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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8740 |
COH-SR4
COH-SR4 (Mitochondria uncoupler SR4) |
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) 是线粒体氧化磷酸化的解偶联剂,可调节 amp 依赖性激酶 (ampk)-雷帕霉素 (mtor) 信号的哺乳动物靶点,并抑制 hepg2 肝癌细胞的增殖。它对白血病、黑色素瘤、乳腺癌和肺癌显示出强大的抗增殖活性。它是一种AMPK 活化剂,通过激活 AMPK 来抑制脂肪细胞分化,可用于肥胖及代谢紊乱相关的研究。 | |||
T67855 |
ISX-3
|
Others | Others |
ISX-3 是有效的促成骨剂和抗脂肪生成剂。ISX-3 可以增加 PPARγ 的表达。ISX-3 可用于研究骨质减少和骨质疏松症。 | |||
T12828 |
Salicortin
|
NF-κB; JNK | MAPK; NF-κB |
Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity. | |||
T36471 |
Ternatin
|
||
Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations. Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM. Note that this metabolite should not be confused with the plant flavonoid of the same name. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3739 |
2,6-Dimethoxyquinone
2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone,2,6-二甲氧基-1,4-苯醌 |
Others | Others |
2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) 是一种植物中提取吸脂诱导因子。它具有抗脂肪、抗癌、抗菌、抗疟疾和抗炎的作用。 | |||
T4S1173 |
Agrimol B
仙鹤草酚B,仙鹤草酚 B |
Sirtuin; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。 | |||
T2882 |
Genistin
染料木甙,Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside,染料木苷 |
Apoptosis; Estrogen Receptor/ERR; Others | Apoptosis; Endocrinology/Hormones; Others |
Genistin (Genistoside) 是一种植物雌激素家族的异黄酮,是一种抗脂肪生成剂。它通过调节ERalpha 信号通路抑制乳腺癌细胞生长和促进凋亡细胞死亡。 | |||
TN1836 |
Kudinoside D
|
LDL; AMPK; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Kudinoside D 是 Ilex kudingcha 中三萜皂苷的主要天然成分之一。它能够调节 3T3-L1 脂肪细胞中 AMPK 途径,并可抑制脂肪形成。 | |||
TN1803 |
Isoscoparin
|
Antioxidant; TNF; NO Synthase; Fatty Acid Synthase | Apoptosis; Immunology/Inflammation; Metabolism; oxidation-reduction |
Isoscoparin 源自 Gentiana algida Pall,具有抗氧化和抗脂肪生成活性。Isoscoparin 可用于预防和治疗肥胖的研究。 | |||
TN1189 |
13-Methylberberine chloride
13-甲基小檗碱,13-Methylberberine |
Others | Others |
13-Methylberberine chloride 是一种黄连素类似物,可增加 IL-12 的产生,并在 LPS 激活的巨噬细胞转录后抑制 iNOS 的表达,具有抗脂肪和抗肿瘤作用。 | |||
T8184 |
Fucosterol
岩皂甾醇,岩藻甾醇 |
PARP; Endogenous Metabolite; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇,具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制 PPARα和C/EBPα的表达调控脂肪生成,可用于抗肥胖试剂开发研究。 | |||
T2S0410 |
Euphorbia factor L1
Euphorbiasteroid,大戟因子L1,大戟因子 L1 |
Apoptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬,具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。 | |||
T5S2361 |
Epiberberine
|
ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE | Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling |
Epiberberine 是一种从黄连中得到的生物碱,是AChE 和BChE 抑制剂,和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期,它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用,能够清除 ONOO-,可用于阿尔滋海默症和糖尿病的研究。 | |||
T13205 | Triphala | Others | Others |
Triphala is an Ayurvedic polyherbal formulation. Triphala inhibits NF-κB activation. Triphala exerts antifungal action, and with anti-adipogenic, anti-inflammatory, and antineoplastic activities. | |||
TN2896 |
3,5-Dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane
|
Others | Others |
(3R,5R)-3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane may have anti-adipogenic activity. | |||
TN4092 | Galanolactone | 5-HT Receptor | GPCR/G Protein; Neuroscience |
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through do | |||
TN3366 | Ailanthoidol | IL Receptor; NOS; COX; Prostaglandin Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailanthoidol has anti-adipogenic activit | |||
TN2641 | 15-Methoxypinusolidic acid | ERK; IL Receptor; p38 MAPK; Calcium Channel; NOS; NF-κB; COX; JNK; NMDAR; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dep |