Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut. 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 LP-533401 hydrochloride 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 5,390 | 35日内发货 | ||
10 mg | ¥ 9,530 | 35日内发货 | ||
25 mg | ¥ 19,800 | 35日内发货 |
LP-533401 的其他形式现货产品:
产品描述 | LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut. |
体外活性 | At a dose of 1 μM, LP-533401 fully suppresses serotonin production in Tph1–expressing cells [1]. |
体内活性 | Mice treated repeatedly with LP-533401 (30–250 mg/kg per day) exhibit marked 5-HT content reductions in the gut, lungs, and blood, but not in the brain. Adult, healthy mice treated with the Tph-1 inhibitor LP-533401 display a 30% decrease in circulating serotonin levels, with a consequent 30% increase in osteoblast numbers. Pharmacokinetic studies in rodents show that the LP-533401 level in the brain is negligible following oral administration, indicating that it is virtually unable to cross the blood-brain barrier[1]. Lung and gut 5-HT contents decrease by 50%, after a single LP533401 dose (250 mg/kg), whereas blood 5-HT levels remain unchanged, suggesting gut and lung 5-HT synthesis[2]. Administration of LP533401 to mice injected with EL4 cells inhibits the decrement in osteoblast numbers and trabecular bone volume prolongs survial, and decreases leukemic infiltration[3]. |
分子量 | 526.48 |
分子式 | C27H22F4N4O3 |
CAS No. | 945976-43-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LP-533401 945976-43-2 Metabolism Hydroxylase LP533401 LP 533401 Inhibitor inhibitor inhibit