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70

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1237	Azathioprine 硫唑嘌呤,BW 57-322	Apoptosis; GPR; Rho	Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein
	Azathioprine (BW 57-322) 是一种免疫抑制剂。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T7222	GS-441524 GS 441524 triphosphate	Others; SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	GS-441524 是 Remdesivir 的主要活性代谢物，活性更优于 Remdesivir ，治疗患有自然发生的猫传染性腹膜炎的猫。
T40019	Thalidomide-5-NH2-CH2-COOH	Others	Others
	Thalidomide-5-NH2-CH2-COOH (compound 114) 是原肌球蛋白受体激酶的选择性抑制剂。它是 E3 连接酶的配体，具有研究一种或多种疾病的潜力。
T4990	Cefcapene pivoxil hydrochloride hydrate Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯	Antibacterial; Antibiotic	Microbiology/Virology
	Cefcapene pivoxil hydrochloride hydrate 是一种头孢菌素的前药，具有口服活性和广谱抗菌活性。它可研究掌跖脓疱病等感染性疾病。
T9567	Samatasvir ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) 是 NS5A HCV 复制抑制剂。它能够有效的选择复制子及感染性 HCV，在基因型 1至5 复制子中，EC50= 2~24 pM。
T26804	Biclotymol	Others	Others
	Biclotymol 可用于感染性口咽疾病研究。
T16465	Penicillin G benzathine Benzathine benzylpenicillin,Benzathine penicilline G	Antibacterial	Microbiology/Virology
	Penicillin G benzathine 具有抗细菌感染活性，可用于研究早期梅毒。
T8686	VUN65671	Others	Others
	Compound 35 是埃博拉 (Mayinga) 和马尔堡 (安哥拉) 传染性病毒的优良抑制剂。
T72910	APOBEC3G-IN-1	Others	Others
	APOBEC3G-IN-1 (MN136.0185) 是一种靶向 APOBEC3G 抑制剂，具有抗 HIV 活性，可用于研究传染病和癌症。
T11815	Lanopepden GSK 1322322,GSK-1322322B,GSK-1322322J	Antibiotic	Microbiology/Virology
	Lanopepden (GSK 1322322) 是一种有效的肽去甲酰酶抑制剂，抑制金黄色葡萄球菌，抑制 ATCC 29213 和 ATCC 25923 菌株，可用于研究肺炎、皮肤病和传染病。
T14044	4E2RCat	PERK	Apoptosis
	4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂，IC50为13.5 μM。
T78748	MtUng-IN-1	Antibacterial	Microbiology/Virology
	MtUng-IN-1（Compound 18a）可抑制分枝杆菌尿嘧啶DNA糖基化酶（MtUng），IC50值为300 μM。MtUng-IN-1适用于癌症和传染病研究领域。
T6229	Daclatasvir Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂，EC50 为 9-50 pM，适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。
T76687	Ibalizumab TNX-355,TMB-355	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ibalizumab(TMB-355) 是一种人源化 IgG4 单克隆抗体，可作为 CD4 受体抑制，通过与 CD4 受体结合来阻止 HIV-1进入细胞。Ibalizumab 具有抗HIV-1感染活性，可用于维持机体正常免疫功能。
T76251L	Ac-FEID-CMK TFA	Pyroptosis	Apoptosis; Immunology/Inflammation
	Ac-FEID-CMK TFA 是一种选择性斑马鱼 GSDMEb 衍生肽抑制剂，可减少感染性休克的死亡率和肾损伤。Ac-FEID-CMK TFA 在体内可抑制焦亡，缓解败血性 AKI (急性肾损伤)，抑制 caspy2 介导的非典型炎症小体通路发挥作用。
T60440	Antiviral agent 17
	Antiviral agent 17 (Compound 4) 是一种抗感染剂，在人类复制子试验中显著保留其抗病毒作用，EC50值为0.015 μM。Antiviral agent 17 对小鼠诺如病毒(MNV)表现出良好的抗病毒活性。Antiviral agent 17 在研究传染性和恶性疾病方面具有潜力。
T38894	IHVR-17028	Influenza Virus; Glucosidase	Metabolism; Microbiology/Virology
	IC50 为 0.24 μMIHVR-17028 是一种有效的广谱的 ER α-葡萄糖苷酶 I (α-glucosidase?I) 抑制剂，IC50 为 0.24 μM，具有抗病毒活性。 IHVR-17028 对 BVDV、TCRV 和 DENV 具有抑制作用， EC50 分别为0.4 μM、0.26 μM 和0.3 μM。IHVR-17028 可用于研究传染病。
T0454L	Florfenicol SCH-25298,氟苯尼考,(-)-Florfenicol	Antibacterial; Antibiotic	Microbiology/Virology
	Florfenicol (SCH-25298) 是一种常见得兽用抗生素，能用于研究牛呼吸疾病，在水产养殖业中可以用来控制鲶鱼肠道败血病，也可诱导鸡蛋早期胚胎死亡，LC50 值为 1.07 μg/g。
T28329	PD 134922 PD134922,PD-134922
	PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.
T28330	PD 135390 PD135390,PD-135390
	PD 135390 is a HIV-1 protease inhibitors identified by rational selection. Inactivation of the protease prevents infectious virion formation.
T60875	Polvitolimod
	Polvitolimod 是一种用于治疗传染病和癌症的 TLR7激动剂。
T63406	HCV-IN-35
	HCV-IN-35 是 HCV 的有效抑制剂，表现出潜力进行感染性疾病的研究。
T61523	FWM-5
	FWM-5 is a powerful inhibitor of NSP13 helicase, a key enzyme in the life cycle of the SARS-CoV-2 virus. With its potential in researching infectious diseases, FWM-5 emerges as a promising compound [1].
T69657	GS-441524 HCl
	GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations ...
T61591	SARS-CoV-2-IN-20
	SARS-CoV-2-IN-20 (Compound 1a) is a highly effective inhibitor of SARS-CoV-2, displaying an impressive EC50 value of 6.5 μM. With its exceptional inhibitory properties, SARS-CoV-2-IN-20 holds great potential for advancing research on infectious diseases [1].
T5351	PU-WS13 PU WS13	Estrogen/progestogen Receptor	Endocrinology/Hormones

T75166	Influenza virus-IN-7
	Influenza virus-IN-7 (Example 16) 是一种口服活性的帽依赖性核酸内切酶抑制剂，适用于流感病毒感染疾病的研究。
T73416	BiCAPPA
	BiCAPPA 是一个二价抗朊病毒配体。BiCAPPA 可以减少痒病感染细胞中传染性构象形式的朊病毒蛋白 (PrPSc)，EC50值为 0.32 μM。
TP1362	Angiogenin (108-122) Angiogenin 108-122
	Angiogenin (108-122) is an angiogenin peptide. Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an autoimmune
T70050	Boditrectinib
	Boditrectinib 是一种有效的酪氨酸激酶抑制剂。Boditrectinib 是一种抗肿瘤药物。Boditrectinib 可用于癌症、炎症、神经退行性疾病和某些感染性疾病的研究。
TP1320	Angiogenin (108-122) TFA (112173-49-6 free base) Angiogenin (108-122) TFA
	Angiogenin (108-122) TFA is an angiogenin peptide.Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an autoimmu
T62341	(R)-Larotrectinib
	(R)-Larotrectinib 是一种 TRK 的有效抑制剂，作用于 TrkA (IC50: 28.5 nM)。(R)-Larotrectinib 能够用于研究癌症、炎症以及某些感染性疾病。
T61860	Enpp-1-IN-9
	Enpp-1-IN-9, a powerful inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1), exhibits wide substrate specificity, capable of cleaving various bonds such as phosphodiester bonds of nucleotides and nucleotide sugars, as well as pyrophosphate bonds of nucleotides and nucleotide sugars. Its potential application lies in the fields of cancer and infectious disease research[1].
T76321	Brain Derived Basic Fibroblast Growth Factor (1-24)
	Brain Derived BasicFibroblast Growth Factor(1-24) (FGF basic 1-24) 是一种合成肽，表现出抗细菌和抗HBV 的活性。Brain Derived BasicFibroblast Growth Factor(1-24) 可用于感染性疾病和免疫性疾病的研究。
T25365	EGA	Others	Others
	EGA 抑制致命毒素的中毒，并阻止多种其他酸依赖性细菌毒素和病毒进入哺乳动物细胞。EGA 是研究膜运输的有力工具，可用于治疗传染病。
T40211	eIF4E-IN-1 eIF4E-IN-1
	eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases.
T81943	Lemalesomab IMMU-MN3
	Lemalesomab (IMMU-MN3)为小鼠IgG1抗NCA-90单克隆抗体，具有Fab'片段结构。该化合物主要应用于炎症、感染性病变及其感染显像的研究领域。
T63888	Axl-IN-12
	Axl-IN-12 是 AXL 的有效抑制剂。Axl-IN-12 能够用于研究增生性疾病、过敏性疾病、自身免疫性疾病、炎症性疾病、癌症、移植排斥、病毒性传染病或其他哺乳动物疾病。
T60673	Antiviral agent 18
	Antiviral agent 18 (Compound 5) 对鼠诺如病毒显示出良好的抗病毒活性。Antiviral agent 18 是一种抗感染剂，具有用于传染性和恶性疾病的研究潜力。
T63683	Axl-IN-11
	Axl-IN-11 是 AXL 的有效抑制剂。Axl-IN-11 能够用于研究增生性疾病、过敏性疾病、自身免疫性疾病、炎症性疾病、癌症、移植排斥、病毒性传染病或其他哺乳动物疾病。
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].
T69925	NVR3-778 hydrate
	NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 µM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication.
T81388	Propiolactone Betaprone,β-propiolactone,2-Oxetanone	SARS-CoV	Microbiology/Virology
	Propiolactone (β-propiolactone; 2-Oxetanone) 作为一种病毒化学灭活剂，能够使病毒失去传染性。以1:1000 (v:v) 的比例与SARS-CoV共孵育，Propiolactone可用于制备流感病毒疫苗中的抑菌剂（Flu-BPL）。
T11819	Lascufloxacin 拉库沙星,KRP-AM1977X	Others	Others
	Lascufloxacin () 是一种有效的、具有口服活性的氟喹诺酮类抗菌剂。Lascufloxacin 有效抑制由多种病原体 (包括对喹诺酮类耐药的菌株) 引起的感染。Lascufloxacin 可用于多种传染病的研究，包括下呼吸道感染。
T70642	Lanopepden camsylate
	Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea...
T63607	PD-1/PD-L1-IN-22
	PD-1/PD-L1-IN-22 是 PD-1/PD-L1 蛋白-蛋白相互作用的小分子抑制剂，能够阻断 PD-1/PD-L1相互作用 (IC50: 0.732 μM)。PD-1/PD-L1-IN-22 能够用于研究癌症、传染病和自身免疫性疾病。
T75313	Methdilazine
	Methdilazine hydrochloride，一种口服活性抗生素（组胺拮抗剂），在体外和体内均能有效抑制多种分枝杆菌的活性。其最小抑菌浓度（MIC）值介于5-15 μg/mL之间，适用于传染病相关研究。
T76526	Ac-D-DGla-LI-Cha-C
	Ac-D-DGla-LI-Cha-C 是一种有效的HCV 蛋白酶抑制剂肽。Ac-D-DGla-LI-Cha-C 可用于癌症、自身免疫性疾病、纤维化疾病、炎症性疾病、神经退行性疾病、感染性疾病、肺部疾病、心脏和血管疾病以及代谢性疾病的研究。
T62903	Enpp-1-IN-6
	Enpp-1-IN-6 是抑一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。其中 ENPP 1 具有广泛的特异性，能够切割多种底物（包括核苷酸和核苷酸糖的磷酸二酯键、核苷酸和核苷酸糖的焦磷酸键）。Enpp-1-IN-6 具有潜力用于癌症和传染病的研究。

化合物

Cat.No: T1237

Synonym: 硫唑嘌呤,BW 57-322

Target: Apoptosis, GPR, Rho

Cat.No: T15017

Target: TLR

Cat.No: T7222

Synonym: GS 441524 triphosphate

Target: Others, SARS-CoV, DNA/RNA Synthesis

Thalidomide-5-NH2-CH2-COOH

Cat.No: T40019

Target: Others

Cefcapene pivoxil hydrochloride hydrate

Cat.No: T4990

Synonym: Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯

Target: Antibacterial, Antibiotic

Cat.No: T9567

Synonym: ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719

Target: HCV Protease

Cat.No: T26804

Target: Others

Penicillin G benzathine

Cat.No: T16465

Synonym: Benzathine benzylpenicillin,Benzathine penicilline G

Target: Antibacterial

Cat.No: T8686

Target: Others

Cat.No: T72910

Target: Others

Cat.No: T11815

Synonym: GSK 1322322,GSK-1322322B,GSK-1322322J

Target: Antibiotic

Cat.No: T14044

Target: PERK

Cat.No: T78748

Target: Antibacterial

Cat.No: T6229

Synonym: Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052

Target: HCV Protease

Cat.No: T76687

Synonym: TNX-355,TMB-355

Target: HIV Protease

Ac-FEID-CMK TFA

Cat.No: T76251L

Target: Pyroptosis

Antiviral agent 17

Cat.No: T60440

Cat.No: T38894

Target: Influenza Virus, Glucosidase

Cat.No: T0454L

Synonym: SCH-25298,氟苯尼考,(-)-Florfenicol

Target: Antibacterial, Antibiotic

Cat.No: T28329

Synonym: PD134922,PD-134922

Cat.No: T28330

Synonym: PD135390,PD-135390

Cat.No: T60875

Cat.No: T63406

Cat.No: T61523

Cat.No: T69657

SARS-CoV-2-IN-20

Cat.No: T61591

Cat.No: T5351

Synonym: PU WS13

Target: Estrogen/progestogen Receptor

Influenza virus-IN-7

Cat.No: T75166

Cat.No: T73416

Angiogenin (108-122)

Cat.No: TP1362

Synonym: Angiogenin 108-122

Cat.No: T70050

Angiogenin (108-122) TFA (112173-49-6 free base)

Cat.No: TP1320

Synonym: Angiogenin (108-122) TFA

(R)-Larotrectinib

Cat.No: T62341

Cat.No: T61860

Brain Derived Basic Fibroblast Growth Factor (1-24)

Cat.No: T76321

Cat.No: T25365

Target: Others

Cat.No: T40211

Synonym: eIF4E-IN-1

Cat.No: T81943

Synonym: IMMU-MN3

Cat.No: T63888

Antiviral agent 18

Cat.No: T60673

Cat.No: T63683

SARS-CoV-2 3CLpro-IN-1

Cat.No: T63537

NVR3-778 hydrate

Cat.No: T69925

Cat.No: T81388

Synonym: Betaprone,β-propiolactone,2-Oxetanone

Target: SARS-CoV

Cat.No: T11819

Synonym: 拉库沙星,KRP-AM1977X

Target: Others

Lanopepden camsylate

Cat.No: T70642

PD-1/PD-L1-IN-22

Cat.No: T63607

Cat.No: T75313

Ac-D-DGla-LI-Cha-C

Cat.No: T76526

Cat.No: T62903

Cat. No.	Product Name	Target	Signaling Pathways
T8360	(-)-β-pinene (-)-β-Pinene,左旋-beta-蒎烯,Nopinene,β-蒎烯	Antibacterial	Microbiology/Virology
	(-)-β-pinene (Nopinene) 是松节油的主要成分，具有抗菌活性，可抑制传染性支气管炎病毒，IC50为 1.32 mM。
TN1145	Isofebrifugine	Parasite	Microbiology/Virology
	Isofebrifugine 是一种来自虎耳草科植物常山的生物碱，具有抗疟抗感染活性。
T9218	Andrograpanin 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE,新穿心莲内酯苷元	p38 MAPK	MAPK
	Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) 是来自穿心莲的一种天然产物，具有抗炎和抗感染活性。
T3028	Tripterin Celastrol,Tripterine,雷公藤红素	Apoptosis; Mitophagy; Proteasome; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
	Tripterin (Celastrol) 属于天然产物，是一种蛋白酶体抑制剂，抑制 20S 蛋白酶体的胰凝乳蛋白酶样活性 (IC50=2.5 μM)。Tripterin 具有抗炎、抗感染和免疫调节的作用。
TN1853	Lariciresinol (+)-落叶松树脂醇	VEGFR; Antifection	Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Lariciresinol 是一种肠木脂素前体，它通过破坏真菌质膜具有杀真菌活性，并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。
T38141	Glycerophospholipids, cephalins Phosphatidylethanolamines (egg)
	Glycerophospholipids, cephalins (Phosphatidylethanolamines (egg)) 是一种从鸡蛋中分离出来的磷脂酰乙醇胺的混合物，在 sn-1和 sn-2位置有各种脂肪酰基。Glycerophospholipids, cephalins 完全水解可得到1mol 的甘油、磷酸、乙醇胺和2mol 的脂肪酸。Phosphatidylethanolamines 在膜融合和细胞分裂过程中收缩环的拆卸中起作用，可调节膜的弯曲度。Phosphatidylethanolamines 能够在没有任何蛋白质或核酸的帮助下传播传染性朊病毒。Phosphatidylethanolamines 在细菌膜中的主要作用之一是分散由阴离子膜磷脂引起的负电荷。
TN3834	Derrone	Antifection	Microbiology/Virology
	Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. It is also a novel Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.
TN3708	Coronarin D	BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i

天然产物

Cat.No: T8360

Synonym: (-)-β-Pinene,左旋-beta-蒎烯,Nopinene,β-蒎烯

Target: Antibacterial

Cat.No: TN1145

Target: Parasite

Cat.No: T9218

Synonym: 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE,新穿心莲内酯苷元

Target: p38 MAPK

Cat.No: T3028

Synonym: Celastrol,Tripterine,雷公藤红素

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

Cat.No: TN1853

Synonym: (+)-落叶松树脂醇

Target: VEGFR, Antifection

Glycerophospholipids, cephalins

Cat.No: T38141

Synonym: Phosphatidylethanolamines (egg)

Cat.No: TN3834

Target: Antifection

Cat.No: TN3708

Target: BCL, c-Myc, TNF, NF-κB, Caspase, COX, Antifection

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