Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TES-991 is a potent and selective inhibitor of human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)(IC50 of 3 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 3,330 | 5日内发货 | ||
5 mg | ¥ 4,570 | 5日内发货 | ||
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,930 | 5日内发货 |
产品描述 | TES-991 is a potent and selective inhibitor of human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)(IC50 of 3 nM). |
靶点活性 | ACMSD (human):3 nM |
体外活性 | TES-991 significantly increase intracellular NAD+ levels, providing further proof of their mechanism of action. TES-991 exhibits an inhibition of cytochrome P450 2C19, suggesting a possible involvement of the 2H-tetrazole motif. |
体内活性 | TES-991(intravenous,0.5 mg/kg) shows low blood clearance, with low volumes of distribution and halflives (t1/2) of about 4.0 and 5.0 h, respectively, although after oral administration at 5 mg/kg, the blood concentrations of TES-991 is quantifiable for up to 8 h. A moderate systemic exposure is observed for the 2H-tetrazole analogue, TES-991, a good systemic exposure is recorded for the free acid. |
分子量 | 393.45 |
分子式 | C17H11N7OS2 |
CAS No. | 1883602-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (158.85 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5416 mL | 12.7081 mL | 25.4162 mL | 63.5405 mL |
5 mM | 0.5083 mL | 2.5416 mL | 5.0832 mL | 12.7081 mL | |
10 mM | 0.2542 mL | 1.2708 mL | 2.5416 mL | 6.354 mL | |
20 mM | 0.1271 mL | 0.6354 mL | 1.2708 mL | 3.177 mL | |
50 mM | 0.0508 mL | 0.2542 mL | 0.5083 mL | 1.2708 mL | |
100 mM | 0.0254 mL | 0.1271 mL | 0.2542 mL | 0.6354 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TES-991 1883602-20-7 Others TES 991 TES991 Inhibitor inhibitor inhibit