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84

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T17043	TES	Others	Others
	TES 可用于制备 pH 范围为 6.8-8.2 的缓冲溶液，其 pKa 值为 7.550。
T17042	TES-1025	Others	Others
	TES-1025 是一种有效且特异性的人 α-氨基-β-羧基粘康酸-ε-半醛脱羧酶 (ACMSD, IC50 = 13 nM) 抑制剂。
T13132	TES-991	Others	Others
	TES-991 is a potent and selective inhibitor of human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)(IC50 of 3 nM).
T2544	Bazedoxifene acetate 醋酸巴多昔芬,WAY-TES 424,TSE 424,WAY-140424	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Bazedoxifene acetate (WAY-TES 424) 是一种非甾体的、有口服活性的、选择性的雌激素受体调节剂，能够作用于 ERα (IC50:26 nM) 和 ERβ (IC50:99 nM) ，可用于研究骨质疏松症。它也是一种IL-6/GP130蛋白相互作用抑制剂，可用于研究胰腺癌。
T73082	TES sodium
	TES sodium，作为Good's缓冲剂之一，具有pH 6.8-8.2的缓冲范围，其在25°C时的pKa值为7.550。
T76831	Tesidolumab LFG316	Complement System	Immunology/Inflammation
	Tesidolumab (LFG316) 是一种全人IgG1/λ抗c5单克隆抗体。Tesidolumab (LFG316)对crovalimab和C5有抑制作用，阻断C5的切割，防止膜攻击复合体的后续形成，可用于研究血管外溶血。
T17044	Tesaglitazar	PPAR	DNA Damage/DNA Repair; Metabolism
	Tesaglitazar 是一种有效且具有选择性的过氧化物 PPAR α / γ受体双重激动剂，对 PPARγ的亲和力比 PPARα更有效，对大鼠PPARα和人PPARα的EC50分别为13.4 μM 和3.6 μM,对大鼠PPARγ和人类 PPARγ的EC50都是0.2 μM。Tesaglitazar 诱导大鼠皮下组织间质间充质细胞DNA 合成和纤维肉瘤形成。
T16994	Pimitespib TAS-116	HSP	Cytoskeletal Signaling; Metabolism
	Pimitespib (TAS-116) 是一种 ATP 竞争性和高度特异性的 HSP90α/HSP90β 抑制剂，Ki 值分别为 34.7 nM 和 21.3 nM。
T2288L	Motesanib Diphosphate Motesanib,AMG 706,二磷酸莫替沙尼	VEGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Motesanib Diphosphate (AMG 706) 是一种有效的VEGFR1/2/3的 ATP 竞争性抑制剂，IC50值为 2 nM/3 nM/6 nM，与对 Kit 的选择性相似，是 PDGFR 和 Ret 的 10 倍多。
T77404	Tesnatilimab IPH-23XX,JNJ-64304500,JNJ 4500	Others	Others
	Tesnatilimab 是一种有效的人源化 IgG4 单克隆抗体，可与免疫激活受体 NKG2D 结合。Tesnatilimab 具有潜在的免疫调节和抗炎活性，可用于研究活动性溃疡性结肠炎。
TP2219L	Alytesin acetate	Others	Others
	Alytesin acetate 是一种两栖类铃蟾肽样肽。
TQ0166	Tesevatinib KD-019,XL-647,EXEL-7647	EGFR; VEGFR; FLT; Ephrin Receptor	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tesevatinib (XL-647) 是一种口服的多靶点酪氨酸激酶抑制剂，对 EGFR、ErbB2、KDR、Flt4和 EphB4的 IC50值分别为 0.3、16、1.5、8.7和 1.4 nM。
T2309	Ganetespib STA-9090	Apoptosis; HSP; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Ganetespib (STA-9090) 是一种热休克蛋白 90 抑制剂，通过抑制 HIF-1α 和 STAT3 对大肠癌具有抗血管生成作用。它还具有细胞毒性。
T16412	Oteseconazole VT-1161	P450; Antifungal	Metabolism; Microbiology/Virology
	Oteseconazole (VT-1161) 是一种口服有效的抗真菌剂，结合并抑制白色念球菌的 CYP51，Kd 值小于 39 nM。
T22746	Tesmilifene fumarate DPPE fumarate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Tesmilifene fumarate (DPPE fumarate) 是一种 H1C 受体拮抗剂，可增强化疗的细胞毒性且保护正常细胞。
T9170	Testosterone decanoate	Others	Others
	Testosterone decanoate 是天然存在的雄激素睾酮酯，具有长效男性抗生育活性。
T2288	Motesanib AMG 706,莫特塞尼,莫替沙尼	VEGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Motesanib (AMG 706) 是有效的、ATP 竞争性的 VEGFR1/2/3 的抑制剂，其IC50值为 2 nM/3 nM/6 nM，与对 Kit 的选择性相似，是 PDGFR 和 Ret 的 10 倍多。
T38565	Testosterone glucuronide	Others	Others
	Testosterone glucuronide 是睾酮的主要尿液代谢物，是一种潜在的尿液生物标记物。
T9035	Testosterone undecanoate	Others; Androgen Receptor	Endocrinology/Hormones; Others
	Testosterone undecanoate 是一种睾酮酯，是睾酮的代谢产物，睾酮是很有前途的男性激素避孕雄激素。
T81135	Sodium caseinates Casein sodium salt from bovine milk	Others	Others
	Sodium caseinates (CasNa) 是一种可溶性酪蛋白，也是一种食品添加剂和乳化剂，广泛应用于食品工业。 Sodium caseinates （CasNa）在体外诱导小鼠带粒细胞的分化和 M-CSF 产生，诱导功能性粒细胞的粒细胞生成。
TP2058L	Catestatin acetate Catestatin acetate(142211-96-9 free base)	Endogenous Metabolite; AChR	Metabolism; Neuroscience
	Catestatin acetate 是 nAChR 的非竞争性拮抗剂，可抑制儿茶酚胺的释放。 Catestatin acetate 调节心脏功能和血压。
T6791	BPTES	transporter; Glutaminase	Metabolism; Proteases/Proteasome
	BPTES 是一种特异性 GlutamiN/Ase GLS1 (KGA) 抑制剂，IC50=0.16 μM。
T62684	Lartesertib ATM Inhibitor-5,M4076	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Lartesertib (ATM Inhibitor-5) 是一种丝氨酸/苏氨酸蛋白激酶 ATM 的抑制剂，具有潜在的抗癌活性，可用于研究肺癌。
T18873	VHL Ligand-Linker Conjugates 17	Others	Others
	VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].
T17895	cIAP1 Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 41	Others	Others
	cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1].
T39609	cIAP1 Ligand-Linker Conjugates 16 cIAP1 Ligand-Linker Conjugates 16
	cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs.
T17364	AhR Ligand-Linker Conjugates 1 E3 Ligase Ligand-Linker Conjugates 57	Others	Others
	AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].
T17884	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].
T17898	cIAP1 Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 44	Others	Others
	cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1].
T28952	Testosterone glucoside
	Testosterone glucoside is an androgen receptor agonist.
T17894	cIAP1 Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 40	Others	Others
	cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1].
T81012	Testololactone
	Testololactone，一种芳香酶抑制剂，常用于乳腺癌研究。
TP2058	Catestatin
	Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhi
TMIH-0560	Testosterone-d3
	Testosterone-d3 是 Testosterone 的氘代化合物。
T24454	Metesind Glucuronate AG 331,AG331,AG-331
	Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.
T17886	cIAP1 Ligand-Linker Conjugates 15 hydrochloride E3 ligase Ligand-Linker Conjugates 34 hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1].
T28951	Tesofensine NS 2330,NS2330,NS-2330
	Tesofensine, a serotonin–noradrenaline–dopamine reuptake inhibitor, is used potentially for the treatment of obesity.
T72241	Teslexivir hydrochloride BTA074 hydrochloride ; AP 611074 hydrochloride,BTA074 hydrochloride,AP 611074 hydrochloride
	Teslexivir (BTA074) hydrochloride 是一种有效的抗病毒剂。Teslexivir hydrochloride 是两种关键病毒蛋白 (E1和 E2) 相互作用的强效选择性抑制剂，这两种蛋白的相互作用是人乳头瘤病毒 (HPV) 6 和 11 的 DNA 复制和病毒产生的重要步骤。Teslexivir hydrochloride 可用于尖锐湿疣的研究。
T76938	Camoteskimab
	Camoteskimab (AVTX-007)为全人源、高亲和力抗IL-18单克隆抗体，展现于自身炎症性疾病研究潜力，包括成人斯蒂尔病(AOSD)。
T76960	Verpasep caltespen
	Verpasep caltespen (HspE7) 是一种重组融合蛋白，来源于Mycobacterium bovis Calmette-Guérin 热休克蛋白 65 (Hsp65)，其 C 末端与HPV16 的 E7 蛋白共价连接。Verpasep caltespen 可用于人乳头瘤病毒 (HPV)引起的癌前病变和癌性病变研究。
T126122	Matesaponin 1
	Matesaponin 1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126122，CAS号为 126622-38-6。
T70409	6alpha-Fluorotestosterone
	6alpha-Fluorotestosterone is a synthetic nonaromatizable androgen analog of testosterone. It binds to and activates specific nuclear receptors inhibits and is equipotent to testosterone.
T17045	Teslexivir BTA074,AP 611074	Others	Others
	Teslexivir is a topical antiviral agent that is an effective and selective inhibitor of the interaction between two essential viral proteins, E1 and E2.
T34812	Tesicam
	Tesicam is a bioactive chemical.
T34303	Retrotestosterone Lumitestosterone
	Retrotestosterone, a biochemical, can affect testosterone.
T18364	Tesirine MP-PEG8-VA-PABC-PBD Dimer	Others	Others
	MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].
T17899	cIAP1 Ligand-Linker Conjugates 9 E3 ligase Ligand-Linker Conjugates 45	Others	Others
	cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1].
T28023	Metesind AG331,AG-341,AG-331,AG341
	Metesind, a thymidylate synthase inhibitor, is used potentially for the treatment of brain cancer and solid tumours.
TP2219	Alytesin	Others	Others
	Amphibian bombesin-like peptide
T76567	Met-RANTES (human)
	Met-RANTES (human) 为一部分CCR5拮抗剂，能够降低血液单核细胞向肝脏浸润的程度。

化合物

Cat.No: T17043

Target: Others

Cat.No: T17042

Target: Others

Cat.No: T13132

Target: Others

Bazedoxifene acetate

Cat.No: T2544

Synonym: 醋酸巴多昔芬,WAY-TES 424,TSE 424,WAY-140424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T73082

Cat.No: T76831

Synonym: LFG316

Target: Complement System

Cat.No: T17044

Target: PPAR

Cat.No: T16994

Synonym: TAS-116

Target: HSP

Motesanib Diphosphate

Cat.No: T2288L

Synonym: Motesanib,AMG 706,二磷酸莫替沙尼

Target: VEGFR, c-Kit

Cat.No: T77404

Synonym: IPH-23XX,JNJ-64304500,JNJ 4500

Target: Others

Alytesin acetate

Cat.No: TP2219L

Target: Others

Cat.No: TQ0166

Synonym: KD-019,XL-647,EXEL-7647

Target: EGFR, VEGFR, FLT, Ephrin Receptor

Cat.No: T2309

Synonym: STA-9090

Target: Apoptosis, HSP, HIF

Cat.No: T16412

Synonym: VT-1161

Target: P450, Antifungal

Tesmilifene fumarate

Cat.No: T22746

Synonym: DPPE fumarate

Target: Histamine Receptor

Testosterone decanoate

Cat.No: T9170

Target: Others

Cat.No: T2288

Synonym: AMG 706,莫特塞尼,莫替沙尼

Target: VEGFR, c-Kit

Testosterone glucuronide

Cat.No: T38565

Target: Others

Testosterone undecanoate

Cat.No: T9035

Target: Others, Androgen Receptor

Sodium caseinates

Cat.No: T81135

Synonym: Casein sodium salt from bovine milk

Target: Others

Catestatin acetate

Cat.No: TP2058L

Synonym: Catestatin acetate(142211-96-9 free base)

Target: Endogenous Metabolite, AChR

Cat.No: T6791

Target: transporter, Glutaminase

Cat.No: T62684

Synonym: ATM Inhibitor-5,M4076

Target: ATM/ATR

VHL Ligand-Linker Conjugates 17

Cat.No: T18873

Target: Others

cIAP1 Ligand-Linker Conjugates 1

Cat.No: T17895

Synonym: E3 ligase Ligand-Linker Conjugates 41

Target: Others

cIAP1 Ligand-Linker Conjugates 16

Cat.No: T39609

Synonym: cIAP1 Ligand-Linker Conjugates 16

AhR Ligand-Linker Conjugates 1

Cat.No: T17364

Synonym: E3 Ligase Ligand-Linker Conjugates 57

Target: Others

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

Cat.No: T17884

Synonym: E3 ligase Ligand-Linker Conjugates 33 Hydrochloride

Target: Others

cIAP1 Ligand-Linker Conjugates 7

Cat.No: T17898

Synonym: E3 ligase Ligand-Linker Conjugates 44

Target: Others

Testosterone glucoside

Cat.No: T28952

cIAP1 Ligand-Linker Conjugates 3

Cat.No: T17894

Synonym: E3 ligase Ligand-Linker Conjugates 40

Target: Others

Testololactone

Cat.No: T81012

Cat.No: TP2058

Testosterone-d3

Cat.No: TMIH-0560

Metesind Glucuronate

Cat.No: T24454

Synonym: AG 331,AG331,AG-331

cIAP1 Ligand-Linker Conjugates 15 hydrochloride

Cat.No: T17886

Synonym: E3 ligase Ligand-Linker Conjugates 34 hydrochloride

Target: Others

Cat.No: T28951

Synonym: NS 2330,NS2330,NS-2330

Teslexivir hydrochloride

Cat.No: T72241

Synonym: BTA074 hydrochloride ; AP 611074 hydrochloride,BTA074 hydrochloride,AP 611074 hydrochloride

Cat.No: T76938

Verpasep caltespen

Cat.No: T76960

Cat.No: T126122

6alpha-Fluorotestosterone

Cat.No: T70409

Cat.No: T17045

Synonym: BTA074,AP 611074

Target: Others

Cat.No: T34812

Retrotestosterone

Cat.No: T34303

Synonym: Lumitestosterone

Cat.No: T18364

Synonym: MP-PEG8-VA-PABC-PBD Dimer

Target: Others

cIAP1 Ligand-Linker Conjugates 9

Cat.No: T17899

Synonym: E3 ligase Ligand-Linker Conjugates 45

Target: Others

Cat.No: T28023

Synonym: AG331,AG-341,AG-331,AG341

Cat.No: TP2219

Target: Others

Met-RANTES (human)

Cat.No: T76567

Cat. No.	Product Name	Target	Signaling Pathways
TC0025	Testosterone acetate NSC523836,NSC-523836,NSC 523836,醋酸睾酮	Others	Others
	Testosterone acetate (NSC-523836) 是一种 Testosterone 前药，是一种天然存在的雄激素睾酮酯。它可用于阳痿、虚弱、疲劳和性腺机能减退的研究。
T3130	Testosterone phenylpropionate Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate	Others	Others
	Testosterone phenylpropionate (Testosterone 17-phenylpropionate) 是一种长效雄激素。d3-Testosterone phenylpropionate 可用作内标物。
TC0026	Testosterone benzoate	Others	Others
	Testosterone benzoate 是一种合成的注射合成代谢雄激素类固醇 (AAS) 和一种雄激素酯。
T0433	Artesunate WR-256283,青蒿琥酯	Virus Protease; Ferroptosis; STAT; Parasite	Apoptosis; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Artesunate (WR-256283) 是治疗疟疾的青蒿素组药物的一部分。它是青蒿素的半合成衍生物，具有水溶性。
TN6511	Tessaric acid
	Tessaric acid has antifeedant and allelochemical effects. Tessaric acid derivatives induce G/M cell cycle arrest in human solid tumor cell lines.

天然产物

Testosterone acetate

Cat.No: TC0025

Synonym: NSC523836,NSC-523836,NSC 523836,醋酸睾酮

Target: Others

Testosterone phenylpropionate

Cat.No: T3130

Synonym: Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate

Target: Others

Testosterone benzoate

Cat.No: TC0026

Target: Others

Cat.No: T0433

Synonym: WR-256283,青蒿琥酯

Target: Virus Protease, Ferroptosis, STAT, Parasite

Tessaric acid

Cat.No: TN6511

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