43
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14981 |
Clobetasone butyrate
|
Glucocorticoid Receptor | Endocrinology/Hormones |
Clobetasone butyrate 是糖皮质类固醇,特别是在皮肤上,具有局部抗炎活性。它可用于改善皮质类固醇反应性症状,如特应性皮炎、牛皮癣。 | |||
T27172 |
Difamilast
|
PDE | Metabolism |
Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂,对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。 | |||
T7893 |
Bepotastine
Bepotastine free base,贝托斯汀 |
Others; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others |
Bepotastine (Bepotastine free base) 是一种选择性可口服的组胺 H1 受体拮抗剂,可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。 | |||
T6405 |
Bepotastine Besilate
Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bepotastine Besilate (TAU 284) 是一种选择性可口服的组胺 H1 受体拮抗剂,可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。 | |||
T2690 |
Tranilast
曲尼司特,MK 341,SB 252218 |
RAAS; Prostaglandin Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation |
Tranilast (SB 252218) 是一种抗过敏药物,可抑制炎症细胞释放脂质介质和细胞因子,抑制前列腺素 D2 (PGD2)产生,IC50为 0.1 mM。它拮抗血管紧张素 II 并抑制其在血管平滑肌细胞中的生物学作用,具有抗炎和免疫调节作用。 | |||
T4966 |
Ufenamate
氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯 |
Others | Others |
Ufenamate (Flufenamic acid butyl ester) 是一种基于邻氨基苯甲酸的抗炎药。它可用于皮肤疾病研究。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T29096L |
Vapitadine
R 129160 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Vapitadine 是一种非镇静性抗组胺化合物,可缓解特应性皮炎引起的瘙痒。 | |||
T16792 |
Rovazolac
ALX-101 |
Liver X Receptor | Metabolism |
Rovazolac (ALX-101) 是一种肝脏x受体 (LXR)调节剂,可用于研究免疫系统疾病和特应性皮炎。 | |||
T75113 |
GLPG2534
GLPG-2534 |
IRAK | Immunology/Inflammation; NF-κB |
GLPG2534 是一种具有口服活性、选择性和有效性的 IRAK4 抑制剂,具有抗炎活性。GLPG2534 对人和小鼠 IRAK4 具有抑制作用,可用于研究银屑病和特应性皮炎。 | |||
T3987 |
Lotamilast
E6005,RVT-501 |
PDE | Metabolism |
Lotamilast (RVT-501) 是一种磷酸二酯酶4(PDE4) 选择性抑制剂,IC50=2.8 nM。 | |||
T76775 |
Fezakinumab
ILV 094 |
Interleukin | Immunology/Inflammation |
Fezakinumab 是一种有效的白细胞介素 22 (IL-22) 单克隆抗体。Fezakinumab 可用于研究银屑病、类风湿性关节炎和特应性皮炎等免疫系统疾病和炎症相关疾病。 | |||
T77369 |
Telazorlimab
ISB-830,GBR-830 |
Immunology/Inflammation related | Immunology/Inflammation |
Telazorlimab (GBR-830) 是一种靶向活化 T 细胞上 OX40 共刺激受体的人源化单克隆抗体。Telazorlimab 可用于治疗红斑狼疮和特应性皮炎。 | |||
T2392 |
Nafamostat mesylate
甲磺酸萘莫司他,FUT-175 |
Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂,血管舒缓素抑制剂,能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性,可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。 | |||
T76704 |
Tralokinumab
CAT-354,LP 0162 |
IL Receptor | Immunology/Inflammation |
Tralokinumab 是一种全人源 IgG4 单克隆抗体,对单独的 IL-13 亲和力较高。Tralokinumab 具有潜在的抗炎活性,可预防IL-13与受体相互作用和随后的下游信号传导,可用于研究特应性皮炎 (AD) 。 | |||
T9043 |
AS1810722
|
P450; STAT | JAK/STAT signaling; Metabolism; Stem Cells |
AS1810722 是口服有效的STAT6抑制剂,IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物,对有良好的CYP3A4抑制作用,具有用于过敏性疾病,如哮喘和特应性疾病的研究潜力。 | |||
T2270 |
Trans-Tranilast
Tranilast trans-,反式-曲尼司特,反-曲尼司特 |
RAAS | Endocrinology/Hormones |
Trans-Tranilast 是抗过敏剂,可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。 | |||
T13666 |
Dupilumab
REGN-668,SAR-231893 |
IL Receptor | Immunology/Inflammation |
Dupilumab (REGN-668) 是一种用于AD 的全身免疫调节剂。Dupilumab 是一种针对白细胞介素-4受体α亚基的完全人类单克隆抗体,可抑制IL-4和IL-13下游信号传导,具有改善特应性皮炎的作用。 | |||
T76724 |
Nemolizumab
CIM331 |
Interleukin | Immunology/Inflammation |
Nemolizumab (CIM331) 是一种人源化的抗人白细胞介素-31 受体 a 单克隆抗体,对白细胞介素-31 (IL-31) 与其受体的结合和随后的信号转导有抑制作用。Nemolizumab 可用于研究特应性皮炎伴瘙痒。 | |||
T76884 |
Spesolimab
BI 655130 |
IL Receptor | Immunology/Inflammation |
Spesolimab (BI 655130) 是一种抗白细胞介素-36 受体抗体。IL-36 在免疫系统中具有重要作用,与先天性 Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。Spesolimab 可用于研究全身性脓疱型银屑病、掌跖脓疱病 (PPP) 和特应性皮炎。。 | |||
T41005 |
PA-8
|
PACAP | GPCR/G Protein |
PA-8是一种小分子的的 PACAP I 型(PAC1)受体拮抗剂,有 选择性、有效性和口服活性。PA-8抑制PACAP 诱导的CREB 在PAC1-受体上的磷酸化,但对VPAC11或VPAC2受体无抑制作用。PA-8也抑制pacap 诱导的体外cAMP 水平升高(IC50 = 2 nM)和体内鞘内注射后pacap 诱导的厌恶反应和机械异位性痛。 | |||
T23472 |
Tranilast Sodium
|
Others | Others |
Tranilast Sodium has been used for the treatment of bronchial asthma. Tranilast is also used to autoimmune diseases, atopic and fibrotic pat. | |||
T67202 | Benvitimod | ||
Benvitimod is a non-steroidal anti-inflammatory drug (NSAID) potentially for the treatment of atopic dermatitis. | |||
T38540 |
BAY 1003803
|
||
BAY 1003803 is a glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis. | |||
T35076 |
VTP-766
|
||
VTP-766 is an effective orally active and selective liver X receptor β (lxrβ) agonist, targeted to treat atopic dermatitis and acute coronary syndrome. | |||
T39646 | Atinvicitinib | ||
Atinvicitinib, a pyrazole compound, exhibits promise for investigating atopic dermatitis. | |||
T26555 |
Acreozast
TYB 2285,TYB-2285,TYB2285 |
||
Acreozast, a histamine release inhibitor, is used potentially for the treatment of asthma and atopic dermatitis. | |||
T70974 |
Cipamfylline
|
||
Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study revealed that cipamfylline was more effective than vehicle in treating atopic dermatitis, but less effective than a group II steroid, hydrocortisone-17-butyrate both in the treatment of atopic derm... | |||
T72391 | Clocortolone pivalate | ||
Clocortolone pivalate是一种合成糖皮质激素和皮质类固醇酯,适用于治疗脂溢性皮炎、接触性皮炎、特应性皮炎及银屑病。 | |||
T14154 |
Alclometasone
7a-Chloro-16a-methyl prednisolone |
||
Alclometasone (7a-Chloro-16a-methyl prednisolone), a glucocorticoid, inhibits leukocytes from releasing pro-inflammatory mediators. It is effective in treating corticosteroid-responsive dermatoses such as atopic dermatitis, psoriasis, allergic dermatitis, and eczema [1]. | |||
T78207 |
Lepzacitinib
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Lepzacitinib为Janus激酶抑制剂,特异性针对JAK1/3,具备显著的抗炎效能,适用于治疗特应性皮炎及其他皮肤疾病。 | |||
T76679 | Etokimab | ||
Etokimab(Antibody ANB 020),一种人源化单克隆抗体,靶向IL-33,主要用于特应性皮炎的研究。 | |||
T71561 | LEO-29102 | ||
LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis. | |||
T78299 |
Amlitelimab
KY1005,SAR445229 |
||
Alvircept sudotox是一种针对OX40配体(OX40L)的单克隆抗体(mAb),能够抑制OX40与OX40L之间的相互作用,其主要用途为特应性皮炎研究。 | |||
T76816 | Lokivetmab | ||
Lokivetmab(Anti-Canine IL31 Recombinant Antibody)为针对犬特应性皮炎(AD)研究的抗犬IL-31单克隆抗体。 | |||
T78333 |
Rocatinlimab
AMG 451,KHK4083 |
||
Rocatinlimab(AMG 451)(KHK4083)为全人源非岩藻糖化IgG1抗OX40单克隆抗体,旨在用于特应性皮炎(AD)研究。 | |||
T38002 | LEO 39652 | ||
LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1]. LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin... | |||
T69615 | AWD12-281 sodium | ||
AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor for the treatment of lung inflammation using inhalative administration. AWD 12-281 Is Active in a New Guinea-Pig Model of Allergic Skin Inflammation Predictive of Human Skin Penetration and Suppresses Both Th1 and Th2 Cytokines in Mice. AWD 12-281 is a very promising drug candidate not only for the treatment of lung inflammation using inhalative administration but also for the treatment of atopic dermatitis. | |||
T35807 |
C18 dihydro Ceramide (d18:0/18:0)
C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0) |
||
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in... | |||
T64013 |
RPT193
|
||
RPT193 是一种口服具有活力的 CCR4 抑制剂,对 Th2 炎性免疫细胞募集到炎症组织表现出抑制作用,在特应性皮炎、哮喘、过敏性炎症等疾病中发挥着重要作用。 | |||
T78208 |
Leramistat
HMC-C-01-A,MBS2320 |
Mitochondrial Metabolism | Metabolism |
Leramistat (HMC-C-01-A; MBS2320)为线粒体复合物1抑制剂,关与调控细胞代谢及免疫代谢。该化合物被用于抑制诸如特应性皮炎的皮肤病、自身免疫性与炎症性疾病和癌症,以及破骨细胞介导的疾病。 | |||
T60521 | Doxepin | ||
作为三环类抗抑郁药,Doxepin 抑制血清素和去甲肾上腺素的再摄取。Doxepin 具有抗炎作用,可减少抗氧化应激。Doxepin 显示出对特应性皮炎和慢性荨麻疹的治疗效果,并且能改善认知过程和保护中枢神经系统。 | |||
T37187 |
D-erythro/L-threo Lysosphingomyelin (d18:1)
D-erythro/L-threo Lysosphingomyelin (d18:1) |
||
Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1236 |
3',4',7-Trihydroxyisoflavone
|
MAPK; JNK | MAPK |
3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物,是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂,具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用,可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能,可用于研究特应性皮炎。 | |||
T6S0232 |
Eriodictyol
圣草酚,Huazhongilexone |
Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物,具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 18 nM。它可诱导Nrf2信号通路。 |