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75

抑制剂 & 化合物

27

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T62125	Colistin adjuvant-1
	Colistin adjuvant-1 是一种粘菌素佐剂 (colistin adjuvant)，对革兰氏阴性细菌具有增强的粘菌素增强活性。Colistin adjuvant-1 对 NF-κB 表现出抑制作用 (IC50: 0.209 μM)。
T61154	Colistin adjuvant-2
	Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].
T10466	BAY-1797	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	BAY-1797 是具有口服活性的选择性P2X4高效拮抗剂，对人 P2X4 的IC50为 211 nM，具有抗伤害和抗炎作用。
T2067	NS11394 NS 11394	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	NS11394 是可口服GABAA 的阳性变构调节剂 (PAM)，Ki 值为 0.5 nM。它对GABAA 的选择性依次为 α5、α3、α2 和α1 受体，具有抗炎和抗焦虑活性。
T2125	Trametinib GSK1120212,曲美替尼,JTP-74057	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Trametinib (GSK1120212) 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM)，具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬，诱导凋亡。
T5857	Trametinib (DMSO solvate) Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis; MEK	Apoptosis; MAPK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂，抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬，诱导凋亡。
T16871	Semustine	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	Semustine 是一种 DNA 烷化剂，是一种癌症化疗化合物，在接受辅助化疗的恶性黑色素瘤患者中具有肾毒性，可用于辅助治疗白血病。
T67912	PA3552-IN-1
	PA3552-IN-1 是一种抗生素佐剂，可以降低 PA3552 的表达，恢复 MDR 铜绿假单胞菌 DK2 菌株对 Polymyxin B 的敏感性。
T4027	KIN1148	Influenza Virus	Microbiology/Virology
	KIN1148 是一种新型小分子佐剂，是IRF3激动剂，用于增强流感疫苗效率。
T68088	Iodofiltic acid
	Iodofiltic acid 可用于辅助治疗急性冠脉综合征（Zeus-ACS），可成像以检测心肌缺血。
T13545	Aluminum Hydroxide	Others	Others
	Aluminum Hydroxide 是一种具有口服活性的铝佐剂的主要形式。它也可作为佐剂补偿亚单位疫苗的低固有免疫原性。基于它辅助的研究包括储存库效应、促吞噬作用和激活促炎症的 NLRP3 通路。
T19967	Fendosal 芬度柳,HP 129,P 71-0129,P71-0129,P-71-0129,HP129,HP-129	Immunology/Inflammation related	Immunology/Inflammation
	Fendosal (HP-129) 是一种非甾体抗炎药。在预防性和治疗性辅助诱导的慢性炎症多关节炎模型中，它的活性是阿司匹林的 6.9 至 9.5 倍。
T14513	BBIQ	TLR	Immunology/Inflammation
	BBIQ 是一种有效且选择性的 toll 样受体 7 (TLR7) 激动剂，对人 TLR7 的 EC50 为 59.1 nM。BBIQ 还是一种功能强大的疫苗佐剂，可增强机体的先天免疫应答。
T0806	Flunarizine dihydrochloride Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪	Calcium Channel; Dopamine Receptor; Sodium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。
T72253	AXC-715 trihydrochloride T785 trihydrochloride	TLR	Immunology/Inflammation
	AXC-715 trihydrochloride (T785 trihydrochloride) 是一种 TLR7/TLR8 双激动剂，可用于合成抗体佐剂免疫偶联物。偶联物多为程序性死亡配体 1 (PD-L1) 连接到一个或多个佐剂的抗体结构上。
T63056	Dovramilast
	Dovramilast (CC-11050) 是一种口服具有活力的磷酸二酯酶 4 (PDE4) 抑制剂，可以降低炎症反应，改善 INH 介导的肺部细菌清除。Dovramilast (CC-11050) 能够作为辅助试剂，用于研究结核病。
T77796	DL-Borneol (endo)-Borneol,Borneol,(±)-Borneol	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	DL-Borneol ((endo)-Borneol) 是一种从中药中提取的小分子，是一种可口服的生物佐剂，可以改善药物向大脑的输送，常用作治疗心脑血管疾病的中药的辅助成分。
TP1938L	RS09 2TFA (1449566-36-2 free base) RS09 2TFA 1449566-36-2(free base)	TLR	Immunology/Inflammation
	RS09 2TFA (1449566-36-2 free base) 是一种 TLR4 激动剂。促进 NF-κB 核转位并在体外诱导 RAW264.7 巨噬细胞分泌炎性细胞因子。它在体内充当佐剂并提高 X-15 特异性抗体血清浓度。
T21320	Methoxyamine HCl 甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102	Others	Others
	Methoxyamine HCl (Methoxyamine) 与脱嘌呤/脱嘧啶 (AP) DNA 损伤位点共价结合并抑制碱基切除修复 (BER)，这可能导致 DNA 链断裂和细胞凋亡增加。 Methoxyamine 是一种具有潜在佐剂活性的口服生物可利用的小分子抑制剂。该药剂可增强烷化剂的抗肿瘤活性。
T64914	Vitamin E succinate D-α-Tocopherol Succinate	Apoptosis	Apoptosis
	Vitamin E succinate (D-α-Tocopherol Succinate) 是一种具有抗氧化作用的生育酚，属于维生素 E 类化合物。Vitamin E succinate 具有抗肿瘤活性，可诱导细胞凋亡，可用于辅助治疗癌症和合成 INVITE （一种生物偶联物）。
T21543	AP 18	TRP/TRPV Channel	Membrane transporter/Ion channel
	AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活，在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。
T15003	CP-20961	Others	Others
	CP-20961 is a synthetic non-immunogenic adjuvant. It induces arthritis.
T29846	Alcuronium free base Alcuronium,Alcuronum,Diallylnortoxiferine,Alcuronium kation,Alloferine
	Alcuronium free base is a non-depolarizing skeletal muscle relaxant similar to Tubocurarine. It is used as an anesthesia adjuvant.
T39527	Se-DMC
	Se-DMC effectively reduces the inflammatory response, nociception, and neurobehavioral deficits induced by complete Freund's adjuvant (CFA) in mice.
T19590	Trehalose 6-behenate	Others	Others
	Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.
T31914	Gantacurium chloride GW 280430A,AV4430A,AV 4430A,GW280430,GW 280430,GW-0430
	Gantacurium chloride is a benzylisoquinoline alkaloid, which may be used as an adjuvant in anesthesia.
T68926	Indomethacin salicylate
	Indomethacin salicylate is an antiinflammatory drug. It has shown remarkable inhibitory effects on carrageenin edema, ultraviolet erythema and adjuvant arthritis.
T32085	HM30181AK HM-30181AK,HM 30181AK
	HM30181AK is an inhibitor of the adenosine triphosphate (ATP) binding cassette (ABC) transporter P-glycoprotein (P-gp) with adjuvant activity.
T24994	MreB Perturbing Compound A22 hydrochloride A22 hydrochloride,MreB Perturbing Compound A22
	A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.
T28916	TAK-603 TAK603,TAK 603
	TAK-603 is an anti-rheumatic drug and is also anti-inflammatory compound. It selectively suppresses Th1 cytokine production and inhibits the progression of adjuvant arthritis.
T69385	Baicalein monohydrate
	Baicalein monohydrate is an inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis.
T6287L	Tariquidar dimesylate D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576
	Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs.
T21392	Flunarizine Flunarizinum,Flunarizin,Sibelium,Flunarizina,R-14950
	Flunarizine is a non-selective calcium entry blocker and a histamine H1 receptor blocker. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of
T40152	AXC-715 hydrochloride
	AXC-715 hydrochloride is a TLR7/TLR8 dual agonist, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.
T38619	GSK1795091 CRX-601
	GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.
T15167	Draflazine R-75231	Others	Others
	Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carrageenan inflammation model of therma
T74916	ODN M362
	ODN M362 是一种 C 类寡核苷酸，是 TLR-9激动剂，可用作疫苗佐剂。ODN M362 诱导癌细胞凋亡（apoptosis）。
T74240	Vaxfectin
	Vaxfectin 是一种阳离子脂质佐剂，可用于基于质粒 DNA 和蛋白质的疫苗。
T69451	R-130823
	R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated ...
T14035	3M-011	TLR	Immunology/Inflammation
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
T72871	IMD-biphenylC	NF-κB	NF-κB
	IMD-biphenylC是一款新型NF-κB免疫调节剂二聚体，能够有效抑制肿瘤增殖，并诱导较低的全身性炎症反应，同时减轻佐剂的毒性。
T74909	ODN 2395
	ODN 2395为C类寡核苷酸，作为疫苗佐剂和TLR9激动剂应用。其序列为5'-tcgtcgttttcggcgc:gcgccg-3'。(注:碱基为硫代磷，ODN 2395特征为包含部分回文序列cggcgc:gcgccg)
T38327	Cryogenine
	Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.2 \|1. Lema, W.J., Blankenship, J.W., and Malone, M.H. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15(2), 161-167 (1986).\|2. Kosersky, D.S., Brown, J.K., and Malon...
T70268	3A-MPLA
	Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.
T5317L	Cridanimod sodium XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101
	Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, cancer cells could be eradicated thro
T72869	IMD-biphenylA	NF-κB	NF-κB
	IMD-biphenylA是NF-κB免疫调节二聚体中的新型咪唑喹啉酮类化合物，具有增强小分子免疫增强剂免疫佐剂性的能力。
T74902	ODN 1018
	ODN 1018 (1018 ISS)为一种寡脱氧核苷酸，兼具TLR-9激动剂与合成免疫刺激序列的特性，广泛应用作疫苗佐剂。序列为5′-TGACTGTGAACGTTCGAGATGA-3′。
T72870	IMD-biphenylB	NF-κB	NF-κB
	IMD-biphenylB作为NF-κB免疫调节剂二聚体，具有抑制肿瘤增殖的功能，并能诱导低全身炎症反应，同时减少佐剂毒性。
T72688	STING agonist-20
	STINGagonist-20 是一种有效的STING 激动剂，用于合成 XMT-2056。STINGagonist-20 可作为疫苗佐剂，用于癌症以及其他炎症，免疫性疾病的研究。
T78672	I-287
	I-287为一种口服活性PAR2选择性抑制剂，能对Gαq和Gα12/13的活性以及其下游效应物施加负异构调控。该化合物能够减轻Complete Freund's adjuvant引发的小鼠炎症，适用于免疫炎症研究。

化合物

Colistin adjuvant-1

Cat.No: T62125

Colistin adjuvant-2

Cat.No: T61154

Cat.No: T10466

Target: P2X Receptor

Cat.No: T2067

Synonym: NS 11394

Target: GABA Receptor

Cat.No: T2125

Synonym: GSK1120212,曲美替尼,JTP-74057

Target: Apoptosis, MEK, Autophagy

Trametinib (DMSO solvate)

Cat.No: T5857

Synonym: Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)

Target: Apoptosis, MEK

Cat.No: T16871

Target: DNA Alkylator/Crosslinker

Cat.No: T67912

Cat.No: T4027

Target: Influenza Virus

Iodofiltic acid

Cat.No: T68088

Aluminum Hydroxide

Cat.No: T13545

Target: Others

Cat.No: T19967

Synonym: 芬度柳,HP 129,P 71-0129,P71-0129,P-71-0129,HP129,HP-129

Target: Immunology/Inflammation related

Cat.No: T14513

Target: TLR

Flunarizine dihydrochloride

Cat.No: T0806

Synonym: Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪

Target: Calcium Channel, Dopamine Receptor, Sodium Channel

AXC-715 trihydrochloride

Cat.No: T72253

Synonym: T785 trihydrochloride

Target: TLR

Cat.No: T63056

Cat.No: T77796

Synonym: (endo)-Borneol,Borneol,(±)-Borneol

Target: GABA Receptor, Endogenous Metabolite

RS09 2TFA (1449566-36-2 free base)

Cat.No: TP1938L

Synonym: RS09 2TFA 1449566-36-2(free base)

Target: TLR

Methoxyamine HCl

Cat.No: T21320

Synonym: 甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102

Target: Others

Vitamin E succinate

Cat.No: T64914

Synonym: D-α-Tocopherol Succinate

Target: Apoptosis

Cat.No: T21543

Target: TRP/TRPV Channel

Cat.No: T15003

Target: Others

Alcuronium free base

Cat.No: T29846

Synonym: Alcuronium,Alcuronum,Diallylnortoxiferine,Alcuronium kation,Alloferine

Cat.No: T39527

Trehalose 6-behenate

Cat.No: T19590

Target: Others

Gantacurium chloride

Cat.No: T31914

Synonym: GW 280430A,AV4430A,AV 4430A,GW280430,GW 280430,GW-0430

Indomethacin salicylate

Cat.No: T68926

Cat.No: T32085

Synonym: HM-30181AK,HM 30181AK

MreB Perturbing Compound A22 hydrochloride

Cat.No: T24994

Synonym: A22 hydrochloride,MreB Perturbing Compound A22

Cat.No: T28916

Synonym: TAK603,TAK 603

Baicalein monohydrate

Cat.No: T69385

Tariquidar dimesylate

Cat.No: T6287L

Synonym: D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576

Cat.No: T21392

Synonym: Flunarizinum,Flunarizin,Sibelium,Flunarizina,R-14950

AXC-715 hydrochloride

Cat.No: T40152

Cat.No: T38619

Synonym: CRX-601

Cat.No: T15167

Synonym: R-75231

Target: Others

Cat.No: T74916

Cat.No: T74240

Cat.No: T69451

Cat.No: T14035

Target: TLR

Cat.No: T72871

Target: NF-κB

Cat.No: T74909

Cat.No: T38327

Cat.No: T70268

Cridanimod sodium

Cat.No: T5317L

Synonym: XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101

Cat.No: T72869

Target: NF-κB

Cat.No: T74902

Cat.No: T72870

Target: NF-κB

STING agonist-20

Cat.No: T72688

Cat.No: T78672

Cat. No.	Product Name	Target	Signaling Pathways
T12500	Platycoside E Platycodin E,桔梗苷E	Others	Others
	Platycoside E (Platycodin E) 是一种桔梗皂苷元型皂苷，从桔梗的根中分离获得，能够促进 ovalbumin 免疫小鼠中血清 OVA 特异性IgG2a 和IgG2b 抗体的产生。它具有溶血活性和佐剂潜力。
TJS2216	Aurantiamide acetate 金色酰胺醇酯,Asperglaucide	Cysteine Protease	Proteases/Proteasome
	Aurantiamide acetate (Asperglaucide) 是抑制口服有活性的 cathepsin 选择性抑制剂，分离自 Portulaca oleracea L。它具有抗炎作用，可用于研究炎性相关疾病。
TN6925	Pristane 姥鲛烷,2,6,10,14-tetramethylpentadecane	Others	Others
	Pristane (2,6,10,14-tetramethylpentadecane) 是一种天然存在的烃油，是矿物油中最活跃的成分，较少存在于许多植物、各种海洋生物中。它是一种非抗原性佐剂，可诱导大鼠中 MHC II 类限制性关节炎 T 细胞。
TN2232	Soyasaponin Ab	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Soyasaponin Ab 是一种大豆皂苷。Soyasaponin Ab 在 3T3-L1 脂肪细胞中通过下调 PPARγ 产生抗肥胖的作用。
T6431	Levoleucovorin Calcium 左亚叶酸钙,Calcium Levofolinate,CL307782	Others; Antifolate	Cell Cycle/Checkpoint; Others
	Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐，在癌症化疗中用作辅助剂。
T24403	Folinic acid HSDB 6544,Leucovorin	Endogenous Metabolite; Antifolate	Cell Cycle/Checkpoint; Metabolism
	Folinic acid (Leucovorin) 是一种可用于治疗甲氨蝶呤的生物叶酸，通常与 Methotrexate (MTX) 联用来降低 MTX 诱导的毒性，可用于辅助治疗结肠癌。
T6S1485	Ginsenoside Rh4 人参皂苷Rh4	Others	Others
	Ginsenoside Rh4 可以安全地用作佐剂，具有低溶血作用或无溶血作用。它具有细胞毒活性，其苷元对癌细胞系具有杀伤作用。
T5781	taraxasteryl acetate 蒲公英甾醇醋酸酯,醋酸蒲公英酯	Antibacterial	Microbiology/Virology
	Taraxasteryl acetate 是分离自矢状疟原虫中，具有广谱的抗炎活性。它能够改善右旋糖酐、酵母聚糖及花生四烯酸诱导的大鼠后爪水肿。它可用于研究局部炎症。
TN2088	Platycodin D2 桔梗皂苷D2	IL Receptor; HBV	Immunology/Inflammation; Microbiology/Virology
	Platycodin D2 是分离自桔梗的皂苷类物质，显示除抗癌活性。
TJS0339	Coumarin-3-carboxylic acid 香豆素-3-羧酸,3-Carboxycoumarin	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Coumarin-3-carboxylic acid (3-Carboxycoumarin) 是一种合成香豆素的重要起始化合物。其中香豆素是具有多种生物活性的天然产物。它的镧系复合物对 K-562 细胞具有抗增殖活性。
T7028	Licochalcone C LICOCHALCONEC,甘草查尔酮C	Phosphatase; Antioxidant; Glucosidase	Metabolism; oxidation-reduction
	Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶，其对 α-葡萄糖苷酶的 IC50 <100 nM，对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。
T6S0735	Flavokawain B 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis; Others	Apoptosis; Others
	Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中，分离出的查尔酮。它是一种凋亡诱导剂，可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成，具有抗血管生成活性。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。
T35000	Uproleselan sodium GMI 1271,GMI1271,GMI-1271
	Uproleselan sodium (GGI-1271) is a small molecule E-selector antagonist originally targeted at AML as an adjuvant to standard chemotherapy for hematological malignancies.
T11392	Germacrene D	Antibacterial	Microbiology/Virology
	Germacrene D has antibacterial and antifungal activities and can be used as an adjuvant agent in the application of aminoglycosides and azoles. Germacrene D is isolated from Bursera species.
T13472	α-Carotene	Others	Others
	α-Carotene is isolated from yellow-orange and dark-green vegetables. α-Carotene is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs.
TN4804	Platycoside A	Antifection	Microbiology/Virology
	Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice.
TN3383	α-Amyrin palmitate alpha-Amyrin palmitate	PKA	Tyrosine Kinase/Adaptors
	alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki=6 microM), it also shows weak cytotoxicity against the A2780 human ovarian cancer cell line.
TN4410	Lappaol C	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
T38838	QS-21 Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.
TN1072	Lappaol A	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
T38241	2-Aminoimidazole
	2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. Additionally, 2-Aminoimidazole acts as a weak noncompetitive inhibitor of human arginase I, with a Ki value of 3.6 mM[1][2][3].
T78492	D-Mannuronic acid sodium
	D-Mannuronic acid sodium，一种可从Macrocystis pyrifera中分离得到的化合物，显示出在自身免疫性脑脊髓炎(EAE)、佐剂性关节炎(AIA)、肾病综合征以及急性肾小球肾炎的研究中具有潜在应用价值。
TN5530	Volkensiflavone Talbotaflavone	Others	Others
	Volkensiflavone (Talbotaflavone) 是一种天然产物，存在于黄芪和藤黄中。它具有植物代谢物的作用,是一种次生代谢产物。Volkensiflavone 是一种双类黄酮，属于羟黄酮和羟黄酮。Volkensiflavone 可以作为佐剂用于过表达外排泵的多药耐药金黄色葡萄球菌的抗生素治疗。
T13606L	cGAMP disodium
	cGAMP disodium 是在细菌中发现的一种环二核苷酸 (CDN) ，可作为内源性第二信使，影响干扰素的产生以响应胞浆 DNA。cGAMP disodium 通过激活干扰素基因刺激因子 (STING)使 I 型干扰素和其他免疫介质的信号产生级联现象。cGAMP disodium 是一种有效的舌下免疫佐剂，能使免疫功能（血清抗 PA 中和和气道分泌物抗 PA SIgA 反应）更好的发挥作用。
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

Cat.No: T12500

Synonym: Platycodin E,桔梗苷E

Target: Others

Aurantiamide acetate

Cat.No: TJS2216

Synonym: 金色酰胺醇酯,Asperglaucide

Target: Cysteine Protease

Cat.No: TN6925

Synonym: 姥鲛烷,2,6,10,14-tetramethylpentadecane

Target: Others

Cat.No: TN2232

Target: NOS, NF-κB, COX

Levoleucovorin Calcium

Cat.No: T6431

Synonym: 左亚叶酸钙,Calcium Levofolinate,CL307782

Target: Others, Antifolate

Cat.No: T24403

Synonym: HSDB 6544,Leucovorin

Target: Endogenous Metabolite, Antifolate

Ginsenoside Rh4

Cat.No: T6S1485

Synonym: 人参皂苷Rh4

Target: Others

taraxasteryl acetate

Cat.No: T5781

Synonym: 蒲公英甾醇醋酸酯,醋酸蒲公英酯

Target: Antibacterial

Cat.No: TN2088

Synonym: 桔梗皂苷D2

Target: IL Receptor, HBV

Coumarin-3-carboxylic acid

Cat.No: TJS0339

Synonym: 香豆素-3-羧酸,3-Carboxycoumarin

Target: VEGFR

Cat.No: T7028

Synonym: LICOCHALCONEC,甘草查尔酮C

Target: Phosphatase, Antioxidant, Glucosidase

Cat.No: T6S0735

Synonym: 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Uproleselan sodium

Cat.No: T35000

Synonym: GMI 1271,GMI1271,GMI-1271

Cat.No: T11392

Target: Antibacterial

Cat.No: T13472

Target: Others

Cat.No: TN4804

Target: Antifection

α-Amyrin palmitate

Cat.No: TN3383

Synonym: alpha-Amyrin palmitate

Target: PKA

Cat.No: TN4410

Target: P-gp, JNK

Cat.No: T38838

Synonym: Stimulon,QS-21

Cat.No: TN1072

Target: P-gp, JNK

2-Aminoimidazole

Cat.No: T38241

D-Mannuronic acid sodium

Cat.No: T78492

Volkensiflavone

Cat.No: TN5530

Synonym: Talbotaflavone

Target: Others

Cat.No: T13606L

Cat.No: TN4411

Target: CDK, P-gp, JNK

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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