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Search Results for " doxorubicin "

74

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31567	Doxorubicin-MVCP MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox
	Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
T70775	Zoptarelin doxorubicin
	Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates in...
T15161	Doxorubicin-SMCC	Others	Others
	Doxorubicin-SMCC is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18418	N-(Iodoacetamido)-Doxorubicin	Others	Others
	N-(Iodoacetamido)-Doxorubicin is an ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T29673	Doxorubicinone Adriamycinone,Adriamycin Aglycone,Doxorubicin Aglycone
	Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.
T27200	DOX−NOP1 HCl doxorubicin-NOP1 conjugate,doxorubicin-NOP1 HCl,DOX−NOP1 Hydrochloride
	DOX−NOP1 is a molecular hybrid covalently joining doxorubicin (DOX) and NOP1. DOX−NOP1 showed similar increased toxicity toward resistant cancer cells and, in addition, lower cardiotoxicity than DOX.
T11090	MC-DOXHZN Doxorubicin(6-maleimidocaproyl)hydrazone	Others	Others
	Mc-doxhzn is a protein-binding prodrug of DOXUbicin (DNA topoisomerase II inhibitor) with acid sensitivity.
TQ0049	MC-DOXHZN hydrochloride MC-DOXHZN盐酸盐,Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
T77832	Azide-PEG4-VC-PAB-Doxorubicin
	Azide-PEG4-VC-PAB-Doxorubicin 为链接剂 Azide-PEG4-VC-PAB 与毒性分子 Doxorubicin 结合形成，适用于抗体药物偶联物（ADCs）的制备。
T4469	Nemorubicin Methoxymorpholinyldoxorubicin,PNU-152243A,PNU 152243,奈莫柔比星	Others	Others
	Nemorubicin (PNU 152243) 是一种 Doxorubicin 衍生物，具有抗肿瘤活性。它需要完整的核苷酸切除修复系统才能发挥活性。它对多药耐药表型的多种肿瘤细胞系具有细胞毒性。
T6928	Pantoprazole SKF96022,泮托拉唑,BY1023	Apoptosis; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole (BY1023) 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
T6909	NSC348884 N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺	Apoptosis; p53	Apoptosis
	NSC348884 是一种核磷蛋白抑制剂，可破坏寡聚体形成并诱导细胞凋亡，在不同的癌细胞系中以 IC50 为 1.7-4.0 μM 抑制细胞增殖。
T0161	Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis; Potassium Channel; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T6929	Pantoprazole sodium Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc	Apoptosis; Others; Proton pump; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others
	Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂，是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，IC50为 6.8 μM。它可以改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T11090L1	Aldoxorubicin hydrochloride Aldoxorubicin hydrochloride (1361644-26-9 Free base）	Topoisomerase	DNA Damage/DNA Repair
	Aldoxorubicin hydrochloride 是 Doxorubicin (DNA 拓扑异构酶 II 抑制剂) 的白蛋白结合前药。Aldoxorubicin hydrochloride 在酸性条件下从白蛋白中释放出来。 Aldoxorubicin hydrochloride 显示出有效的抗肿瘤活性。
T40736	Doxorubicinol hydrochloride 13-Dihydroadriamycin hydrochloride
	Doxorubicinol hydrochloride, also known as 13-Dihydroadriamycin hydrochloride, is a secondary alcohol metabolite derived from Doxorubicin.
T25349	Doxorubicinol RP-27706,Antibiotic 27706RP,13-Dihydrodoxorubicin,Adriamycinol,RP 27706
	Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.
T11090L	Aldoxorubicin DOXO-EMCH,INNO-206	Topoisomerase	DNA Damage/DNA Repair
	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
T81721	N,N-Dimethyldoxorubicin
	N,N-Dimethyldoxorubicin为一Doxorubicin类似物，表现出对多种肿瘤细胞系的显著细胞毒性，其半数抑制浓度(IC50s)均小于0.3 μM。
T28396	PGP-4008 PGP 4008,PGP4008	P-gp	Membrane transporter/Ion channel; Neuroscience
	PGP-4008 是一种具有选择性和有效性的 P-糖蛋白 (Pgp) 抑制剂,通过与Doxorubicin联合给药来抑制肿瘤生长。
T67846	AKR1C3-IN-9	NADPH	Metabolism
	AKR1C3-IN-9 是选择性的醛酮还原酶 1C3 (AKR1C3) 抑制剂 (IC50= 8.92 nM)。AKR1C3-IN-9 显著逆转在耐药乳腺癌细胞系对 Doxorubicin (DOX) 耐药性。
T4047	Bisantrene CL216942,比生群	Topoisomerase	DNA Damage/DNA Repair
	Bisantrene (CL216942) 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的 II 型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。
T6588	Mitoxantrone 米托蒽醌,mitozantrone	Topoisomerase; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Mitoxantrone (mitozantrone) 是一种拓扑异构酶 II 的抑制剂，也可抑制蛋白激酶C (PKC)，IC50值为8.5 μM。
T10952	Dabuzalgron 达布扎琼,Ro 115-1240	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Dabuzalgron (Ro 115-1240) 是一种口服活性选择性 α-1A 肾上腺素受体激动剂，用于治疗尿失禁。它通过维持线粒体功能来预防多柔比星引起的心脏毒性。
T67970	GPX-100 13-deoxydoxorubicin	Others	Others
	GPX-100 (13-deoxydoxorubicin) 是蒽环类抗肿瘤抗生素多柔比星的类似物。GPX-100 插入DNA 并与拓扑异构酶II 相互作用，从而抑制DNA 复制和修复以及RNA 和蛋白质合成。
T17224	VER-246608	Dehydrogenase; PDK	Metabolism; PI3K/Akt/mTOR signaling
	VER-246608 是ATP 竞争性的丙酮酸脱氢酶激酶抑制剂，对PDK-1，PDK-3，PDK-2，和PDK-4的IC50分别为 35 nM，40 nM，84 nM 和 91 nM。
T4247	I-CBP112 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	I-CBP112 hydrochloride 是含溴结构域转录因子的选择性抑制剂，靶向 CBP/p300 溴结构域。在体内外，它以剂量依赖性方式显着降低 MLL-AF9(+) 急性髓细胞白血病细胞的白血病起始潜力，还增加 BET 溴结构域抑制剂 JQ1 以及阿霉素的细胞毒活性。
T24294	L 377202 L 377,202,L377202,L-377,202,L-377202,L377,202
	L 377202 is a peptide-doxorubicin conjugate activated.
T12794	(S)-Carvedilol (S)-BM 14190,(S)-卡维地洛	Others	Others
	(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
T68961	Esorubicin
	Esorubicin is a synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class. Check for active clinic...
T25688	Leurubicin Leurubicina,N-Leucyldoxorubicin
	Leurubicin is used as a prodrug of doxorubicin.
T71713	Pirarubicin HCl
	Pirarubicin HCl is the hydrochloride salt form of pirarubicin, an analogue of the anthracycline antineoplastic antibiotic doxorubicin with antineoplastic activity. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
T25892	N-Trifluoroacetyladriamycin NSC-283464,NSC 283464,AD 41,AD-41,NSC283464
	N-Trifluoroacetyladriamycin is a metabolite of Valrubicin (N-trifluoroacetyladriamycin-14-valerate, trade name Valstar). Valrubicin is a chemotherapy drug utilized to treat bladder cancer. Valrubicin is the anthracycline doxorubicin analog and is administ
T77017	Gancotamab
	Gancotamab (MM-302) 是HER2靶向的抗体-脂质体 Doxorubicin 偶连物，表现出抗肿瘤活性。通过封装 Doxorubicin，Gancotamab 促进该药物向HER2过表达的肿瘤细胞的递送。
T74364	SDOX	Topoisomerase	DNA Damage/DNA Repair
	SDOX为Doxorubicin的前体药物，通过脂质体递送至肿瘤细胞内，在GSH过量释放条件下，触发DOX释放。该机制在不损害抗癌效果的同时，极大地降低了对正常组织的毒副作用。
T19728	SPRC S-Propargyl-cysteine
	SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity.
T61230	Anticancer agent 74
	Anticancer agent 74 exhibits moderate anticancer activity with lower selectivity and cytotoxicity compared to doxorubicin towards normal cells [1].
T12615	(R)-Carvedilol (R)-BM 14190,(R)-卡维地洛	Others	Others
	(R)-Carvedilol is a non-selective blocker of β/α-1. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
T27946	LY-329146 LY 329146
	LY-329146 is a selective estrogen receptor modulator (SERM). LY-329146 prevents doxorubicin resistance in tumor cells expressing multidrug resistance-associated protein (MRP) by inhibiting the binding of MRP substrates to the estrogen receptor.
T69896	Sabarubicin MEN 10755
	Sabarubicin 是一种阿霉素双糖类似物，具有显著的抗肿瘤活性。Sabarubicin 作为一种拓扑异构酶 II 毒药比阿霉素更有效，并在较低的细胞内浓度下刺激 DNA 片段。
T28455	ProTAME pro-Tosyl-L-Arginine Methyl Ester
	ProTAME is an inhibitor of APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, doxorubicin and etoposide, significantly increase cell death in primary cells and Multiple Myeloma (MM) cell lines, particularly if TOPIIα levels ar
T83922	Pep2 Peptide
	Pep2 peptide是一种针对跨膜糖蛋白CD36的肽配体，CD36也被称为清道夫受体B2。在1 mM浓度使用时，Pep2 peptide在无细胞检测中选择性地与CD36结合，相比于人血清白蛋白(HSA)、IgG和CD44具有更高的亲和力。与不含Pep2 peptide的胶束相比，包裹抗癌剂多柔比星的Pep2 peptide功能化胶束能增加多柔比星在过表达CD36的HepG2肝细胞癌细胞中的细胞内输送，并提升细胞毒性。
T10968	DC0-NH2	Others	Others
	The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then ade
T36323	C8 Galactosylceramide (d18:1/8:0) C8 Galactosylceramide (d18:1/8:0)
	C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo....
T68928	GPX100 HCl
	GPX-100 is a n analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
T68326	Annamycin
	Annamycin is a semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including P-glycoprotein (P-gp).
TP1498	FFAGLDD TFA
	FFAGLDD TFA is an MMP9 selective cleavage peptide, which is used for the cytoplasmic transfer of doxorubicin (DOX) to realize the controlled slow drug delivery and release.
T72678	P-gp inhibitor 4
	P-gp inhibitor 4 是一种选择性的 P-glycoprotein 调节剂，EC50值为 94 nM。P-gp inhibitor 4 增加药物通过胃肠道屏障的能力，恢复 doxorubicin 在耐药癌细胞中的毒性。
T37584	Tryptoquivaline D
	Tryptoquivaline D is a fungal metabolite that has been found inNeosartorya siamensisand has anticancer activity.1,2It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 μM.1Tryptoquivaline D (1-100 μM), alone or in combination with doxorubicin , reduces the viability of A549 lung cancer cells.2
T69093	Epirubicin IMI-28,表柔比星,4-epi DX,4'-Epidoxorubicin,IMI 28,4-epidoxorubicin,epi DX,4-epiadriamycin
	Epirubicin (4'-Epidoxorubicin) 是阿霉素的半合成的 L-阿拉伯糖衍生物，能够抑制 Topoisomerase，起到抗肿瘤的作用。Epirubicin 抑制 DNA 和 RNA 合成。Epirubicin 是一种 Forkhead box 蛋白 p3 (Foxp3) 抑制剂，可抑制调节性 T 细胞活性。

化合物

Doxorubicin-MVCP

Cat.No: T31567

Synonym: MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox

Zoptarelin doxorubicin

Cat.No: T70775

Doxorubicin-SMCC

Cat.No: T15161

Target: Others

N-(Iodoacetamido)-Doxorubicin

Cat.No: T18418

Target: Others

Doxorubicinone

Cat.No: T29673

Synonym: Adriamycinone,Adriamycin Aglycone,Doxorubicin Aglycone

Cat.No: T27200

Synonym: doxorubicin-NOP1 conjugate,doxorubicin-NOP1 HCl,DOX−NOP1 Hydrochloride

Cat.No: T11090

Synonym: Doxorubicin(6-maleimidocaproyl)hydrazone

Target: Others

MC-DOXHZN hydrochloride

Cat.No: TQ0049

Synonym: MC-DOXHZN盐酸盐,Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride

Target: Topoisomerase

Azide-PEG4-VC-PAB-Doxorubicin

Cat.No: T77832

Cat.No: T4469

Synonym: Methoxymorpholinyldoxorubicin,PNU-152243A,PNU 152243,奈莫柔比星

Target: Others

Cat.No: T6928

Synonym: SKF96022,泮托拉唑,BY1023

Target: Apoptosis, Proton pump, Autophagy

Cat.No: T6909

Synonym: N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺

Target: Apoptosis, p53

Pantoprazole Sodium Hydrate

Cat.No: T0161

Synonym: SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

Cat.No: T6929

Synonym: Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Aldoxorubicin hydrochloride

Cat.No: T11090L1

Synonym: Aldoxorubicin hydrochloride (1361644-26-9 Free base）

Target: Topoisomerase

Doxorubicinol hydrochloride

Cat.No: T40736

Synonym: 13-Dihydroadriamycin hydrochloride

Doxorubicinol

Cat.No: T25349

Synonym: RP-27706,Antibiotic 27706RP,13-Dihydrodoxorubicin,Adriamycinol,RP 27706

Cat.No: T11090L

Synonym: DOXO-EMCH,INNO-206

Target: Topoisomerase

N,N-Dimethyldoxorubicin

Cat.No: T81721

Cat.No: T28396

Synonym: PGP 4008,PGP4008

Target: P-gp

Cat.No: T67846

Target: NADPH

Cat.No: T4047

Synonym: CL216942,比生群

Target: Topoisomerase

Cat.No: T6588

Synonym: 米托蒽醌,mitozantrone

Target: Topoisomerase, PKC

Cat.No: T10952

Synonym: 达布扎琼,Ro 115-1240

Target: Apoptosis, Adrenergic Receptor

Cat.No: T67970

Synonym: 13-deoxydoxorubicin

Target: Others

Cat.No: T17224

Target: Dehydrogenase, PDK

I-CBP112 hydrochloride

Cat.No: T4247

Target: Epigenetic Reader Domain

Cat.No: T24294

Synonym: L 377,202,L377202,L-377,202,L-377202,L377,202

Cat.No: T12794

Synonym: (S)-BM 14190,(S)-卡维地洛

Target: Others

Cat.No: T68961

Cat.No: T25688

Synonym: Leurubicina,N-Leucyldoxorubicin

Pirarubicin HCl

Cat.No: T71713

N-Trifluoroacetyladriamycin

Cat.No: T25892

Synonym: NSC-283464,NSC 283464,AD 41,AD-41,NSC283464

Cat.No: T77017

Cat.No: T74364

Target: Topoisomerase

Cat.No: T19728

Synonym: S-Propargyl-cysteine

Anticancer agent 74

Cat.No: T61230

Cat.No: T12615

Synonym: (R)-BM 14190,(R)-卡维地洛

Target: Others

Cat.No: T27946

Synonym: LY 329146

Cat.No: T69896

Synonym: MEN 10755

Cat.No: T28455

Synonym: pro-Tosyl-L-Arginine Methyl Ester

Cat.No: T83922

Cat.No: T10968

Target: Others

C8 Galactosylceramide (d18:1/8:0)

Cat.No: T36323

Synonym: C8 Galactosylceramide (d18:1/8:0)

Cat.No: T68928

Cat.No: T68326

Cat.No: TP1498

P-gp inhibitor 4

Cat.No: T72678

Tryptoquivaline D

Cat.No: T37584

Cat.No: T69093

Synonym: IMI-28,表柔比星,4-epi DX,4'-Epidoxorubicin,IMI 28,4-epidoxorubicin,epi DX,4-epiadriamycin

Cat. No.	Product Name	Target	Signaling Pathways
T1456	Doxorubicin Hydroxydaunorubicin,阿霉素,Adriamycin	Topoisomerase; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
T37341	N-Acetyltyramine	Antibacterial	Microbiology/Virology
	N-Acetyltyramine 是一种群体感应抑制剂，由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。
T8198	Visnagin	Others	Others
	Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用，可用于缓解疼痛的研究。
TN2269	Tetramethylcurcumin	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Tetramethylcurcumin 是一种新型姜黄素类似物，是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T72735	Coleon-U-quinone
	Coleon-U-quinone 是一种有效的P-gp 抑制剂。Coleon-U-quinone 能抑制癌细胞活力，能提高多药耐药肿瘤细胞对Doxorubicin 的敏感性。
TN3653	Cimidahurinine	BCL; ROS	Apoptosis; Immunology/Inflammation
	Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins.
T81956	Ladanetin-6-O-β-(6′′-O-acetyl)glucoside
	Ladanetin-6-O-β-(6′′-O-acetyl)glucoside 是一种从甘青青兰 (Dracocephalum tanguticum) 全株中提取的黄酮化合物，具备抗氧化特性。该化合物能够保护H9c2心肌细胞免受Doxorubicin(DOX)引起的细胞毒性。
T81532	Pedaliin 6''-acetate
	Pedaliin 6''-acetate (compound 10) 为甘青青兰中分离得到的天然产物，具有抗氧化活性，并能对抗DOX诱导的H9c2心肌细胞毒性，表现出细胞保护效应，其EC50为19.1 μM。
TN1951	Moracin O 桑辛素 O,桑辛素O	HIF	Angiogenesis; Chromatin/Epigenetic
	Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exhibits potent in vitro inhibitory ac
TN3753	Dalbergioidin	Tyrosinase; ROS; Akt; PI3K; TGF-beta/Smad	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced ...
TN5414	Wallichinine
	Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa

天然产物

Cat.No: T1456

Synonym: Hydroxydaunorubicin,阿霉素,Adriamycin

Target: Topoisomerase, AMPK

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

N-Acetyltyramine

Cat.No: T37341

Target: Antibacterial

Cat.No: T8198

Target: Others

Tetramethylcurcumin

Cat.No: TN2269

Target: Apoptosis, STAT

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Coleon-U-quinone

Cat.No: T72735

Cat.No: TN3653

Target: BCL, ROS

Ladanetin-6-O-β-(6′′-O-acetyl)glucoside

Cat.No: T81956

Pedaliin 6''-acetate

Cat.No: T81532

Cat.No: TN1951

Synonym: 桑辛素 O,桑辛素O

Target: HIF

Cat.No: TN3753

Target: Tyrosinase, ROS, Akt, PI3K, TGF-beta/Smad

Cat.No: TN5414

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