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Search Results for " diterpene "

17

抑制剂 & 化合物

36

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T33887	Paspaline
	Paspaline is an indole-diterpene.
T34500	Salviarin
	Salviarin is a clerodane diterpene isolated from Salvia splendens.
T32274	Jatropholone A CCRIS 1441,CCRIS1441,CCRIS-1441
	Jatropholone A is a type of diterpene derivative of jarophone.
T31186	Dactylomelol
	Dactylomelol is a new type of diterpene from sea hare.
T32216	Isolinearol
	Isolinearol is a secodolastane diterpene.
T34537	Saudin
	Saudin is a naturally occurring hypoglycemic diterpene.
T32365	Kaurene
	Kaurene is a tetracyclic diterpene.
T34526	Sarcophytol B Sarcophytol-B
	Sarcophytol B is a cembrane-type diterpene isolated from a soft coral, Sarcophyton glaucum.
T23847	Cajucarinolide
	Cajucarinolide is a clerodane diterpene. It inhibits bee venom phospholipase A2 in vitro. Cajucarinolide possesses anti-inflammatory activity.
T40905	Levopimaric acid
	Levopimaric acid is a plant-derived diterpene resin acid that exhibits multiple beneficial properties. It promotes cancer cell apoptosis, while also possessing anticancer, antioxidant, antibacterial, and cardiovascular activities.
T29788	Ajugarin I
	Ajugarin I is a clerodane diterpene, the major component of the shrub Ajuga remota.
T39306	7-Oxodehydroabietic acid
	7-Oxodehydroabietic acid is a diterpene resin acid found in the roots of Pinus densiflora pine. It acts as a defensive compound against herbivorous insects by disrupting their endocrine system.
T25735	Linearol
	Linearol is a diterpene found in Sideritis L. spp. (Lamiaceae) with a broad range of demonstrated properties including antioxidant, anti-inflammatory, and anti-apoptotic activities.
T79945	Ferroptosis-IN-1	Ferroptosis	Apoptosis
	Ferroptosis-IN-1为弯草二萜类化合物，其抑制ferroptosis的EC50为10 μM，可用于神经炎症疾病研究。
T36720	Deacetylforskolin
	Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucose transport in rat adipocyte plasma membranes.2Deactylforskolin (30-1,000 μg/kg) reduces blood pressure in spontaneously hypertensive rats.3It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4 1.Gabetta, B., Zini, G., and Danieli, B.Minor...
T74771	Diaporthein B
	Diaporthein B 是氧化程度极高的 pimarane 二萜之一。Diaporthein B 表现出抗结核分枝杆菌的活性，MIC 为 3.1 μg/mL。Diaporthein B 显示对 HCT 116 和 LoVo 结肠癌细胞的 IC50为 1.5-3 μM/L。
T74284	SH379
	SH379为2-甲基嘧啶-稠合三环二萜衍生物，是具有口服活性的有效抗迟发性性腺机能减退剂。它显著促进StAR与3β-HSD等关键睾酮合成相关酶的表达，并通过调节AMPK/mTOR信号通路刺激自噬。

化合物

Cat.No: T33887

Cat.No: T34500

Cat.No: T32274

Synonym: CCRIS 1441,CCRIS1441,CCRIS-1441

Cat.No: T31186

Cat.No: T32216

Cat.No: T34537

Cat.No: T32365

Cat.No: T34526

Synonym: Sarcophytol-B

Cat.No: T23847

Levopimaric acid

Cat.No: T40905

Cat.No: T29788

7-Oxodehydroabietic acid

Cat.No: T39306

Cat.No: T25735

Ferroptosis-IN-1

Cat.No: T79945

Target: Ferroptosis

Deacetylforskolin

Cat.No: T36720

Cat.No: T74771

Cat.No: T74284

Cat. No.	Product Name	Target	Signaling Pathways
TN4972	Sculponeatin N	Others	Others
	Sculponeatin N 是一种 ent-kaurane 二萜衍生物，分离自 Isodon sculponeata 植物。
T9135	Epirosmanol	Others	Others
	Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性（基本中性）的化合物（基于其 pKa）。
T5689	20-DEOXYINGENOL	Others; Autophagy	Autophagy; Others
	20-Deoxyingenol 是从甘遂的根中分离出的一种二萜类天然产物。它可通过促进体外转录因子 EB 的核易位来促进自噬和溶酶体生物发生，可研究骨关节炎。
T3254	PHYTOL 植醇,trans-Phytol,(E)-Phytol	Antibacterial; PPAR; Parasite	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	PHYTOL (trans-Phytol) 是一种从叶绿素中提取的二萜醇，广泛应用于食品添加剂和医药领域，具有很好的抗血吸虫特性。它具有抗伤害、抗氧化、抗炎、抗过敏等作用。它对结核分枝杆菌和金黄色葡萄球菌具有抗菌活性。
TN7123	Enmein, 13-deoxy-19-hydroxy-, (19R)-	Others	Others
	Enmein, 13-deoxy-19-hydroxy-, (19R)- 是 Enmein 型二萜衍生物，可用于抗肿瘤药物的制备。
T12014	Methyl carnosate	Others	Others
	Methyl camosate, a diterpene sourced from Salvia officinalis or Rosmarinus officinalis, exhibits pronounced antioxidant and antibacterial properties.
T3S0631	Fuziline	Anti-infection	Microbiology/Virology
	Fuziline 是一种在附子侧根中发现的二萜生物碱。它在功能上与乌头有关。
T2906	Tanshinone IIA 丹参酮IIA,Tanshinone B,Dan Shen ketone	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tanshinone IIA (Tanshinone B) 是红根丹参根系中的一种主要组合物。它能够利用靶向 VEGF/VEGFR2的蛋白激酶结构域，抑制血管生成。
T3020	Sclareol	Apoptosis; Others	Apoptosis; Others
	Sclareol 是一种从快乐鼠尾草中分离出来的拉丹型二萜，对多种人类 Y 细胞系具有生长抑制和细胞毒活性，诱导细胞凋亡。
T2788	Baccatin III 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ	Others	Others
	Baccatin III (Baccatin Ⅲ) 是一种分离自太平洋紫杉树和其近缘种中的天然产物，能够减少 MDSCs 积累并抑制其功能，延缓肿瘤发展进程。
T4037	Phorbol 4β-Phorbol,佛波醇,(+)-Phorbol	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Phorbol (4β-Phorbol) 是具有毒性的二萜类化合物，其酯类具有强大的生物活性。
T4S1869	12-Epinapelline 12-表欧乌头碱,12-表-欧乌头碱	Others	Others
	12-Epinapelline 是一种二萜生物碱，分离自Aconitum baikalense 中。它具有抗炎作用，能刺激成纤维细胞前体克隆的生长。
T2S1040	Jolkinolide B	ERK; IL Receptor; BCL; p38 MAPK; TNF; NF-κB; Akt; Caspase; PI3K; JAK; JNK; STAT; mTOR	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Jolkinolide B 是一种从 Euphorbia fischeriana Steud 的根中分离出来的具有生物活性的二萜。 Jolkinolide B 诱导癌细胞凋亡。 Jolkinolide B 可用于预防和治疗骨溶解的研究。
T3791	Atractyloside A	AChR	Neuroscience
	Atractyloside A 是存在于一些植物中的贝壳杉类二萜糖苷，具有降血压、降血糖、抗肿瘤等活性。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
TN1854	Lasiodin 毛栲利素,Lasiokaurin	P450; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome
	Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物，可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性，可诱导细胞周期组长和凋亡，诱导细胞迁移和侵袭，可用于研究鼻咽癌
TN2601	12-O-Methylcarnosic acid	Reductase	Endocrinology/Hormones; Metabolism
	12-O-Methylcarnosic acid 是分离自小叶丹参的丙酮提取物的一种二萜肉桂酸，可抑制 5α-还原酶 (5α-reductase) 活性，IC50为 61.7 μM。它抑制 LNCaP 细胞的增殖。它具有抗微生物活性、抗氧化和抗癌活性。
T81131	Solidagolactone II
	Solidagolactone II is a clerodane diterpene isolated from the plant Solidago virgaurea L.
T82444	Erinacine U
	Erinacine U, a cyanhydrin diterpene isolated from Hericium erinaceus, exhibits neurotrophic activity and notably promotes neurite outgrowth in PC12 cells.
T40586	Neophytadiene
	Neophytadiene, a diterpene discovered in Turbinaria ornate, showcases desirable bioactive properties including anti-inflammatory, antioxidant, and cardioprotective effects.
TN4477	Macrocarpal E	Antibacterial	Microbiology/Virology
	Macrocarpal E 是一种来自蓝桉的间苯三酚二醛二萜衍生物，具有抗菌活性。
T13740	Isotanshinone IIA	Others	Others
	Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.
T82145	Hydroxymethylenetanshiquinone
	Hydroxymethyltanshinquinone为松香烷二萜类化合物，具有抑制肿瘤细胞增殖作用。
TN4749	Pepluanin A	P-gp	Membrane transporter/Ion channel; Neuroscience
	Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated daunomycin transport.
T36776	Terpendole C
	Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth.
TN4936	Salvisyrianone
	Salvisyrianone 是从台湾隐生植物和叙利亚鼠尾草中分离出二萜，具有潜在的抗高血压活性和抗肿瘤活性。
T5706	8-epidiosbulbin E acetate	Others	Others
	8-epidiosbulbin E acetate 是亚洲国家广泛使用的传统草药 Dioscorea bulbifera L. (DB) 中含量丰富的二萜内酯。
T82069	Ingol 7,8,12-triacetate 3-phenylacetate
	Ingol 7,8,12-triacetate 3-phenylacetate (compound 1) 是一种从大戟属植物乳胶中分离得到的高度功能化的ingol二萜。此化合物对细胞周期没有显著影响。
T81408	Preleoheterin
	Preleoheterin（化合物3）为一类从L. japonicus分离得到的拉丹烷二萜。
T83517	(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate
	(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate (compound 7a) 是一种特定立体化学配置的二萜类化合物。
T83215	Abiesadine Q
	Abiesadine Q (化合物 17)，一种从 Abies georgei Orr 地上部分提取的二萜化合物。
T11834	Leelamine hydrochloride	Others	Others
	Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.
T72533	4-Deoxy-4α-phorbol
	4-Deoxy-4α-phorbol 是在 E. desmondi 中发现的一种四环二萜类物质。4-Deoxy-4α-phorbol 可用于半合成 HIV-1诱导的 MT-4 细胞的细胞病理学效应抑制剂和 4α-山梨醇酯。
T82070	Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate
	Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate是一种高度功能化的双环石萜类化合物，源自Euphorbia officinarum的乳胶。
T78479	Manool
	Manool为Salvia officinalis中的一种二萜，能在癌细胞中引发选择性细胞毒性，并导致癌细胞在细胞周期的G(2)/M期停滞。
T26545	Acanthoic acid NP1302,NP 1302: NP-1302
	Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits infla

天然产物

Cat.No: TN4972

Target: Others

Cat.No: T9135

Target: Others

20-DEOXYINGENOL

Cat.No: T5689

Target: Others, Autophagy

Cat.No: T3254

Synonym: 植醇,trans-Phytol,(E)-Phytol

Target: Antibacterial, PPAR, Parasite

Enmein, 13-deoxy-19-hydroxy-, (19R)-

Cat.No: TN7123

Target: Others

Methyl carnosate

Cat.No: T12014

Target: Others

Cat.No: T3S0631

Target: Anti-infection

Cat.No: T2906

Synonym: 丹参酮IIA,Tanshinone B,Dan Shen ketone

Target: VEGFR

Cat.No: T3020

Target: Apoptosis, Others

Cat.No: T2788

Synonym: 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ

Target: Others

Cat.No: T4037

Synonym: 4β-Phorbol,佛波醇,(+)-Phorbol

Target: PKC

12-Epinapelline

Cat.No: T4S1869

Synonym: 12-表欧乌头碱,12-表-欧乌头碱

Target: Others

Cat.No: T2S1040

Target: ERK, IL Receptor, BCL, p38 MAPK, TNF, NF-κB, Akt, Caspase, PI3K, JAK, JNK, STAT, mTOR

Atractyloside A

Cat.No: T3791

Target: AChR

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Cat.No: TN1854

Synonym: 毛栲利素,Lasiokaurin

Target: P450, PARP, Caspase

12-O-Methylcarnosic acid

Cat.No: TN2601

Target: Reductase

Solidagolactone II

Cat.No: T81131

Cat.No: T82444

Cat.No: T40586

Cat.No: TN4477

Target: Antibacterial

Isotanshinone IIA

Cat.No: T13740

Target: Others

Hydroxymethylenetanshiquinone

Cat.No: T82145

Cat.No: TN4749

Target: P-gp

Cat.No: T36776

Cat.No: TN4936

8-epidiosbulbin E acetate

Cat.No: T5706

Target: Others

Ingol 7,8,12-triacetate 3-phenylacetate

Cat.No: T82069

Cat.No: T81408

(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate

Cat.No: T83517

Cat.No: T83215

Leelamine hydrochloride

Cat.No: T11834

Target: Others

4-Deoxy-4α-phorbol

Cat.No: T72533

Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate

Cat.No: T82070

Cat.No: T78479

Cat.No: T26545

Synonym: NP1302,NP 1302: NP-1302

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