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71

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)	NADPH-oxidase	Immunology/Inflammation
	NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。
T80229	Noxa B BH3
	Noxa B BH3是一款具有生物活性的肽，源自Noxa蛋白的BH3结构域。
T80227	Noxa A BH3
	Noxa A BH3是一种具有生物活性的肽，源自于Noxa蛋白的BH3结构域。
T80228	r8-Gly-Noxa A BH3
	r8-Gly-Noxa A BH3 是一种源自 Noxa A BH3 (死亡结构域) 结构域氨基酸残基 17 至 36 的具有生物活性的细胞渗透性肽。该肽在氨基末端通过添加 8 个 D-精氨酸残基和一个甘氨酸接头残基而进行了修饰。
T0300	Pargyline Pargylamine,Paragyline,优降宁	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Pargyline (Pargylamine) 是不可逆的单胺氧化酶抑制剂，对MAO-A 和MAO-B 的Ki 分别为 13 μM 和 0.5 μM，具有降压和抗癌作用。
T1578	Pargyline hydrochloride 优降宁盐酸盐,Pargylamine hydrochloride	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Pargyline hydrochloride (Pargylamine hydrochloride) 是不可逆的单胺氧化酶抑制剂，可作用于 MAO-A (Ki=13 μM) 和 MAO-B (Ki=0.5 μM) ，具有降压和抗癌作用。
TP1886	NoxA1ds
	Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary
T75949	NoxA1ds TFA
	NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits NOX1-derived O2- production in HT-29 human colon cancer cells and attenuates VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro.
T7804	Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)	Antibacterial	Microbiology/Virology
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮，具有强抗菌活性，抗呼吸道病原体。
T19805	Benoxacor BRN-4190275,解草酮,BRN 4190275,BRN4190275	Others	Others
	Benoxacor (BRN-4190275) 是一种惰性农业化学品。它作为一种除草剂安全剂，可保护作物免受除草剂毒性。
T0717L	Enoxacin 依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919	DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin (NSC-629661) 是一种可干扰DNA 复制的氟喹诺酮，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，可有效抑制革兰氏阳性和阴性细菌。
T1177	Sulfaquinoxaline 磺胺喹恶啉,Avicocid,磺胺喹噁啉,Sulphaquinoxaline,Sulfabenzpyrazine	Others; Antibacterial; Antibiotic; Parasite	Microbiology/Virology; Others
	Sulfaquinoxaline (Sulfabenzpyrazine) 是一种兽用抗菌剂，对革兰氏阴性菌和革兰氏阳性菌均有活性。它能用于预防球虫病和细菌感染。
T0917	Sulfaquinoxaline sodium salt SQ-Na,磺胺喹恶啉钠盐,Sulfaquinoxaline sodium,磺胺喹啉钠	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Sulfaquinoxaline sodium salt (SQ-Na) 是一种兽用广谱抗菌剂，有抗革兰氏阴性菌和革兰氏阳性菌活性。Sulfaquinoxaline 能用于预防球虫病和细菌感染。
T19679	Benoxaprofen 氧苯恶唑丙酸,NSC 299582,LY-90459,Benoxaphen. Compound 90459	COX	Immunology/Inflammation; Neuroscience
	Benoxaprofen (NSC-299582) 是长效的、强效的抗炎和解热化合物，在体外具有较弱的对环氧合酶的抑制作用，也可以抑制脂氧合酶，在一些炎症动物模型中抑制单核细胞迁移。
T0717	Enoxacin hydrate CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物	DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin hydrate (AT-2266 hydrate) 是氟喹诺酮，可干扰DNA 复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，抑制革兰氏阳性和阴性细菌。
T9932	2(1H)-Quinoxalinone	Others	Others
	2(1H)-Quinoxalinone 是从 Clitoria ternatea 和 Hibiscus rosa sinensis 等食用花卉中提取的天然产物。
T10459	Banoxantrone dihydrochloride AQ4N dihydrochloride,AZD1689 2HCl	NOS	Immunology/Inflammation
	Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。
T7902	Ozenoxacin 奥泽沙星,T-3912	Antibacterial	Microbiology/Virology
	Ozenoxacin (T-3912) 是一种非氟喹诺酮抗菌剂，对大多数从在皮肤和软组织感染中分离的微生物有活性。
T22323	Enoxaparin sodium	Thrombin	Proteases/Proteasome
	Enoxaparin sodium 是一种低分子量肝素 (LMWH)，已获得美国 FDA 批准，可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用，并抑制凝血因子 XIa、IXa、Xa 和 IIa（凝血酶），从而防止血栓形成。
T14953	Chloroquinoxaline sulfonamide NSC-339004,Chloroquinoxaline	Topoisomerase	DNA Damage/DNA Repair
	Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T1401	Meclofenoxate hydrochloride Meclofenoxate (Centrophenoxine) HCl,Lucidril,盐酸甲氯芬酯,Cerutil,盐酸甲氯酚酯,Meclofenoxate HCl	Lipoxygenase; COX; AChR; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Meclofenoxate hydrochloride (Lucidril) 是二甲基氨基乙醇和对氯苯氧乙酸的酯，有刺激记忆和提高认知的活性。
T2222	Carbinoxamine Maleate Salt Lergefin,马来酸罗托沙敏,CarbinoxaMine Maleate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Carbinoxamine Maleate Salt (Lergefin) 是一种乙醇胺类 H1 抗组胺药，具有温和的抗毒蕈碱和镇静作用。
T7564	Chlorphenoxamine Contristamine,氯苯沙明	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Chlorphenoxamine (Contristamine) 是一种抗组胺药和抗胆碱能药，用作止痒药和抗帕金森病药。
T0274	Cinoxacin 西诺沙星,Compound 64716	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Cinoxacin (Compound 64716) 是一种喹诺酮类的合成抗生素, 与Oxolinic acid 和 Nalidixic acid 活性相似。
T14955	Chlorthenoxazine 氯西诺嗪,Chlorethylbenzmethoxazone	Immunology/Inflammation related	Immunology/Inflammation
	Chlorthenoxazine (Chlorethylbenzmethoxazone) 是非甾体抗炎药。
T13285	Vatinoxan hydrochloride MK-467 hydrochloride,L-659066 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.
T16711	Flesinoxan	5-HT Receptor	GPCR/G Protein; Neuroscience
	Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
T61664	Benzoquinoquinoxaline
	Benzoquinoquinoxaline (BQQ) is a heterocyclic compound featuring an aminoalkyl side chain. BQQ exhibits preferential binding to DNA triplex structures, intercalating between the bases to stabilize the triplex conformation. Additionally, conjugation of BQQ to 1,10-phenanthroline enables specific binding and cleavage of double-strand DNA at the site where a triplex structure forms [1].
T68194	Flesinoxan HCl
	Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.
T71298	Ipenoxazone HCl
	Ipenoxazone HCl is a glutamate receptor antagonist potentially for the treatment of Alzheimer's disease.
T74821	Nemonoxacin
	Nemonoxacin (TG-873870) 是一种口服有效的广谱抗生素，对多种葡萄球菌、链球菌、肠球菌、淋病奈瑟菌和流感嗜血杆菌显示出强效的抑制活性。适用于研究细菌感染和社区获得性肺炎。
T26249	TANDEM (quinoxaline) Tandem
	TANDEM (quinoxaline) is a synthetic analog of antibiotics quinoxaline.
T29950	Ambenoxan Ambenoxanum
	Ambenoxan is a centrally acting muscle relaxant.
T29638	Adafenoxate Adafenoxato
	Adafenoxate is an intelligent compound related to centrophenoxine.
T28154	Nemonoxacin Malate TG-873870,TG873870,TG 873870
	Nemonoxacin is a non-fluorinated quinolone antibiotic.
T15591	Ipenoxazone NC-1200,MLV-6976,伊培沙宗	Others	Others
	Ipenoxazone is an effective and centrally acting muscle relaxant.
T11512	Guanoxabenz Hydroxyguanabenz	Others	Others
	Guanoxabenz is an α2 adrenergic receptor agonist.
T76543	NoxaBH3
	NoxaBH3，一种基于半胱氨酸的交联肽，具备提高的细胞渗透性及较高对Mcl-1的抑制效能。该化合物通过与CXCR4的内源性配体结合，形成泛素-NoxaBH3偶联物，进而被导向癌细胞。
T19951	Enoxastrobin
	Enoxastrobin is a reagent biochemical.
T10304	Aminochlorthenoxazin ICI 350	Others	Others
	Aminochlorthenoxazin is an antipyretic and analgesic agent.
T66640	2,3-Bis((R)-tert-butyl(methyl)phosphino)quinoxaline
	2,3-Bis((R)-tert-butyl(methyl)phosphino)quinoxaline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66640，CAS号为 866081-62-1。
T19201	Banoxantrone-d12 dihydrochloride AQ4N D12 dihydrochloride	Others	Others
	Banoxantrone D12 (AQ4N D12) dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.
T67021	(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
	(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67021，CAS号为 313369-26-5。
TNU1456	N1-(tert-Butoxycarbonylmethyl)-6-[2-(N-Cbz-amino)ethoxy)]-phenoxazine
	PNA-related Derivatives; Heterocyclic Compounds - Fused polyheterocycles
T7804L	Garenoxacin mesylate Garenoxacin mesilate,BMS 284756,BM-284756,BMS284756
	Garenoxacin mesylate, a novel oral des-fluoro quinolone, has potent antimicrobial activity against common respiratory pathogens, including resistant strains and Gram-negative and Gram-positive bacterial infections.
T14528	Benoxafos HOE 2910	Others	Others
	Benoxafos, HOE 2910, is an insecticide.
T67023	(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
	(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67023，CAS号为 313368-85-3。
T19321	Fenoxaprop-P-ethyl	Others	Others
	Fenoxaprop-P-ethyl, a post-emergent herbicide within the aryloxyphenoxy propionate group, belongs to the phenoxy class of chemicals.
T78422	2,3-Di(furan-2-yl)quinoxaline
	2,3-Di(furan-2-yl)quinoxaline (Compound 5)为喹诺啉类化合物, 赋予蓝色荧光。该化合物展现出良好的细胞渗透性，并在微摩尔浓度（1.5 μM）下展现出充分的亮度。
T41355	3-Methyl-2-quinoxalinecarboxylic acid

化合物

NoxA1ds acetate(1435893-78-9 free base)

Cat.No: TP1886L1

Target: NADPH-oxidase

Cat.No: T80229

Cat.No: T80227

r8-Gly-Noxa A BH3

Cat.No: T80228

Cat.No: T0300

Synonym: Pargylamine,Paragyline,优降宁

Target: MAO, Monoamine Oxidase

Pargyline hydrochloride

Cat.No: T1578

Synonym: 优降宁盐酸盐,Pargylamine hydrochloride

Target: MAO, Monoamine Oxidase

Cat.No: TP1886

Cat.No: T75949

Garenoxacin mesylate hydrate

Cat.No: T7804

Synonym: Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)

Target: Antibacterial

Cat.No: T19805

Synonym: BRN-4190275,解草酮,BRN 4190275,BRN4190275

Target: Others

Cat.No: T0717L

Synonym: 依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919

Target: DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Sulfaquinoxaline

Cat.No: T1177

Synonym: 磺胺喹恶啉,Avicocid,磺胺喹噁啉,Sulphaquinoxaline,Sulfabenzpyrazine

Target: Others, Antibacterial, Antibiotic, Parasite

Sulfaquinoxaline sodium salt

Cat.No: T0917

Synonym: SQ-Na,磺胺喹恶啉钠盐,Sulfaquinoxaline sodium,磺胺喹啉钠

Target: Antibacterial, Antibiotic, Parasite

Cat.No: T19679

Synonym: 氧苯恶唑丙酸,NSC 299582,LY-90459,Benoxaphen. Compound 90459

Target: COX

Enoxacin hydrate

Cat.No: T0717

Synonym: CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

2(1H)-Quinoxalinone

Cat.No: T9932

Target: Others

Banoxantrone dihydrochloride

Cat.No: T10459

Synonym: AQ4N dihydrochloride,AZD1689 2HCl

Target: NOS

Cat.No: T7902

Synonym: 奥泽沙星,T-3912

Target: Antibacterial

Enoxaparin sodium

Cat.No: T22323

Target: Thrombin

Chloroquinoxaline sulfonamide

Cat.No: T14953

Synonym: NSC-339004,Chloroquinoxaline

Target: Topoisomerase

Meclofenoxate hydrochloride

Cat.No: T1401

Synonym: Meclofenoxate (Centrophenoxine) HCl,Lucidril,盐酸甲氯芬酯,Cerutil,盐酸甲氯酚酯,Meclofenoxate HCl

Target: Lipoxygenase, COX, AChR, iGluR

Carbinoxamine Maleate Salt

Cat.No: T2222

Synonym: Lergefin,马来酸罗托沙敏,CarbinoxaMine Maleate

Target: Histamine Receptor

Chlorphenoxamine

Cat.No: T7564

Synonym: Contristamine,氯苯沙明

Target: Histamine Receptor

Cat.No: T0274

Synonym: 西诺沙星,Compound 64716

Target: Topoisomerase, Antibacterial, Antibiotic

Chlorthenoxazine

Cat.No: T14955

Synonym: 氯西诺嗪,Chlorethylbenzmethoxazone

Target: Immunology/Inflammation related

Vatinoxan hydrochloride

Cat.No: T13285

Synonym: MK-467 hydrochloride,L-659066 hydrochloride

Target: Adrenergic Receptor

Cat.No: T16711

Target: 5-HT Receptor

Benzoquinoquinoxaline

Cat.No: T61664

Cat.No: T68194

Ipenoxazone HCl

Cat.No: T71298

Cat.No: T74821

TANDEM (quinoxaline)

Cat.No: T26249

Synonym: Tandem

Cat.No: T29950

Synonym: Ambenoxanum

Cat.No: T29638

Synonym: Adafenoxato

Nemonoxacin Malate

Cat.No: T28154

Synonym: TG-873870,TG873870,TG 873870

Cat.No: T15591

Synonym: NC-1200,MLV-6976,伊培沙宗

Target: Others

Cat.No: T11512

Synonym: Hydroxyguanabenz

Target: Others

Cat.No: T76543

Cat.No: T19951

Aminochlorthenoxazin

Cat.No: T10304

Synonym: ICI 350

Target: Others

2,3-Bis((R)-tert-butyl(methyl)phosphino)quinoxaline

Cat.No: T66640

Banoxantrone-d12 dihydrochloride

Cat.No: T19201

Synonym: AQ4N D12 dihydrochloride

Target: Others

(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate

Cat.No: T67021

N1-(tert-Butoxycarbonylmethyl)-6-[2-(N-Cbz-amino)ethoxy)]-phenoxazine

Cat.No: TNU1456

Garenoxacin mesylate

Cat.No: T7804L

Synonym: Garenoxacin mesilate,BMS 284756,BM-284756,BMS284756

Cat.No: T14528

Synonym: HOE 2910

Target: Others

(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

Cat.No: T67023

Fenoxaprop-P-ethyl

Cat.No: T19321

Target: Others

2,3-Di(furan-2-yl)quinoxaline

Cat.No: T78422

3-Methyl-2-quinoxalinecarboxylic acid

Cat.No: T41355

Cat. No.	Product Name	Target	Signaling Pathways
T0073	Octinoxate 2-Ethylhexyl 4-methoxycinnamate,ethylhexyl methoxycinnamate,Octyl 4-methoxycinnamate,甲氧基肉桂酸辛酯,Octyl methoxycinnamate,对甲氧基肉桂酸辛酯	Others	Others
	Octinoxate (Octyl 4-methoxycinnamate) 能够吸收来自太阳的 UV-B 射线，保护皮肤免受损伤，也可用于减少疤痕的外观，常用于是防晒霜和唇膏等化妆品中。
T10010	1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol	Others	Others
	1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol is an endogenous metabolite.
T19091	2-(2',3',4'-Trihydroxybutyl)quinoxaline	Others	Others
	2-(2',3',4'-Trihydroxybutyl)quinoxaline is a food metabolite.
TN4774	Physalin A	ERK; BCL; p38 MAPK; NF-κB; Androgen Receptor; ROS; JAK; JNK; STAT; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; Stem Cells
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex

天然产物

Cat.No: T0073

Synonym: 2-Ethylhexyl 4-methoxycinnamate,ethylhexyl methoxycinnamate,Octyl 4-methoxycinnamate,甲氧基肉桂酸辛酯,Octyl methoxycinnamate,对甲氧基肉桂酸辛酯

Target: Others

1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol

Cat.No: T10010

Target: Others

2-(2',3',4'-Trihydroxybutyl)quinoxaline

Cat.No: T19091

Target: Others

Cat.No: TN4774

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

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