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52

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T82221	Head activator neuropeptide
	Head activator neuropeptide 是一种源自哺乳动物细胞系的神经元或神经内分泌的有丝分裂原，其通过与GPR37结合来进行信号传递并促进细胞分裂。
T7459	Abametapir 5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183	MMP; Others; Parasite	Microbiology/Virology; Others; Proteases/Proteasome
	Abametapir (BRN 0123183) 是一种金属蛋白酶抑制剂，能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。
T26889	Borofalan(10B) L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸	Others	Others
	Borofalan(10B) (L-4-Boronophenylalanine) 具有抗肿瘤作用，可用于研究复发性或局部晚期头颈癌。
TP1114L	Leucokinin VIII acetate Leucokinin 8	Others	Others
	Leucokinin VIII acetate (Leucokinin 8) 是一种从蟑螂头部提取物中分离的利尿八肽。
T25284	DAC-2-25 DAC 225,DAC-225,DAC 2 25	Others	Others
	DAC-2-25是 Hydra 头部再生调节剂。它通过诱导 Hydra 的同源转化而起作用。
T5330	Fluralaner AH252723,氟雷拉纳,A1443	GABA Receptor; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Fluralaner (A1443) 是一种异恶唑啉杀外寄生虫剂。它有效且选择性地抑制 GABA 受体通道阻滞剂 EBOB 与家蝇头膜的结合，IC50值为 455 pM。
T17035	Temoporfin 替莫卟吩,替莫泊芬	Others	Others
	Temoporfin 能够用于头颈部鳞状细胞癌的光动力学研究。
T0790	Carbaryl 1-naphthyl methylcarbamate,甲萘威,Sevin	AChR	Neuroscience
	Carbaryl (1-naphthyl methylcarbamate) 可作为一种杀虫剂。
T10337	Antimicrobial Compound 1	Antibacterial	Microbiology/Virology
	Antimicrobial Compound 1 是一种烷基吡啶鎓化合物，尾部为 12C，头部为 4-羧基。 Antimicrobial Compound 1 对枯草芽孢杆菌和大肠杆菌具有抗菌活性。
T76696	Onvatilimab JNJ-61610588	Others	Others
	Onvatilimab (JNJ-61610588) 是一种人 IgG1κ 抗 VISTA (T 细胞激活的 V 域 Ig 抑制剂) 单克隆抗体。Onvatilimab 具有抗肿瘤活性，可用于治疗晚期头颈癌。。
T2618	LGK974 LGK 974,LGK-974,NVP-LGK974,WNT974	Porcupine	Stem Cells
	LGK974 (NVP-LGK974) 是一种有效的、特异性的、具有口服活性的Porcupine(PORCN) 抑制剂(IC50:0.1 nM)。
T77423	Lirilumab ONO-4483,IPH2102	Virus Protease	Microbiology/Virology
	Lirilumab (IPH2102) 是一种针对杀伤性免疫球蛋白样受体抗体 KIR2D 的抗体，具有抗肿瘤活性，通过 Vav1 依赖性 NF-κB 去抑制增强自然杀伤细胞的抗 HPV+ 宫颈癌活性，可用于研究白血病、头颈部鳞状细胞癌 (SCCHN)。
T76890	Petosemtamab MCLA 158	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Petosemtamab (MCLA 158) 是一种高效的抗 EGFR (Kd: 0.22 nM) 和抗 LGR5 (Kd: 0.86 nM) 单克隆抗体。Petosemtamab 促使 LGR5+ 癌细胞中的 EGFR 信号传导中断和受体分解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。
T71912	PD 173955-Analog1
	PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.
T25683	Leucomyosuppressin p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2
	Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction.
T29965	Amethopterin DL-Amethopterin
	Amethopterin is a chemotherapy drug and immune system inhibitor used to treat cancers of the blood, bone, lung, breast, head, and neck. In addition, it can treat rheumatoid arthritis and psoriasis.
TP1114	Leucokinin VIII Leucokinin 8
	Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.
T20688	Leucokinin I
	Leucokinin I is an eight amino acid neuropeptide. It is found in the nervous system of the bowfly and isolated from the head of Madeira cockroach Leucophaea maderae.
T21119	Cevimeline AF-102B,西维美林,FKS 508,SNI 2011,HSDB 7286
	Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy.
T74742	TRPV1 activator-2
	TRPV1 activator-2 (compound 9)为辣椒素类似物，特异性与脂-水通道残基相互作用。
T69857	DB293
	DB293 is an inhibitor of PIT-1 and BRN-3 transcription factors. DB293 binds as head-to-tail stacked dimers in the minor groove of 5'-ATGA sequence, thereby leading to an increase in the size of minor groove.
T19377	Ioxilan	Others	Others
	Ioxilan is a low-osmolar, nonionic, and tri-iodinated diagnostic contrast agent used for excretory urography and contrast-enhanced computed tomographic (CECT) imaging of the head and body. Intravascularly injected causes opacification of vessels, allowing for radiographic visualization of internal structures until significant hemodilution occurs.
T79506	Topoisomerase II inhibitor 15	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseII inhibitor 15 (compound 2g) 为 TopoisomeraseII 的一种抑制剂，能有效诱导细胞凋亡 (apoptotic) 并对头颈部肿瘤展示出较高选择性。
T76918	Barecetamab
	Barecetamab (ISU-104) 是一种人源话抗 ErbB3单克隆抗体。Barecetamab 可用于复发/转移性 (R/M) 头颈部鳞状细胞癌 (HNSCC) 的研究。
T28494	R-82913 NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib
	R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold
T77268	C13-112-tetra-tail
	C13-112-tetra-tail 是一种阳离子类脂化合物，可用于配制脂质纳米颗粒。
T74288	SQDG
	SQDG 是一种膜脂，头部基团含有糖部分，用于研究结构脂在LNP制剂中的作用。
T77266	C13-112-tri-tail
	C13-112-tri-tail 是一种阳离子类脂化合物，可用于配制脂质纳米颗粒。
T77267	C13-113-tri-tail
	C13-113-tri tail 是一种阳离子类脂化合物，可用于配制脂质纳米颗粒。
T77269	C13-113-tetra-tail
	C13-113-tetra-tail 是一种阳离子类脂化合物，可用于配制脂质纳米颗粒。
T82188	HN-1
	HN-1为一种12-mer多肽，在头颈部鳞状细胞癌(HNSCC)细胞上展现特异性活性。作为肿瘤特异性肽，HN-1可渗透肿瘤组织，并在细胞膜上转移活性分子。
T83423	1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine
	1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine 是一种荧光探针，其极性磷脂酰乙醇胺头基适用于测定脂蛋白与血浆表面脂质的氧化。
T35907	Paraherquamide A
	Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).
T21964	KP372-1
	KP372-1是一种 Akt 的抑制剂，通过阻断 PI3K 通路信号，抑制细胞增殖，同时诱导癌细胞凋亡，可用于头颈部鳞状细胞癌的研究。
T62790	JH-XIV-68-3
	JH-XIV-68-3 是一种选择性的 DYRK1A/B 大环抑制剂。JH-XIV-68-3 在生化和细胞测定中能够选择性作用于 DYRK1A 和近亲 DYRK1B。JH-XIV-68-3 在头颈部鳞状细胞癌 (HNSCC) 细胞系中具有抗肿瘤作用。
T76372	TRAF6 peptide
	TRAF6 peptide 是一种特异性的TRAF6-p62相互作用抑制剂。TRAF6 peptide 能消除 NGF 依赖性TrkA 泛素化。TRAF6 peptide 在诸如阿尔茨海默症 (AD)、帕金森、ALS、头部外伤、癫痫和中风等神经系统性疾病中具有较好的研究潜力。
T68297	Dilmapimod tosylate
	Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and...
T68661	Edatrexate CGP 30694
	Edatrexate (CGP 30694)，即 10-乙基-10-去甲氨基蝶呤，是甲氨蝶呤Methotrexate 的类似物，对耐 MTX 肿瘤具有抗肿瘤活性。Edatrexate 是一种抗叶酸抗代谢物，可用于研究非小细胞肺癌，乳腺癌，非霍奇金淋巴瘤和头颈部癌症的研究。
T78221	TRAF6 peptide TFA	E1/E2/E3 Enzyme	Ubiquitination
	TRAF6 peptide TFA是一种抑制TRAF6-p62相互作用的特异性分子，可抑制NGF依赖的TrkA泛素化，展现在阿尔茨海默症（AD）、帕金森病、ALS、创伤性脑损伤、癫痫和中风等神经系统疾病研究中的应用潜力。
T36368	2H-Cho-Arg (trifluoroacetate salt)
	2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and t...
T71491	Enadoline (Free Base)
	Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating com...
T71211	Rizatriptan-d6 benzoate salt
	Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors. Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries. In vivo, rizatriptan reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mou...
T37217	N-Decanoyl p-Nitroaniline
	N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate anandamide (AEA). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. Exposure of DepNA to FAAH activity results in the release of the yellow colori...
T74566	Phospholipid-PEG-Biotin (MW 5000)
	Phospholipid-PEG-Biotin (MW 5000)为含有磷脂的PEG衍生物，适用于脂质体和细胞表面的修饰，及胰岛细胞移植。Phospholipid具亲水性“头部”与疏水性“尾部”结构，PEG为亲水性低毒聚合物，生物素则作为酶辅因子，用于蛋白质标记。
T35810	C24 dihydro Ceramide (d18:0/24:0) Cer(d18:0/24:0)
	C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squam...
T36350	Cho-Arg (trifluoroacetate salt)
	Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...
T72776	NR2F1 agonist 1
	NR2F1 agonist 1 是一种核受体 NR2F1激动剂，可特异性激活恶性细胞的休眠程序。NR2F1 agonist 1 上调 NR2F1 和调节休眠的下游靶基因。NR2F1 agonist 1 通过 NR2F1 激活在头颈部鳞状细胞癌 (HNSCC) 中诱导神经嵴样生长抑制。NR2F1 agonist 1 在小鼠原发肿瘤模型中抑制肿瘤生长。
T74564	Phospholipid-PEG-Biotin (MW 2000)
	Phospholipid-PEG-Biotin (MW 2000) 是一种PROTAClinker，属于 PEG 类。可用于合成PROTAC 分子。Phospholipid 是一类含有亲水“头”和疏水“尾”的脂类；PEG 是一种低毒性的亲水水溶性聚合物；生物素是一种酶辅因子，可用于标记蛋白质。
T63556	EGFR-IN-59
	EGFR-IN-59 是 EGFR 抑制剂，其IC50值为190 nM，也是一直凋亡 (apoptosis) 诱导剂。EGFR-IN-59 对非小肺癌细胞系 (A549) 和正常肺成纤维细胞 (WI38) 表现出细胞毒性的IC50分别为 8.62 和 52.6 μM。EGFR-IN-59 能够用于研究非小细胞肺癌 (NSCLC)、头颈癌、乳腺癌和结直肠癌等多种癌症。
T36359	Dios-Arg (trifluoroacetate salt)
	Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...

化合物

Head activator neuropeptide

Cat.No: T82221

Cat.No: T7459

Synonym: 5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183

Target: MMP, Others, Parasite

Cat.No: T26889

Synonym: L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸

Target: Others

Leucokinin VIII acetate

Cat.No: TP1114L

Synonym: Leucokinin 8

Target: Others

Cat.No: T25284

Synonym: DAC 225,DAC-225,DAC 2 25

Target: Others

Cat.No: T5330

Synonym: AH252723,氟雷拉纳,A1443

Target: GABA Receptor, Parasite

Cat.No: T17035

Synonym: 替莫卟吩,替莫泊芬

Target: Others

Cat.No: T0790

Synonym: 1-naphthyl methylcarbamate,甲萘威,Sevin

Target: AChR

Antimicrobial Compound 1

Cat.No: T10337

Target: Antibacterial

Cat.No: T76696

Synonym: JNJ-61610588

Target: Others

Cat.No: T2618

Synonym: LGK 974,LGK-974,NVP-LGK974,WNT974

Target: Porcupine

Cat.No: T77423

Synonym: ONO-4483,IPH2102

Target: Virus Protease

Cat.No: T76890

Synonym: MCLA 158

Target: EGFR

PD 173955-Analog1

Cat.No: T71912

Leucomyosuppressin

Cat.No: T25683

Synonym: p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2

Cat.No: T29965

Synonym: DL-Amethopterin

Leucokinin VIII

Cat.No: TP1114

Synonym: Leucokinin 8

Cat.No: T20688

Cat.No: T21119

Synonym: AF-102B,西维美林,FKS 508,SNI 2011,HSDB 7286

TRPV1 activator-2

Cat.No: T74742

Cat.No: T69857

Cat.No: T19377

Target: Others

Topoisomerase II inhibitor 15

Cat.No: T79506

Target: Topoisomerase

Cat.No: T76918

Cat.No: T28494

Synonym: NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib

C13-112-tetra-tail

Cat.No: T77268

Cat.No: T74288

C13-112-tri-tail

Cat.No: T77266

C13-113-tri-tail

Cat.No: T77267

C13-113-tetra-tail

Cat.No: T77269

Cat.No: T82188

1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine

Cat.No: T83423

Paraherquamide A

Cat.No: T35907

Cat.No: T21964

Cat.No: T62790

Cat.No: T76372

Dilmapimod tosylate

Cat.No: T68297

Cat.No: T68661

Synonym: CGP 30694

TRAF6 peptide TFA

Cat.No: T78221

Target: E1/E2/E3 Enzyme

2H-Cho-Arg (trifluoroacetate salt)

Cat.No: T36368

Enadoline (Free Base)

Cat.No: T71491

Rizatriptan-d6 benzoate salt

Cat.No: T71211

N-Decanoyl p-Nitroaniline

Cat.No: T37217

Phospholipid-PEG-Biotin (MW 5000)

Cat.No: T74566

C24 dihydro Ceramide (d18:0/24:0)

Cat.No: T35810

Synonym: Cer(d18:0/24:0)

Cho-Arg (trifluoroacetate salt)

Cat.No: T36350

NR2F1 agonist 1

Cat.No: T72776

Phospholipid-PEG-Biotin (MW 2000)

Cat.No: T74564

Cat.No: T63556

Dios-Arg (trifluoroacetate salt)

Cat.No: T36359

Cat. No.	Product Name	Target	Signaling Pathways
T7727	Se-Methylselenocysteine Se MSC,SeMCys,MSeC,L-硒甲基硒代半胱氨酸,Se-MSC,SeMSC	BCL; IAP; Caspase	Apoptosis; Proteases/Proteasome
	Se-Methylselenocysteine (Se-MSC) 是具有口服活性的甲基硒前体，具有强大的抗氧化活性和抗癌活性。Se-Methylselenocysteine 可诱导细胞凋亡。
T3674	Hydroxysafflor yellow A 藏红花,羟基红花黄色素A,HSYA,Safflomin A	TGF-beta/Smad	Stem Cells
	Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物，从中药红花中分离得到，具有抗癌作用。
TN2539	1beta-Hydroxyalantolactone	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	1beta-Hydroxyalantolactone 是从药用植物大英花的花头中分离出的小分子化合物，可抑制细胞中TNF-α、IL-17、IFN-γ的表达，促进TNF-α、IFN-γ、IL-17的分泌，可防治类风湿性关节炎。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
T0729	Benzyl benzoate Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester	Parasite	Microbiology/Virology
	Benzyl benzoate (Benzoic acid benzyl ester) 是化妆品中的香料成分，可研究疥疮和蠕形螨相关的炎症性皮肤病。
T4889	2,6-Diaminoheptanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。
TN7240	Erinacine A	ROS	Immunology/Inflammation
	Erinacine A 是一种可从猴头菇中提取出的抗癌化合物，能够通过活性氧类 (ROS) 的产生促使癌细胞死亡。Erinacine A 可能通过参与信号通路的调节从而发挥其抗癌活性。Erinacine A 具有抗癌、抗肿瘤和神经保护活性。

天然产物

Se-Methylselenocysteine

Cat.No: T7727

Synonym: Se MSC,SeMCys,MSeC,L-硒甲基硒代半胱氨酸,Se-MSC,SeMSC

Target: BCL, IAP, Caspase

Hydroxysafflor yellow A

Cat.No: T3674

Synonym: 藏红花,羟基红花黄色素A,HSYA,Safflomin A

Target: TGF-beta/Smad

1beta-Hydroxyalantolactone

Cat.No: TN2539

Target: IL Receptor, TNF

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Benzyl benzoate

Cat.No: T0729

Synonym: Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester

Target: Parasite

2,6-Diaminoheptanedioic acid

Cat.No: T4889

Target: Others, Endogenous Metabolite

Cat.No: TN7240

Target: ROS

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