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Search Results for " edema "

68

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5102	TGN-020 TGN020	Aquaporin; PROTAC Linker	Membrane transporter/Ion channel; PROTAC
	TGN-020 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。TGN020 是一种选择性水通道蛋白 4 (AQP4) 抑制剂，IC50为 3.1 μM。TGN020 减轻大鼠脊髓压迫损伤后的水肿并抑制神经胶质瘢痕的形成。
T6581	Methyclothiazide Duretic,Enduron,甲氯噻嗪,Aquatensen	Others; Carbonic Anhydrase	Metabolism; Others
	Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂，也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性，也可以抑制内源性血管收缩刺激导致的血管反应。
T4074	GSK-872 GSK872,GSK'872,GSK2399872A	RIP kinase	Apoptosis; NF-κB
	GSK-872 (GSK2399872A) 是一种有效且特异性的 RIP3 激酶抑制剂，降低 RIPK3 介导的坏死和随后的 HMGB1 的细胞质易位和表达，可改善早期脑损伤中的脑水肿和神经功能缺损。它以高亲和力结合 RIP3 激酶结构域，IC50为1.8 nM，并抑制激酶活性，IC50为1.3 nM。
T14968	Cinanserin hydrochloride SQ 10643	Influenza Virus; 5-HT Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Cinanserin hydrochloride (SQ 10643) 是一种高亲和力拮抗剂，对 5-HT2 受体的Ki 值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
T23333	SC-58125 SC 58125,1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑	COX	Immunology/Inflammation; Neuroscience
	SC-58125 是一种选择性的环氧合酶2 (COX-2)的抑制剂，IC50值为 0.04 μM。它在体内外均表现出抗肿瘤活性，还可抑制炎症部位的水肿并具有缓解疼痛作用。
T21412	Ketorolac Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular	COX	Immunology/Inflammation; Neuroscience
	Ketorolac (Acuvail) 是非甾体抗炎剂，是非选择性的COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
T34485	Safotibant LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542	Bradykinin Receptor	GPCR/G Protein
	Safotibant (LF-22-0542) 是一种缓激肽 B1 受体拮抗剂，具有抗炎和镇痛活性，可用于局部治疗糖尿病性黄斑水肿。
T19286	Dixyrazine UCB 3412	Others	Others
	Dixyrazine（UCB 3412）具有短暂的降压作用，可预防注射硫酸鱼精蛋白引起的脑水肿，可用于研究与神经系统相关的疾病。
T16950	Sudoxicam 舒多昔康,4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide	COX	Immunology/Inflammation; Neuroscience
	Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) 是一种可逆的 COX 拮抗剂，具有抗炎、抗水肿和解热特性。
T8807	Benzydamine	Others	Others
	Benzydamine 是一种苄基吲唑，具有镇痛、解热和抗炎作用。 Benzydamine 用于减少手术后和创伤后的疼痛和水肿，并促进愈合。
T60351	Acetazolamide sodium OT-302 sodium	Carbonic Anhydrase	Metabolism
	Acetazolamide sodium (OT-302 sodium) 是一种高效的碳酸酐酶 (CA)IX抑制剂，具有利尿、抗淋球菌和降压活性，可用于癫痫、青光眼、水肿和高原反应等适应症。
T36619	Aligeron	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aligeron 是一种非选择性的prostaglandin (PG)拮抗剂，对PGF2α和PGE2诱导的猫血压下降有抑制作用，可用于抑制PGF2α诱导的小鼠腹泻和PGE2诱导的大鼠爪水肿。Aligeron 对血管并发症具有抗氧化保护作用。
T12721	Rho-Kinase-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Rho-Kinase-IN-1 是一种 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 Kis 分别为 30.5 nM 和 3.9 nM。 Rho-Kinase-IN-1 可用于细胞过度增殖、重塑、水肿和炎症疾病的研究。
T36534	SDZ 224-015 SDZ 224015	IL Receptor; Caspase	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	SDZ 224-015 是白细胞介素-1β（IL-1β）转化酶和 Caspase-1 的口服活性抑制剂。SDZ 224-015 具有抗 COVID-19 和抗炎活性，可减少角叉菜胶诱导的大鼠爪子水肿。
T0477	Zileuton Abbott 64077,齐留通,A 64077	Ferroptosis; Lipoxygenase; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Zileuton (A 64077) 是羟基脲的合成衍生物，是一种选择性的5-脂氧合酶抑制剂，具有平喘特性。
TP1168	N-Formyl-Met-Leu-Phe-Lys fMLFK	Others	Others
	N-Formyl-Met-Leu-Phe-Lys (fMLFK) 是一种多肽，是选择性FPR1激动剂，作用于 FPR1(IC50:3.5 nM)，FPR2(IC50:6.7 nM) 和 FPR2-D2817.32G(IC50:0.88 nM) 。
T35336	Furosemide sodium Frusemide Sodium,Lasix	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Furosemide sodium (Frusemide Sodium) 是 Na+/K+/2Cl- (NKCC)，NKCC1 和 NKCC2 共转运蛋白的有效的和具有口服活性抑制剂。Furosemide sodium 也是 GABAA 受体拮抗剂，对含 α6 受体的选择性是含 α1 受体的 100 倍。Furosemide sodium 用作利尿试剂，用于充血性心力衰竭，高血压和水肿的研究。
T0755	Carglumic Acid Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid	Others	Others
	Carglumic Acid (Ureidoglutaric acid) 是一种 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1(CPS1)的活化剂，可用于与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症的研究。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
T31725	Etozolin GO 687,W-2900A,W2900A,GO-687,W 2900A
	Ezozolin (Diulozin, W-2900A) is a diuretic used for the treatment of edema and hypertension.
T33276	Mefruside FDA1902,FDA-1902,FDA 1902,FBA-1500,FBA1500,FBA 1500
	Mefruside is a diuretic indicated for the treatment of edema and hypertension.
T33600	Naxifylline CVT 124,CVT-124,CVT124,BG9719
	Naxifylline is an A1 adenosine receptor antagonist that promotes urine volume to prevent the decline in renal function observed during diuretic therapy for the treatment of edema associated with congestive heart failure.
T27391	FSBA
	FSBA inhibits covalently anthrax edema factor.
T33294	Mercaptomerin sodium Diucardyn sodium,Mercaptomerine sodique,Thiomerin sodium,Letorin
	Mercaptomerin sodium can be used to treat cardiac edema.
T38544	Fasitibant chloride MEN16132 free base,Fasitibant chloride
	Fasitibant chloride (MEN16132 free base) is a powerful and specific nonpeptide antagonist of the bradykinin B2 receptor (B2R). This compound effectively reduces joint pain and mitigates joint edema in a rat model of Carrageenan-induced arthritis.
T24950	VUF-10214 VUF 10214,VUF10214
	VUF-10214 is an H4 receptor-ligand. VUF-10214 has significant anti-inflammatory properties in the carrageenan-induced paw edema model in vivo studies in the rat reveal.
T27670	JNJ-26076713 JNJ26076713
	JNJ-26076713, an orally active alpha V integrin antagonist, represents a potential therapeutic candidate for the treatment of macular edema, age-related macular degeneration, and proliferative diabetic retinopathy.
T33725	Norgestrienone Planor,A-301,A301,Ogyline,A 301
	Nogotrienone is an anabolic steroid with fertility and contraceptive activity that has been studied as a therapeutic agent for hereditary angioneurotic edema.
T27042	Clobenoside Ba-43853,Ba 43853,Ba43853
	Clobenoside is a non-steroidal anti-inflammatory agent. Clobenoside also has an edema-protective effect while not influencing blood pressure nor heart rat and not producing any direct vasoactive effects.
T68926	Indomethacin salicylate
	Indomethacin salicylate is an antiinflammatory drug. It has shown remarkable inhibitory effects on carrageenin edema, ultraviolet erythema and adjuvant arthritis.
T34107	Polythiazide P2525,NSC-108161,NSC 108161,P-2525,NSC108161
	Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.
T61403	Plasma kallikrein-IN-3
	Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].
T33851	Ozolinone W 3282,W3282,W-3282
	Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hypertension and edema often due to cong
T72337	Plasma kallikrein-IN-2
	Plasma kallikrein-IN-2 是一个有效的 plasma kallikrein (PKal)抑制剂，IC50值为 0.1 nM。Plasma kallikrein-IN-2 可用于遗传性血管水肿、糖尿病性黄斑水肿、糖尿病视网膜病变的研究。
T15434	GSK2798745	TRP/TRPV Channel	Membrane transporter/Ion channel
	GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the treatment of pulmonary edema associated with congestive heart failure.
T80502	P4pal10
	P4pal10为PAR4拮抗剂，能在体内抑制凝血酶介导的小鼠血小板聚集，并显著减少Carrageenan引起的水肿及粒细胞浸润。
T61711	COX-2-IN-14
	COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory activity, COX-2-IN-14 effectively reduces ear edema and myeloperoxidase (MPO) activity in mice [1].
T38327	Cryogenine
	Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.2 \|1. Lema, W.J., Blankenship, J.W., and Malone, M.H. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15(2), 161-167 (1986).\|2. Kosersky, D.S., Brown, J.K., and Malon...
T83048	Anti-inflammatory agent 64	ROS Kinase	Tyrosine Kinase/Adaptors
	Anti-inflammatory agent 64（compound 4b）能抑制IL-6和TNF-α的分泌，具备抗氧化及抗炎活性，无论在体内外均有效，能显著减轻足跖水肿。
T78253	Faricimab RG7716	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Faricimab是一种双特异性抗体，针对angiopoietin-2和血管内皮生长因子-A (VEGF-A)。该化合物可应用于糖尿病黄斑水肿(DME)的研究。
T69990	Ruboxistaurin mesylate monohydrate
	Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
T36623	Antileukinate
	Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...
TP1408	Peptide 401
	Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhibits some anti-inflammatory activit
T71893	Clobetasol Propionate-d5
	Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t...
T69244	Betulonaldehyde
	Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively). Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in t...
T68665	Yonkenafil Tunodafil
	Yonkenafil (Tunodafil) 是一种新型PDE5抑制剂，对脑梗塞、神经功能缺损、水肿及梗塞区域神经元损伤具有显著降低效果。通过调节神经发生，Yonkenafil 可改善认知功能，展现出在阿尔茨海默病研究中的潜在价值。
T26447	A 78773 A78773,A-78773
	A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflamma
T76195	Stresscopin-related peptide (human)
	Stresscopin-related peptide (human) 是 2 型 CRH 受体的特异性配体。Stresscopin-related peptide (human) 抑制食物摄入，延迟胃排空，并减少热引起的水肿。Stresscopin-related peptide (human) 在应激后维持体内平衡，可用于应激相关疾病的研究。

化合物

Cat.No: T5102

Synonym: TGN020

Target: Aquaporin, PROTAC Linker

Methyclothiazide

Cat.No: T6581

Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen

Target: Others, Carbonic Anhydrase

Cat.No: T4074

Synonym: GSK872,GSK'872,GSK2399872A

Target: RIP kinase

Cinanserin hydrochloride

Cat.No: T14968

Synonym: SQ 10643

Target: Influenza Virus, 5-HT Receptor

Cat.No: T23333

Synonym: SC 58125,1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑

Target: COX

Cat.No: T21412

Synonym: Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular

Target: COX

Cat.No: T34485

Synonym: LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542

Target: Bradykinin Receptor

Cat.No: T19286

Synonym: UCB 3412

Target: Others

Cat.No: T16950

Synonym: 舒多昔康,4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Target: COX

Cat.No: T8807

Target: Others

Acetazolamide sodium

Cat.No: T60351

Synonym: OT-302 sodium

Target: Carbonic Anhydrase

Cat.No: T36619

Target: Prostaglandin Receptor

Rho-Kinase-IN-1

Cat.No: T12721

Target: ROCK

Cat.No: T36534

Synonym: SDZ 224015

Target: IL Receptor, Caspase

Cat.No: T0477

Synonym: Abbott 64077,齐留通,A 64077

Target: Ferroptosis, Lipoxygenase, COX

N-Formyl-Met-Leu-Phe-Lys

Cat.No: TP1168

Synonym: fMLFK

Target: Others

Furosemide sodium

Cat.No: T35336

Synonym: Frusemide Sodium,Lasix

Target: Na-K-Cl cotransporter

Cat.No: T0755

Synonym: Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid

Target: Others

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Cat.No: T31725

Synonym: GO 687,W-2900A,W2900A,GO-687,W 2900A

Cat.No: T33276

Synonym: FDA1902,FDA-1902,FDA 1902,FBA-1500,FBA1500,FBA 1500

Cat.No: T33600

Synonym: CVT 124,CVT-124,CVT124,BG9719

Cat.No: T27391

Mercaptomerin sodium

Cat.No: T33294

Synonym: Diucardyn sodium,Mercaptomerine sodique,Thiomerin sodium,Letorin

Fasitibant chloride

Cat.No: T38544

Synonym: MEN16132 free base,Fasitibant chloride

Cat.No: T24950

Synonym: VUF 10214,VUF10214

Cat.No: T27670

Synonym: JNJ26076713

Cat.No: T33725

Synonym: Planor,A-301,A301,Ogyline,A 301

Cat.No: T27042

Synonym: Ba-43853,Ba 43853,Ba43853

Indomethacin salicylate

Cat.No: T68926

Cat.No: T34107

Synonym: P2525,NSC-108161,NSC 108161,P-2525,NSC108161

Plasma kallikrein-IN-3

Cat.No: T61403

Cat.No: T33851

Synonym: W 3282,W3282,W-3282

Plasma kallikrein-IN-2

Cat.No: T72337

Cat.No: T15434

Target: TRP/TRPV Channel

Cat.No: T80502

Cat.No: T61711

Cat.No: T38327

Anti-inflammatory agent 64

Cat.No: T83048

Target: ROS Kinase

Cat.No: T78253

Synonym: RG7716

Target: VEGFR

Ruboxistaurin mesylate monohydrate

Cat.No: T69990

Cat.No: T36623

Ethacrynic acid D5

Cat.No: T11240

Target: Others

Cat.No: TP1408

Clobetasol Propionate-d5

Cat.No: T71893

Betulonaldehyde

Cat.No: T69244

Cat.No: T68665

Synonym: Tunodafil

Cat.No: T26447

Synonym: A78773,A-78773

Stresscopin-related peptide (human)

Cat.No: T76195

Cat. No.	Product Name	Target	Signaling Pathways
T5781	taraxasteryl acetate 蒲公英甾醇醋酸酯,醋酸蒲公英酯	Antibacterial	Microbiology/Virology
	Taraxasteryl acetate 是分离自矢状疟原虫中，具有广谱的抗炎活性。它能够改善右旋糖酐、酵母聚糖及花生四烯酸诱导的大鼠后爪水肿。它可用于研究局部炎症。
TN6706	3-demethylcolchicine 3-去甲秋水仙碱,3-去甲基秋水仙碱	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	3-Demethylcolchicine 是一种从金莲花中分离得到的天然产物，对纯化的牛脑微管蛋白的聚合有抑制作用。
T2978	Mogroside V	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Mogroside V 是三萜糖苷，是非糖类甜味剂，甜度比蔗糖甜高300倍。它具有抗氧化，抗糖尿病和抗癌作用。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。
T4S0176	Alnustone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one,桤木酮	Others	Others
	Alnustone ((4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one) 是一种非酚双苯庚烷类化合物，在草药和香料中发现，是姜黄的成分之一，具有抗吐、抗炎作用。
T3S0401	Piceatannol 3'-O-glucoside 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷	Arginase; NO Synthase	Immunology/Inflammation
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分，通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶，抑制Arginase I 和Arginase II，IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压，减少肺间质水肿，从而保护肺损伤。
T0522	Diammonium Glycyrrhizinate 甘草酸二铵,Glycyrrhizin	Dehydrogenase	Metabolism
	Diammonium Glycyrrhizinate (Glycyrrhizin) 是分离自甘草中的化合物，有抗炎作用。
T2798	Esculetin 秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin	Lipoxygenase; Akt; PI3K	Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling
	Esculetin (Cichorigenin) 是主要提取自水曲柳的树皮中的活性成分。它能够抑制PI3K/Akt 途径，阻碍血小板衍生生长因子诱导的气道平滑肌细胞表型转换。它具有抗氧化，抗炎和抗肿瘤的活性。
TN4493	Mannioside A
	Mannioside A has anti-inflammatory activity, inhibits carrageenan-induced paw edema in the rat.
TN4406	Lamiide
	Lamiide has anti-inflammatory activity in carrageenin-induced paw edema test. It shows lipid peroxidation inhibition on rat-brain phospholipid peroxidation.
TN5151	Tomentin
	Tomentin has anti-inflammatory effects, it can inhibit the formation of Î»-carrageenan footpad edema at 58%.
TN1191	16α-Hydroxytrametenolic acid 16 alpha-Hydroxytrametenolic acid	Others	Others
	16 alpha-Hydroxytrametenolic acid can inhibit 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced mouse ear edema.
T40634	Perilla ketone
	Perilla ketone is a naturally occurring xenobiotic compound that undergoes activation by pulmonary P450 cytochrome enzymes within the lung. This activation leads to the manifestation of severe pulmonary damage and the development of diffuse pulmonary edema.
TN4185	Hautriwaic acid
	Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the infl
T21893	Luffariellolide
	Luffariellolide 是人滑膜蛋白磷脂酶A2 (HSF-PLA2) 抑制剂 (IC50=5 μM)。Luffariellolide (ED50=50 μg/耳)可有效抑制佛波酯 (PMA) 引起的耳水肿。
T81975	Kopsininic acid
	Kopsininic acid, 源自Kopsia hainanensis的天然产物，主要用于类风湿性关节炎、咽炎、扁桃体炎和水肿的研究。
TN1080	Kaji-ichigoside F1 蔷薇苷
	Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibite
TN1623	Escin IIB	Others; NOS	Immunology/Inflammation; Others
	Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice.
TN3447	Arjunglucoside I
	Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM.
TN1606	(-)-Epiafzelechin (-)-表阿夫儿茶精,表阿夫儿茶精	COX	Immunology/Inflammation; Neuroscience
	(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on th
T73066	Thielavin B
	Thielavin B为Thielavin terricola产生的前列腺素生物合成抑制剂。该化合物能有效抑制内过氧物酶介导的前列腺素E2合成，并在静脉注射后显著降低大鼠因角叉菜胶引发的水肿。
T81324	Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside
	Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside 是一种从天竺葵属植物中分离的酚类化合物，具有口服活性和抗炎特性，可能在治疗水肿和改善主动脉内皮依赖性舒张损伤方面有应用潜力。
TN3395	Alpinone 3-acetate	IFNAR	Immunology/Inflammation
	Alpinone 3-acetate 具有抗炎作用，可抑制12-O-tetradecanophenol 13-acetate 所致小鼠耳部水肿模型的炎症反应。Alpinone 3-acetate 是Alpinone 衍生物。Alpinone 是一种具有活性的天然化合物，来源于向日葵，具有免疫调节和抗病毒活性。
TN4505	Masticadienolic acid	Others	Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac

天然产物

taraxasteryl acetate

Cat.No: T5781

Synonym: 蒲公英甾醇醋酸酯,醋酸蒲公英酯

Target: Antibacterial

3-demethylcolchicine

Cat.No: TN6706

Synonym: 3-去甲秋水仙碱,3-去甲基秋水仙碱

Target: Reactive Oxygen Species

Cat.No: T2978

Target: AMPK

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Cat.No: T4S0176

Synonym: (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one,桤木酮

Target: Others

Piceatannol 3'-O-glucoside

Cat.No: T3S0401

Synonym: 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷

Target: Arginase, NO Synthase

Diammonium Glycyrrhizinate

Cat.No: T0522

Synonym: 甘草酸二铵,Glycyrrhizin

Target: Dehydrogenase

Cat.No: T2798

Synonym: 秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin

Target: Lipoxygenase, Akt, PI3K

Cat.No: TN4493

Cat.No: TN4406

Cat.No: TN5151

16α-Hydroxytrametenolic acid

Cat.No: TN1191

Synonym: 16 alpha-Hydroxytrametenolic acid

Target: Others

Cat.No: T40634

Hautriwaic acid

Cat.No: TN4185

Luffariellolide

Cat.No: T21893

Kopsininic acid

Cat.No: T81975

Kaji-ichigoside F1

Cat.No: TN1080

Synonym: 蔷薇苷

Cat.No: TN1623

Target: Others, NOS

Arjunglucoside I

Cat.No: TN3447

(-)-Epiafzelechin

Cat.No: TN1606

Synonym: (-)-表阿夫儿茶精,表阿夫儿茶精

Target: COX

Cat.No: T73066

Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside

Cat.No: T81324

Alpinone 3-acetate

Cat.No: TN3395

Target: IFNAR

Masticadienolic acid

Cat.No: TN4505

Target: Others

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