87
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13173 |
TMPA
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。 | |||
T8944 |
TTA-A2
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
TTA-A2 是一种选择性 T 型钙通道拮抗剂,是一种有效的抗惊厥药,可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用,IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究,包括睡眠障碍和癫痫。 | |||
T0283 |
Trimethadione
三甲双酮,3,5,5,-Trimethyloxazolidine-2,4-dione |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) 是恶唑烷二酮类抗惊厥剂,也是一种 T 型钙通道阻滞剂,具有抗痛觉过敏作用,可用于研究失神发作。 | |||
T64203 | T-Type calcium channel inhibitor 2 | ||
T-Type calcium channel inhibitor 2 (compound 6g) 是一种 T 型钙通道的有效抑制剂,能够作用于 Cav3.1 (α1G) (IC50: 31.0 μM)、Cav3.2 (α1H) (IC50: 83.1 μM)、Cav3.3 (α1I) (α1H) (IC50: 69.3 μM)。T-Type calcium channel inhibitor 2 对 A549、HCT-116 细胞表现出细胞毒性,IC50s 分别为5.0、6.4 μM。 | |||
T12032 |
Mibefradil dihydrochloride
盐酸米贝地尔,Ro 40-5967 (dihydrochloride),米贝拉地尔 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Mibefradil dihydrochloride (Ro 40-5967 (dihydrochloride)) 是一种钙离子通道抑制剂,选择性作用于 T 型 Ca2+通道,对 T 型和 L 型通道的IC50分别为 2.7 和 18.6 μM。 | |||
T71990 |
TTA-A8
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
TTA-A8 是 T 型钙通道的拮抗剂。 | |||
T3703 |
ABT-639
ABT 639 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ABT-639 是一种有效的选择性 T 型钙通道阻滞剂。 | |||
T26174 |
SAK3
SAK 3,SAK-3 |
Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
SAK3 是一种新型的 nAChR 活性调节剂,可增强 T 型电压门控 Ca2+ 通道 (T-VGCC) 的活性,对 Cav3.1 和 Cav3.3 T 型 Ca2+ 通道电流均有增强作用。SAK3 对人神经母细胞瘤 SH-SY5Y 细胞中东莨菪碱诱导的胆碱能功能障碍有神经保护作用。SAK3 可用于研究记忆缺陷和阿尔茨海默病。 | |||
T2323 |
Efonidipine
(±)-Efonidipine,NZ-105,依福地平 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Efonidipine (NZ-105) 是一种二氢吡啶类钙通道阻滞剂,可阻断 T 型和 L 型钙通道。 | |||
T5632 |
Suvecaltamide
MK-8998 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Suvecaltamide (MK-8998) 是一种选择性的 T 型钙通道抑制剂。 | |||
T6571 |
Lomerizine dihydrochloride
Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lomerizine dihydrochloride (KB-2796) 是双重 L 和 T 型电压门控钙通道拮抗剂。 | |||
T12238 |
NNC 55-0396
NNC 55-0396 dihydrochloride |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
NNC 55-0396 是一种高特异性的 T 型钙通道阻滞剂,IC50 为 6.8 μM。 NNC 55-0396 可用于预防人类卵巢癌细胞增殖的研究。 | |||
T8448 |
ZSET1446
ZSET-1446,ST-101 |
Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
ZSET1446 (ST-101) 是一种 T 型钙通道激活剂,用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。 | |||
T29201 |
Z944
Z 944,Z-944 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Z944 是有效的 T 型钙通道拮抗剂,对跨模态和视觉识别记忆障碍有缓解作用。 | |||
T23411L |
T-0156
T 0156 |
PDE; Parasite | Metabolism; Microbiology/Virology |
T-0156 是一种新型高效且具有选择性的 5 型磷酸二酯酶抑制剂,抑制环磷酸鸟苷 (cGMP) 的水解,对 PDE6、PDE1、PDE2、PDE3 和 PDE4 较低的亲和力。 | |||
T64387 |
2-Nitrobenzoic acid
o-Nitrobenzoic acid |
Others | Others |
2-Nitrobenzoic acid (o-Nitrobenzoic acid) 是一种抗增殖化合物,对表达 T 型钙通道α1H 或其剪接变体δ25的 jurkat 细胞系显示出8.3μM 的 IC50。 | |||
T37427 |
(2R/S)-6-PNG
6-Prenylnaringenin,(±)-6-Prenylnaringenin |
Calcium Channel; HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
(2R/S)-6-PNG (6-Prenylnaringenin) 是新型天然组蛋白脱乙酰酶抑制剂,具有抗癌抗肿瘤活性,可阻断T型钙通道可减轻小鼠的神经性和内脏疼痛。 | |||
T68123 |
Oxodipine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Oxodipine 是一种二氢吡啶型钙拮抗剂 ,抑制了KCl 诱导的兔主动脉收缩,降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中,Oxodipine 降低了L 型Ca 电流(I),IC 为0.24μM,对T 型Ca 电流(I)的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。 | |||
T13219 |
TTA-Q6
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
TTA-Q6 是一种选择性 T 型 Ca2+ 通道拮抗剂,具有潜在的抗肿瘤和免疫调节活性,可抑制肿瘤细胞摄取细胞外钙离子,诱导细胞内钙缺乏和内质网(ER)应激,用于治疗神经系统疾病。 | |||
T10570 |
Fostemsavir Tris
BMS-663068 Tris |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。 | |||
T9906 |
Ipilimumab
|
Others | Others |
Ipilimumab 是全人类单克隆抗体 IgG1κ,能够抗 CTLA-4。其中CTLA-4是一种由活化的 T 细胞产生的免疫抑制分子。 | |||
T0267 |
Zonisamide
AD 810,唑尼沙胺,CI 912 |
Calcium Channel; Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
TQ0153 |
Mibefradil
米贝地尔,Ro 40-5967 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents). | |||
T71202 |
A-1048400
|
||
A-1048400 is a potent and selective N-type and T-type calcium channel blocker. | |||
T33891 |
PBI-1393
PBI1393,BCH1393,BCH 1393,BCH-1393,PBI 1393 |
||
PBI-1393 can be used as an enhancer for Th1 type cytokine production and primary T cell activation. | |||
T62402 | TTA-P2 | ||
TTA-P2 (T-Type calcium channel inhibitor) 是一种 T 型钙通道的有效抑制剂。TTA-P2 能够有效的穿透 CNS 并阻断小脑深部核神经元中的天然 T 型电流,完全消除野生型和突变型 Cav3.1 通道的窗口电流。TTA-P2 具有潜力进行神经疾病的研究。 | |||
T80496 |
Kurtoxin
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Kurtoxin是一种选择性Cav3 (T-type) 电压门控Ca2+通道抑制剂,对Cav3.1 (α1G T-type) Ca2+通道的Kd值为15 nM。该化合物与中枢和外周神经元的L型、N型和P型Ca2+通道有高度亲和性,并对电压门控Na+通道也有交叉反应性。 | |||
T13220 |
TTA-Q6(isomer)
|
Others | Others |
TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective antagonist of the T-type Ca2+ channel. | |||
T25874 |
NMP-7
NMP7,NMP 7 |
||
NMP-7 is a non-selective CB1 and CB2 cannabinoid receptor agonist that works by blocking T-type calcium channels. | |||
T24738 |
RQ-00311651
|
||
RQ-00311651 is a novel T-type Ca2+ channel blocker. RQ-00311651 also inhibited high K-induced Ca signaling in those cells. | |||
T12076 |
ML218 hydrochloride
|
Others | Others |
ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively). | |||
T69809 | NNL-2 | ||
NNL-2 is a synthetic cannabinoid and T-type calcium channel inhibitor. This product is for research use only. | |||
T63312 |
ABT-639 hydrochloride
|
||
ABT-639 hydrochloride 是选择性的、新型的 T 型 Ca2+通道阻滞剂。 | |||
T61393 | IAA65 | ||
IAA65 是一种有效的 T 型钙通道抑制剂 (T-type calcium channel),IC50值为 18.9 μM。IAA65 可用于癫痫研究。 | |||
T14120 |
ACT-709478
|
Others | Others |
ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1]. | |||
T60648 | IAB15 | ||
IAB15 是可用于癫痫研究的,T 型钙通道的有效抑制剂。 | |||
T63350 | Cav 3.2 inhibitor 3 | ||
Cav 3.2 inhibitor 3 是 Cav3.2 T-type Ca2+channel 的有效抑制剂 (IC50: 0.1534 μM),且对 D2受体的结合亲和力很低。 | |||
T75792 |
Huwentoxin XVI TFA
|
||
Huwentoxin XVI TFA,一种来自鸟蛛 Ornithoctonus huwena 的止痛剂,一种高度可逆和选择性的哺乳动物 N 型钙通道 (N-type calcium channel) (IC50约为 60 nM) 拮抗剂。Huwentoxin XVI TFA 对电压门控的 T 型钙通道,钾通道或钠通道没有影响。 | |||
T40590 |
NY-ESO-1 (87-111)
|
||
NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide that interacts with various HLA-DR and HLA-DP4 molecules, inducing activation of CD4+ T cells with Th1-type and Th-2/Th0-type responses, when presented in conjunction with HLA-DR and HLA-DP4 molecules. | |||
T37966 |
T-91825
|
||
T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2]. | |||
T62876 | MONIRO-1 | ||
MONIRO-1 是一种 T 型和 N 型钙通道阻断剂,作用于 hCav2.2 (IC50: 34 μM)、hCav3.1 (IC50: 3.3 μM)、hCav3.2 (IC50: 1.7 μM) 和 hCav3.3 (IC50: 7.2 μM)。 | |||
T26968 |
CCT036477
CCT 036477,CCT-036477 |
||
CCT036477 is a selective inhibitor of wingless-type MMTV integration site family dependent transcription. CCT036477reduces the transcriptional activity of the T-cell factor and lymphoid enhancer factor transcription factor family at the ß-catenin level. | |||
TQ0007L |
Cintirorgon sodium
LYC-55716 sodium salt,LYC 55716,LYC55716 |
||
Cintirorgon (LYC-55716) is an orally active RORgamma agonist with potential immunomodulatory and antineoplastic activities. LYC-55716 selectively binds to the RORg, and binds to ROR response elements, enhancing the function, proliferation, and survival of | |||
T11730 | JTT 551 | Others | Others |
JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. | |||
T81697 | NBI-6024 | ||
NBI-6024 是一种变构肽配体(APL),可被1型糖尿病患者中产生炎症性干扰素-γ的T辅助淋巴细胞识别的表位。 | |||
T63606 | Cav 3.2 inhibitor 2 | ||
Cav 3.2 inhibitor 2 是一种 Cav3.2 T-type Ca2+channels 的抑制剂,-80mV 恒定电位下,其IC50=0.09339 μM。Cav 3.2 inhibitor 2 对小鼠 T 通道依赖性的躯体和内脏疼痛表现出有效的抑制作用。Cav 3.2 inhibitor 2 能够用于研究顽固性疼痛。 | |||
T29033 |
U-7524
2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA |
||
U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attac | |||
T61747 |
TTA-P1
|
||
TTA-P1 is a highly potent compound that effectively inhibits human T-type calcium channels, which are involved in various physiological processes such as neuronal burst firing, hormone secretion, and cell growth. With its unique state-independent properties, TTA-P1 holds promising potential for advancing research on absence epilepsy [1]. | |||
T78291 |
Tregalizumab
BT-061 |
||
Tregalizumab为人源化抗CD4单克隆抗体(IgG1型),体外能选择性激活调节性T细胞(Tregs)功能。适用于研究自身免疫性疾病(因Treg功能不足)及过敏反应。 | |||
T36858 |
C12 Galactosylceramide (d18:1/12:0)
|
||
C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10024 |
1-Octanol
Octanol,正辛醇 |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
1-Octanol (Octanol) 是一种饱和脂肪醇,是一种 T 型钙通道抑制剂,对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。 | |||
T8716 |
physalin F
酸浆苦味素F,酸浆苦素 F |
Apoptosis | Apoptosis |
Physalin F 是一种分泌型甾体,诱导人外周血单个核细胞凋亡,降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生,具有强烈抗炎和免疫调节作用。 | |||
T0728 |
Ethosuximide
Zarontin,乙琥胺 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Ethosuximide (Zarontin) 是一种抗癫痫药物,可改善多种神经退行性疾病模型的表型,且阻断低电压激活的 T 型钙通道。 | |||
T6S1885 |
Benzoylmesaconine
Mesaconine 14-benzoate,苯甲酰新乌头原碱 |
Others | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。 | |||
T2S1792 |
Lycobetaine
石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐 |
Antibacterial | Microbiology/Virology |
Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性(IC(50) 值为 0.35 microM)。 它具有抗原生动物活性,在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。 | |||
TN4587 | Mulberrofuran C | HSV | Microbiology/Virology |
Mulberrofuran C shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 0.41 ± 0.48 uM ; it also shows protective effects on glutamate-induced cell death with the EC50 value of 16.50 ± 7.82 uM. Mulberrofuran C has antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2). | |||
T73073 |
PTP1B-IN-21
|
||
PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50>100 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。 | |||
T73072 |
PTP1B-IN-20
|
||
PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50=78.0 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。 | |||
T36845 |
Isogarcinol
|
||
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto... | |||
T83864 |
Plipastatin A1
SNA-60-367-3,Fengycin IX |
||
Plipastatin A1是一种在B. cereus中发现的脂肽类化合物,具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2(PLA2)、PLC和PLD(IC50分别为2.9、1.3和1.4 µM)。Plipastatin A1(100 µg/ml)能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内,Plipastatin A1(0.1 mg/动物)能抑制小鼠的迟发型超敏反应。 | |||
T35577 |
Phosphatidylserines (bovine)
|
||
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi... | |||
T37452 |
Stephacidin B
|
||
Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... | |||
T35779 |
Oosporein
|
||
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |