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149

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12019	Methylproamine	Others	Others
	Methylproamine 是一种与DNA 结合的辐射保护剂，可以修复辐射诱导的短暂活性氧。
T6878	LJI308	S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	LJI308 是泛RSK 抑制剂，对 RSK1、RSK2 和 RSK3 的IC50分别为 6、4 和 13 nM。它抑制辐照、EGF 处理和表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。
T9168	NSC 617145 NSC617145,NSC-617145	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂，IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶，并诱导双链断裂和染色体异常。
T4310	Prexasertib 5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368	Apoptosis; Chk	Apoptosis; Cell Cycle/Checkpoint
	Prexasertib (LY2606368) 是一种具有潜在抗肿瘤活性的检查点激酶 1 抑制剂。它可引起双链 DNA 断裂和复制突变，导致细胞凋亡。
T4327	Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis; Chk; S6 Kinase	Apoptosis; Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling
	Prexasertib dihydrochloride (LY2606368) 是一种选择性的，ATP 竞争性的细胞周期检测点激酶 1 抑制剂，Ki 为 0.9 nM，IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变，导致细胞凋亡，有抗肿瘤活性。
T24925	UNC-2170 UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others	Others
	UNC-2170 (UNC2170 Maleate) 是53BP1(IC50=29 µM;Kd=22 µM) 选择性的、功能活性的片段状配体，对 53BP1 的选择性比其他九种甲基赖氨酸读取器蛋白质高出至少17倍。53BP1 是 Kme 结合蛋白，在 DNA 损伤修复途径中起核心作用，并被招募到双链断裂位点。
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T20318	Benzylideneaniline N-苄叉苯胺,N-Benzylideneaniline	Others	Others
	Benzylideneaniline (N-Benzylideneaniline) 是一种有效的木质芪-α,β-双加氧酶抑制剂，它是氧化裂解木质芪中心双键的关键酶。
T27830	Lifarizine RS 87476,RS 87476-000,RS-87476,RS-87476-000,RS87476	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lifarizine (RS-87476) 是一种钙钠通道拮抗剂，在简化的大鼠双血管闭塞存活模型中显示出神经保护活性。
T18883	2-Di-1-ASP	Others	Others
	2-Di-1-ASP 是单苯乙烯基染料，对 G-四链体和双链 DNA 具有选择性。它普遍用作双链 DNA 的线粒体染色和凹槽结合荧光探针。
T23171	Polyinosinic-polycytidylic acid Poly(I:C),聚胞苷酸	TLR	Immunology/Inflammation
	Polyinosinic-polycytidylic acid (Poly(I:C)) 是一种双链 RNA (dsRNA)，是一种 TLR3 激动剂。Polyinosinic-polycytidylic acid 可以诱导哺乳动物天然免疫。
T13038	Sultamicillin	Antibacterial; Antibiotic	Microbiology/Virology
	Sultamicillin 是一种具有口服活性的氨苄西林/舒巴坦双前药。它是一种半合成 β-内酰胺酶抑制剂。
T14858	Calicheamicin Calicheamicin γ1,卡奇霉素	Others	Others
	Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素，可引起DNA 双链断裂，抑制DNA 合成。
T20511	6-Thioguanosine 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422	Others	Others
	6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷，是 Azathioprine 的代谢物，是低分子量凝胶剂。6-Thioguanosine 具有免疫抑制作用，可用于研究RNA 双螺旋结构的形成。
T8880	PFM01	Others	Others
	PFM01 是 MRE11核酸内切酶抑制剂，是 N-烷基化的 Mirin 衍生物。它可以通过非同源末端连接 (NHEJ) 和同源重组 (HR) 调节双链断裂修复 (DSBR)。
T19836	2-Aminopurine	DNA/RNA Synthesis; PKA	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	2-Aminopurine 是一种鸟苷和腺苷的荧光类似物，是基于荧光衰变的 DNA 结构探针。当它插入寡核苷酸后，其荧光会通过与天然碱基堆积而被高度淬灭。它可用于核酸的结构和动力学的探测。
T8637	DMNB 6-Nitroveratraldehyde,6-硝基藜芦醛	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	DMNB (6-Nitroveratraldehyde) 可用于合成no-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA)。它可用于研究多巴胺能系统的PET。
T21578	NSC 66811	Mdm2	Apoptosis
	NSC 66811 是一种MDM2-p53抑制剂，其结合到 MDM2 的Ki 值为 120 nM。
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
T63228	Simmiparib SMOCL-9112	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Simmiparib (SMOCL-9112) 是一种新型有效的 PARP1 和 PARP2 抑制剂，是一种Olaparib 衍生物。Simmiparib 在同源重组修复 (HR) 缺陷细胞中诱导 DNA 双链断裂 (DSB) 和细胞周期阻滞，从而促使细胞凋亡 (apoptosis)。Simmiparib 可用于研究帕金森病、阿尔茨海默病、乳腺癌和黑色素瘤。
T4434	Tirapazamine Tirazone,Win59075,SR4233,替拉扎明,SR259075	Others	Others
	Tirapazamine (Win59075) 是抗癌剂，对实体瘤中的缺氧细胞具有选择性细胞毒性，促使 DNA 中的单链和双链断裂，碱基损伤和细胞死亡。
T17257L	WR99210 hydrochloride(47326-86-3 free base) WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others	Others
	WR99210 hydrochloride 是恶性疟原虫二氢叶酸还原酶 (pfDHFR) 的有效抑制剂，pfDHFR 是主要的疟疾药物靶点。它对野生型、双突变体和四突变体二氢叶酸还原酶具有亚纳摩尔效力。
T11163	EGFR-IN-9	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-9 是一种有效的 EGFR 激酶抑制剂，对于野生型 EGFR 激酶和双重突变型 EGFR 激酶 (L858R/T790M) 的 IC50 分别为 7 nM 和 28 nM。EGFR-IN-9 具有抗肿瘤活性。
T19003	HOE-S 785026 trihydrochloride meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)
	HOE-S 785026 trihydrochloride 是一种活细胞标记染料，通过结合 DNA 双链中的小沟而结合核酸。 HOE-S 785026 trihydrochloride 倾向于结合富含 A/T 的 DNA 链（富含 A/T 的双链 DNA 使荧光强度显著增强）。HOE-S 785026 trihydrochloride 可穿过细胞膜，与活细胞或固定细胞结合。HOE-S 785026 trihydrochloride 的荧光强度随着溶液 pH 升高而增加。
T0609	Azobenzene 偶氮苯,Diazene,Diphenyldiazene	Others	Others
	Azobenzene (Diazene) 是一种光触发器，可用于设计和合成各种光响应系统。
T9760	IC 86621	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂，IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性，其 EC50 为 68 µM，用于 DNA-PK 介导的细胞 DSB 修复。
T60400	LDCA	Apoptosis; Dehydrogenase	Apoptosis; Metabolism
	LDCA 是一种双hit 代谢调节剂，展现出强大的抗增殖活性。LDCA 能竞争性地抑制LDH-A 酶的活性，改变线粒体的超极化并同时颠覆细胞凋亡。LDCA 在癌细胞中作用明显且不显示出毒性。
TP2496	Octapeptide-2 Acetate Octapeptide-2 Acetate(1374396-34-5 Free base)	Others	Others
	Octapeptide-2 Acetate 作为一种促进毛发生长的活性物质，是一种双层封装的仿生肽，有助于促进细胞生长和迁移。它通过激活毛囊的干细胞来促进头发生长。它比天然蛋白质更稳定且作用时间更长。
T31221	dBRD9 dBRD-9,dBRD 9	PROTACs	PROTAC
	dBRD9是一种 PROTAC。dBRD9是一种双重作用的分子，一部分连接 Bromodomain-containing protein 9 （BRD9）的溴域，另一部分招募小脑 E3泛素连接酶的配体（ligand that recruits the cereblon E3 ubiquitin ligase）。dBRD9对 MOLM-13细胞中 BRD9具有抑制作用，可使其降解，IC50为104 nM。
T67931	[Tyr3]Octreotate	Others	Others
	[Tyr3]Octreotate 是一个含有8个氨基酸的长肽化合物，是具有共价键DOTA 双功能螯合剂。[Tyr3]Octreotate 与SSR2活性的NETs 的跨膜受体结合，并通过内吞作用主动运输到细胞中，可能会增加所需的双链DNA 断裂，是治疗肿瘤的潜在药物。
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
T10534	BI-4020	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BI-4020 是一种第四代，口服有效，非共价的 EGFR 酪氨酸激酶抑制剂。BI-4020 表现出对三联突变的 EGFR del19 T790M C797S 突变体 ( BaF3 细胞系，IC50=0.2 nM)，双重突变的 EGFR del19 T790M 以及单突变的 EGFR del19 (IC50=1 nM)的抑制剂活性。BI-4020 保留了抑制 EGFR wt 的活性 (IC50=190 nM)。BI-4020 具有高激酶组选择性和良好的 DMPK 性质。
T6960L	PU-H71 HCl PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl	HSP; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism
	PU-H71 HCl (Zelavespib HCl) 是一种新型Hsp90抑制剂，是一种新型嘌呤基类似物，也是一种可能是CIRT的一种有前途的放射增敏剂。PU-H71 HCL 在许多恶性肿瘤临床前模型中显示出抗肿瘤活性。PU-H71 HCL 对 Rad51 和Ku70 的蛋白表达水平有抑制作用，这可能与双链断裂修复的同源重组途径和非同源末端连接途径有关。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T11931	MA242	Mdm2	Apoptosis
	MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
T30425	BePI Be-PI,NSC 664711,NSC-664711,NSC664711,Be PI
	BePI can be a specific intercalator of both double and triple-helical DNA.
T16283	Neocarzinostatin	5-HT Receptor	GPCR/G Protein; Neuroscience
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potential for EpCAM-positive cancer treatment.
T24702	Rabacfosadine succinate VDC-1101 succinate,GS-9219 succinate,VDC 1101 succinate VDC1101 succinate,GS-9219-01
	Rabacfosadine succinate is the acyclic nucleoside phosphonate PMEG double prodrug.
T21303	Etoposide Phosphate Eposin Etopophos Vepesid VP16,磷酸依托泊苷
	Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell proliferation.
T68394	MI-219
	MI-219 is a human double minute 2 (HDM2) inhibitor.
TD0003L	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO
	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak fluorescence, but the fluorescence is greatly enhanced once they are combined with the double-stranded DNA. Therefore, the fluorescence signal strength of CelGreen is related to the amount of double-stranded DNA, and the amount of double-stranded DNA in the PCR system can be detec...
T71825	BEPP monohydrochloride
	BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator.
T70328	HDM-201 succinate
	HDM-201 succinate is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity.
T13728	Hydrocortisone buteprate HBP,Hydrocortisone probutate	Others	Others
	Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders.
T39122	Inclisiran ALN-PCSsc
	Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (CVD).
TD0003	CelGreen nucleic acid gel stain 10,000× concentrate in water	Others	Others
	CelGreen 是一种具有独特参与性的荧光染料，可与所有 dsDNA 双螺旋沟区域结合。在游离状态下，侧链和 CelGreen 发出微弱的荧光，但一旦与双链DNA 结合，荧光就会大大增强。因此，CelGreen 的荧光信号强度与双链DNA 的量有关，可以根据荧光信号检测PCR 系统中双链DNA 的量。
T69283	Amikhellin HCl
	Amikhellin HCl, an antimitotic drug, is a synthetic water-soluble derivative of khellin, an alkaloid extracted from seeds of Ammi Visnaga. Amikhellin has been used so far mostly as a vasodiator. Amikhellin binds to double-stranded DNA by an intercalation process. It inhibits the DNA-polymerase from murine sarcoma leukemia virus.
T29453	5-Formylcytosine
	5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymerase II.
T37494	11-trans Leukotriene E4 11-trans Leukotriene E4
	Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
T19149	5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Others	Others
	5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.

化合物

Cat.No: T12019

Target: Others

Cat.No: T6878

Target: S6 Kinase

Cat.No: T9168

Synonym: NSC617145,NSC-617145

Target: DNA/RNA Synthesis

Cat.No: T4310

Synonym: 5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368

Target: Apoptosis, Chk

Prexasertib dihydrochloride

Cat.No: T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

Cat.No: T24925

Synonym: UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate

Target: Others

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Benzylideneaniline

Cat.No: T20318

Synonym: N-苄叉苯胺,N-Benzylideneaniline

Target: Others

Cat.No: T27830

Synonym: RS 87476,RS 87476-000,RS-87476,RS-87476-000,RS87476

Target: Calcium Channel

Cat.No: T18883

Target: Others

Polyinosinic-polycytidylic acid

Cat.No: T23171

Synonym: Poly(I:C),聚胞苷酸

Target: TLR

Cat.No: T13038

Target: Antibacterial, Antibiotic

Cat.No: T14858

Synonym: Calicheamicin γ1,卡奇霉素

Target: Others

6-Thioguanosine

Cat.No: T20511

Synonym: 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422

Target: Others

Cat.No: T8880

Target: Others

Cat.No: T19836

Target: DNA/RNA Synthesis, PKA

Cat.No: T8637

Synonym: 6-Nitroveratraldehyde,6-硝基藜芦醛

Target: DNA-PK

Cat.No: T21578

Target: Mdm2

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Cat.No: T63228

Synonym: SMOCL-9112

Target: Apoptosis, PARP

Cat.No: T4434

Synonym: Tirazone,Win59075,SR4233,替拉扎明,SR259075

Target: Others

WR99210 hydrochloride(47326-86-3 free base)

Cat.No: T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Target: Others

Cat.No: T11163

Target: EGFR

HOE-S 785026 trihydrochloride

Cat.No: T19003

Synonym: meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)

Cat.No: T0609

Synonym: 偶氮苯,Diazene,Diphenyldiazene

Target: Others

Cat.No: T9760

Target: DNA-PK

Cat.No: T60400

Target: Apoptosis, Dehydrogenase

Octapeptide-2 Acetate

Cat.No: TP2496

Synonym: Octapeptide-2 Acetate(1374396-34-5 Free base)

Target: Others

Cat.No: T31221

Synonym: dBRD-9,dBRD 9

Target: PROTACs

[Tyr3]Octreotate

Cat.No: T67931

Target: Others

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Cat.No: T10534

Target: EGFR

Cat.No: T6960L

Synonym: PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl

Target: HSP, DNA/RNA Synthesis

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Cat.No: T11931

Target: Mdm2

Cat.No: T30425

Synonym: Be-PI,NSC 664711,NSC-664711,NSC664711,Be PI

Neocarzinostatin

Cat.No: T16283

Target: 5-HT Receptor

Rabacfosadine succinate

Cat.No: T24702

Synonym: VDC-1101 succinate,GS-9219 succinate,VDC 1101 succinate VDC1101 succinate,GS-9219-01

Etoposide Phosphate

Cat.No: T21303

Synonym: Eposin Etopophos Vepesid VP16,磷酸依托泊苷

Cat.No: T68394

CelGreen nucleic acid gel stain *10,000× concentrate in DMSO*

Cat.No: TD0003L

BEPP monohydrochloride

Cat.No: T71825

HDM-201 succinate

Cat.No: T70328

Hydrocortisone buteprate

Cat.No: T13728

Synonym: HBP,Hydrocortisone probutate

Target: Others

Cat.No: T39122

Synonym: ALN-PCSsc

CelGreen nucleic acid gel stain *10,000× concentrate in water*

Cat.No: TD0003

Target: Others

Cat.No: T69283

5-Formylcytosine

Cat.No: T29453

11-trans Leukotriene E4

Cat.No: T37494

Synonym: 11-trans Leukotriene E4

5-BrdUTP sodium salt

Cat.No: T19149

Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T20041	2'-Deoxyadenosine 2'-脱氧腺苷,NSC-141848,NSC141848,NSC 141848	Endogenous Metabolite	Metabolism
	2'-Deoxyadenosine (NSC-141848) 是核苷腺苷的一种衍生物，能够与双链 DNA 中的脱氧胸苷配对。
T21498	Phleomycin	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Phleomycin 是在链霉菌中发现的，引起 DNA 切割的抗癌糖肽抗生素之一。它类似于博来霉素，它结合并插入 DNA 以破坏双螺旋的完整性。
T8240	Cis-5-Dodecenoic Acid	Others	Others
	Cis-5-Dodecenoic Acid 是一种单不饱和脂肪酸，具有 C12 链作为主链，C5 位具有顺式双键。
TN2030	P-Hydroxyphenethyl trans-ferulate 反式-阿魏酸对羟基苯乙酯	5-HT Receptor	GPCR/G Protein; Neuroscience
	p-Hydroxyphenethyl trans-ferulate 具有抗高血糖（酵母α-葡萄糖苷酶，IC5019.24 ± 1.73 µmol L-1），抗氧化，抗炎活性，也具有抗癌特性和血清素能特性。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
T5803	D(-)-Tartaric acid	Others	Others
	D(-)-Tartaric acid 存在于许多植物中，特别是罗望子和葡萄，口服后通过与碳酸氢钠相互作用产生二氧化碳。二氧化碳会延伸胃部并在双造影射线照相期间提供负造影剂。
T13592	Calf thymus DNA DNA from calf thymus, Thymonucleic acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) 是一种从牛胸腺中提取出来的高质量双链模板DNA，可广泛应用于DNA 结合抗癌剂和调节DNA 结构和功能的DNA 结合剂的研究。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。
TN4582	Moracin T	c-Myc; COX	Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience
	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo
T40610	Kaempferol 3-O-(2′′-O-α-rhamnosyl-6′′-O-malonyl-β-glucoside)
	Kaempferol 3-O-(2′′-O-α-rhamnosyl-6′′-O-malonyl-β-glucoside)是一种天然化合物，属于黄酮类糖苷。它可以从Clitoria ternatea cv. Double Blue 的花瓣中分离得到。
TN2762	2-Hydroxy-3-(hydroxymethyl)anthraquinone	Others	Others
	2-Hydroxy-3-(hydroxymethyl)anthraquinone 在 Hepa lclc7 细胞中表现出醌还原酶 (QR) 诱导活性，其 QR 活性加倍所需的浓度为 0.94 microM。
T5276	4,4'-Disulfanediylbis(2-aminobutanoic acid) DL-Homocystine,DL-高胱氨酸	Others; Endogenous Metabolite	Metabolism; Others
	4,4'-Disulfanediylbis(2-aminobutanoic acid) (DL-Homocystine) 是内源性代谢产物的一种。
TN4094	Gallocatechin gallate	IL Receptor; NF-κB; ROS; MAPK; PPAR; Fatty Acid Synthase	DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; NF-κB
	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-ÎºB signaling; it also may have anti-diabetic effects by increasing sensitivity
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...
T37911	cis-Resveratrol 顺式白藜芦醇,(Z)-Resveratrol
	Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ...

天然产物

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

2'-Deoxyadenosine

Cat.No: T20041

Synonym: 2'-脱氧腺苷,NSC-141848,NSC141848,NSC 141848

Target: Endogenous Metabolite

Cat.No: T21498

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Cis-5-Dodecenoic Acid

Cat.No: T8240

Target: Others

P-Hydroxyphenethyl trans-ferulate

Cat.No: TN2030

Synonym: 反式-阿魏酸对羟基苯乙酯

Target: 5-HT Receptor

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

D(-)-Tartaric acid

Cat.No: T5803

Target: Others

Calf thymus DNA

Cat.No: T13592

Synonym: DNA from calf thymus, Thymonucleic acid

Target: DNA/RNA Synthesis

Cat.No: T4877

Target: Endogenous Metabolite

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

Cat.No: TN4582

Target: c-Myc, COX

Kaempferol 3-O-(2′′-O-α-rhamnosyl-6′′-O-malonyl-β-glucoside)

Cat.No: T40610

2-Hydroxy-3-(hydroxymethyl)anthraquinone

Cat.No: TN2762

Target: Others

4,4'-Disulfanediylbis(2-aminobutanoic acid)

Cat.No: T5276

Synonym: DL-Homocystine,DL-高胱氨酸

Target: Others, Endogenous Metabolite

Gallocatechin gallate

Cat.No: TN4094

Target: IL Receptor, NF-κB, ROS, MAPK, PPAR, Fatty Acid Synthase

Cylindrospermopsin

Cat.No: T35770

cis-Resveratrol

Cat.No: T37911

Synonym: 顺式白藜芦醇,(Z)-Resveratrol

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