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47

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11515	Gut restricted-7 GR-7	Potassium Channel	Membrane transporter/Ion channel
	Gut restricted-7 (GR-7) 是一种具有口服活性的共价泛胆盐水解酶 (BSH) 抑制剂，对肠道有组织选择性。它可减少小鼠粪便中肠道细菌的BSH 活性并降低去结合型胆汁酸水平。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T13385	Zamifenacin fumarate 扎非那星富马酸盐,UK-76654 fumarate	AChR	Neuroscience
	Zamifenacin fumarate (UK-76654 fumarate) 是肠道选择性毒蕈碱M3受体的有效拮抗剂，可显著降低肠易激综合症的结肠蠕动。
T76977	Timigutuzumab
	Timigutuzumab (GEXMab73) 是一种靶向 ErbB2的人源化单克隆抗体。 Timigutuzumab 可用于癌症的研究。
T30747	Cargutocin Y-5350,Y 5350,Y5350
	Cargutocin is a biochemical.
T76944	Cergutuzumab amunaleukin
	Cergutuzumab amunaleukin (CEA-IL2v) 是一种靶向癌胚抗原 (CEA) 的IL-2变体，作为免疫细胞因子，展现出免疫刺激与抗肿瘤活性。
T83297	5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT
	5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT 是带有荧光素 FAM 标记的寡核苷酸。
T77071	Lonigutamab
	Lonigutamab (hz208F2-4) 是一种人源化抗 IGF-1R 单克隆抗体，可用于合成抗体-活性分子偶联物 (ADC)。
T1242	Alvimopan 爱维莫潘	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂，IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中，可用于术后肠梗阻的研究。
T35898	Izencitinib
	Izencitinib (TD-1473) is an orally active, gut-restricted JAK inhibitor with non-selective properties. It is primarily employed in the investigation of ulcerative colitis [1].
T25984	Prenalterol H80/62,H-80/62,H 80/62
	Prenalterol 是一种选择性的β1- 肾上腺素能受体激动剂，不影响肠道平滑肌的收缩活动。Prenalterol 具有心血管疾病的研究潜力。
T1053	Mebeverine hydrochloride 盐酸麦皮凡林,Colofac Hydrochloride,Duspatalin Hydrochloride,Duspatal Hydrochloride	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Mebeverine hydrochloride (Colofac Hydrochloride) 是 β-苯乙胺的衍生物，一种增肌剂，可有效阻止肠道蠕动。它也是电压控制的钠通道 (voltage-operated sodium channels)阻断剂，抑制细胞内钙的积累。
TP1083L	Neuromedin U (rat) acetate	Others	Others
	Neuromedin U (rat) acetate 是一种 23 个氨基酸的脑肠肽。 Neuromedin U (NMU) 通过其在中枢神经系统中的同源受体 NMUR2 调节几种重要的生理功能，包括能量平衡、压力反应和伤害感受。
T10623	BSH-IN-1	Potassium Channel	Membrane transporter/Ion channel
	BSH-IN-1 是一种重组的肠道细菌胆汁盐水解酶 (BSHs) 的有效和共价抑制剂，对 B. longum BSH (革兰氏阳性) 和 B. theta BSH (革兰氏阴性菌) 的 IC50 分别为 108 和 427 nM。
TP1059	Peptide YY (PYY) (3-36), human Peptide YY (3-36)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) 是一种肠胃激素肽，可以激动Y2受体，具有降低食欲的功效。
T15500	HPi1	Others; Antibacterial	Microbiology/Virology; Others
	HPi1 是一种有口服活性的，针对幽门螺杆菌的选择性抗菌剂，IC50为 0.24 μM，MIC 为 0.08-0.16 μg/mL。
T3162	IDE1	Others	Others
	IDE1 是定形内胚层诱导物，有用于器官移植等方面的潜力。
T21327	Uridine triacetate RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate	Others	Others
	Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性，或早发性心脏或中枢神经系统 (CNS) 毒性。
T1600	Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Doxifluridine (AMC 0101) 是一种胸苷磷酸化酶活化剂，对 PC9-DPE2细胞的 IC50为0.62 μM。它是具有抗肿瘤活性的抗肿瘤剂 5-fluorouracil (5-FU) 的氟嘧啶衍生物和口服前药。
TP2309	NEUROTENSIN TFA (39379-15-2 free base) Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素	Others	Others
	Neurotensin TFA (39379-15-2 free base) 是一种内源性 13 个氨基酸的神经肽，具有显着的阿片类非依赖性镇痛作用。它在大脑中充当神经递质，在肠道中充当激素，也充当神经调节剂。由于它与多种神经递质系统如多巴胺能、血清素能、谷氨酸能、GABA 能和胆碱能系统。它具有作为人体代谢物、有丝分裂原、神经递质和创伤的作用。
T17283	Zamifenacin UK-76654	Others	Others
	Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist.
T35403	(±)-Equol 4'-sulfate (sodium salt)
	(±)-Equol 4’-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol .[1] It has been used as a standard for the quantification of unconjugated equol in rat plasma.[2]
TP1084	Neuromedin U, rat TFA (117505-80-3 free base) Neuromedin U (rat) (TFA),Rat neuromedin U-23 TFA,Neuromedin U, rat TFA
	Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide.
T15778	LP-533401	Hydroxylase	Metabolism
	LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
TP1058	Peptide YY (PYY) (3-36), human TFA Peptide YY (3-36) (TFA)
	Peptide YY (PYY) (3-36), human (TFA) is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite[1].
T35374L	(Ala13)-Apelin-13 acetate	Apelin receptor	GPCR/G Protein
	(Ala13)-Apelin-13 acetate，一种 APJ 拮抗剂，可调节CRF 诱导的增强的结肠运动、内脏敏感性和肠屏障。
TP1083	Neuromedin U, rat Rat neuromedin U-23,Neuromedin U (rat)
	Neuromedin U,a 23-amino acid brain-gut peptide, regulates several important physiological functions through its cognate receptor NMUR2 in the central nervous system, including energy balance, stress response, and nociception.
T74465	Colibactin
	Colibactin 是一种复杂的次级代谢产物，由一些具有遗传毒性的肠道大肠杆菌菌株产生。Colibactin 具有研究结直肠癌的潜力。
T75773	Peptide YY (PYY) (3-36), porcine TFA
	Peptide YY (PYY) (3-36), porcine TFA，为一种肠胃激素肽，作用于Y2受体，具有降低食欲的功能。
T74985	MRV03-037
	MRV03-037 是一种选择性的大肠杆菌素活化肽酶 (ClbP) 抑制剂，能阻断Colibactin 对真核细胞的基因毒性作用。MRV03-037 可以防止肠道细菌基因毒素的产生。
T37809	Alphitonin
	Alphitonin is a flavonoid that has been found in L. leptolepis wood.1 It is also a metabolic intermediate that is formed during the catabolism of quercetin by the human gut bacteria E. ramulus.2,3 \|1. Chen, K., Ohmura, W., Doi, S., et al. Termite feeding deterrent from Japanese larch wood. Bioresour. Technol. 95(2), 129-134 (2004).\|2. Braune, A., Gütschow, M., Engst, W., et al. Degradation of quercetin and luteolin by Eubacterium ramulus. Appl. Environ. Microbiol. 67(12), 5558-55567 (2001).\|3. J...
T38072	HSGN-218
	HSGN-218 is a gut-restrictive antibiotic.1It is active againstC. difficile(MIC = 0.007 μg/ml) and clinical isolates ofC. difficile(MICs = 0.003-0.03 μg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 μg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice fromC. difficilerecurrence in mouse models ofC. difficileinfection. 1.Naclerio, G.A., Abutaleb, N.S., Li, D., et al.Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses rec...
T78004	Neuromedin U, rat TFA Rat neuromedin U-23 TFA,Neuromedin U (rat) (TFA)
	Neuromedin U, rat TFA 是一脑肠肽类化合物，含23个氨基酸，主要通过中枢神经系统内的NMUR2同源受体，调控多项生理功能，如能量平衡、应激反应及伤害感知。
TP1831	[Nle11]-Substance P
	[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons.
T35631	Peptide YY (human) (trifluoroacetate salt) Peptide Tyrosine Tyrosine
	Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-induced cAMP accumulation. PYY is cleaved in vivo to PYY (3-36) . Release of PYY occurs postprandially in proportion to calorie intake from intestinal enteroendocrine L cells, indicating it may be a satiety signal. In humans, PYY inhibits food intake and gastrointestinal transit in...
T37854	Cholic Acid 7-sulfate
	Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2]
T79774	Antibacterial agent 159	Antibiotic	Microbiology/Virology
	Antibacterialagent 159 (Compound 6d) 是一款高效抗菌化合物，具备针对脓疱疮和C. difficile感染（CDI）的抗菌活性。其使用过程中未发现C. difficile复发现象，并对益生肠道菌群仅有微弱影响。
T77154	Etrolizumab
	Etrolizumab (rhuMAb Beta7) 是一种肠道选择性抗-β7整合素单克隆抗体。Etrolizuma b 是针对α4β7和 αEβ7 整合素的 β7 亚基的特异性靶向活性分子。Etrolizumab 可用于炎症性肠病 (IBD) 的研究。
T81025	Teduglutide TFA ALX-0600 TFA
	Teduglutide TFA 是一种具有耐受二肽基肽酶 IV 的胰高血糖素样肽 2 (GLP-2) 类似物，与肠道黏膜营养作用相关。它可用于研究短肠综合征 (SBS) 和克罗恩病 (CD)。
T70267	ADL 08-0011 HCl
	ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverse...
T82600	DDAO-C6
	DDAO-C6为酯环酮衍生物，高度特异性荧光探针，专用于检测人血清白蛋白(HSA)。同时，DDAO-C6作为酶激活的近红外荧光探针，适用于通过肠道微生物内源性脂肪酶的活性变化进行目测（Ex/Em=600/658 nm）。
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon...
T70506	Bupranolol HCl
	Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]be...
T36660	Olsalazine-13C6 Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...
T35980	Bilirubin Conjugate (sodium salt)
	Bilirubin conjugate is a stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives. In vivo, bilirubin circulates in the plasma and is taken up by hepatocytes and conjugated to one or two glucuronic acids in a reaction catalyzed by UDP glucuronidase to form bilirubin mono or diglucuronide. This water-soluble form is then excreted from the liver in bile in the feces or is converted to urobilinogen and excreted in the urine. In addition to ...
T83955	MOMBA
	MOMBA是一种针对人类自由脂肪酸2(hFFA2)工程化受体和设计药物激活的设计受体(DREADD)的选择性正交激动剂，对野生型hFFA2、hFFA3和小鼠FFA2无活性。MOMBA能够在表达hFFA2-DREADD受体的细胞中抑制forskolin刺激的cAMP水平，其功效改善且与山梨酸的效力相当。在hFFA2-DREADD转基因小鼠中，MOMBA治疗显著降低肠道传输速度，并促进依赖浓度的结肠隐窝GLP-1释放。该化合物具有口服生物利用度。
T14382	AZD7687	Others	Others
	AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). IC50 value: 80 nM [1] Target: DGAT1 in vitro: Plasma AZD7687 exposure was measured repeatedly. AZD7687 markedly reduced postprandial TAG excursion with a steep concent

化合物

Gut restricted-7

Cat.No: T11515

Synonym: GR-7

Target: Potassium Channel

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Zamifenacin fumarate

Cat.No: T13385

Synonym: 扎非那星富马酸盐,UK-76654 fumarate

Target: AChR

Cat.No: T76977

Cat.No: T30747

Synonym: Y-5350,Y 5350,Y5350

Cergutuzumab amunaleukin

Cat.No: T76944

5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT

Cat.No: T83297

Cat.No: T77071

Cat.No: T1242

Synonym: 爱维莫潘

Target: Opioid Receptor

Cat.No: T35898

Cat.No: T25984

Synonym: H80/62,H-80/62,H 80/62

Mebeverine hydrochloride

Cat.No: T1053

Synonym: 盐酸麦皮凡林,Colofac Hydrochloride,Duspatalin Hydrochloride,Duspatal Hydrochloride

Target: Others, Sodium Channel

Neuromedin U (rat) acetate

Cat.No: TP1083L

Target: Others

Cat.No: T10623

Target: Potassium Channel

Peptide YY (PYY) (3-36), human

Cat.No: TP1059

Synonym: Peptide YY (3-36)

Target: Neuropeptide Y Receptor

Cat.No: T15500

Target: Others, Antibacterial

Cat.No: T3162

Target: Others

Uridine triacetate

Cat.No: T21327

Synonym: RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate

Target: Others

Cat.No: T1600

Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

NEUROTENSIN TFA (39379-15-2 free base)

Cat.No: TP2309

Synonym: Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素

Target: Others

Cat.No: T17283

Synonym: UK-76654

Target: Others

(±)-Equol 4'-sulfate (sodium salt)

Cat.No: T35403

Neuromedin U, rat TFA (117505-80-3 free base)

Cat.No: TP1084

Synonym: Neuromedin U (rat) (TFA),Rat neuromedin U-23 TFA,Neuromedin U, rat TFA

Cat.No: T15778

Target: Hydroxylase

Peptide YY (PYY) (3-36), human TFA

Cat.No: TP1058

Synonym: Peptide YY (3-36) (TFA)

(Ala13)-Apelin-13 acetate

Cat.No: T35374L

Target: Apelin receptor

Neuromedin U, rat

Cat.No: TP1083

Synonym: Rat neuromedin U-23,Neuromedin U (rat)

Cat.No: T74465

Peptide YY (PYY) (3-36), porcine TFA

Cat.No: T75773

Cat.No: T74985

Cat.No: T37809

Cat.No: T38072

Neuromedin U, rat TFA

Cat.No: T78004

Synonym: Rat neuromedin U-23 TFA,Neuromedin U (rat) (TFA)

[Nle11]-Substance P

Cat.No: TP1831

Peptide YY (human) (trifluoroacetate salt)

Cat.No: T35631

Synonym: Peptide Tyrosine Tyrosine

Cholic Acid 7-sulfate

Cat.No: T37854

Antibacterial agent 159

Cat.No: T79774

Target: Antibiotic

Cat.No: T77154

Teduglutide TFA

Cat.No: T81025

Synonym: ALX-0600 TFA

ADL 08-0011 HCl

Cat.No: T70267

Cat.No: T82600

β-Endorphin (rat)

Cat.No: T35460

Cat.No: T70506

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Bilirubin Conjugate (sodium salt)

Cat.No: T35980

Cat.No: T83955

Cat.No: T14382

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN7108	Urolithin C	Apoptosis; Calcium Channel; Reactive Oxygen Species; IGF-1R; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Tyrosine Kinase/Adaptors
	Urolithin C 属于多酚类，是鞣花酸的肠道微生物代谢产物，具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C 是 L 型 Ca2+通道开放剂，可增强 Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡，并刺激活性氧的形成。
T4S0554	Theaflavine-3,3'-digallate TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素	Others	Others
	Theaflavine-3,3'-digallate (theaflavin digallate) 和乳酸一起可以减少单纯疱疹病毒的传播。
TN6796	2'-FUCOSYLLACTOSE 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖	Others	Others
	2'-FUCOSYLLACTOSE (2'-Fucosyl-D-lactose) 是一种含岩藻糖的寡糖。
TN5755	Guttiferone G
	Guttiferone G 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5755，CAS号为 666174-75-0。
T8878	urolithin M6 尿石素M6,3,8,9,10-tetrahydroxy urolithin	Others	Others
	urolithin M6 (3,8,9,10-tetrahydroxy urolithin) 是一种由肠道微生物群产生的鞣花单宁代谢物，被确定为推定的没食子黄素模拟物。
T19408	m-Coumaric acid	Endogenous Metabolite	Metabolism
	m-Coumaric acid 是一种多酚代谢物，来自于咖啡酸，由肠道菌群形成，人体体液中的含量取决于饮食。
T8071	L-Lysine hydrochloride 赖氨酸盐酸盐,Lysine hydrochloride,L-赖氨酸盐酸盐	Virus Protease	Microbiology/Virology
	L-Lysine hydrochloride 是一种人类必需氨基酸，能增加钙吸收，减少糖尿病相关疾病和改善肠道健康，可用于疱疹的研究。
T3840	Dihydroresveratrol 3,4',5-Trihydroxybibenzyl,二氢白藜芦醇,二氢藜芦醇	Estrogen Receptor/ERR; Others	Endocrinology/Hormones; Others
	Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) 是一种激素受体调节剂，是一种植物雌激素。它在皮摩尔和纳摩尔浓度下促进前列腺和乳腺癌细胞增殖。
TN6733	Kansuiphorin C KPC,甘遂大戟萜酯C	Others	Others
	Kansuiphorin C (KPC) 是一种具有多种生物活性的天然产物。它能够调节肠道菌群及相关代谢功能，并可以改善恶性腹水。
T4722	O-Acetyl-L-serine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	O-Acetyl-L-serine hydrochloride 是内源性代谢产物的一种。
T2A2428	2-Hydroxy-4-methoxybenzoic acid 2-Hydroxy-p-anisic Acid,4-Methoxysalicylic acid,对甲氧基水杨酸,2-羟基-4-甲氧基苯甲酸	Others	Others
	2-Hydroxy-4-methoxybenzoic acid (2-Hydroxy-p-anisic Acid) 是一种甲氧基苯甲酸的衍生物，它是一种潜在的生物标志物。
T3737	3-(2,4-Dihydroxyphenyl)propanoic acid 3-(2,4-二羟基苯)丙酸,Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid	Tyrosinase	Proteases/Proteasome
	3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) 是竞争性酪氨酸酶 (tyrosinase) 抑制剂，可抑制 L-Tyrosine 和 DL-DOPA，IC50和 Ki 分别为 3.02 μM 和 11.5 μM。
T4840	3-Hydroxybenzoic acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxybenzoic acid 是内源性代谢产物的一种。
T4875	Palatinose hydrate 6-O-α-D-Glucopyranosyl-D-fructose, Isoma,帕拉金糖水合物	Others; Endogenous Metabolite	Metabolism; Others
	Palatinose hydrate (6-O-α-D-Glucopyranosyl-D-fructose, Isoma) 是内源性代谢产物的一种。
TN1237	3-O-Methylgallic acid 3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸	Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物，具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用，可抑制 Caco-2 细胞增殖，IC50值为 24.1 μM。
T13265	Urolithin B 尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮	ERK; NF-κB; Akt; Endogenous Metabolite; JNK; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Urolithin B 是一种 ellagitannins 的肠道微生物代谢产物，具有抗炎和抗氧化作用。它也是骨骼肌质量的调节因子，通过减少 IκBα 的磷酸化和降解来抑制 NF-κB 活性，并抑制 JNK、ERK 和 Akt 的磷酸化，并增强 AMPK 的磷酸化。
T4889	2,6-Diaminoheptanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
T5089	5-Aminovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	5-Aminovaleric acid 被认为是 GABA 的亚甲基同系物，是GABA 的弱激动剂。它是赖氨酸降解产物。它既能够内源性产生，也能够通过赖氨酸的细菌分解代谢产生。
T37404	O-Desmethylangolensin
	O-Desmethylangolensin is a gut microbiota metabolite of daidzein, a soy isoflavone. It demonstrates antioxidant activity[1][2].
T83804	5-(3'-Hydroxyphenyl)-γ-Valerolactone (3’-hydroxy)-PVL,δ-(3’-Hydroxyphenyl)-γ-VL,5-(3’-Hydroxyphenyl)-γ-VL,δ-(3’-Hydroxyphenyl)-γ-Valerolactone
	5-(3'-羟基苯基)-γ-戊内酯是多种多酚的代谢产物，包括(+)-儿茶素和(−)-表儿茶素。这种化合物由肠道微生物从这些多酚中形成。
T37710	5-Hydroxyoxindole	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	5-Hydroxyoxindole 是尿酸的一种结构类似物，具有脂质过氧化抑制活性和自由基 DPPH 清除活性，可用于氧化应激介导的疾病的研究。
T77988	Phenyl sulfate Phenyl hydrogen sulfate	Endogenous Metabolite	Metabolism
	Phenyl sulfate为肠道微生物衍生的口服活性代谢物，能在糖尿病实验模型中诱发蛋白尿及足细胞损伤，其可能成为糖尿病肾病的疾病标志物和未来治疗靶点。
T83673	4-Hydroxyphenylpropionylglycine Phloretylglycine,4-hydroxy PPG,Phloretic Acid Glycine Conjugate
	4-Hydroxyphenylpropionylglycine是一种由条件必需氨基酸酪氨酸代谢形成的代谢产物。通过芳香族氨基酸转氨酶、酪氨酸转氨酶以及肠道微生物作用后，结合甘氨酸共轭生成。此外，4-Hydroxyphenylpropionylglycine也是酚类化合物phloretin的代谢产物。

天然产物

Cat.No: TN7108

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite

Theaflavine-3,3'-digallate

Cat.No: T4S0554

Synonym: TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素

Target: Others

2'-FUCOSYLLACTOSE

Cat.No: TN6796

Synonym: 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖

Target: Others

Guttiferone G

Cat.No: TN5755

Cat.No: T8878

Synonym: 尿石素M6,3,8,9,10-tetrahydroxy urolithin

Target: Others

m-Coumaric acid

Cat.No: T19408

Target: Endogenous Metabolite

L-Lysine hydrochloride

Cat.No: T8071

Synonym: 赖氨酸盐酸盐,Lysine hydrochloride,L-赖氨酸盐酸盐

Target: Virus Protease

Dihydroresveratrol

Cat.No: T3840

Synonym: 3,4',5-Trihydroxybibenzyl,二氢白藜芦醇,二氢藜芦醇

Target: Estrogen Receptor/ERR, Others

Cat.No: TN6733

Synonym: KPC,甘遂大戟萜酯C

Target: Others

O-Acetyl-L-serine hydrochloride

Cat.No: T4722

Target: Others, Endogenous Metabolite

2-Hydroxy-4-methoxybenzoic acid

Cat.No: T2A2428

Synonym: 2-Hydroxy-p-anisic Acid,4-Methoxysalicylic acid,对甲氧基水杨酸,2-羟基-4-甲氧基苯甲酸

Target: Others

3-(2,4-Dihydroxyphenyl)propanoic acid

Cat.No: T3737

Synonym: 3-(2,4-二羟基苯)丙酸,Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid

Target: Tyrosinase

3-Hydroxybenzoic acid

Cat.No: T4840

Target: Others, Endogenous Metabolite

Palatinose hydrate

Cat.No: T4875

Synonym: 6-O-α-D-Glucopyranosyl-D-fructose, Isoma,帕拉金糖水合物

Target: Others, Endogenous Metabolite

3-O-Methylgallic acid

Cat.No: TN1237

Synonym: 3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸

Target: Apoptosis, NF-κB, OCT, DNA/RNA Synthesis, STAT

Cat.No: T13265

Synonym: 尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

2,6-Diaminoheptanedioic acid

Cat.No: T4889

Target: Others, Endogenous Metabolite

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

5-Aminovaleric acid

Cat.No: T5089

Target: Others, Endogenous Metabolite

O-Desmethylangolensin

Cat.No: T37404

5-(3'-Hydroxyphenyl)-γ-Valerolactone

Cat.No: T83804

Synonym: (3’-hydroxy)-PVL,δ-(3’-Hydroxyphenyl)-γ-VL,5-(3’-Hydroxyphenyl)-γ-VL,δ-(3’-Hydroxyphenyl)-γ-Valerolactone

5-Hydroxyoxindole

Cat.No: T37710

Target: Reactive Oxygen Species

Cat.No: T77988

Synonym: Phenyl hydrogen sulfate

Target: Endogenous Metabolite

4-Hydroxyphenylpropionylglycine

Cat.No: T83673

Synonym: Phloretylglycine,4-hydroxy PPG,Phloretic Acid Glycine Conjugate

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