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76

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T28628	RVX-297 RVX297	Epigenetic Reader Domain	Chromatin/Epigenetic
	RVX-297 是口服具有活性的，对BD2有选择性的BET 高效抑制剂，作用于BRD2(BD2)、BRD3(BD2)、BRD4(BD2) 的IC50分别为 0.08、0.05、0.02 μM。它能够阻碍多种免疫细胞炎症基因的表达，对临床前模型急性炎症及自身免疫均有效。
T4172	Methoxy-PMS 1-Methoxyphenazine methosulfate,1-Methoxy PMS	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Methoxy-PMS (1-Methoxyphenazine methosulfate) 是一个稳定的电子传递中介，是一种活性氧生成的诱导剂。
T21343	PTZ-343 PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐	Others	Others
	PTZ-343 是一种鲁米诺的强效发光增强剂 (enhancer)。它极大的增强了过氧化物酶催化的鲁米诺化学发光氧化反应 (>80%) 的光输出。
T26009	Quazolast RHC-3988,RHC 3988,RHC3988	Others	Others
	Quazolast (RHC 3988) 是一种有效的介质释放抑制剂，是对豚草抗原鼻腔挑战的对照。Quazolast 在防止猪笼草鼻腔挑战后的鼻塞和鼻痒方面优于安慰剂。
T6329	3-Aminobenzamide 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	3-Aminobenzamide (PARP-IN-1) 是一种有效的 PARP 抑制剂，在 CHO 细胞中，对 PARP 的 IC50值约为 50 nM。它是再灌注过程中氧化剂诱导的肌细胞功能障碍的介质。
T19814	CP-380736 PF 00520893,CP380736,PF00520893,6,7-二甲氧乙氧基喹唑啉-4-酮,CP 380736,PF-00520893	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	CP-380736 (PF-00520893) 是一种表皮生长因子受体 (EGFR) 抑制剂。 EGFR 是一种酪氨酸激酶，可激活 MAPK、JNK 和 Akt 通路，是多种癌症的重要介质。
T9697	ASK1-IN-1	ASK	Apoptosis
	ASK1-IN-1 是一种凋亡信号调节激酶 1（SK1）抑制剂，具有良好的效价 (细胞IC50=138 nM; BiochemicalIC50=21 nM)。ASK1-IN-1具有中枢神经系统渗透性。
T25360	Eclazolast RHC2871,RHC-2871,REV2871,REV 2871,RHC 2871	Others	Others
	Eclazolast (RHC 2871) 是一种亲脂性抗过敏化合物，在肥大细胞模型中抑制介质释放。Eclazolast 通过在细胞内只影响与Fc(epsilon)RI 相关的直接过程而抑制细胞外分泌。Eclazolast 的效果高度依赖于触发细胞的抗原浓度。
TP1277	Bradykinin 缓激肽	Endogenous Metabolite; Bradykinin Receptor	GPCR/G Protein; Metabolism
	Bradykinin 是由激肽释放酶-激肽系统产生的活性肽。它是炎症调节因子和神经调节因子，对几种血管和肾功能也有调节作用。
T3520	Setipiprant KYTH-105,塞替匹仑,ACT-129968	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Setipiprant (ACT-129968) 是一种口服的选择性 CRTH2 拮抗剂，IC50为6.0 nM。
T2690	Tranilast 曲尼司特,MK 341,SB 252218	RAAS; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Tranilast (SB 252218) 是一种抗过敏药物，可抑制炎症细胞释放脂质介质和细胞因子，抑制前列腺素 D2 (PGD2)产生，IC50为 0.1 mM。它拮抗血管紧张素 II 并抑制其在血管平滑肌细胞中的生物学作用，具有抗炎和免疫调节作用。
T4440	Saclofen	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Saclofen 是竞争性GABAB 受体拮抗剂(IC50:7.8 μM)。它可研究 GABAB 受体调节大脑中缓慢抑制性突触后电位的功能。
T36503	Sodium Hydrogen Sulfide (hydrate)	Others	Others
	Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样，是一种重要的气体介质，对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体，常用于细胞和整个动物实验系统。例如，它被用来证明H2S 促进中性粒细胞迁移，减少气道炎症，保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。
T38260	SP 600125, negative control JNK Inhibitor II, negative control
	SP 600125, negative control 是 SP 600125 的甲基化类似物，可用作SP 600125的阴性对照，对 DTP3和GADD45β/MKK7（生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7）具有抑制作用，能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。
T1139	Salbutamol Albuterol,沙丁胺醇,AH-3365	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。
T3979	Emedastine LY188695,依美斯汀,Emadine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Emedastine (LY188695) 是一种可口服的，选择性和高亲和力的组胺 H1受体拮抗剂，Ki 值为 1.3 nM。它是苯并咪唑衍生物，可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。
T21610	Bradykinin (acetate)	Bradykinin Receptor	GPCR/G Protein
	Bradykinin (acetate) 是一种由激肽释放酶-激肽系统产生的活性肽。它是一种炎症介质，也被认为是多种血管和肾功能的神经介质和调节剂。它由血液中的 kallidin 酶促产生，是一种强大的血管扩张剂，可引起平滑肌收缩，并可能介导炎症。它具有作为人血清代谢物和血管扩张剂的作用。它是缓激肽 (2+) 的互变异构体。
T19635	Repirinast MY-5116,MY 5116,MY5116
	Repirinast is a mediator release inhibitor. It is used to treat asthma.
T23909	Cortistatin A Cortistatin-A
	Cortistatin A is a potent and selective mediator-associated kinase CDK8 and its paralogue CDK19 inhibitor.
T30916	CI 922 CI-922,UNII-5VC7KY707F,CI922
	CI 922 is an anaphylaxis mediator release inhibitor. It inhibits the activation of human neutrophils.
T69349	HPR-611
	HPR-611 is a potent inhibitor of anaphylactic chemical mediator release.
T25173	Bradykinin potentiator-5 BPP-5a\,BPP 5a\,BPP5a\
	Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.
T69301	Picumast dihydrochloride
	Picumast dihydrochloride is a prophylactically active anti-allergic compound which combines inhibition of mediator release and action. The activity profile of PDH differs clearly from that of known prophylactic anti-allergic drugs such as DSCG and ketotifen.
T28433	PNU-142731A HCl PNU142731A,PNU 142731A,PNU-142731A
	PNU-142731A HCl, a mediator release inhibitor and an IL-5 production inhibitor, is used potentially for the treatment of asthma.
T41059	Resolvin D3 RvD3
	Resolvin D3 (RvD3) is a dysregulated mediator originating from docosahexaenoic acid (DHA). It plays a crucial role in reducing arthritic inflammation.
T69192	Nivimedone Free Base
	Nivimedone Free Base inhibits mediator release & capillary permeability.
T11473	GSK-5498A	Others	Others
	GSK-5498A is a selective blocker of CARC (IC50, 1 μM). It inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.
T10054	CI-949	Others	Others
	CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM).
T28564	Ro 19-1400 Ro19-1400,Ro-19-1400
	Ro 19-1400, a platelet-activating factor antagonist, directly inhibits immunoglobulin E-dependent mediator release.
T68374	8-Nitro-cGMP
	8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation.
T37268	PAF C-16 Carboxylic Acid
	PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis
T25366	Elaidyl-sulfamide Elaidylsulfamide,ES
	Elaidyl-sulfamide is a sulfamoyl analogue of oleoylethanolamide (OEA). ES is a lipid mediator of satiety that acts through the PPARα.
TP1836	BMf-BH3
	BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetylation and acetylation.
T32783	Lipoxin C4 15-OH-Ltc3
	Lipoxin C4 is a bioactive autacoid metabolites of arachidonic acid made by various cell types. It is categorized as a nonclassic eicosanoid and member of the specialized pro-resolving mediator (SPMs) family of polyunsaturated fatty acid (PUFA) metabolites
T71531	Metamizil hydrochloride
	Metamizil hydrochloride is a cholinolytic agent -- an agent that blocks the transmission of excitation from cholinergic nerve fibers -- and an antagonist of the mediator acetylcholine.
T37238	(±)19(20)-EpDPA
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic...
T71849	STK683963
	STK683963 是细胞ATG4B 活性的强激活剂。STK683963 可以作为细胞中 ATG4B 氧化还原调节的介质。STK683963 可用于癌症研究。
T37169	Resolvin D2 methyl ester
	Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. It evokes diverse anti-inflammatory effects which may mediate the resolution of inflammation. RvD2 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.
T37301	PCTR2
	Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 via γ-glutamyl transpeptidase. PCTR2 is found in resolving mouse exudate and in both M1 and M2 macrophages differentiated from isolated human monocytes.
T37235	(±)16(17)-EpDPA (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex...
T71301	Opaganib HCl
	ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a...
T40995	Violuric acid
	Violuric acid is a redox mediator employed in the laccase system, specifically in the context of the violuric acid assay. This assay serves to verify and ensure the preservation of the high-redox potential characteristic of laccase throughout the process of directed evolution.
T68482	CE-326597
	CE-326597 is a potent and selective CCK1R agonist. The type 1 cholecystokinin receptor (CCK1R) has multiple physiologic roles relating to nutrient homeostasis,including mediation of postcibal satiety. The type 1 cholecystokinin (CCK) receptor (CCK1R) is a key mediator of postcibal satiety and a potential target for drugs that may be useful to prevent and/or treat obesity.
T36043	17(R)-Protectin D1 17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)97...
T75729	Neurokinin A TFA
	Neurokinin A TFA (Substance K TFA) 为速激肽家族内的一种肽类神经递质，主要通过NK-2受体发挥作用，在人类气道和胃肠道组织中充当关键介体。
T37234	(±)14(15)-EpETE
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoi...
T37583	XTT (sodium salt hydrate)
	XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3 1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas...
T71177	LCRF-0004
	LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.
TQ0032L	Rosiptor acetate AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate
	Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast cells and inhibits human leukocyte
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3 via peptidases. PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma. It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.

化合物

Cat.No: T28628

Synonym: RVX297

Target: Epigenetic Reader Domain

Cat.No: T4172

Synonym: 1-Methoxyphenazine methosulfate,1-Methoxy PMS

Target: Reactive Oxygen Species

Cat.No: T21343

Synonym: PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐

Target: Others

Cat.No: T26009

Synonym: RHC-3988,RHC 3988,RHC3988

Target: Others

3-Aminobenzamide

Cat.No: T6329

Synonym: 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001

Target: PARP

Cat.No: T19814

Synonym: PF 00520893,CP380736,PF00520893,6,7-二甲氧乙氧基喹唑啉-4-酮,CP 380736,PF-00520893

Target: EGFR

Cat.No: T9697

Target: ASK

Cat.No: T25360

Synonym: RHC2871,RHC-2871,REV2871,REV 2871,RHC 2871

Target: Others

Cat.No: TP1277

Synonym: 缓激肽

Target: Endogenous Metabolite, Bradykinin Receptor

Cat.No: T3520

Synonym: KYTH-105,塞替匹仑,ACT-129968

Target: GPR, Prostaglandin Receptor

Cat.No: T2690

Synonym: 曲尼司特,MK 341,SB 252218

Target: RAAS, Prostaglandin Receptor

Cat.No: T4440

Target: GABA Receptor

Sodium Hydrogen Sulfide (hydrate)

Cat.No: T36503

Target: Others

SP 600125, negative control

Cat.No: T38260

Synonym: JNK Inhibitor II, negative control

Cat.No: T1139

Synonym: Albuterol,沙丁胺醇,AH-3365

Target: Adrenergic Receptor

Cat.No: T3979

Synonym: LY188695,依美斯汀,Emadine

Target: Histamine Receptor

Bradykinin (acetate)

Cat.No: T21610

Target: Bradykinin Receptor

Cat.No: T19635

Synonym: MY-5116,MY 5116,MY5116

Cat.No: T23909

Synonym: Cortistatin-A

Cat.No: T30916

Synonym: CI-922,UNII-5VC7KY707F,CI922

Cat.No: T69349

Bradykinin potentiator-5

Cat.No: T25173

Synonym: BPP-5a\,BPP 5a\,BPP5a\

Picumast dihydrochloride

Cat.No: T69301

PNU-142731A HCl

Cat.No: T28433

Synonym: PNU142731A,PNU 142731A,PNU-142731A

Cat.No: T41059

Synonym: RvD3

Nivimedone Free Base

Cat.No: T69192

Cat.No: T11473

Target: Others

Cat.No: T10054

Target: Others

Cat.No: T28564

Synonym: Ro19-1400,Ro-19-1400

Cat.No: T68374

PAF C-16 Carboxylic Acid

Cat.No: T37268

Elaidyl-sulfamide

Cat.No: T25366

Synonym: Elaidylsulfamide,ES

Cat.No: TP1836

Cat.No: T32783

Synonym: 15-OH-Ltc3

Metamizil hydrochloride

Cat.No: T71531

(±)19(20)-EpDPA

Cat.No: T37238

Cat.No: T71849

Resolvin D2 methyl ester

Cat.No: T37169

Cat.No: T37301

(±)16(17)-EpDPA

Cat.No: T37235

Synonym: (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA

Cat.No: T71301

Cat.No: T40995

Cat.No: T68482

17(R)-Protectin D1

Cat.No: T36043

Synonym: 17(R)-Protectin D1

Neurokinin A TFA

Cat.No: T75729

(±)14(15)-EpETE

Cat.No: T37234

XTT (sodium salt hydrate)

Cat.No: T37583

Cat.No: T71177

Rosiptor acetate

Cat.No: TQ0032L

Synonym: AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate

Cat.No: T37302

Cat. No.	Product Name	Target	Signaling Pathways
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
TN1922	Meranzin hydrate	ERK; Adrenergic Receptor	GPCR/G Protein; MAPK; Neuroscience
	Meranzin hydrate 是来源于中药柴胡疏肝散中的吸收的生物活性化合物，表现出抗抑郁和抗动脉粥样硬化活性。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN5146	Thunalbene	Others	Others
	Thunalbene shows weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator.
TN6539	Pd-C-II
	Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by
T16733	Resolvin E1 RvE1	Others	Others
	Resolvin E1 is an effective endogenous pro-resolving mediator of inflammation. Resolvin E1 has unique counterregulatory actions that inhibit PMN transendothelial migration. Resolvin E1 also acts as an effective inhibitor of leukocyte infiltration, dendrit
TN1952	Moracin P 桑辛素 P,桑辛素P	Others; ROS; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Others
	Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
TN1235	3,4,5-Tricaffeoylquinic acid	TNF; Akt; HIV Protease	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
TN1208	2-Amino-3-carboxy-1,4-naphthoquinone	NADPH-oxidase	Immunology/Inflammation
	2-Amino-3-carboxy-1,4-naphthoquinone 是电子转移介质，可改变同型发酵乳酸菌的葡萄糖代谢，可作为双歧杆菌生长刺激剂，它通过NAD(P)H 介导的氧化作用影响双歧杆菌的终产物形态。
T75561	Chloranthalactone B
	Chloranthalactone B 是一种茚满烷型倍半萜类化合物，是可以从中药Sarcandra glabra 中分离得到的天然产物。Chloranthalactone B 通过抑制AP-1和p38 MAPK 通路来抑制炎症介质的产生。
TN2766	2'-Hydroxydaidzein	Cannabinoid Receptor; Antioxidant	GPCR/G Protein; oxidation-reduction
	2'-Hydroxydaidzein 是一种在植物中发现的异黄酮类植物素，是一种天然化合物。2'-Hydroxydaidzein 具有抗氧化活性，主要由o -氢键解离焓(BDE)和氢原子转移(HAT)机制驱动。2'-Hydroxydaidzein 抑制炎症细胞中的化学介质，可能对治疗和预防与化学介质产生过多有关的中枢和外周炎症性疾病有作用。2'-Hydroxydaidzein 对大鼠中性粒细胞和formyl-Met-Leu-Phe/cytochalasin B（fMLP/CB）的释放具有抑制作用，IC（50）值分别为2.8+/-0.1和5.9+/-1.4 microM。
TN1951	Moracin O 桑辛素 O,桑辛素O	HIF	Angiogenesis; Chromatin/Epigenetic
	Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exhibits potent in vitro inhibitory ac
T21500	Sphingosine-1-phosphate S1P	Endogenous Metabolite; S1P Receptor; LPL Receptor	GPCR/G Protein; Metabolism
	Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。

天然产物

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

Meranzin hydrate

Cat.No: TN1922

Target: ERK, Adrenergic Receptor

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Cat.No: TN5146

Target: Others

Cat.No: TN6539

Cat.No: T16733

Synonym: RvE1

Target: Others

Cat.No: TN1952

Synonym: 桑辛素 P,桑辛素P

Target: Others, ROS, HIF

3,4,5-Tricaffeoylquinic acid

Cat.No: TN1235

Target: TNF, Akt, HIV Protease

2-Amino-3-carboxy-1,4-naphthoquinone

Cat.No: TN1208

Target: NADPH-oxidase

Chloranthalactone B

Cat.No: T75561

2'-Hydroxydaidzein

Cat.No: TN2766

Target: Cannabinoid Receptor, Antioxidant

Cat.No: TN1951

Synonym: 桑辛素 O,桑辛素O

Target: HIF

Sphingosine-1-phosphate

Cat.No: T21500

Synonym: S1P

Target: Endogenous Metabolite, S1P Receptor, LPL Receptor

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