Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂,IC50为13.5 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 878 | 现货 | ||
5 mg | ¥ 2,230 | 现货 | ||
10 mg | ¥ 3,290 | 现货 | ||
25 mg | ¥ 5,290 | 现货 | ||
50 mg | ¥ 7,460 | 现货 | ||
100 mg | ¥ 9,860 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,230 | 现货 |
产品描述 | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression and the production of infectious virus. |
靶点活性 | eIF4E-eIF4G:13.5 μM |
体外活性 | 4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner[1]. |
体内活性 | 4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1]. |
分子量 | 455.93 |
分子式 | C22H14ClNO4S2 |
CAS No. | 432499-63-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15.5 mg/mL (34.00 mM), Sonification and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1933 mL | 10.9666 mL | 21.9332 mL | 54.833 mL |
5 mM | 0.4387 mL | 2.1933 mL | 4.3866 mL | 10.9666 mL | |
10 mM | 0.2193 mL | 1.0967 mL | 2.1933 mL | 5.4833 mL | |
20 mM | 0.1097 mL | 0.5483 mL | 1.0967 mL | 2.7416 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
4E2RCat 432499-63-3 Apoptosis PERK 4E-2RCat Virus Protease Inhibitor inhibit Autophagy Eukaryotic Initiation Factor (eIF) inhibitor