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8-epidiosbulbin E acetate

产品编号 T5706 CAS 1092368-67-6

8-epidiosbulbin E acetate 是亚洲国家广泛使用的传统草药 Dioscorea bulbifera L. (DB) 中含量丰富的二萜内酯。

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8-epidiosbulbin E acetate Chemical Structure

8-epidiosbulbin E acetate, CAS 1092368-67-6

规格	价格/CNY		货期	数量
2 mg	￥ 2,530		5日内发货

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8-epidiosbulbin E acetate 的其他形式现货产品:

8-Epidiosbulbin E acetate

其他形式的 8-epidiosbulbin E acetate:

8-Epidiosbulbin E acetate
现货

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

结构类型

天然产物 > 其他

产品描述	8-epidiosbulbin E acetate is an abundant diterpene lactone in Dioscorea bulbifera L. (DB), a traditional herbal medicine widely used in Asian countries.
体外活性	EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective. The antibiotic resistance patternrevealed that the compound was effective in the reversal of bacterial resistance to various antibiotics[1].
体内活性	EEA exhibits time- and dose-dependent liver injury in mice.?Pretreatment with ketoconazole prevented the animals from developing EEA-induced liver injury, caused 7- and 13-fold increases in the plasma Cmax and AUC of EEA, and decreased urinary excretion of glutathione conjugates derived from EEA.?Pretreatment with buthionine sulfoximine exacerbated EEA-induced hepatotoxicity[2].
细胞实验	The ?minimal inhibitory concentration and subinhibitory concentration ?of EEA were determined by the agar dilution method .?Pathogenic bacterial cultures were grown in the presence of EEA at specified concentrations for 24 h at 37℃ and then plated on Luria agar plates to obtain isolated colonies.?The isolated colonies were then replica plated onto Luria agar and Luria agar containing antibiotics.?Colonies that failed to grow in the presence of antibiotics were considered as putative cured derivatives.?Physical loss of the plasmid in the cured derivative was confirmed by agarose gel electrophoresis of the plasmid DNA preparation of respective cultures.?The percentage curing efficiency was expressed as the number of colonies with cured phenotype per 100 colonies tested.?The antibiotic resistance profiles of plasmid-harbouring strains and plasmid-cured strains were determined by the disc diffusion method .?The zone of growth inhibition around the antibiotic disc was measured in millimetres following incubation at 37℃ for 24 h. The cultures were interpreted as resistant, intermediate or sensitive[1] .
动物实验	Mice had free access to food and water and were housed in a temperature-controlled (22 +— 4 ℃) facility with a 12 h dark/light cycle for at least 5 days before treatment. EEA and tetrahydro-EEA (100 mg) was individually suspended in 10 mL of corn oil. The animals were randomly divided into six groups, and each group contained four mice. One group was treated intraperitoneally with corn oil as the control, and the other groups were given EEA at dosages of 50, 75, 100, or 150 mg/kg, or tetrahydro-EEA (100 mg/kg), respectively. The animals were sacrificed 12, 24, 36, and 48 h after the treatment[2].

分子量	374.39
分子式	C20H22O7
CAS No.	1092368-67-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Shriram V , Jahagirdar S , Latha C , et al. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria[J]. Int J Antimicrob Agents, 2008, 32(5):405-410. 2. Lin D , Li W , Peng Y , et al. Role of metabolic activation in 8-epidiosbulbin E acetate-induced liver injury: Mechanism of action of the hepatotoxic furanoid[J]. Chemical Research in Toxicology, 2016:acs.chemrestox.5b00501.

剂量换算

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请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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