77
12
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10511 |
Anti-hypertensive sulfonanilide 1
|
Others | Others |
Anti-hypertensive sulfonanilide 1 is an antihypertensive compound. | |||
T3474 |
RO 46-8443
|
Endothelin Receptor | GPCR/G Protein |
Ro 46-844 是选择性非肽内皮素受体拮抗剂。它对ETB(IC50: 34-69 nM) 的选择性比ETA 受体 (IC50: 6800 nM) 高的100倍以上。 | |||
T22398 |
Phenidone
菲尼酮,1-phenyl-3-pyrazolidinone |
Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience |
Phenidone (1-phenyl-3-pyrazolidinone) 是可口服发环氧化酶和脂氧合酶双重抑制剂,可改善实验性自身免疫性脑脊髓炎大鼠的瘫痪,降低自发性高血压大鼠的血压,可用作照片显像剂。 | |||
T0993 |
Methoxamine hydrochloride
Methoxamine HCl,盐酸甲氧明 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出,但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。 | |||
T28482 |
Firibastat
QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150 |
Aminopeptidase | Metabolism |
Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM),选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III,降低血压。 | |||
T5329 |
Trandolapril
|
Angiotensin-converting Enzyme (ACE) | Metabolism |
Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂,在高血压和充血性心力衰竭及心肌梗死领域有研究价值。 | |||
T0287 |
Hexamethonium Bromide
Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide |
Apoptosis; Dopamine Receptor; AChR | Apoptosis; GPCR/G Protein; Neuroscience |
Hexamethonium Bromide (Hexamethonium Dibromide) 是神经节中神经元型烟碱型 AChR 的特异性拮抗剂。在自发性高血压动物模型中,它能降低其交感神经活动和血压。 | |||
T22236 |
Alprenolol hydrochloride
阿普洛尔盐酸盐,盐酸阿普洛尔 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alprenolol hydrochloride 是一种非选择性β受体阻滞剂,也是5-HT1A 受体拮抗剂。 | |||
T3046 |
BMY 7378 dihydrochloride
BMY7378 HCl |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
BMY 7378 dihydrochloride (BMY7378 HCl) 是选择性 α1D 肾上腺素受体拮抗剂,也是5-HT1A 受体部分激动剂。它同表达克隆大鼠 α1D-AR 的膜结合的亲和力 (Ki=2 nM) 是同克隆大鼠 α1A-AR (Ki=800 nM) 或仓鼠 α1B-AR (Ki=600 nM) 结合的亲和力 的100 以上。 | |||
T9097 |
Guanadrel
|
Others | Others |
Guanadrel 是一种抗高血压药。 | |||
T1615 |
Irbesartan
厄贝沙坦,SR-47436,BMS-186295 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。 | |||
T23044 |
N,N'-Dicyclohexylurea
DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲 |
Epoxide Hydrolase | Metabolism |
N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。 | |||
T6835 |
Fenoldopam mesylate
Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fenoldopam mesylate (Corlopam mesylate) 是一种多巴胺受体D1选择性激动剂。 | |||
T80661 |
Antihypertensive sulfonanilide XVII
|
Others | Others |
Antihypertensive sulfonanilide XVII 是一种可口服的抗高血压磺酰苯胺类小分子化合物,可用于研究高血压。 | |||
T79267 |
Antihypertensive agent 3
|
||
Antihypertensive agent 3 (compound 4a) 是一种针对血管紧张素 II 受体 1(AT1) 的拮抗剂,其在自发性高血压大鼠(SHRs)的模型中表现出显著的降压效果。 | |||
T79266 |
Antihypertensive agent 2
|
||
Antihypertensive agent 2 (Compound 4g) 为一种有效的血管紧张素 II 受体 1 拮抗剂,其降血压效能可与Losartan媲美或更胜一筹。 | |||
T16329 |
Nitroflurbiprofen
NO-flurbiprofen,Nitroxybutyl flurbiprofen,硝基氟比洛芬,HCT 1206 |
COX | Immunology/Inflammation; Neuroscience |
Nitroflurbiprofen (Nitroxybutyl flurbiprofen) 是一种释放 NO 的环氧合酶抑制剂,可调节门脉高压性肝硬化大鼠肝内血管张力的增加。 | |||
T17111 |
Todralazine hydrochloride
Ecarazine hydrochloride,盐酸托屈嗪 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Todralazine hydrochloride (Ecarazine hydrochloride) 是一种 β2AR 阻滞剂,具有抗氧化和自由基清除活性。 Todralazine hydrochloride 可用于抗高血压的研究。 | |||
T14942 |
CGP48369
|
RAAS | Endocrinology/Hormones |
CGP48369 是一种有效的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂,具有降血压作用,可增强自发性高血压大鼠冠状动脉的内皮依赖性松弛。 | |||
T2528 |
Latanoprost
Xalatan,PHXA41,拉坦前列腺素,拉坦前列素 |
GPR; Prostaglandin Receptor; RAR/RXR | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
Latanoprost (Xalatan) 是前列腺素 F2α 类似物,是一种前列腺素受体激动剂,能够降低眼内压。 | |||
T0126 |
Diazoxide
氯甲苯噻嗪,二氮嗪,SRG-95213,Sch-6783,Proglycem |
ATPase; Potassium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel |
Diazoxide (Proglycem) 是一种 ATP 敏感性的钾离子通道激活剂,是一种苯并噻二嗪衍生物,是一种用于高血压急症的外周血管扩张剂。 | |||
T36506 |
Tempone
4-Oxo-tempo |
||
Tempone 是一种氨基氧烷,具有自由基清除剂的作用,会与活性氧(ROS)发生反应。静脉注射 Tempone 可降低自发性高血压大鼠的平均动脉。 | |||
T10595 |
BQ-788
BQ788 |
Endothelin Receptor | GPCR/G Protein |
BQ-788 是一种具有选择性和有效性的 ETB 受体拮抗剂,具有潜在的高血压活性,抑制 ET-1 与 ETB 受体结合,抑制外源性 ET-1 诱导的冠状动脉灌注压升高。 | |||
T37496L |
Alamandine TFA
|
RAAS | Endocrinology/Hormones |
Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员,是一种血管活性肽,是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。 | |||
T24932 |
Vatanidipine
AE-0047,AE 0047,AE0047 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Vatanidipine (AE0047) 是一种新型的双氢吡啶(DHP)型钙通道阻滞剂,具有缓慢起效的药理作用。在各种实验性高血压模型中观察到缓慢起效和持久的降压作用。 | |||
T1275 |
Phentolamine mesylate
Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的,具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂,能够扩张使血管,降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压,心力衰竭和勃起功能障碍。 | |||
T12596 |
(4E)-SUN9221
|
5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
(4E)-SUN9221 是一种有效的 α1-adrenergic 受体和 5-HT2 受体双重拮抗剂,在高血压大鼠中显示出抗高血压和抗血小板聚集活性。 | |||
T20570 |
Labetalol
Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Labetalol (Apo-Labetalol) 是一种抗高血压药物,可用于心血管疾病的研究,如妊娠期高血压。它是一种口服具有活性的选择性 α1- 和非选择性 β-肾上腺素能受体 (adrenergic receptor) 竞争性拮抗剂。 | |||
T31598 |
Ecadotril
S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049 |
||
Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role. | |||
T24478 |
MK-8141
MK 8141,ACT 077825,ACT077825,ACT-077825 |
||
MK-8141 is a renin inhibitor. It displays some antihypertensive efficacy in hypertensive patients. | |||
T34945 |
Trimazosin hydrochloride
CP19106-1,CP 19106-1,Trimazosin HCl,CP-19106-1 |
||
Trimazosin hydrochloride is used in the treatment of hypertensive patients failing to respond to thiazides. | |||
T28039 |
Milfasartan
LR-B081,LRB-081,LR-B-081,LRB 081,LR-B 081 |
||
Milfasartan is a potent, selective antagonist of AT1 receptor with oral activity. It markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats. | |||
T17112 |
Todralazine
Ecarazine |
Others | Others |
Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity. | |||
T71396 |
FCE-24379
|
||
FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats. | |||
T38424 |
(R)-Fadrozole
FAD286,(R)-CGS 16949A free base,(R)-Fadrozole |
||
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.. | |||
T40688 |
Fulvine
|
||
Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo. | |||
T21416 |
Hydroflumethiazide
Diurometon,Glomerulin,Diuredemina,Flutizide,Hidroflumetiazid |
||
Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive. | |||
T27743 |
KRH-594 free acid
WK14922K,WK-1492,WK-14922K,WK1492 |
||
KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-prone spontaneously hypertensive/Izm ra | |||
T13328 |
AE0047 Hydrochloride
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease. | |||
T27306 |
Fasidotril
BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137 |
||
Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in patients with essential hypertension. | |||
T11642 |
Imidaprilate
Imidaprilat,6366A |
RAAS | Endocrinology/Hormones |
Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin-converting enzyme (ACE) inhibitor (IC50: 2.6 nM). It is used in the research of the hypertensive disease. | |||
T78063 |
Endothelin-1 (1-31) (Human) TFA
|
ERK | MAPK |
Endothelin-1 (1-31) (Human) TFA 是源自chymase对大ET-1选择性水解的一种有效血管收缩剂和血压升高剂。 | |||
TP2126 |
R 892
|
||
Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive | |||
T26802 |
BIBS-222
BIBS 222 |
||
BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat. | |||
T15680 |
L-159282
MK 996 |
Others | Others |
L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity. | |||
T81681 |
Neuromedin U-25 (porcine)
|
||
Neuromedin U-25 (porcine) 是一类具有子宫刺激和升高血压作用的肽。 | |||
T14672 | BMS-248360 | Others | Others |
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1]. | |||
T71065 |
Quinapril-d5
|
||
Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con... | |||
T62288 | AD013 | ||
AD013 是一种双重的 cACE 和 NEP 抑制剂。AD013 是通过 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成。AD013 具有潜力提供强效抗高血压和心脏保护作用。 | |||
TP1892 |
γ1-MSH
|
||
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8158 |
Tilianin
香清兰苷,田蓟苷 |
Others | Others |
Tilianin 是一种广泛存在于多种药用植物中的活性黄酮类苷,具有降压、保护心肌、降血脂、抗糖尿病、抗炎、抗氧化等作用。 | |||
T6S1369 |
Vitexin
牡荆素,Apigenin-8-C-glucoside |
Antioxidant | oxidation-reduction |
Vitexin 是一种存在于多种药用植物(如榕树、螺旋藻)中的 c-糖基化的黄酮。 它具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。 | |||
T8044 |
Ajmalicine
阿吗里新,Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Ajmalicine (Raubasine) 是一种有效的抗肾上腺素 (adrenolytic) 剂,优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂,IC50 为 72.3 μM。Ajmalicine 还可用于降压、蛇毒,具有镇静活性。 | |||
T5581 |
6-(γ,γ-Dimethylallylamino)purine
N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine |
Others | Others |
6-(γ,γ-Dimethylallylamino)purine (Triacanthine) 是植物生长调节剂。 | |||
T6S0657 |
Isorhynchophylline
IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline |
Others | Others |
Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物,具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。 | |||
TCS1704 |
Artemitin
艾黄素,Artemetin,Artemisetin,Erianthin |
Antioxidant | oxidation-reduction |
Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮,具有抗氧化、抗炎、抗病毒活性。 | |||
T4S1102 |
Liensinine diperchlorate
莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate |
Mitophagy; Others; Autophagy | Autophagy; Others |
Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬,具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。 | |||
TN1065 |
Hirsutine
|
Apoptosis | Apoptosis |
Hirsutine 是一种来自钩藤的吲哚生物碱,可诱导细胞凋亡,是一种登革热病毒抑制剂,且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。 | |||
T1035 |
Hesperidin
橙皮甙,Hesperetin 7-rutinoside,Cirantin,橙皮苷 |
Apoptosis; Reactive Oxygen Species; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Hesperidin (Cirantin) 是一种广泛存在于柑橘类水果中黄烷酮糖苷,具有减少炎症介质并发挥重要的抗氧化作用,还有抗肿瘤和抗过敏活性。 | |||
T12789 |
S-1-Propenyl-L-cysteine
|
Others | Others |
S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models. | |||
TN2990 |
3alpha-dihydrocadambine
|
Others | Others |
3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. | |||
T69254 |
Ajmalicine hydrochloride
Raubasine hydrochloride |
||
Ajmalicine (Raubasine) hydrochloride 是一种有效的抗肾上腺素 (adrenolytic) 剂,优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine hydrochloride 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂,其 IC50为 72.3 μM。Ajmalicine hydrochloride 还可用于降压、蛇毒,具有镇静活性。 |