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181

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39778	Influenza A virus-IN-1
	Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.
T9231	Mbx2329	Antiviral	Immunology/Inflammation
	MBX2329 是一种流感病毒抑制剂，能特异性地抑制血凝素介导的病毒进入，HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
T22868	Influenza A virus fragment	Others	Others
	Influenza A virus fragment has the RNA sequence of Leu-Lys-Phe-Ala-Phe-Ser-Met-Met.
T8793	CBS1117	Influenza Virus	Microbiology/Virology
	CBS1117 是一种病毒进入抑制剂，对甲型流感病毒 A/Puerto Rico/8/34 的 IC50为 70 nM。它干扰血凝素介导的融合过程。
T22838	hemagglutinin (332-340) [Influenza A virus]	Others	Others
	Influenza hemagglutinin is a type of hemagglutinin found on the surface of the influenza viruses. It is an antigenic glycoprotein. It is responsible for binding the virus to the cell that is being infected. Influenza hemagglutinin proteins bind to cells w
TP1644	Influenza A NP(366-374) Strain A/PR/8/35
	This peptide is an H2-Db-restricted epitope from the Influenza A/PR/8/34 nucleoprotein.
TP2232	hemagglutinin precursor (114-122) amide [Influenza A virus]	Others	Others
	Partial antigenic glycoprotein
T8555	Neuraminidase-IN-1 Novel NA Inhibitor,Compound Y-1	Others; Influenza Virus	Microbiology/Virology; Others
	Neuraminidase-IN-1 (Compound Y-1) 是一种神经氨酸酶抑制剂，其IC50值为 0.21 μM，具有抗H1N1流感病毒的活性。
T2479	Tyrphostin A9 Malonoben,Tyrphostin 9,SF 6847,AG 17,RG-50872	EGFR; VEGFR; Influenza Virus; PDGFR	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Tyrphostin A9 (SF 6847) 是一种线粒体分裂诱导剂，是 PDGFR 抑制剂，具有抗流感病毒的活性。
T8936	Proteinase K proteinase K for tritirachium album,Protease K,蛋白酶 K	Others	Others
	Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶，可用于蛋白消化。它在有 SDS 或尿素存在的情况下，在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。
T61557	Influenza A virus-IN-4
	Influenza A virus-IN-4 (compound 23b), a derivative of Oseltamivir, is a highly effective neuraminidase inhibitor. It exerts potent inhibitory effects on influenza viruses [1].
TP1735L	Influenza HA 126-138 acetate Influenza HA 126-138 acetate(207349-63-1 free base)	Others	Others
	Influenza HA 126-138 acetate 是一种流感病毒血凝素 (HA) 肽乙酸盐，包含氨基酸 126-138。它诱导胸腺和外周 T 细胞凋亡。
T38719L	Influenza HA (110-119) acetate	Others	Others
	Influenza HA (110-119) acetate 是流感病毒血凝素的 110-119 片段，可刺激 Treg 细胞增殖。
T62888	Influenza A virus-IN-7
	Influenza A virus-IN-7 (compound 16r) 是一种有效的、口服具有活力的甲型流感病毒抑制剂 (IC50: 3.43 μM, CC50>100 μM)。Influenza A virus-IN-7 具有抗 IAV 作用，细胞毒性低，对病毒 RNA 的转录和复制表现出抑制作用。
T61877	Influenza A virus-IN-5
	Influenza A virus-IN-5 (Compound 16e) is a highly potent and orally active agent against the influenza A virus (IAV), exhibiting an IC 50 of 1.29 μM. It effectively inhibits the transcription and replication of viral RNA while maintaining acceptable levels of cytotoxicity [1].
T62059	Influenza A virus-IN-6
	Influenza A virus-IN-6 (compound 16j) 是有效的选择性甲型流感病毒抑制剂(IC50= 3.88 μM, CC50= 36.64 μM)。Influenza A virus-IN-6 显示出抗 IAV 活性和较低的细胞毒性。
T74762	Influenza A virus-IN-8
	Influenza A virus-IN-8 (S5) 为一种大环肽，无细胞毒性，并作为甲型流感病毒 (IAV) 的有效抑制剂，显示出较好的蛋白酶稳定性。其对 H1 和 H5 变体的IC50值分别低至 6.7 nM 和 6.6 nM。此外，Influenza A virus-IN-8 能够与 HA 茎的一个保守区域结合，特别是对 H1 变体展现出 1.0 nM 的高亲和性Kd 值。
TP1527	CEF8, Influenza Virus NP (383-391) CEF8, Influenza Virus NP 383-391	Others	Others
	CEF8, Influenza Virus NP (383-391) 是一种甲型流感病毒核蛋白，含有 383-391 残基，是甲型流感病毒核蛋白中重要的 HLA-B*2705 限制性表位，与细胞毒性 T 淋巴细胞介导的免疫逃逸有关。
T38719	Influenza HA (110-119)
	Influenza HA (110-119) refers to a specific fragment (110-119) derived from the hemagglutinin protein of the influenza virus. This fragment has the ability to induce the proliferation of Treg cells.
T38687	Influenza Matrix Protein (61-72)
	Influenza Matrix Protein (61-72) is a peptide derived from the matrix protein of influenza viruses and encompasses amino acids 61-72. This specific epitope, Influenza Matrix Protein (61-72), has the ability to elicit a CD4+ T-cell response.
T60697	Influenza virus-IN-1
	Influenza virus-IN-1 (compound 14) 具有抗甲型流感病毒活性，它是甲型流感病毒的有效抑制剂，其CC50值 >200 μM，EC50值为 2.46 μM。Influenza virus-IN-1 对 PAN 核酸内切酶显示出浓度依赖性的抑制活性 (EC50 = 312.36 nM)。
T60810	Influenza virus-IN-2
	Influenza virus-IN-2 (compound 19) 具有抗甲型流感病毒活性，是有效的流感病毒抑制剂，CC50值为 150.85 μM，EC50值为 2.58 μM,。Influenza virus-IN-2 浓度依赖性的抑制 PAN 核酸内切酶，EC50为 489.39 nM。
T83046	Anti-Influenza agent 5	Influenza Virus	Microbiology/Virology
	Anti-Influenza agent 5 (Compound IIB-2)为查耳酮类衍生物，具有抑制流感病毒核输出的活性。该化合物能有效抑制对Oseltamivir具有耐药性的病毒株，主要通过阻断流感病毒核蛋白输出作用来抑制病毒复制。
T39292	NS2 (114-121), Influenza NS2 (114-121), Influenza
	NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses.
T62216	Influenza virus-IN-5
	Influenza virus-IN-5 (Compound 5f) 是一种流感病毒血球凝集素 (hemagglutinin (HA)) 抑制剂，能够作用于 A/H3N2 病毒 (EC50: 1 nM)。
T62197	Influenza virus-IN-4
	Influenza virus-IN-4 (compound 11e) 是一种流感病毒神经氨酸酶的有效抑制剂，能够作用于 H5N1 (IC50: 3.4 μM)、H5N2 (IC50: 0.094 μM)、H5N6 (IC50: 0.79 μM)、H5N8 (IC50: 0.077 μM)。Influenza virus-IN-4 能够抑制 NA（神经氨酸酶），并具有低细胞毒性(CC50>200 μM)。Influenza virus-IN-4 在1500 mg/kg 时，对小鼠没有明显的毒性。
T72450	Influenza virus-IN-6	Influenza Virus	Microbiology/Virology
	Influenza virus-IN-6 (Compound 35) 是一种针对流感病毒聚合酶酸性蛋白亚基内切酶N端结构域(PAN)的高效抑制剂，展现出0.20 μM的IC50值。
T62837	Influenza virus-IN-3
	Influenza virus-IN-3 (compound 9) 是一种选择性流感病毒的有效抑制剂，能够作用于 H5N1 (IC50: 0.88 μM)、H5N2 (IC50: 0.10 μM)、H5N6 (IC50: 5.5 μM)、H5N8 (IC50: 0.51 μM)。Influenza virus-IN-3 具有抗病毒和 NA (神经氨酸酶) 抑制作用，且细胞毒性低 (CC50>200 μM)。
T75166	Influenza virus-IN-7
	Influenza virus-IN-7 (Example 16) 是一种口服活性的帽依赖性核酸内切酶抑制剂，适用于流感病毒感染疾病的研究。
T60778	Anti-Influenza agent 3
	Anti-Influenza agent 3 (compound 11h) 是有效的抗流感药物，对 MDCK 上皮细胞显示出低细胞毒性。Anti-Influenza agent 3 抑制 M2 WT 和 S31N 离子通道的传导性。Anti-Influenza agent 3 对 A/HK/68 (H3N2, M2-WT) 菌株的 EC50值为 3.29 μM，对 A/WSN/33 (H1N1, M2-S31N) 菌株的 EC50值为 2.45 μM。
T82071	Influenza NP (311-325)
	Influenza NP (311-325) 是具有生物活性的肽段，对应于流感病毒核蛋白(NP)的311至325氨基酸。作为MHC II类限制性表位，它用于研究宿主在感染期间的免疫响应。该肽能在细胞内细胞因子检测中诱导强烈的γ干扰素(IFN-γ)产生，但不激活小鼠CD8 T细胞。谷氨酰胺(Q)或谷氨酸(E)位于N端时，焦谷氨酰(pGlu)肽可自发形成。Q或E向pGlu的自然转化及其疏水性γ-内酰胺环在肽的胃肠道蛋白酶稳定性中可能起作用。焦谷氨酰肽作为常见肽的一部分，在HPLC分析中评估肽的纯度。
T38236	2′-Deoxy-2′-fluoroguanosine	Nucleoside Antimetabolite/Analog; Influenza Virus	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	2′-Deoxy-2′-fluoroguanosine 是一种核苷类似物，有效抑制流感病毒，抑制A 型和B 型流感病毒的EC90值 <0.35 μM。2′-Deoxy-2′-fluoroguanosine 显著抑制流感病毒在上呼吸道中的复制，从而改善鼻腔炎症和发烧。
T2529	Zanamivir 扎那米韦,GG167	Influenza Virus; Antibiotic	Microbiology/Virology
	Zanamivir (GG167) 是神经氨酸酶抑制剂，对于流感病毒 A 和B 的IC50值分别为0.95 nM 和2.7 nM。
T9124	Laninamivir octanoate 辛酸拉尼米韦,CS-8958	Influenza Virus	Microbiology/Virology
	Laninamivir octanoate (CS-8958) 是一种长效流感神经氨酸酶抑制剂，是Laninamivir 的前药，具有优异的抗流感病毒活性。
T21339	Peramivir RWJ 270201,BCX1812,BCX 1812,帕拉米韦,RWJ270201
	Peramivir, a neuraminidase inhibitor, acts as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. It is used as an antiviral drug for the treatment of influenza.
T19849L	2-PADQZ hydrochloride 2-PADQZ hydrochloride (60547-97-9 Free base)	Antiviral; Influenza Virus	Immunology/Inflammation; Microbiology/Virology
	2-PADQZ hydrochloride 显示出抗病毒活性并靶向甲型流感病毒 RNA 启动子。
TP1276	HA Peptide	Others	Others
	HA Peptide 是一种由九个氨基酸组成的多肽，来自于人类流感血凝素 (HA) 。它普遍用于细胞生物学和生物化学中分离，纯化，检测和追踪目标蛋白。
T72037	Anti-Influenza agent 4	Influenza Virus	Microbiology/Virology
	Anti-Influenza agent 4 是一种有效且具有选择性的流感病毒抑制剂，对A/Parma 和 A/Roma 毒株具有抑制作用， EC50 分别为 62 nM 和150 nM。
T77632	Antiviral agent 34	Antiviral; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
	Antiviral agent 34 是一种可口服且作用效果较强的抗病毒化合物，抑制甲型和乙型流感病毒。Antiviral agent 34 通过调节 RNA 聚合酶来抑制流感病毒的增殖。Antiviral agent 34 可用于研究病毒感染。
TP1782L	CEF3 acetate(199727-62-3 free base)	Influenza Virus	Microbiology/Virology
	CEF3 acetate(199727-62-3 free base) 对应于甲型流感病毒 M1蛋白的氨基酸13-21。甲型流感病毒的基质 (M1) 蛋白是一种多功能蛋白，在病毒生命周期中发挥重要的结构和功能作用。
T4377	Pimodivir VX-787	Influenza Virus	Microbiology/Virology
	Pimodivir (VX-787) 是一种通过口服的甲型流感病毒聚合酶抑制剂，与病毒 PB2 亚基相互作用。
T5186	Oseltamivir acid GS 4071,oseltamivir carboxylate,奥斯他伟酸,Ro 64-0802	Influenza Virus; Drug Metabolite	Metabolism; Microbiology/Virology
	Oseltamivir acid (GS 4071) 是Oseltamivir phosphate 的活性代谢产物，是一种有效的流感病毒神经氨酸酶抑制剂和 GS4071 的前药。
T26873	BMY-27709 BMY 27709,BMY27709	Influenza Virus	Microbiology/Virology
	BMY-27709 是一种流感病毒生长抑制剂，对 A/WSN/33 病毒生长的 IC50 值为 3-8 μM，对流感病毒的部分亚型也展现出抑制活性。BMY-27709 对 H1 和 H2 病毒感染的早期起作用，通过抑制血凝素蛋白展现其抗病毒活性。然而，BMY-27709 对 H3 亚型病毒以及 B 型/Lee/40 流感病毒没有作用。
T7330	Nucleozin [4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮	Influenza Virus	Microbiology/Virology
	Nucleozin 靶向流感 A 核蛋白，这是一种病毒复制所必需的多功能 RNA 结合蛋白。
T16914	SP187 UV4,MON-DNJ	Others; Virus Protease; Influenza Virus	Microbiology/Virology; Others
	SP187 (MON-DNJ) 是一种靶向作用于宿主的亚氨基糖。它具有抗丝状病毒感染活性。SP187可用于治疗抗流感和登革热病毒。
T6195	Baloxavir marboxil S-033188	Influenza Virus	Microbiology/Virology
	Baloxavir marboxil (S-033188) 是一种新型的帽依赖性核酸内切酶抑制剂，用于治疗甲型和乙型流感病毒感染。
T60951	Molnupiravir EIDD-2801,Lagevrio,MK-4482	SARS-CoV; Influenza Virus	Microbiology/Virology
	Molnupiravir (MK-4482) (EIDD-2801) 是核糖核苷类似物 EIDD-1931 的异丙酯前体药物，具有口服生物利用度。Molnupiravir 可用于 COVID-19 ，季节性和流行性流感的研究，对多种冠状病毒和流感病毒具有广谱的抗病毒活性，例如，SARS-CoV-2，MERS-CoV，SARS-CoV。
TP1814L	CEF4 acetate CEF4 acetate(199727-68-9 free base)	Others	Others
	CEF4 acetate (CEF4 acetate (199727-68-9 free base)) 是对应于甲型流感病毒核壳蛋白的氨基酸序列342-351的多肽。
TP1822L	CEF6 acetate(913545-15-0 free base)	Influenza Virus	Microbiology/Virology
	CEF6 acetate(913545-15-0 free base) 是 HLA-B7限制性流感病毒核蛋白表位，属于 CEF 对照肽。 CEF 对照肽长度为 8-12 个氨基酸，其序列来自人类巨细胞病毒、爱泼斯坦-巴尔病毒和流感病毒。
T5186L	Oseltamivir
	Oseltamivir 是一种合成的乙酯衍生物前药，具有抗病毒活性。通过阻断流感病毒表面的神经氨酸酶，Oseltamivir 干扰宿主细胞释放完整病毒颗粒。

化合物

Influenza A virus-IN-1

Cat.No: T39778

Cat.No: T9231

Target: Antiviral

Influenza A virus fragment

Cat.No: T22868

Target: Others

Cat.No: T8793

Target: Influenza Virus

hemagglutinin (332-340) [Influenza A virus]

Cat.No: T22838

Target: Others

Influenza A NP(366-374) Strain A/PR/8/35

Cat.No: TP1644

hemagglutinin precursor (114-122) amide [Influenza A virus]

Cat.No: TP2232

Target: Others

Neuraminidase-IN-1

Cat.No: T8555

Synonym: Novel NA Inhibitor,Compound Y-1

Target: Others, Influenza Virus

Cat.No: T2479

Synonym: Malonoben,Tyrphostin 9,SF 6847,AG 17,RG-50872

Target: EGFR, VEGFR, Influenza Virus, PDGFR

Cat.No: T8936

Synonym: proteinase K for tritirachium album,Protease K,蛋白酶 K

Target: Others

Influenza A virus-IN-4

Cat.No: T61557

Influenza HA 126-138 acetate

Cat.No: TP1735L

Synonym: Influenza HA 126-138 acetate(207349-63-1 free base)

Target: Others

Influenza HA (110-119) acetate

Cat.No: T38719L

Target: Others

Influenza A virus-IN-7

Cat.No: T62888

Influenza A virus-IN-5

Cat.No: T61877

Influenza A virus-IN-6

Cat.No: T62059

Influenza A virus-IN-8

Cat.No: T74762

CEF8, Influenza Virus NP (383-391)

Cat.No: TP1527

Synonym: CEF8, Influenza Virus NP 383-391

Target: Others

Influenza HA (110-119)

Cat.No: T38719

Influenza Matrix Protein (61-72)

Cat.No: T38687

Influenza virus-IN-1

Cat.No: T60697

Influenza virus-IN-2

Cat.No: T60810

Anti-Influenza agent 5

Cat.No: T83046

Target: Influenza Virus

NS2 (114-121), Influenza

Cat.No: T39292

Synonym: NS2 (114-121), Influenza

Influenza virus-IN-5

Cat.No: T62216

Influenza virus-IN-4

Cat.No: T62197

Influenza virus-IN-6

Cat.No: T72450

Target: Influenza Virus

Influenza virus-IN-3

Cat.No: T62837

Influenza virus-IN-7

Cat.No: T75166

Anti-Influenza agent 3

Cat.No: T60778

Influenza NP (311-325)

Cat.No: T82071

2′-Deoxy-2′-fluoroguanosine

Cat.No: T38236

Target: Nucleoside Antimetabolite/Analog, Influenza Virus

Cat.No: T2529

Synonym: 扎那米韦,GG167

Target: Influenza Virus, Antibiotic

Laninamivir octanoate

Cat.No: T9124

Synonym: 辛酸拉尼米韦,CS-8958

Target: Influenza Virus

Cat.No: T21339

Synonym: RWJ 270201,BCX1812,BCX 1812,帕拉米韦,RWJ270201

2-PADQZ hydrochloride

Cat.No: T19849L

Synonym: 2-PADQZ hydrochloride (60547-97-9 Free base)

Target: Antiviral, Influenza Virus

Cat.No: TP1276

Target: Others

Anti-Influenza agent 4

Cat.No: T72037

Target: Influenza Virus

Antiviral agent 34

Cat.No: T77632

Target: Antiviral, DNA/RNA Synthesis

CEF3 acetate(199727-62-3 free base)

Cat.No: TP1782L

Target: Influenza Virus

Cat.No: T4377

Synonym: VX-787

Target: Influenza Virus

Oseltamivir acid

Cat.No: T5186

Synonym: GS 4071,oseltamivir carboxylate,奥斯他伟酸,Ro 64-0802

Target: Influenza Virus, Drug Metabolite

Cat.No: T26873

Synonym: BMY 27709,BMY27709

Target: Influenza Virus

Cat.No: T7330

Synonym: [4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮

Target: Influenza Virus

Cat.No: T16914

Synonym: UV4,MON-DNJ

Target: Others, Virus Protease, Influenza Virus

Baloxavir marboxil

Cat.No: T6195

Synonym: S-033188

Target: Influenza Virus

Cat.No: T60951

Synonym: EIDD-2801,Lagevrio,MK-4482

Target: SARS-CoV, Influenza Virus

Cat.No: TP1814L

Synonym: CEF4 acetate(199727-68-9 free base)

Target: Others

CEF6 acetate(913545-15-0 free base)

Cat.No: TP1822L

Target: Influenza Virus

Cat.No: T5186L

Cat. No.	Product Name	Target	Signaling Pathways
T7004	Tubercidin 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine	Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素，抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂，并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T1648	α-Vitamin E 天然维生素E,Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,D-α-生育酚,(+)-alpha-Tocopherol	Others; Ferroptosis; Influenza Virus; Reactive Oxygen Species; Endogenous Metabolite; Antibacterial; PKC; GST	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Others; oxidation-reduction
	α-Vitamin E (Dexrabeprazole Sodium) 是一种天然存在的维生素 E，也是抗氧化剂。
T4765	L-Norleucine (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸	Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology
	L-Norleucine ((S)-Norleucine) 是亮氨酸的异构体，特异性影响骨骼肌中的蛋白质合成，具有抗病毒活性。
TN1073	Nuezhenidic acid 女贞子酸,女贞酸	Influenza Virus	Microbiology/Virology
	Nuezhenidic acid 是分离自Ligustrum lucidum 中，具有抑制流感病毒 A 作用。
TN2353	8-Hydroxyapigenin Isoscutellarein	Antioxidant; Influenza Virus	Microbiology/Virology; oxidation-reduction
	8-Hydroxyapigenin (Isoscutellarein) 是从植物黄芩中提取的黄铜类化合物，具有抗炎抗氧和抗流感病毒的活性。
TN3120	5-Hydroxy-7-acetoxy-8-methoxyflavone	Histone Demethylase; Antiviral	Chromatin/Epigenetic; Immunology/Inflammation
	5-Hydroxy-7-acetoxy-8-methoxyflavone 是一种类黄酮化合物，可以抑制脂质过氧化，可能具有抗流感病毒活性。
T4S0217	HOMOPLANTAGININ	TNF; NF-κB	Apoptosis; NF-κB
	Homoplantaginin 是来自中药荔枝草的一种类黄酮，具有抗炎和抗氧化活性。
T2862	Desaminotyrosine Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,对羟基苯丙酸,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid,根皮酸	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) 是一种与微生物相关的代谢物，通过增强 I 型干扰素信号传导来预防流感。
TN2166	Rupestonic acid	ERK; p38 MAPK; Influenza Virus; Nrf2	Immunology/Inflammation; MAPK; Microbiology/Virology
	Rupestonic acid 是青蒿 Artemisia rupestris L. 中的一种化合物，Artemisia rupestris L. 是一种著名的治疗感冒的维吾尔族传统药物。 Rupestonic acid 具有抗流感病毒活性。
T0875	Acetylcysteine 乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,易咳净	Apoptosis; TNF; Ferroptosis; Influenza Virus; Reactive Oxygen Species; ROS; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Acetylcysteine (NAC) 是半胱氨酸的 N-乙酰衍生物，是一种 ROS 抑制剂和粘液溶解剂。Acetylcysteine 可诱导细胞凋亡，可用于减少粘液的厚度，还具有抗流感病毒活性。
T75675	Nepasaikosaponin K	Antiviral	Immunology/Inflammation
	Nepasaikosaponin K 是一种从柴胡根中分离出来小分子化合物，具有抗流感和抗病毒活性，可用于研究病毒感染。
TN1051	1-Caffeoylquinic acid 金银花,1-咖啡酰奎宁酸	NF-κB	NF-κB
	1-Caffeoylquinic acid 是一种有效的NF-κB 抑制剂，对 p105 的 RH 结构域显示高结合亲和力，Ki= 0.002 μM，结合能为 1.50 Kcal/mol。它抑制PD-1/PD-L1相互作用。它具有抗氧化应激能力。
T26288	Clovamide trans-Clovamide,N-trans-Caffeoy-L-dopa	Apoptosis; Influenza Virus; ROS; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Clovamide (trans-Clovamide) 是一种天然存在的咖啡酰结合物，具有抗菌、抗炎、抗氧化和神经保护作用。它是一种极好的活性氧和氧自由基清除剂。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T8263	3,4'-Dihydroxyflavone	Influenza Virus	Microbiology/Virology
	3,4'-Dihydroxyflavone 是一种口服活性黄酮类化合物，具有抗甲型流感病毒的抗病毒活性。
T27380	FR-198248
	FR-198248, a new anti-influenza agent, shows antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro.
TN3461	Asebotin	Influenza Virus	Microbiology/Virology
	Asebotin shows anti-influenza A virus activity, it also possesses potent antiviral activity (100% inhibition at the concentration of 1 ug /mL) against highly pathogenic avian influenza strain H5N1. Asebotin can inhibit the proliferation of murine B cells.
T75533	Dihydromaniwamycin E
	Dihydromaniwamycin E 是一种热休克代谢物，对influenza 和SARS-CoV-2病毒具有抗病毒活性。
T11364	Ganoderic acid TR	Others	Others
	Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H1N1 and H5N1 neuraminidases. The IC50 values of 4.6 and 10.9 μM, respectively.
TN2311	Wulignan A1 五脂素 A1	Antifection	Microbiology/Virology
	Wulignan A1 exhibits activity against leukemia P-388 in vitro; it also may have anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities.
T36734	Methyl brevifolincarboxylate
	Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultane...
T70355	Flutimide
	Flutimide是一种针对流感病毒核酸内切酶的选择性抑制剂，具有3 μM的IC50值，表现出细胞培养中的抗病毒活性，适用于流感等急性传染性呼吸道疾病的研究。
TN2176	Sanggenol A	Influenza Virus; Antifection	Microbiology/Virology
	Sanggenol A 抑制甲型流感病毒和肺炎球菌神经氨酸酶，因此可作为双重作用的抗感染试剂。
TN4804	Platycoside A	Antifection	Microbiology/Virology
	Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice.
TN4392	Koaburaside	IL Receptor; TNF; Influenza Virus	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.
T75534	Maniwamycin E
	Maniwamycin E，一种耐热链霉菌培养提取物中分离得到的马尼瓦霉素衍生物，展示了对SARS-CoV-2和H1N1流感病毒的抗病毒活性。
TN1347	8-Prenylkaempferol 去甲脱水淫羊藿黄素	p38 MAPK; NF-κB; PI3K	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and
T73465	Goitrin L-5-Vinyl-2-thiooxazolidone,(S)-Goitrin,(S)-Goitrin ; L-5-Vinyl-2-thiooxazolidone
	Goitrin ((S)-Goitrin) 为芥子油苷-黑芥子酶反应产物，有效抑制甲状腺过氧化物酶并阻碍碘在甲状腺的利用。此外，该化合物亦展现出对抗流感病毒(H1N1)的活性。
TN6204	Santin 5,7-Dihydroxy-3,6,4'-trimethoxyflavone	Influenza Virus	Microbiology/Virology
	Santin (5,7-Dihydroxy-3,6,4'-trimethoxyflavone) 是从桦树芽中提取的黄酮类化合物，具有抗增殖、抗流感和抗癌活性。 Santin 可用于有关抗 IAV 药物的研究。
T38015	Herquline A
	Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively).
TN4456	Lucidadiol	AChR; HSV	Microbiology/Virology; Neuroscience
	Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol shows antiviral activity against i
T75743	HA Peptide TFA
	HA Peptide (TFA) 为源自人类流感血凝素 (HA) 的九氨基酸多肽，在细胞生物学与生物化学领域内广泛应用于目标蛋白的分离、纯化、检测及追踪。
TN4108	Ganoderic acid Z	Antifection	Microbiology/Virology
	The binding affinities of ganoderic acid DM and ganoderic acid Z (ÎGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors....
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

Cat.No: T7004

Synonym: 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine

Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T1648

Synonym: 天然维生素E,Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,D-α-生育酚,(+)-alpha-Tocopherol

Target: Others, Ferroptosis, Influenza Virus, Reactive Oxygen Species, Endogenous Metabolite, Antibacterial, PKC, GST

Cat.No: T4765

Synonym: (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸

Target: Influenza Virus, Endogenous Metabolite

Nuezhenidic acid

Cat.No: TN1073

Synonym: 女贞子酸,女贞酸

Target: Influenza Virus

8-Hydroxyapigenin

Cat.No: TN2353

Synonym: Isoscutellarein

Target: Antioxidant, Influenza Virus

5-Hydroxy-7-acetoxy-8-methoxyflavone

Cat.No: TN3120

Target: Histone Demethylase, Antiviral

HOMOPLANTAGININ

Cat.No: T4S0217

Target: TNF, NF-κB

Desaminotyrosine

Cat.No: T2862

Synonym: Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,对羟基苯丙酸,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid,根皮酸

Target: Others, Influenza Virus, Endogenous Metabolite

Rupestonic acid

Cat.No: TN2166

Target: ERK, p38 MAPK, Influenza Virus, Nrf2

Cat.No: T0875

Synonym: 乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,易咳净

Target: Apoptosis, TNF, Ferroptosis, Influenza Virus, Reactive Oxygen Species, ROS, Endogenous Metabolite

Nepasaikosaponin K

Cat.No: T75675

Target: Antiviral

1-Caffeoylquinic acid

Cat.No: TN1051

Synonym: 金银花,1-咖啡酰奎宁酸

Target: NF-κB

Cat.No: T26288

Synonym: trans-Clovamide,N-trans-Caffeoy-L-dopa

Target: Apoptosis, Influenza Virus, ROS, Antibacterial

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

3,4'-Dihydroxyflavone

Cat.No: T8263

Target: Influenza Virus

Cat.No: T27380

Cat.No: TN3461

Target: Influenza Virus

Dihydromaniwamycin E

Cat.No: T75533

Ganoderic acid TR

Cat.No: T11364

Target: Others

Cat.No: TN2311

Synonym: 五脂素 A1

Target: Antifection

Methyl brevifolincarboxylate

Cat.No: T36734

Cat.No: T70355

Cat.No: TN2176

Target: Influenza Virus, Antifection

Cat.No: TN4804

Target: Antifection

Cat.No: TN4392

Target: IL Receptor, TNF, Influenza Virus

Cat.No: T75534

8-Prenylkaempferol

Cat.No: TN1347

Synonym: 去甲脱水淫羊藿黄素

Target: p38 MAPK, NF-κB, PI3K

Cat.No: T73465

Synonym: L-5-Vinyl-2-thiooxazolidone,(S)-Goitrin,(S)-Goitrin ; L-5-Vinyl-2-thiooxazolidone

Cat.No: TN6204

Synonym: 5,7-Dihydroxy-3,6,4'-trimethoxyflavone

Target: Influenza Virus

Cat.No: T38015

Cat.No: TN4456

Target: AChR, HSV

Cat.No: T75743

Ganoderic acid Z

Cat.No: TN4108

Target: Antifection

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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