Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GS-441524 是 Remdesivir 的主要活性代谢物,活性更优于 Remdesivir ,治疗患有自然发生的猫传染性腹膜炎的猫。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 293 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 129 | 现货 |
产品描述 | GS-441524 treatment of cats with naturally occurring feline infectious peritonitis. |
靶点活性 | FIPV:0.78 μM (EC50) |
体内活性 | Four of the 31 cats that presented with severe disease died or were euthanized within 2-5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment(GS-441524). Eighteen of these 26 cats remain healthy at the time of publication after one round of treatment, while eight others suffered disease relapses within 3-84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy . However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy[1]. |
动物实验 | Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h[1]. |
别名 | GS 441524 triphosphate |
分子量 | 291.26 |
分子式 | C12H13N5O4 |
CAS No. | 1191237-69-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (171.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4334 mL | 17.1668 mL | 34.3336 mL | 85.834 mL |
5 mM | 0.6867 mL | 3.4334 mL | 6.8667 mL | 17.1668 mL | |
10 mM | 0.3433 mL | 1.7167 mL | 3.4334 mL | 8.5834 mL | |
20 mM | 0.1717 mL | 0.8583 mL | 1.7167 mL | 4.2917 mL | |
50 mM | 0.0687 mL | 0.3433 mL | 0.6867 mL | 1.7167 mL | |
100 mM | 0.0343 mL | 0.1717 mL | 0.3433 mL | 0.8583 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GS-441524 1191237-69-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others SARS-CoV DNA/RNA Synthesis Inhibitor feline SARS coronavirus virus GS-441524 Triphosphate GS441524 FIPV infectious peritonitis inhibit GS 441524 Triphosphate GS 441524 triphosphate GS 441524 GS441524 Triphosphate inhibitor