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49

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6800	CCF642 AC1LYELL	Others	Others
	CCF642 (AC1LYELL) 是蛋白质二硫键异构酶抑制剂(IC50:2.9 μM)。它在多发性骨髓瘤细胞中引起急性内质网应激，并伴随凋亡诱导的钙释放，表现出广泛的抗多发性骨髓瘤作用。
T8719	SC99	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SC99 是一种口服有效选择性STAT3抑制剂，靶向 JAK2-STAT3 途径，抑制血小板活化和聚集，有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中，抑制 JAK2 和 STAT3 的磷酸化。
T3661	Citarinostat ACY241,HDAC-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤活性，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。
T11141	E64FC26	Others	Others
	E64FC26 是一种有效的蛋白质二硫键异构酶 (PDI) 家族泛抑制剂，具有抗肿瘤活性，抑制 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6，可用于研究多发性骨髓瘤和胰腺癌。
T76788	Demcizumab OMP 21M18	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Demcizumab (OMP 21M18) 是一种抗 DLL4 单克隆抗体。Demcizumab 是一种有效的 Notch 通路抑制剂。Demcizumab 在多种癌症模型中无论使单独还联合化疗试剂使用都是有效的。
T0094	Budesonide Entocort,Pulmicort,布地奈德,Rhinocort	Glucocorticoid Receptor	Endocrinology/Hormones
	Budesonide (Pulmicort) 是吸入型糖皮质类固醇，是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积，逆转 DNA 低度甲基化，调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。
T35386	Elotuzumab Elotuzumab (anti-SLAMF7),BMS 901608,PDL 063,HuLuc 63	Others	Others
	Elotuzumab(HuLuc 63) (anti-SLAMF7) 是一种靶向 SLAMF7 受体的单克隆抗体。Elotuzumab (anti-SLAMF7) 是一种直接激活NK细胞并诱导抗体依赖性细胞毒性的化合物，可联合来那度胺和地塞米松（Ld）用于治疗多发性骨髓瘤。
T76713	Inebilizumab MEDI 551,MT-0551,16C4-aFuc,VIB-0551	Others	Others
	Inebilizumab 是一种人源化抗 CD19 单克隆抗体，对 B 细胞具有增强的抗体依赖细胞介导的细胞毒性。Inebilizumab 可用于治疗多发性硬化和视神经脊髓炎等一些与 CD19的B细胞相关的一系列自身免疫性疾病。
T68170	xl-281
	XL-281是一种有效的,选择性的,口服活性的野生型和突变型 RAF 激酶抑制剂,在多种异种移植模型中具有抗肿瘤活性；通过调节肿瘤和替代组织中的 RAF 途径证明生物活性,细胞增殖减少,细胞凋亡增加。
T0153	Oltipraz 吡噻硫酮,NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活，IC50为 10 μM，浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。
T76794	Ulocuplumab BMS 936564,MDX 1338	Apoptosis; CXCR	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation
	Ulocuplumab (BMS-936564) 是一种完全人抗 CXCR4 的 IgG4 抗体。Ulocplumab 在急性髓系白血病 (AML)，非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 激活下的迁移有抑制作用，诱导癌细胞凋亡 (apoptosis)，。
T13063	T6167923	MyD88	Immunology/Inflammation
	T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好，破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性，并且改善抗炎活性，对 IFN-γ，IL-1β，IL-6 和 TNF-α 的 IC50分别为 2.7 μM，2.9 μM，2.66 μM 和 2.66 μM。
T28805	SLM6 NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6
	SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.
T24566	O-1663 O 1663
	O-1663 is an advanced stage breast cancer inhibitor that acts by targeting multiple cannabinoid anti-tumor pathways.
T41070	LP-184
	LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, and pancreatic.
T16354	NSC745885	Others	Others
	NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities
T70677	PLS-123
	PLS-123 is a novel covalent irreversible Btk inhibitor with potential anti-proliferative activity. PLS-123 exhibited more potent anti-proliferative effects than ibrutinib in multiple cellular and in vivo preclinical models of B-cell lineage malignancy, including 14 kinds of cell lines, patients’ primary tumor cells and mouse xenograft model.
T61792	HDAC6-IN-10
	HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1].
T36625	LSD1/HDAC6-IN-1 LSD1/HDAC6-IN-1
	LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity and is particularly valuable for research focused on multiple myeloma (MM) [1].
T37815	PM226 PM 226
	Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.
T70838	RO27-3225 TFA
	RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.
T76677	Dacetuzumab
	Dacetuzumab (SGN-40) 是一种人源化的 IgG1，抗 CD40单克隆抗体，具有抗淋巴瘤活性。Dacetuzumab 通过免疫效应作用(抗体依赖性细胞毒性和吞噬作用[ADCC/ADCP]) 杀死肿瘤细胞。Dacetuzumab ((SGN-40) 可用于多发性骨髓瘤研究。
T15158	Dolastatin 15 DLS 15	Others	Others
	Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m
T69323	Dexamethasone sodium succinate
	Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regul...
T77091	Modakafusp alfa
	Modakafusp alfa (TAK-573) 是一种融合蛋白，由人源化抗CD38 IgG4 单克隆抗体和2个减毒IFNα2b分子组成。该化合物主要用于多发性骨髓瘤的研究。
T81580	Ozanezumab GSK1223249
	Ozanezumab (GSK1223249) 是一种anti-Nogo-A 单克隆抗体，用于肌萎缩侧索硬化症 (ALS) 及多发性硬化症研究。
T36761	KRAS inhibitor-10
	KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer research, specifically in pancreatic cancer, breast cancer, multiple myeloma, leukemia, and lung cancer. KRAS inhibitor-10 is classified as a tetrahydroisoquinoline compound. Its inhibitory properties provide valuable insights and potential therapeutic applications in the field of ...
T74414	S-Allylmercaptocysteine
	S-allylmercaptocysteine 是一种从大蒜中提取的有机硫化合物，对各种肺部疾病具有抗炎和抗氧化作用。S-allylmercaptocysteine 通过多种途径发挥抗癌作用，如通过 TGF-β 信号通路诱导癌细胞凋亡 (apoptosis)，或通过降低NF-κb 活性和上调 Nrf2 来达到抗炎和抗氧化的作用。
T73485	BT-GSI
	BT-GSI 是一种 γ-分泌酶抑制剂 (GSI) 和骨靶向 Notch 抑制剂。BT-GSI 具有双重抗骨髓瘤和抗吸收特性，可用于多发性骨髓瘤及相关骨病的研究。BT-GSI 抑制肿瘤生长和溶骨性疾病进展。
T63906	hGGPPS-IN-2
	hGGPPS-IN-2 是一种 C-2 取代的噻吩并嘧啶基双膦酸盐 (C2-ThP-BPs) 的类似物，是一种有效的人类香叶基香叶基焦磷酸合成酶 (hGGPPS) 抑制剂。hGGPPS-IN-2 能够靶向作用于多发性骨髓瘤 (MM) 细胞，诱导其选择性凋亡 (apoptosis)，并在体内显示出抗骨髓瘤作用。
T76840	Vunakizumab
	Vunakizumab (Anti-Human IL17A Recombinant Antibody) 是一种重组的人源化 IgGκ 单克隆抗体，可以靶向 IL-17A 并抑制其与 IL-17受体的相互作用。Vunakizumab 可用于研究银屑病关节炎、强直性脊柱炎、多发性硬化症和炎症性关节炎等自身免疫性疾病。
T61313	Antitumor agent-70
	Antitumor agent-70 (compound 8b) is a highly potent multi-targeted kinase inhibitor, particularly targeting c-Kit. It demonstrates remarkable anti-tumor activity and the ability to induce cell apoptosis. This compound also exhibits strong inhibition of multiple myeloma, with an IC 50 value of 0.12 μM. Therefore, Antitumor agent-70 holds great potential as an effective therapy for combating cancer, especially in cases involving c-Kit. [1]
T73693	Peginterferon beta-1a
	Peginterferon beta-1a (Peginterferon β-1a) 是一个聚乙二醇化干扰素 beta-1a 分子。Peginterferon beta-1a 诱导癌细胞凋亡并且在裸鼠模型中显示出抗肿瘤活性。Peginterferon beta-1a 可用于癌症和多发性硬化 (RMS) 的研究。
T77009	Firivumab
	Firivumab (CT-P22; CT120)是一种针对人类IgG1单克隆的抗甲型流感病毒血凝素（Anti-IAV HA）抗体。该抗体能有效中和多种亚型，包括H1N1、H5N1、H6N1、H6N2、H8N4、H8N8、H9N2和H12N7。研究发现，Firivumab在小鼠模型中对H1N1病毒展现出显著的保护效果。
T61673	Anticancer agent 56
	Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat...
T76935	Briakinumab
	Briakinumab (ABT-874) 是一种全人抗 IL-12/23p40单克隆抗体。Briakinumab 靶向并中和 IL-12和 IL-23。Briakinumab 可用于类风湿性关节炎、炎症性肠病和多发性硬化症的研究。
T76729	Lucatumumab
	Lucatumumab (HCD122) 是一种全人抗 CD40拮抗剂单克隆抗体，可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除，可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。
T79523	HDAC6-IN-18	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6-IN-18（化合物4）是首个针对HDAC6亚型的不可逆选择性抑制剂，显示出有效的抗多发性骨髓瘤活性。该抑制剂在RPMI8266、U266以及MM.1S细胞系中表现出对HDAC6的抑制效力，其IC50值分别为0.17、0.7和0.42 μM[1]。
T35747	Quinacrine analog 34
	Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels ...
T77084	Mezagitamab
	Mezagitamab (TAK-079) 是一种 IgG1λ 类型的抗CD38单克隆抗体。其通过促进抗体和补体依赖性的细胞毒性，来耗尽表达CD38的肿瘤细胞，显示出在复发/难治性多发性骨髓瘤 (RRMM) 及原发性血小板减少性紫癜 (ITP) 等疾病中的治疗潜力。
T78296	IMAB027 ASP1650
	IMAB027 (ASP1650)是针对CLDN6 (Claudin 6)的特异性单克隆抗体，CLDN6作为一种紧密连接蛋白，其在多种人类癌症中异常高表达，尤其显著于卵巢癌。IMAB027展现出抗肿瘤特性，并能诱导表达CLDN6的卵巢癌和睾丸癌细胞走向凋亡。
T61945	hGGPPS-IN-1
	hGGPPS-IN-1 是 C-2 取代的噻吩并嘧啶基双膦酸盐 (C2-ThP-BPs) 的类似物，对人类香叶基香叶基焦磷酸合成酶 (hGGPPS) 具有有效的抑制作用。hGGPPS-IN-1 可选择性诱导多发性骨髓瘤 (MM) 细胞凋亡 (apoptosis)。hGGPPS-IN-1在体内表现出抗骨髓瘤活性。
T62468	CB1/2 agonist 1
	CB1/2 agonist 1 是一种有效的、能够透过血脑屏障的 CB1/2 激动剂，能够作用于 CB1R (EC50: 56.15 nM) 和 CB2R (EC50: 11.63 nM)。CB1/2 agonist 1 能够降低谷氨酸释放，并减少 LPS 诱导的小胶质细胞活化，具有抗炎和镇痛活性。CB1/2 agonist 1 具有潜力进行多发性硬化症的研究。
T68389	LY2457546
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...
T37419	Zetomipzomib
	KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. KZR-616 also inhibits MECL-1 subunit (IC50=623 nM) and constitutive proteasome β5 subunit (IC50=688 nM). KZR-616 maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. KZR-616 (250 nM) shows a comparable cytokine inhib...
T71382	KRC-108
	KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo...
T61572	FNDR-20123 free base
	FNDR-20123 free base 是一种有效、安全、首创的抗疟疾HDAC 抑制剂，对疟原虫和人类 HDAC 的IC50分别为 31 nM 和 3 nM。FNDR-20123 free base 对恶性疟原虫 (Plasmodium falciparum) 无性期 (IC50=41 nM) 和性血期 (雄性配子体 IC50=190 nM) 具有抗疟疾活性。FNDR-20123 free base 抑制 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 的 IC50分别为 25，29，2，11，282 nM，并在纳摩尔浓度下抑制 III 类 HDAC 亚型。
T35802	ML-345
	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de...
T38174	Mpro inhibitor N3 hemihydrate
	Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses...

化合物

Cat.No: T6800

Synonym: AC1LYELL

Target: Others

Cat.No: T8719

Target: Apoptosis, JAK, STAT

Cat.No: T3661

Synonym: ACY241,HDAC-IN-2

Target: HDAC

Cat.No: T11141

Target: Others

Cat.No: T76788

Synonym: OMP 21M18

Target: Gamma-secretase

Cat.No: T0094

Synonym: Entocort,Pulmicort,布地奈德,Rhinocort

Target: Glucocorticoid Receptor

Cat.No: T35386

Synonym: Elotuzumab (anti-SLAMF7),BMS 901608,PDL 063,HuLuc 63

Target: Others

Cat.No: T76713

Synonym: MEDI 551,MT-0551,16C4-aFuc,VIB-0551

Target: Others

Cat.No: T68170

Cat.No: T0153

Synonym: 吡噻硫酮,NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Cat.No: T76794

Synonym: BMS 936564,MDX 1338

Target: Apoptosis, CXCR

Cat.No: T13063

Target: MyD88

Cat.No: T28805

Synonym: NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6

Cat.No: T24566

Synonym: O 1663

Cat.No: T41070

Cat.No: T16354

Target: Others

Cat.No: T70677

Cat.No: T61792

LSD1/HDAC6-IN-1

Cat.No: T36625

Synonym: LSD1/HDAC6-IN-1

Cat.No: T37815

Synonym: PM 226

Cat.No: T70838

Cat.No: T76677

Cat.No: T15158

Synonym: DLS 15

Target: Others

Dexamethasone sodium succinate

Cat.No: T69323

Modakafusp alfa

Cat.No: T77091

Cat.No: T81580

Synonym: GSK1223249

KRAS inhibitor-10

Cat.No: T36761

S-Allylmercaptocysteine

Cat.No: T74414

Cat.No: T73485

Cat.No: T63906

Cat.No: T76840

Antitumor agent-70

Cat.No: T61313

Peginterferon beta-1a

Cat.No: T73693

Cat.No: T77009

Anticancer agent 56

Cat.No: T61673

Cat.No: T76935

Cat.No: T76729

Cat.No: T79523

Target: HDAC

Quinacrine analog 34

Cat.No: T35747

Cat.No: T77084

Cat.No: T78296

Synonym: ASP1650

Cat.No: T61945

CB1/2 agonist 1

Cat.No: T62468

Cat.No: T68389

Cat.No: T37419

Cat.No: T71382

FNDR-20123 free base

Cat.No: T61572

Cat.No: T35802

Mpro inhibitor N3 hemihydrate

Cat.No: T38174

Cat. No.	Product Name	Target	Signaling Pathways
T2844	Hyperoside Quercetin 3-galactoside,金丝桃甙,金丝桃苷,Hyperin	Others; Influenza Virus; Antifungal	Microbiology/Virology; Others
	Hyperoside (Hyperin) 是一种从Camptotheca acuminate 提取的黄酮，具有多种生物活性，如心肌保护、抗氧化还原和抗炎活性。
T5S1026	Apigenin-7-glucuronide Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸	MMP	Proteases/Proteasome
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。
T3752	4-Hydroxybenzyl alcohol 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物，具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长，有神经保护作用。
T3851	Vicenin 2 Vicenin -2,维采宁 2,新西兰牡荆苷	RAAS	Endocrinology/Hormones
	Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。
T4S1469	Cucurbitacin IIb 葫芦素IIB,雪胆素乙	Apoptosis; Others	Apoptosis; Others
	Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3，JNK 和 Erk1/2 的磷酸化，提高 IκB 和 NF-κB (p65) 的磷酸化水平，抑制 NF-κB (p65) 的核转位，降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡，具有抗炎作用。
T3398	Icaritin Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin	Apoptosis; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。
T12403	Penitrem A	Others	Others
	Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat
T78539	(+)-Coclaurine hydrochloride d-Coclaurine hydrochloride,(R)-Coclaurine hydrochloride,(+)-(R)-Coclaurine hydrochloride	Others	Others
	(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride 是从多种植物中分离得到的四氢异喹啉类生物碱，具有抗衰老活性。
TN4286	Isodunnianol	NOS; NF-κB; ROS; AChR	Immunology/Inflammation; Neuroscience; NF-κB
	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant
TN5280	(-)-Zeylenol Zeylenol	Apoptosis	Apoptosis
	(-)-Zeylenol (Zeylenol) 是一种从 Uvaria grandiflora 的茎中提取的天然产物，具有抗炎、拒食和抗肿瘤生物活性，通过抑制多种炎症介质的合成或释放发挥作用。 zezelenol 对油菜根系生长有抑制作用，具有诱导人乳腺癌 MDA-MB231细胞凋亡的潜力。

天然产物

Cat.No: T2844

Synonym: Quercetin 3-galactoside,金丝桃甙,金丝桃苷,Hyperin

Target: Others, Influenza Virus, Antifungal

Apigenin-7-glucuronide

Cat.No: T5S1026

Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

Target: MMP

4-Hydroxybenzyl alcohol

Cat.No: T3752

Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Target: Apoptosis, Endogenous Metabolite

Cat.No: T3851

Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷

Target: RAAS

Cucurbitacin IIb

Cat.No: T4S1469

Synonym: 葫芦素IIB,雪胆素乙

Target: Apoptosis, Others

Cat.No: T3398

Synonym: Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Cat.No: T12403

Target: Others

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

(+)-Coclaurine hydrochloride

Cat.No: T78539

Synonym: d-Coclaurine hydrochloride,(R)-Coclaurine hydrochloride,(+)-(R)-Coclaurine hydrochloride

Target: Others

Cat.No: TN4286

Target: NOS, NF-κB, ROS, AChR

Cat.No: TN5280

Synonym: Zeylenol

Target: Apoptosis

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