224
24
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1214L |
β-Amyloid 15-21 acetate
Beta-Amyloid (15-21) acetate |
Beta Amyloid | Neuroscience |
β-Amyloid 15-21 acetate (Beta-Amyloid(15-21) acetate) 是 Amyloid-β 肽的片段,可用于神经系统疾病的研究。该片段参与β折叠形成。 | |||
TP1229 |
β-Amyloid (1-15)
Amyloid β-Protein (1-15) |
Beta Amyloid | Neuroscience |
β-Amyloid (1-15) (Amyloid β-Protein (1-15)) 是 β-淀粉样蛋白片段,可用于研究阿尔茨海默病。 | |||
T7562 |
β-Amyloid (31-35)
异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸,β-Amyloid 31-35(TFA),β-Amyloid 31-35 |
Beta Amyloid | Neuroscience |
β-Amyloid (31-35) (β-Amyloid 31-35) 是一种天然 Amyloid-β 肽的最短序列,具有神经毒性。 | |||
T14284 |
β-Amyloid (25-35)
β-Amyloid peptide(25-35),Aβ25-35,BETA-淀粉样蛋白片断25-35,Amyloid beta-peptide(25-35) |
Beta Amyloid | Neuroscience |
β-Amyloid (25-35) (Aβ25-35) 是一种阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段,在培养细胞中显示出神经毒性作用。 | |||
TP1786L |
Amyloid β-Protein 10-20 acetate
Amyloid β-Protein 10-20 acetate(152286-31-2 free base) |
Beta Amyloid | Neuroscience |
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) 是 Amyloid-β 肽的片段,可能用于神经系统疾病的研究。Amyloid β 蛋白片段含有 α-分泌酶加工位点(Lys16-Leu17 键)。它还包含负责与小胶质细胞结合的 HHQK 结构域(残基 13-16)。 | |||
T35499 |
β-Amyloid (1-42), (rat/mouse) (TFA)
Amyloid β-peptide (1-42) (human) TFA,166090-74-0 TFA |
||
β-Amyloid (1-42), (rat/mouse) (TFA) 是由 42 个氨基酸组成的多肽片段,可用于研究阿尔茨海默症。 | |||
TP1359L |
Amyloid β Peptide (42-1)(human) acetate
Amyloid β Peptide (42-1)(human) acetate(317366-82-8 free base) |
Beta Amyloid | Neuroscience |
Amyloid β Peptide (42-1)(human) acetate 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。Amyloid β Peptide (42-1)(human) acetate 是由 42 个氨基酸组成的肽,其在阿尔茨海默病的发病机制中起关键作用。 | |||
TP1007L |
β-Amyloid (1-42), acetate (human)
β-Amyloid (1-42), human acetate (107761-42-2 Free base) |
||
β-Amyloid (1-42), acetate (human) 是由 42 个氨基酸组成的肽,是 β-Amyloid 的一部分,常用于阿尔茨海默病造模。 | |||
TP1866L |
β-amyloid 1-11 acetate(190436-05-6 free base)
|
Beta Amyloid | Neuroscience |
β-amyloid 1-11 acetate(190436-05-6 free base) 是 Amyloid-β 肽的片段,可用于神经系统疾病的研究。 | |||
T21890 |
JLK6
|
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
JLK-6 是一种γ分泌酶抑制剂,选择性作用于 HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解 APP,抑制 Aβ的生成,但对不 Notch 受体的裂解无影响。 | |||
T14199 |
ALZ-801
Valiltramiprosate |
Beta Amyloid | Neuroscience |
ALZ-801 是一种可口服的小分子 β-淀粉样蛋白抗寡聚体和聚集抑制剂,是曲米酸的缬氨酸偶联前药,与母体化合物相比,具有显著改善的 PK 特性和胃肠道耐受性。它是治疗阿尔茨海默病的先进且显著改善的候选药物。 | |||
TP1227 |
β-Amyloid (12-28)
β-amyloid 12-28,Amyloid β-Protein (12-28) |
||
Amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo. | |||
T39285 |
Biotin-β-Amyloid (1-40)
|
||
Biotin-β-Amyloid (1-40) is a N-terminal-labelled biotinylated amyloid- -(1-40) peptide. | |||
TP1228 |
β-Amyloid (1-16)
Amyloid β-Protein (1-16),β-Amyloid 1-16 |
||
β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is responsible for the formation of amyloid plaques in the brains of individuals affected by Alzheimer's disease (AD). | |||
TP1225 |
β-Amyloid (22-35)
β-Amyloid 22-35,Amyloid β-Protein (22-35) |
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β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. | |||
TP1303 |
β-Amyloid (1-40)
β-Amyloid 1-40 |
||
Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases. | |||
TP1544 |
β-Amyloid (22-40)
β-Amyloid 22-40 |
||
This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein. This peptide sequence is often used in beta amyloid structure and aggregation studies. | |||
TP1538 |
β-Amyloid (1-20)
β-Amyloid 1-20 |
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This synthetic peptide consists of amino acids 1 to 20 of beta amyloid protein. | |||
TP1599 |
β-Amyloid (1-34)
β-Amyloid 1-34 |
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This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34. | |||
TP1645 |
β-Amyloid (1-9)
β-Amyloid 1-9 |
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This is an N-terminal fragment of beta amyloid. It consists of amino acid residues 1 to 9. Truncated beta amyloid peptide (10-40) still forms amyloid fibrils and shows fibril polymorphism. | |||
TP1633 |
β-Amyloid (18-28)
β-Amyloid 18-28 |
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Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice. These peptides have only amino acid residues VFF at position 18 to 20 in common, suggesting the amnestic effect of the triad. | |||
TP1494 |
β-Amyloid (4-10)
β-Amyloid 4-10 |
||
Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in mice. This peptide does not elicit an inflammatory response. | |||
TP1231 |
β-Amyloid (29-40)
Amyloid beta-protein(29-40),β-Amyloid 29-40 |
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β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th | |||
T7490 |
ARN2966
|
Beta Amyloid | Neuroscience |
ARN2966 是高效的,针对 APP 表达的转录后调节剂,能够抑制 APP 的表达从而使 Aβ的量降低。 | |||
TP1786 |
β-Amyloid (10-20)
Amyloid β-Protein 10-20 |
||
Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains the HHQK domain (residues 13-16) re | |||
TP1866 |
β-Amyloid (1-11)
β-amyloid 1-11 |
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Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients. | |||
T3259 |
FPS-ZM1
|
Beta Amyloid; advanced glycation end products | Neuroscience; Others |
FPS-ZM1 是一种高亲和力的 RAGE 特异性抑制剂,可阻断 Aβ 与 RAGE 的 V 结构域的结合。 | |||
T5447 |
Anle138b
|
Beta Amyloid; Others | Neuroscience; Others |
Anle138b 是一种毒性低,口服生物利用度高,血脑屏障通透性好的低聚物聚集抑调节剂,可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。 | |||
TP1719 |
β-Amyloid (33-40)
β-Amyloid 33-40 |
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β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein. | |||
TP1586 |
β-Amyloid (35-42)
β-Amyloid 35-42 |
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β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein. | |||
TP1673 |
β-Amyloid (11-22)
β-Amyloid 11-22 |
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β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerat | |||
TP1500 |
β-Amyloid (1-17)
β-Amyloid 1-17 |
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This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies. | |||
T37768 |
β-Amyloid (1-37) (human)
|
||
β-Amyloid (1-37) (human) 与阿尔茨海默病的精神状态有潜在关联。 | |||
T38149 |
β-Amyloid (1-43)(human)
|
||
The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro. | |||
T22694 |
CRANAD 2
|
Others | Others |
CRANAD 2 是一种特异性近红外 (NIR) 荧光探针,可用于检测 Aβ 斑块。它可透过血脑屏障,且对 Aβ 聚集体有高亲和性,其 Kd=38 nM。 | |||
T7527 |
Frentizole
|
Beta Amyloid | Neuroscience |
Frentizole 是一种 FDA 批准的免疫抑制剂,是一种新型 Aβ-ABAD 相互作用抑制剂。 | |||
T7905 |
PBD-150
|
Beta Amyloid | Neuroscience |
PBD-150 是一种人谷氨酰胺酰基环化酶 Y115E-Y117E 变体的抑制剂,其 Ki=490 nM。 | |||
TP1226 |
β-Amyloid (1-28)
Amyloid β-Protein (1-28),β-Amyloid 1-28 |
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β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. | |||
T12532 |
PQM130
|
Beta Amyloid | Neuroscience |
PQM130是一种魏罗酮-多奈哌齐杂化化合物,能透过大脑。PQM130是多靶点的候选药物,可用于Aβ1-42低聚物引起的神经毒性,还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。 | |||
TP1692 |
β-Amyloid (13-27)
β-Amyloid 13-27 |
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β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein. This synthetic peptide consists of amino acids 26 to 40 of beta amyloid protein. It can be used to study the kinetics of beta amyloid formation. | |||
TP1480 |
β-Amyloid (12-20)
β-Amyloid 12-20 |
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β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad has amnestic effects. | |||
TP1856 |
Colivelin
|
Beta Amyloid; STAT | JAK/STAT signaling; Neuroscience; Stem Cells |
Colivelin 是一种神经保护肽和 STAT3 的激活剂,是一种合成的杂合肽,可增强 humanin (HN) 的神经保护作用。它通过激活 STAT3 在体外抑制神经元死亡,具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。 | |||
T37368 | Amyloid-β (1-8) Peptide | ||
Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide . | |||
TP1214 |
β-Amyloid 15-21
Beta-Amyloid (15-21) |
||
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation. | |||
TP1007 |
β-Amyloid (1-42), human
大豆肽,β-Amyloid (1-42), human,Amyloid β-Peptide (1-42) human |
Beta Amyloid | Neuroscience |
β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽,在阿尔茨海默病的发病机制中起关键作用。 | |||
T21825 |
TAE-1
|
Beta Amyloid; AChE | Neuroscience |
TAE-1 是淀粉样蛋白-β 原纤维形成和聚集的抑制剂。它抑制胆碱酯酶 AChE 和 BuChE,IC50 分别为 0.3 μM 和 3.9 μM。 | |||
T4398 |
LX2343
|
Beta Amyloid; Beta-Secretase; BACE; PI3K; Autophagy | Autophagy; Neuroscience; PI3K/Akt/mTOR signaling |
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。 | |||
TP1441 |
β-Amyloid (1-40) (rat)
Amyloid β-peptide (1-40) rat,β淀粉样肽(1-40)(鼠) |
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Rat form of the beta-Amyloid (1-40) peptide | |||
T39146 |
β-Amyloid (1-40), FAM-labeled
|
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β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λ ex = 492 nm and λ em = 518 nm). | |||
T4364 |
Aftin-4
Aftin 4,Aftin4 |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2212 |
Geniposide
栀子苷,京尼平甙 |
Beta Amyloid; Influenza Virus | Microbiology/Virology; Neuroscience |
Geniposide 是从栀子花中提取的一种环烯醚萜甙,具有如神经保护、抗糖尿病、抗增殖和抗氧化多种生物活性。 它可调节 Nrf2 易位。 | |||
TN6919 |
Methyl tridecanoate
|
Beta Amyloid; AChE | Neuroscience |
Methyl tridecanoate 能够适度抑制 β-淀粉样蛋白聚集,弱抑制乙酰胆碱酯酶。 | |||
T8012 |
Scyllo-Inositol
Scyllitol,鲨肌醇 |
Beta Amyloid; Endogenous Metabolite | Metabolism; Neuroscience |
Scyllo-Inositol (Scyllitol) 是淀粉样抑制剂,能够抑制 α-突触核蛋白聚集。它在体外能够稳定非纤维状无毒形式的淀粉样蛋白-β 肽,逆转阿尔茨海默病小鼠模型的认知缺陷,抑制突触毒性和淀粉样斑块。 | |||
T3914 |
Saikosaponin C
柴胡皂苷C,柴胡皂苷 C |
Beta Amyloid; Caspase | Apoptosis; Neuroscience; Proteases/Proteasome |
Saikosaponin C 是一种柴胡中的活性成分,能够抑制 Aβ1-40 和 Aβ1-42 的释放,抑制异常 tau 蛋白的磷酸化,但对 BACE1 的活性和表达无作用。它在阿尔滋海默症中主要靶作用于amyloid beta 和tau 蛋白。 | |||
T4S0350 |
Licochalcone B
甘草查尔酮 B,甘草查尔酮B |
Beta Amyloid; Others | Neuroscience; Others |
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。 | |||
T0795 |
Rutin
Quercetin 3-O-rutinoside,芦丁,Rutoside |
Beta Amyloid; Prostaglandin Receptor; Autophagy | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Rutin (Quercetin 3-O-rutinoside) 是槐果实中的一种黄酮类天然产物,具有抗炎、降糖、抗氧化、神经保护、肾脏保护、肝脏保护和降低Aβ低聚物活性等多种生物活性。它能穿过血脑屏障,通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。 | |||
TMS1461 |
Qingyangshengenin B
青阳参甙元B,青阳参苷元B,Otophylloside B |
Beta Amyloid | Neuroscience |
Qingyangshengenin B (Otophylloside B) 是一种分离自 Qingyangshen 的 C-21 甾体苷。它能够在 mRNA 水平上抑制 Aβ 的表达来减少 Aβ 的沉积,对 Aβ 的毒性有保护作用。它具有抗癫痫作用。 | |||
T6S1918 |
Schisantherin B
Gomisin-B,Wuweizi ester-B,五味子酯乙,Schizantherin-B |
Beta Amyloid; Others | Neuroscience; Others |
Schisantherin B (Schizantherin-B) 是一种天然产物。 | |||
T22417 |
Rutin hydrate
芦丁,Rutoside,Sophorin,Quercetin-3-O-rutinoside |
Beta Amyloid; Others; Autophagy | Autophagy; Neuroscience; Others |
Rutin hydrate (Sophorin) 是一种广泛存在于多种植物中的黄酮类天然产物,具有降糖、抗炎、抗氧化、神经保护、肾脏保护、肝脏保护和降低 Aβ 低聚物活性等多种生物活性。它能穿过血脑屏障,通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。 | |||
T0883 |
Tramiprosate
Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed,高牛黄酸 |
Beta Amyloid; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Tramiprosate (Alzhemed) 是一种具有口服活性的、可透过血脑屏障的天然氨基酸,存在于各种红色海藻中,能够可溶性 Aβ 结合并以非原纤维形式维持 Aβ。它是一种 GABA 类似物,具有神经保护,抗惊厥和抗高血压的活性。 | |||
T1686 |
Hematoxylin
苏木精,Hydroxybrazilin,Natural Black 1,Haematoxylin |
Beta Amyloid; Others | Neuroscience; Others |
Hematoxylin (Natural Black 1) 是一种天然存在的类黄酮化合物,衍生自木柴树Haematoxylon campechianum。它是一种组织学上的核染色剂,也是一种有效的Aβ42原纤维形成的抑制剂,IC50=1.6 µM。 | |||
T2872 |
Ginsenoside Re
人参皂苷 Re,Ginsenoside B2,Panaxoside Re,Chikusetsusaponin Ivc,Sanchinoside Re,人参皂苷Re |
Beta Amyloid; NF-κB; Endogenous Metabolite; JNK | MAPK; Metabolism; Neuroscience; NF-κB |
Ginsenoside Re (Ginsenoside B2) 是一种人参提取物,可降低 β-淀粉样蛋白 (Aβ),还通过抑制 JNK 和 NF-κB 发挥抗炎作用。 | |||
T2961 |
Notoginsenoside R1
Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1 |
Apoptosis; ERK; Beta Amyloid | Apoptosis; MAPK; Neuroscience |
Notoginsenoside R1 (Sanchinoside R1) 是一种从三七中分离出来的皂苷,具有抗氧化、抗炎、抗血管生成和抗凋亡的活性。它有神经保护和抗缺血/再灌注损伤的心脏保护作用。 | |||
T2873 |
Ginsenoside Rg2
Chikusetsusaponin I,Panaxoside Rg2,人参皂苷Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2,人参皂苷 Rg2 |
Beta Amyloid; GSK-3; NF-κB | Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Stem Cells |
Ginsenoside Rg2 (Chikusetsusaponin I) 是一种人参的主要活性成分。它能够降低Aβ1-42积聚,抑制脂多糖介导的VCAM-1和ICAM-1表达的增加。 | |||
T2777 |
Ginsenoside Rg1
Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2 |
Apoptosis; Beta Amyloid; NF-κB | Apoptosis; Neuroscience; NF-κB |
Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一,可减少NF-κB 核易位。它改善认知功能受损,通过降低大脑Aβ水平来发挥作用。 | |||
T3402 |
20(S)-Ginsenoside Rg3
20(S)-人参皂苷 Rg3,人参皂苷 Rg3,20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 |
EGFR; Beta Amyloid; Potassium Channel; NF-κB; COX; Sodium Channel; Endogenous Metabolite | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
20(S)-Ginsenoside Rg3 (Rg3) 是红参的主要成分,通过抑制肿瘤细胞的粘附和侵袭来抑制肿瘤细胞肺转移。它抑制Na+和hKv1.4通道,IC50分别为 32.2±4.5 和 32.6±2.2 μM。它还抑制Aβ,NF-κB 活性和COX-2表达,抑制人脐静脉内皮细胞的增殖并具有抗血管生成活性。 | |||
TN1653 |
Fustin
|
ERK; Beta Amyloid; AChR | MAPK; Neuroscience |
Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。 | |||
TN4368 |
Kaempferol-3,7-di-O-β-glucoside
Kaempferol 3,7-di-O-glucoside |
Glucosidase; Amylase | Metabolism |
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种来自 Morettia philaena 的黄酮醇,对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有抑制作用。Kaempferol-3,7-di-O-β-glucoside 具有神经保护活性,可减缓分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 可用于研究阿尔茨海默氏症类的神经系统疾病。 | |||
T3769 |
Tenuifolin
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Others; Beta-Secretase; AChE | Neuroscience; Others |
Tenuifolin 是一种从远志中分离出的三萜,能够抑制β-secretase 以减少 Aβ 蛋白分泌,具有神经保护作用。 它可通过降低 AChE 活性来改善衰老小鼠的学习和记忆能力,有潜力用于阿尔茨海默氏病的研究。 | |||
TL0007 |
Bisdemethoxycurcumin
双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin |
Epigenetic Reader Domain; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells |
Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。 | |||
T32614 |
L-Clausenamide
(-)-Clausenamide |
Microtubule Associated | Cytoskeletal Signaling |
L-Clausenamide 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中提取出来的生物碱,可用于提高认知功能。L-Clausenamide 对β-淀粉样蛋白 (Aβ) 毒性有抑制作用,通过抑制 tau 蛋白磷酸化阻止神经纤维缠结的形成。L-Clausenamide 具有神经保护活性,可用于调节 Aβ25-35 引发的刺激。L-Clausenamide 可用于研究阿尔兹海默症类的神经系统疾病。 | |||
T79968 |
Coumarinic acid
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Coumarinic acid为具有脑穿透性的双重功能抑制剂,能够抑制AChE和β-amyloid,适用于开发治疗阿尔茨海默病的药物研究。 | |||
T37957 |
Setosusin
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Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tremors in mice. | |||
T83407 | 2',3'-Dihydroxy-4',6'-dimethoxychalcone | ||
2',3'-Dihydroxy-4',6'-dimethoxychalcone 能够抑制β淀粉样蛋白(Aβ42)的纤维化与聚集,并具有口服活性,在大脑中可进行检测。 |