一种选择性的，有效的，具有口服活性的盐皮质激素受体 (MR) 调节剂，可用于研究心力衰竭和慢性肾病。
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T80678	(S)-AK-242 (-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242	Others	Others
	(S)-AK-242 ((S)-Resatorvid) 是一种细胞因子抑制剂，可用于治疗心脏病、自身免疫性疾病、炎症性疾病。
T20843	Aplodan Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate	Others	Others
	Aplodan (creatinol-O-phosphate) 表现出抗缺血和抗心律失常的能力以及对细胞膜的保护作用。 Aplodan 可用于缺血性心脏病或伴有持续性室性早搏的缺血性心脏病的研究。
T29687	Afacifenacin Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR	Neuroscience
	Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂，可用于研究缺血性心脏病，尿失禁和膀胱炎和其他疾病。
T28437	Pomisartan BIBR-363,BIBR 363,BIBR363	RAAS	Endocrinology/Hormones
	Pomisartan (BIBR-363) 是一种小分子血管紧张素 1 型受体(AT1R)拮抗剂，可用于治疗心血管疾病，研究心脏衰竭和高血压。
T61028	Mitiperstat AZD4831	Glutathione Peroxidase	Metabolism
	Mitiperstat 是一种强效的骨髓过氧化物酶（MPO）抑制剂。Mitiperstat 对预防如心力衰竭和冠状动脉疾病类的心血管疾病有很好的效果。
T4287	Succinobucol Probucol monosuccinate,AGI-1067	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂，具有抗炎、抗血小板聚集活性。
T0080	Trapidil 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR; PDE	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Trapidil (Avantrin) 是一种抗血小板药物，是一种血管扩张剂，有特异性血小板衍生生长因子。
T10364	Arbutamine GP 21213	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Arbutamine (GP 21213) 是一种新型非选择性β-肾上腺素受体激动剂，具有α-1-拟交感神经活性。Arbutamine 促进心脏应激，增加心率、心脏收缩力。Arbutamine 可用于研究心脏应激和冠状动脉疾病。
T7674	Thrombin Receptor Activator for Peptide	Protease-activated Receptor	GPCR/G Protein
	Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5)，用于研究冠心病 (CHD)。
T6581	Methyclothiazide Duretic,Enduron,甲氯噻嗪,Aquatensen	Others; Carbonic Anhydrase	Metabolism; Others
	Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂，也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性，也可以抑制内源性血管收缩刺激导致的血管反应。
T69760	TT-10 TAZ-K	YAP	Stem Cells
	TT-10 (TAZ-K) 作为YES相关蛋白(YAP)-转录增强因子结构域(TEAD)活性的激活剂，适用于心肌细胞丢失伴随心脏病研究。
T2226	Pergolide mesylate 甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Pergolide mesylate salt(LY127809) 是一种有效的，具有口服活性的多巴胺 D1和 D2受体激动剂，是一种 Ergoline 衍生物，可用于帕金森氏病和高泌乳素血症的研究。
T0988	Trimetazidine dihydrochloride 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F	Autophagy; Fatty Acid Synthase	Autophagy; Metabolism
	Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂，也用作缺血性心脏病或心绞痛的血管扩张剂，具有抗氧化，抗炎，抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
T0056	Oxeladin citrate	Others	Others
	Oxeladin citrate 是止咳剂，能够对各种病因引发咳嗽进行有效研究。
T14390L	(2R,3S)-Azelaprag	Apelin receptor	GPCR/G Protein
	(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide 是一种Apelin 受体激动剂，对Apelin 受体的EC50为0.012 µM。(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide 可用于治疗心力衰竭、动脉粥样硬化、肥胖、糖尿病、肌萎缩侧索硬化、冠心病、高血压、中风和心肌梗塞等疾病。
T13697	FR 58664	Others	Others
	FR 58664 is a drug to treat heart failure disease.
T1605L	Enalapril sodium (-)-Enalapril sodium
	Enalapril sodium is used to treat high blood pressure, diabetic kidney disease, and heart failure and can be generally used with a diuretic such as furosemide for heart failure.
T32782	Lipopeptin A
	Lipopeptin A is a lipoprotein subclass that is a risk factor for atherosclerotic diseases such as coronary heart disease and stroke.
T34107	Polythiazide P2525,NSC-108161,NSC 108161,P-2525,NSC108161
	Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.
T74031	Cardiolipin (Heart, Bovine) (sodium)
	Cardiolipin (Heart, Bovine) sodium，一种线粒体专有磷脂，展现出在神经系统疾病研究中的应用潜力。
T26279	Tiracizine HCl AWD-19-166,AWD19166,Bonnecor,AWD 19 166,Tiracizine Hydrochloride
	Tiracizine HCl 是一种新的I 类抗心律失常药物，对缺血性心脏病患者进行了研究，结果表明该药物可降低心肌收缩功能。
T10812	Cicloprolol hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Cicloprolol hydrochloride 是一种新型有效且具有选择性的 β1-肾上腺素能受体 (β 1-adrenoceptor) 拮抗剂，具有部分激动剂活性，可用于研究冠心病。
T62351	Lotrafiban
	Lotrafiban 是一种口服具有活力的血小板膜糖蛋白 IIb/IIIa 阻滞剂，能够用于治疗冠心病和脑血管疾病的治疗。
TP1320	Angiogenin (108-122) TFA (112173-49-6 free base) Angiogenin (108-122) TFA
	Angiogenin (108-122) TFA is an angiogenin peptide.Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an autoimmu
TP1362	Angiogenin (108-122) Angiogenin 108-122
	Angiogenin (108-122) is an angiogenin peptide. Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an autoimmune
T21485	Perindopril
	Perindopril (S-9490) 是一种长效血管紧张素转换酶（ACE）抑制剂，用于治疗高血压、心力衰竭或稳定性冠状动脉疾病。
T38908	MK-8262
	MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) with potential implications for coronary heart disease (CHD).
T79084	BET bromodomain inhibitor 3	Epigenetic Reader Domain	Chromatin/Epigenetic
	BET bromodomain inhibitor 3为BET溴区结构域抑制剂，对BrdT抑制作用显示Ki值高于40 µM，适用于避孕、癌症和心脏病相关研究。
T39587	APJ receptor agonist 4
	APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.
T7496	Thrombin Receptor Activator for Peptide 5 (TRAP-5) Thrombin Receptor Activator for Peptide	Protease-activated Receptor	GPCR/G Protein
	Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5)，用于研究冠心病 (CHD)。
T62909	SGC agonist 2
	SGC agonist 2 是一种有效的可溶性鸟苷酸环化酶 (SGC) 激动剂。其中可溶性鸟苷酸环化酶是 NO-sGC-cGMP 信号通路中的关键信号转导酶。SGC agonist 2 具有潜力进行心血管疾病 (心力衰竭、心绞痛、肺动脉高压、心肌梗塞) 和纤维化疾病 (肾纤维化、系统性硬化症) 的研究。
T33673	Niludipine Niludipina,BAY-a 7168,Bay a 7168,Niludipinum
	Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug
T63035	Izilendustat hydrochloride
	Izilendustat (hydrochloride) 是一种脯氨酰羟化酶 (prolyl hydroxylase) 的有效抑制剂，能够稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat (hydrochloride) 具有潜力进行 HIF-1α 相关疾病的研究（包括外周血管疾病（PVD）、心力衰竭、冠状动脉疾病（CAD）、缺血、贫血、结肠炎和其他炎症性肠病）。
T37439	C18 Globotriaosylceramide (d18:1/18:0)
	C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma...
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
T63153	APJ receptor agonist 5
	APJ receptor agonist 5 (compound 3) 是一种有效的、口服具有活力的 apelin 受体 (APJ) 激动剂 (EC50: 0.4 nM)。APJ receptor agonist 5 在啮齿动物心力衰竭 (HF) 模型中具有出色的药代动力学特征，在临床前毒理学研究中也具有可接受的安全性。APJ receptor agonist 5 能够改善心脏功能，可用于 HF 疾病的研究。
T64102	hCAI/II-IN-5
	hCAI/II-IN-5 是 hCA I 和 hCA II (人碳酸酐酶同工酶 I 和 II) 的有效抑制剂，他们的IC50值分别为 37.88 和 45.23 nM。 hCAI/II-IN-5 也能够抑制 α-Glycosidase (IC50: 48.98 nM) 和 AChE (IC50: 420.14 nM)。hCAI/II-IN-5 能够用于研究糖尿病、心力衰竭、阿尔茨海默病、溃疡、癫痫等多种疾病。
T80973	TNF-α-IN-8
	TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂，属于异吲哚-亚胺类化合物，适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂，其Azide基团能与含Alkyne的分子配对，通过铜催化的叠氮－炔环加成反应(CuAAc)产生反应，也可与含DBCO或BCN基团的分子进行菌株促进的炔－叠氮环加成反应(SPAAC)。
T70070	Cisapride tartrate
	Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports o...
T63941	α-Glycosidase-IN-1
	α-Glycosidase-IN-1 (compound MZ7) 是 α-GLY(α- 糖苷酶) 的有效抑制剂 (IC50: 44.72 nM, Ki: 44.74 nM)。α-Glycosidase-IN-1 也能够抑制人碳酸酐酶同工酶 I 和 II (hCA I 和hCA II)以及乙酰胆碱酯酶 (AChE)，其IC50值分别为 104.87、100.04 和 654.87 nM。α-Glycosidase-IN-1 能够用于研究糖尿病、阿尔茨海默病、溃疡、心力衰竭、癫痫等多种疾病。
T81609	omega-3 Arachidonic acid ethyl ester (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester,ω-3 Arachidonic acid ethyl ester
	omega-3 Arachidonic Acid ethyl ester 是一种少见的多不饱和脂肪酸，饮食来源稀少。ω-3脂肪酸对婴幼儿生长发育极为重要，能够帮助预防心脏病、血栓、高血压及炎症和自身免疫性疾病。该化合物在人血小板膜中通过抑制花生四烯酰辅酶A合成酶发挥作用，Ki值达到14 μM；同时在小牛脑提取物中也表现出抑制作用，IC50大约5 μM。omega-3 Arachidonic Acid ethyl ester 作为游离酸的亲脂性更强的形式，具备独特的生物活性。
T79358	PF-07247685	Endogenous Metabolite	Metabolism
	PF-07247685是一种BCKDC激酶(BDK)抑制剂，具有较强的活性(EC50=2.2 nM)。该化合物能有效稳定BDK与BCKDH E2核心亚基之间的相互作用，并阻断E1亚基的磷酸化过程。BCKDH的活性受到BDK介导的磷酸化调控，从而控制支链氨基酸(BCAA)降解的关键步骤。BCAA的代谢失调与心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖等多种疾病相关联，尤其在心脏代谢疾病中表现明显。PF-07247685在小鼠模型中对心脏代谢终点产生改善效果，并提升了葡萄糖耐量。
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w...
T79357	PF-07238025	Endogenous Metabolite	Metabolism
	PF-07238025是一种BCKDC激酶(BDK)抑制剂，具有EC50值为19 nM。它通过稳定BDK和BCKDH复合体中的E2亚基相互作用，阻碍E1亚基的磷酸化过程，从而抑制了BCKDH的活性。由于BDK的磷酸化作用是控制支链氨基酸(BCAA)降解过程中的限速步骤，PF-07238025的作用与包括心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖在内的多种代谢性疾病的发病机制相关。研究显示PF-07238025能在小鼠体内改善心脏代谢指标并提升葡萄糖耐量。

化合物

Cat.No: T21687

Target: Parasite

Cat.No: T9022

Synonym: AZD 9977

Target: Glucocorticoid Receptor

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Cat.No: T80678

Synonym: (-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242

Target: Others

Cat.No: T20843

Synonym: Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate

Target: Others

Cat.No: T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Cat.No: T28437

Synonym: BIBR-363,BIBR 363,BIBR363

Target: RAAS

Cat.No: T61028

Synonym: AZD4831

Target: Glutathione Peroxidase

Cat.No: T4287

Synonym: Probucol monosuccinate,AGI-1067

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T0080

Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Target: PDGFR, PDE

Cat.No: T10364

Synonym: GP 21213

Target: Adrenergic Receptor

Thrombin Receptor Activator for Peptide

Cat.No: T7674

Target: Protease-activated Receptor

Methyclothiazide

Cat.No: T6581

Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen

Target: Others, Carbonic Anhydrase

Cat.No: T69760

Synonym: TAZ-K

Target: YAP

Pergolide mesylate

Cat.No: T2226

Synonym: 甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Trimetazidine dihydrochloride

Cat.No: T0988

Synonym: 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F

Target: Autophagy, Fatty Acid Synthase

Oxeladin citrate

Cat.No: T0056

Target: Others

(2R,3S)-Azelaprag

Cat.No: T14390L

Target: Apelin receptor

Cat.No: T13697

Target: Others

Enalapril sodium

Cat.No: T1605L

Synonym: (-)-Enalapril sodium

Cat.No: T32782

Cat.No: T34107

Synonym: P2525,NSC-108161,NSC 108161,P-2525,NSC108161

Cardiolipin (Heart, Bovine) (sodium)

Cat.No: T74031

Cat.No: T26279

Synonym: AWD-19-166,AWD19166,Bonnecor,AWD 19 166,Tiracizine Hydrochloride

Cicloprolol hydrochloride

Cat.No: T10812

Target: Adrenergic Receptor

Cat.No: T62351

Angiogenin (108-122) TFA (112173-49-6 free base)

Cat.No: TP1320

Synonym: Angiogenin (108-122) TFA

Angiogenin (108-122)

Cat.No: TP1362

Synonym: Angiogenin 108-122

Cat.No: T21485

Cat.No: T38908

BET bromodomain inhibitor 3

Cat.No: T79084

Target: Epigenetic Reader Domain

APJ receptor agonist 4

Cat.No: T39587

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Cat.No: T7496

Synonym: Thrombin Receptor Activator for Peptide

Target: Protease-activated Receptor

Cat.No: T62909

Cat.No: T33673

Synonym: Niludipina,BAY-a 7168,Bay a 7168,Niludipinum

Izilendustat hydrochloride

Cat.No: T63035

C18 Globotriaosylceramide (d18:1/18:0)

Cat.No: T37439

Cat.No: T69600

Cat.No: T70990

APJ receptor agonist 5

Cat.No: T63153

Cat.No: T64102

Cat.No: T80973

Cisapride tartrate

Cat.No: T70070

α-Glycosidase-IN-1

Cat.No: T63941

omega-3 Arachidonic acid ethyl ester

Cat.No: T81609

Synonym: (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester,ω-3 Arachidonic acid ethyl ester

Cat.No: T79358

Target: Endogenous Metabolite

Osteocalcin (1-49) (human) (trifluoroacetate salt)

Cat.No: T35604

Cat.No: T79357

Target: Endogenous Metabolite

Cat. No.	Product Name	Target	Signaling Pathways
T4903	Heptadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Heptadecanoic acid 是奇链饱和脂肪酸，与一些疾病（如冠心病、糖尿病前期和 2 型糖尿病以及多发性硬化症）有关。
T3S0128	Hydroprotopine 氢化原阿片碱,氢化物碱	Others	Others
	Hydroprotopine 是一种来自Hypecoum leptocarpumand 的生物碱，能够有效的治疗冠心病及心绞痛。
T14840	Butyrylcarnitine	Endogenous Metabolite	Metabolism
	Butyrylcarnitine 是血浆中的代谢物，是疾病引起异常代谢的指标，可用于诊断心力衰竭和胰腺囊肿。
T10584	Bovinic acid (9Z,11E)-Octadecadienoic acid,Rumenic acid	Endogenous Metabolite	Metabolism
	Bovinic acid ((9Z,11E)-Octadecadienoic acid) 是一种具有抗癌和抗动脉硬化的活性的共轭亚油酸，可用于研究老年冠心病和肥胖。
T3243	Betaine Abromine,glycine betaine,oxyneurine,trimethylglycine,lycine,甜菜碱	Others; Endogenous Metabolite	Metabolism; Others
	Betaine (trimethylglycine) 是许多食物中发现的天然化合物，也是能够维持正常 DNA 甲基化模式的特性甲基供体。它广泛存在于植物，动物，微生物和丰富的膳食来源中。它能够促进各种肠道微生物抵抗渗透变化，从而改善微生物发酵特性。它也能够作为渗透物，通过防止脱水和渗透失活来维持禽类的细胞水和离子平衡，从而提高禽类对热应激的能力。
T13933	Toringin	Others	Others
	Toringin is a bioflavonoid isolated from the bark of Docyniopsis tschonoski, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies.
T4863	DL-Homocysteine DL-高半胱氨酸,2-Amino-4-mercaptobutyric acid	Endogenous Metabolite	Metabolism
	DL-Homocysteine (2-Amino-4-mercaptobutyric acid) 是弱神经毒素，能够影响犬尿酸的产生。
TN4860	Pueroside B	COX; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience
	Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...

天然产物

Heptadecanoic acid

Cat.No: T4903

Target: Others, Endogenous Metabolite

Cat.No: T3S0128

Synonym: 氢化原阿片碱,氢化物碱

Target: Others

Butyrylcarnitine

Cat.No: T14840

Target: Endogenous Metabolite

Cat.No: T10584

Synonym: (9Z,11E)-Octadecadienoic acid,Rumenic acid

Target: Endogenous Metabolite

Cat.No: T3243

Synonym: Abromine,glycine betaine,oxyneurine,trimethylglycine,lycine,甜菜碱

Target: Others, Endogenous Metabolite

Cat.No: T13933

Target: Others

DL-Homocysteine

Cat.No: T4863

Synonym: DL-高半胱氨酸,2-Amino-4-mercaptobutyric acid

Target: Endogenous Metabolite

Cat.No: TN4860

Target: COX, PPAR

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

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