127
29
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14021 |
20-HETE
20-hydroxy Arachidonic Acid |
Others | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, a | |||
T38070 |
Arachidonic Acid-biotin
|
||
Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signalling and inflammation. Arachidonic acid-biotin was designed to allow arachidonic acid to be detected in complex... | |||
T36232 |
20-carboxy Arachidonic Acid
|
||
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-A... | |||
T81609 |
omega-3 Arachidonic acid ethyl ester
(all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester,ω-3 Arachidonic acid ethyl ester |
||
omega-3 Arachidonic Acid ethyl ester 是一种少见的多不饱和脂肪酸,饮食来源稀少。ω-3脂肪酸对婴幼儿生长发育极为重要,能够帮助预防心脏病、血栓、高血压及炎症和自身免疫性疾病。该化合物在人血小板膜中通过抑制花生四烯酰辅酶A合成酶发挥作用,Ki值达到14 μM;同时在小牛脑提取物中也表现出抑制作用,IC50大约5 μM。omega-3 Arachidonic Acid ethyl ester 作为游离酸的亲脂性更强的形式,具备独特的生物活性。 | |||
T22581 |
Arachidonic Acid Leelamide
|
Others | Others |
Arachidonic acid leelamide is a phospholipase A2 inhibitor. Phospholipase A is a hydrolase responsible for the release of arachidonic acid from the sn2 position of phospholipids. The released arachidonic acid is then converted to mediators of inflammation | |||
T38067 |
5,6-dehydro Arachidonic Acid
|
||
5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 μM. In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 μM. | |||
T21815 |
ONO-RS-082
|
Others | Others |
ONO-RS-082 是磷脂酶 A 抑制剂。它抑制PLA2的IC50值为1.0 μM,但即使浓度达到 100 μM 也不抑制 PLC。 | |||
T2367 |
SKF-86002
SKF86002 |
p38 MAPK; TNF | Apoptosis; MAPK |
SKF-86002 是一种可口服的 p38 MAPK 抑制剂,具有抗炎和抗关节炎活性,可用于缓解疼痛的研究。它能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢,还抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α,IC50为 1 μM。 | |||
T0412 |
Idebenone
艾地苯醌,CV-2619 |
Apoptosis; Antioxidant; Mitochondrial Metabolism | Apoptosis; Metabolism; oxidation-reduction |
Idebenone (CV-2619) 是一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障,诱导细胞凋亡。 | |||
T27026 |
CJ-13,610
CJ 13610,CJ-13610 |
Lipoxygenase | Metabolism |
CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。 | |||
T62606 |
ALOX15-IN-2
|
Lipoxygenase | Metabolism |
ALOX15-IN-2 是一种有效的 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂,抑制ALOX15 直系同源物亚油酸 (LA) 和花生四烯酸 (AA)进行氧化作用 , IC50 分别为 1.55 和 2.79 μM。 | |||
T70188 |
ER-34122
|
Lipoxygenase | Metabolism |
ER-34122,一种新型可口服的双重 5-脂氧合酶/环氧合酶抑制剂,在花生四烯酸诱导的耳部炎症模型中具有强大的抗炎活性。 | |||
T60061 |
RU-TRAAK-2
|
Potassium Channel | Membrane transporter/Ion channel |
RU-TRAAK-2 是 TWIK 相关的花生四烯酸刺激的 K+ 通道的可逆抑制剂,对包括 Kv1.2、GIRK2 和 Slo1 在内的非 K2P 通道没有活性。 | |||
T1420 |
Diethylcarbamazine citrate
Caritrol,枸橼酸乙胺嗪,Loxuran,Dicarocide |
Lipoxygenase; COX; Parasite | Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
Diethylcarbamazine citrate (Caritrol) 是驱肠虫药,主要用作治疗丝虫病的柠檬酸盐,是丝虫微丝蚴的花生四烯酸代谢抑制剂。 | |||
T0961 |
Trometamol
三(羟甲基)氨基甲烷,Tromethamine,缓血酸铵 |
COX | Immunology/Inflammation; Neuroscience |
Trometamol (Tromethamine) 是一种在生理范围内控制 pH 值的有效胺类化合物,也是一种低毒性的生物惰性氨基醇,可以在体内和体外缓冲二氧化碳和酸。 | |||
T77638 |
BIRM 271
|
Phospholipase; LTR | Immunology/Inflammation; Metabolism |
BIRM 271 是一种新型花生四烯酸释放抑制剂,可阻断白三烯B4和人中性粒细胞中的血小板活化因子生物合成。BIRM 271 和 BIRM 270 属于对映异构体,对白三烯B4 的产生有抑制作用,IC50 为40 nM。 | |||
T0477 |
Zileuton
Abbott 64077,齐留通,A 64077 |
Ferroptosis; Lipoxygenase; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Zileuton (A 64077) 是羟基脲的合成衍生物,是一种选择性的5-脂氧合酶抑制剂,具有平喘特性。 | |||
T68025 |
Zoliprofen
|
Others | Others |
Zoliprofen 是一种一种高效的且可口服的非甾体抗炎剂,具有抗炎、解热和镇痛活性,对角叉菜素、制霉菌素、刀豆球蛋白A 诱导的大鼠爪水肿,以及抗大鼠兔血清诱导的骨折或背皮水肿具有抑制作用。Zoliprofen 在大鼠和兔子中对胶原蛋白或花生四烯酸引起的血小板聚集方面比布洛芬和非诺洛芬有效20倍。Zoliprofen 对小鼠内毒素诱导的腹泻和花生四烯酸诱导的兔急性死亡抑制作用显著。 | |||
T0196 |
Diclofenac
双氯芬酸,奥尔芬,Diclofenacum,Voltaren |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 | |||
T0463L |
Loxoprofen sodium
CS-600,CS600,Loxoprofen,CS 600 |
COX | Immunology/Inflammation; Neuroscience |
Loxoprofen sodium (CS-600) 是一种有效的和具有口服活性的非选择性 COX 抑制剂,对 COX-1 和 COX-2具有抑制作用, IC50 分别为 6.5 和 13.5 μM。 Loxoprofen sodium 通过减少花生四烯酸合成前列腺素而起作用。Loxoprofen sodium 具有抗炎和抗肿瘤活性,可用来治疗动脉粥样硬化。 | |||
T1574 |
Etoricoxib
Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine,依托考昔 |
COX | Immunology/Inflammation; Neuroscience |
Etoricoxib (MK-663) 是一种合成的非甾体抗炎药 (NSAID),具有解热、镇痛和潜在的抗肿瘤特性。它是可口服的选择性 COX-2抑制剂,对人全血 COX-2 和 COX-1 的 IC50值分别为 1.1 和 116 μM。 | |||
T1185 |
Rofecoxib
MK 966,罗非昔布,罗非考昔,MK-0966 |
COX | Immunology/Inflammation; Neuroscience |
Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂,具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中,对人 COX-2 的 IC50值分别为 26 和 18 nM。 | |||
T6529 |
Halobetasol propionate
卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458 |
Phospholipase | Metabolism |
Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇,具有抗炎,止痒和收缩血管的活性。 | |||
T1561 |
Clobetasol propionate
Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725 |
Glucocorticoid Receptor; P450 | Endocrinology/Hormones; Metabolism |
Clobetasol propionate (CGP9555) 是CYP3A5的选择性抑制剂(IC50:0.206 μM),而对 CYP3A4 或其他主要 CYP 无抑制作用。它是皮质类固醇,对于牛皮癣和其他皮肤病具有潜在的研究价值。 | |||
T35666 |
PRGL493
|
Others | Others |
PRGL493为高效、选择性的长链酰基辅酶a合成酶4 (ACSL4) 抑制剂,能在乳腺和前列腺细胞以及动物模型中抑制细胞增殖和肿瘤生长,主要应用于癌症研究。 | |||
T1666 |
Fludrocortisone acetate
9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate |
Glucocorticoid Receptor; Autophagy | Autophagy; Endocrinology/Hormones |
Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素,可减少尿液中钠丢失量,也用于增加血压,有用于阿狄森氏病的研究潜力。 | |||
T2403 |
Bromfenac sodium hydrate
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠 |
COX | Immunology/Inflammation; Neuroscience |
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) 是一种可口服的 COX 抑制剂,抑制 COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药,有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。 | |||
T28554 |
Ro 12-7310
Ro-12-7310 |
||
Ro 12-7310, a synthetic retinoid, inhibits arachidonic acid release. | |||
T24296 |
L 640035
L640035,L 640,035,L-640035,L640,035,L-640,035 |
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L 640035 inhibits human platelet aggregation which is induced by arachidonic acid, collagen, and the prostaglandin-endoperoxide analog of U44069. | |||
T35847 |
16(R)-HETE
|
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that... | |||
T25787 |
Me-Indoxam
Methyl indoxam,Methyl-indoxam |
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Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis. | |||
T32481 |
L 739059
L-739059,L739059 |
||
L 739059 is a radioiodinated analog of arachidonic acid that binds 5-lipoxygenase-activating protein. | |||
T35849 |
17(S)-HETE
|
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM. | |||
T26072 | Rhazimine | ||
Rhazimine is an indole alkaloid. It is a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. | |||
T37708 |
17(R)-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM. | |||
T35848 |
16(S)-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM. | |||
T26071 |
Rhamnetin tetraacetate
|
||
Rhamnetin tetraacetate 是一种强效抗血小板化合物,可以强烈抑制花生四烯酸、胶原蛋白和 PAF 诱导的血小板聚集。 | |||
T1574L |
Etoricoxib HCl
L-791456 monohydrochloride salt,L791456 hydrochloride,L-791456 hydrochloride,L 791456 hydrochloride,Etoricoxib hydrochloride |
||
Etoricoxib HCl is a synthetic, nonsteroidal anti-inflammatory drug. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2, resulting in inhibition of the conversion of arachidonic acid into prostaglandins. | |||
T11038 |
Dibutyryl-cGMP sodium
Bt2cGMP sodium |
Others | Others |
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma | |||
T72144 |
6-trans-12-epi-Leukotriene B4
|
||
6-trans-12-epi-Leukotriene B4 是一种花生四烯酸代谢物,是一种有效的抗炎剂。 | |||
T37155 |
8(R)-HETE
|
||
8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results. | |||
T35523 |
(±)17-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive. | |||
T36158 |
8-iso Prostaglandin A2
8-iso Prostaglandin A2 |
||
8-iso Prostaglandin A2 是一种异前列腺素,可由花生四烯酸的非酶氧化产生。 | |||
T37399 |
15(S)-HETE methyl ester
|
||
15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. Methyl esters of lipids are commonly used in formulations of nutritional supplements. | |||
T35465 |
(±)16-HETE
|
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits pro... | |||
T25377 |
EP6
EP-6,EP 6 |
||
EP6 is an inhibitor of 5-lipoxygenase (5-LO), which is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions. | |||
T32783 |
Lipoxin C4
15-OH-Ltc3 |
||
Lipoxin C4 is a bioactive autacoid metabolites of arachidonic acid made by various cell types. It is categorized as a nonclassic eicosanoid and member of the specialized pro-resolving mediator (SPMs) family of polyunsaturated fatty acid (PUFA) metabolites | |||
T40826 |
5(S)-HPETE
|
||
5(S)-Hydroperoxyeicosatetraenoic acid (5(S)-HpETE) is a monohydroperoxy polyunsaturated fatty acid (PUFA) generated by the enzymatic conversion of arachidonic acid via 5-lipoxygenase (5-LO). Subsequently, 5(S)-HpETE undergoes metabolism to form leukotriene A4 (LTA4), which serves as a pivotal intermediate in the synthesis of leukotrienes (LTs). | |||
T37556 |
CAY10502
|
||
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits ... | |||
T74039 |
Arachidonoyl coenzyme A lithium
|
||
Arachidonoyl coenzyme A lithium是一种由辅酶A的硫醇基与花生四烯酸的羧基缩合生成的不饱和脂肪酰基辅酶A。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4129 |
Arachidonic acid
Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar |
Others; Endogenous Metabolite | Metabolism; Others |
Arachidonic acid (Immunocytophyte) 是不饱和的必需脂肪酸。 它存在于动物和人类脂肪以及肝脏、大脑和腺体器官中,是动物磷脂的成分。 它由膳食亚油酸合成而成,是前列腺素、血栓素和白三烯生物合成的前体。 | |||
T4P2931 |
Linoleic acid
9,12-octadecadienoic acid,亚油酸,α-亚油酸,acidelinoleique,9,12-Linoleic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Linoleic acid (9,12-octadecadienoic acid) 是一种多不饱和脂肪酸,存在于坚果、种子和植物性油中。它是膜磷脂的一部分,作为膜流动性的结构成分来维持表皮透皮水屏障。它通过氧化作用引起血红蛋白和红细胞损伤。 | |||
T13632 |
D-Erythro-dihydrosphingosine
Dihydrosphingosine,Octadecasphinganine,D-赤式-C 18 - 二氢-D-神经鞘氨醇,C18-Dihydrosphingosine,D-erythro-Sphinganine |
Phospholipase; Endogenous Metabolite | Metabolism |
D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) 可抑制花生四烯酸的释放和cPLA2α活性。 | |||
TN1643 |
Ferulamide
4-Hydroxy-3-methoxycinnamide,阿魏酸酰胺 |
PAFR; AChR | GPCR/G Protein; Neuroscience |
Ferulamide (4-Hydroxy-3-methoxycinnamide) 是从巴豆中分离的阿魏酸衍生物,具有抗胆碱酯酶活性。 | |||
TN1873 |
Lirinidine
|
Others | Others |
Lirinidine 是一种分离自L. tulipifera 叶片生物碱,具有抗氧化 (antioxidant) 和抗癌作用。它在体外表现出中等的铁还原能力和较小的自由基清除能力,可用于研究化妆品。 | |||
T4740 |
Elaidic acid
反油酸,trans-Oleic Acid |
Endogenous Metabolite | Metabolism |
Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪,能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中,反油酸抑制 HHT 和 HETE 的形成,同时诱导前列腺素和血栓素的合成。 | |||
T4775 |
Arachidic acid
eicosanoic acid,Icosanoic Acid,花生酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Arachidic acid (Icosanoic Acid) 是一种存在于所有哺乳动物细胞中的长链脂肪酸,通常酯化为膜磷脂,是人体组织中丰富的多不饱和脂肪酸之一。 | |||
T1168 |
Desonide
Tridesilon,地索奈德,Locapred,Prednacinolone |
Glucocorticoid Receptor | Endocrinology/Hormones |
Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂,能够作用于糖皮质激素受体。 | |||
T7052 |
Gnetol
|
Tyrosinase; COX; HDAC; AChR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂,对鼠酪氨酸酶的 IC50为 4.5 μM,可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC,具有抗氧化、抗增殖、抗癌和保肝活性,还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
TQ0262 |
Dihomo-γ-linolenic acid
Diroleuton,顺式-8,11,14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989 |
Others | Others |
Ro 12-1989 can be converted into prostaglandin E1 (PGE1). Ro 12-1989 competes with arachidonic acid for COX and lipoxygenase, inhibiting the production of arachidonic acid's eicosanoids. | |||
TN5104 |
Taxacin
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Others | Others |
Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a conce | |||
TN5569 |
2-Deacetoxytaxinine B
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2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation. | |||
TN1980 |
Neocryptotanshinone
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Others | Others |
Neocryptotanshinone inhibits rabbit platelet aggregation induced by arachidonic acid. | |||
TN3740 |
Cyclocommunol
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PAFR | GPCR/G Protein |
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation. | |||
TN5661 |
1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one
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1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one shows strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. | |||
TL0017 |
Aristolactam AIIIa
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MAPK; CDK | Cell Cycle/Checkpoint; MAPK |
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid. | |||
TN3153 | 6-Acetyl-2,2-dimethylchroman-4-one | PAFR | GPCR/G Protein |
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro. | |||
TN5113 |
Taxinine B
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Others | Others |
Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA). | |||
TN5105 | Taxagifine | Others | Others |
Taxagifine shows cytotoxic activity toward HepG2 cells; it can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner. | |||
T25687 |
Leukotriene C4
白三烯C4,LTC4,Leukotriene C |
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Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion in the lung and produces contracti | |||
TMA0593 | Broussoflavonol F | Tyrosinase | Proteases/Proteasome |
Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. Broussoflavonol F | |||
TN4382 |
Kazinol A
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AMPK; mTOR | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M against XOD. Kazinol A may be a candidate for the development of effective anti-cancer drug on h | |||
T37972 |
12-OxoETE
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12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence. | |||
T37774 |
Thielavin A
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Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 and the conversion of PGH2 to PGE2 . Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM). | |||
T73776 |
13-Hydroxyoctadecadienoic acid
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13-hydroxyoctadecadienoic acid (13-HODE) 是 Linoleic acid 的一种内源性脂氧合酶代谢产物。13-hydroxyoctadecadienoic acid 通过增强磷脂中花生四烯酸 (AA) 的释放来刺激前列环素的产生。 | |||
TN4664 |
Norarmepavine
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Others | Others |
N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T38330 |
Collinin
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Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... |