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62

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride Leu-Leu-ome hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，能够选择性消除具有细胞毒性潜能的淋巴细胞，也能够诱导溶酶体途径应激。
T1076	Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松	Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性，可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
T32824	LM-1685 LM 1685,LM1685	COX	Immunology/Inflammation; Neuroscience
	LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。
T11877	LR-90	Others	Others
	LR-90, 作为一种高级糖基化终产品(AGE)抑制剂，在糖尿病动物模型研究中被广泛使用。LR-90 有效地抑制了人类单核细胞中的炎症反应。
T5837	Tamerit	Others	Others
	Tamerit 是一种化学发光物质，pKa 值为 6.74 和 15.1，荧光波长为 425 nm。它是法医检测血迹的诊断工具，可用于刑事侦查、生物工程、化学示踪等领域。
T4319	Hispidol (Z)-Hispidol	TNF	Apoptosis
	Hispidol ((Z)-Hispidol) 是一种炎症性肠病的潜在治疗剂，可抑制 TNF-α 诱导的单核细胞与结肠上皮细胞的粘附，IC50 为 0.50 μM。
T15577	Indobufen Ibustrin,吲哚布芬	COX	Immunology/Inflammation; Neuroscience
	Indobufen (Ibustrin) 是一种血小板聚集抑制剂，是下调单核细胞中的组织因子，可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T36527	IL-4-inhibitor-1	IL Receptor	Immunology/Inflammation
	IL-4-inhibitor-1 是 IL-4 的抑制剂 (EC50 = 1.81 µM)。
T2367	SKF-86002 SKF86002	p38 MAPK; TNF	Apoptosis; MAPK
	SKF-86002 是一种可口服的 p38 MAPK 抑制剂，具有抗炎和抗关节炎活性，可用于缓解疼痛的研究。它能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢，还抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α，IC50为 1 μM。
T36879L	H-Leu-Leu-OMe . HBr H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others	Others
	H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。
T10242	ACT-389949	Others	Others
	ACT-389949 是一种高效的甲酰肽受体 2/脂蛋白 A4 受体(FPR2)/(ALX)选择性激动剂，对 FPR2/ALX 进行内化入单核细胞的EC50值为 3 nM。它对炎性疾病具有潜在的研究价值。
TP1597L	Secretoneurin, rat acetate Secretoneurin, rat acetate(149146-12-3 Free base)	Others	Others
	Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽，由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放，它对单核细胞和嗜酸性粒细胞有很强的趋化作用，但对粒细胞没有。
T35617	Mitoguazone MGBG,Methyl-GAG	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Mitoguazone (Methyl-GAG) 是一种可透过血脑屏障的选择性的 S-腺苷-蛋氨酸脱羧酶 (S-adenosyl-methionine decarboxylase) 抑制剂，可破坏多胺的生物合成。Mitoguazone 是一种具有抗肿瘤活性的合成多羰基衍生物，可抑制 HIV DNA 整合到单核细胞和巨噬细胞中的细胞 DNA 中，诱导细胞凋亡 (apoptosis)。Mitoguazone 具可用于预防急性白血病，霍奇金淋巴瘤和非霍奇金淋巴瘤。
TP1592L	C-Reactive Protein (CRP) 174-185 acetate C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base)	Others	Others
	C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base) 是一种急性期血清蛋白，可响应炎性细胞因子而合成，在动物中产生抗肿瘤作用。片段 CRP (174-185) (RS-83277) 通过显着增强体外人单核细胞和肺泡巨噬细胞的杀肿瘤活性显示出相似的活性。
T38361	GSK717	IL Receptor; NOD	Immunology/Inflammation; NF-κB
	GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T14909	CCX140 3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B	CCR	Immunology/Inflammation; Microbiology/Virology
	CCX140 (CCX140-B) 是 CCR2 的拮抗剂。
T19632	Lobucavir BMS180194,BMS 180194,SQ 34,514,SQ-34514,SQ 34514,SQ34514
	Lobucavir inhibits the replication of the HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.
T35773	Gliotoxin-13C13 Gliotoxin-13C13
	Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutr...
T37278	2-chloro Stearic Acid
	2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from primary human neutrophils. 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).
T76567	Met-RANTES (human)
	Met-RANTES (human) 为一部分CCR5拮抗剂，能够降低血液单核细胞向肝脏浸润的程度。
T23962	DA-E 5090 DA-E-5090,DA-E5090,DA E 5090
	DA-E 5090 is a pharmacologically active metabolite of E 5090, is an interleukin-1 antagonist. DA-E 5090 is a novel inhibitor of IL-1 generation, in vitro inhibitory effects on the generation of IL-1 by human monocytes.
T35405	(±)9-HODE cholesteryl ester
	(±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 9-HODE cholesteryl ester.
TP1891	MMK 1
	Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proi
T71240	AS 703026
	AS 703026 has been shown to inhibit LPS-induced TNFα production in macrophages/monocytes as well as protect from LPS-induced endotoxin shock. AS 703026 may be useful as an anti-inflammatory therapy for COPD patients.
T37284	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.
T35404	(±)13-HODE cholesteryl ester
	(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 13-HODE cholesteryl ester.
TP1864	[Glu1]-Fibrinopeptide B [Glu1]-纤维蛋白肽B
	[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts.
TP1592	C-Reactive Protein (CRP) (174-185) C-Reactive Protein (CRP) 174-185
	CRP, an acute phase serum protein synthesized in response to inflammatory cytokines, produces antitumor effects in animals. The fragment CRP (174-185) (RS-83277) shows similar activity by significantly enhancing the tumoricidal activity of human monocytes
T77064	Licaminlimab
	Licaminlimab (OCS-02) 是一种单链抗TNF alpha 抗体片段。TNF alpha 是巨噬细胞和单核细胞在炎症过程中产生的炎症细胞因子。
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3 via peptidases. PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma. It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.
T37907	DL 175
	Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
T81078	Substance P (3-11)
	Substance P (3-11)，作为P 物质 (SP) 的片段肽，具备穿透血脑屏障的能力，且对豚鼠回肠显示出收缩活性。
T61554	CSF1R-IN-13
	CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1].
T37301	PCTR2
	Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 via γ-glutamyl transpeptidase. PCTR2 is found in resolving mouse exudate and in both M1 and M2 macrophages differentiated from isolated human monocytes.
T36180	Azelaoyl PAF
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.
T30774	CC-3052 CC3052
	CC-3052 is a water-soluble, highly stable thalidomide analogue that is an effective inhibitor of HIV-1 expression and activation-induced TNF-α production. CC-3052 also inhibited PHA-induced and rTNF-α induced TNF-α transcription in PBMC, as well as TNF-α
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T73497	GSK761
	GSK761作为Sp 140核体蛋白（SP140）的选择性抑制剂，其IC50值达到77.79 nM。它有效减少了单核细胞向炎性巨噬细胞的分化及脂多糖（LPS）诱导的炎症反应。此外，GSK761通过阻断SP140活动，促进CD206+调节性巨噬细胞的形成。
T36152	14S(15R)-EET
	14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It induces dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM).3Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4 1.Daikh, B.E., Lasker, J.M., Raucy, J.L., ...
T74803	Levonadifloxacin
	Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771)，作为一种宽谱抗葡萄球菌药物，对甲氧西林敏感金黄色葡萄球菌(MSSA)及对甲氧西林耐药金黄色葡萄球菌(MRSA)显示出显著的抗菌活性，并能有效减少THP-1单核细胞对MRSA和MSSA菌株的吞噬。
T68334	AF3442
	AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional re...
T74089	Mifamurtide TFA
	Mifamurtide TFA (MTP-PE TFA) 是穆拉基二肽 (MDP) 的类似物，一种非特异性免疫调节剂，通过刺激激活巨噬细胞和单核细胞的免疫应答而发挥作用。Mifamurtide TFA 是一种孤儿药，是 NOD2的特异性配体，用作胰岛素增敏剂。Mifamurtide TFA 具有用于骨肉瘤研究的潜力。
T69523	BMS-681
	BMS-681 is an orthosteric antagonist of chemokine receptor 2 (CCR2) that forms a ternary complex with CCR2 and its allosteric antagonist, CCR2-RA-[R]. Together, the complex inhibits chemokine binding with BVMS-681 in the orthosteric pocket and CCR2-RA-[R] in the intracellular allosteric G-protein binding site. When chemokine binding is inhibited, modulation responses implicated in several inflammatory and neurodegenerative diseases, including atherosclerosis, multiple sclerosis, asthma, neuropat...
T81171	SH491
	SH491（Compound 33）是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞（BMM）分化为破骨细胞（IC50: 11.8 nM）。同时，SH491降低了破骨细胞形成的相关标记基因（TRAP、CTSK、MMP-9和ATPase v0d2）以及相应蛋白（TRAP、CTSK、MMP-9）的表达。
T69262	ABE171
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrop...
T37439	C18 Globotriaosylceramide (d18:1/18:0)
	C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma...
T69831	RPR-200765A Mesylayte
	RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable m...
T35536	Tpl2 Kinase Inhibitor (hydrochloride)
	Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5...

化合物

L-Leucyl-L-Leucine methyl ester hydrochloride

Cat.No: T7739

Synonym: Leu-Leu-ome hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

Cat.No: T32824

Synonym: LM 1685,LM1685

Target: COX

Cat.No: T11877

Target: Others

Cat.No: T5837

Target: Others

Cat.No: T4319

Synonym: (Z)-Hispidol

Target: TNF

Cat.No: T15577

Synonym: Ibustrin,吲哚布芬

Target: COX

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

IL-4-inhibitor-1

Cat.No: T36527

Target: IL Receptor

Cat.No: T2367

Synonym: SKF86002

Target: p38 MAPK, TNF

H-Leu-Leu-OMe . HBr

Cat.No: T36879L

Synonym: H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Target: Others

Cat.No: T10242

Target: Others

Secretoneurin, rat acetate

Cat.No: TP1597L

Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)

Target: Others

Cat.No: T35617

Synonym: MGBG,Methyl-GAG

Target: Apoptosis, HIV Protease

C-Reactive Protein (CRP) 174-185 acetate

Cat.No: TP1592L

Synonym: C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base)

Target: Others

Cat.No: T38361

Target: IL Receptor, NOD

Cat.No: T14909

Synonym: 3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B

Target: CCR

Cat.No: T19632

Synonym: BMS180194,BMS 180194,SQ 34,514,SQ-34514,SQ 34514,SQ34514

Gliotoxin-13C13

Cat.No: T35773

Synonym: Gliotoxin-13C13

2-chloro Stearic Acid

Cat.No: T37278

Met-RANTES (human)

Cat.No: T76567

Cat.No: T23962

Synonym: DA-E-5090,DA-E5090,DA E 5090

(±)9-HODE cholesteryl ester

Cat.No: T35405

Cat.No: TP1891

Cat.No: T71240

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

Cat.No: T37284

(±)13-HODE cholesteryl ester

Cat.No: T35404

[Glu1]-Fibrinopeptide B

Cat.No: TP1864

Synonym: [Glu1]-纤维蛋白肽B

C-Reactive Protein (CRP) (174-185)

Cat.No: TP1592

Synonym: C-Reactive Protein (CRP) 174-185

Cat.No: T77064

Cat.No: T37302

Cat.No: T37907

Substance P (3-11)

Cat.No: T81078

Cat.No: T61554

Cat.No: T37301

Cat.No: T36180

Cat.No: T30774

Synonym: CC3052

Cat.No: T69205

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T73497

Cat.No: T36152

Levonadifloxacin

Cat.No: T74803

Cat.No: T68334

Mifamurtide TFA

Cat.No: T74089

Cat.No: T69523

Cat.No: T81171

Cat.No: T69262

C18 Globotriaosylceramide (d18:1/18:0)

Cat.No: T37439

RPR-200765A Mesylayte

Cat.No: T69831

Tpl2 Kinase Inhibitor (hydrochloride)

Cat.No: T35536

Cat. No.	Product Name	Target	Signaling Pathways
T3927	Phellopterin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Phellopterin 是一种分离自P. trifoliata 中的天然产物。它能够调节 Akt 和 PKC 通路，抑制 TNF-alpha 诱导的 VCAM-1 表达，进而减少单核细胞与内皮细胞的粘附。
TQ0273	Neopterin D-(+)-Neopterin,2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one,新蝶呤	Endogenous Metabolite	Metabolism
	Neopterin (D-(+)-Neopterin) 是三磷酸腺苷的一种分解产物，是细胞免疫系统激活的标志物。
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
T82565	Diayangambin Syringaresinol dimethyl ether,Lirioresinol C dimethyl ether
	Diayangambin (Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether) 作为一种细胞增殖抑制剂，其对人单核细胞的IC50值为1.5 μM。此外，Diayangambin 还表现出免疫抑制与抗炎特性。

天然产物

Cat.No: T3927

Target: GABA Receptor

Cat.No: TQ0273

Synonym: D-(+)-Neopterin,2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one,新蝶呤

Target: Endogenous Metabolite

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: T82565

Synonym: Syringaresinol dimethyl ether,Lirioresinol C dimethyl ether

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