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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23394 |
SR 57227A
SR57227盐酸盐,SR 57227 hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
SR 57227A (SR 57227 hydrochloride) 是一种有效的、具有口服活性和选择性的 5-HT3 受体激动剂,具有穿越血脑屏障的能力和抗抑郁作用。它对大鼠皮质膜和整个 NG 108-15 细胞或其膜上的 5-HT3 受体结合位点的亲和力,IC50在 2.8 至 250 nM 之间。 | |||
T0692 |
Allopurinol
Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇 |
ROS; Xanthine Oxidase | Immunology/Inflammation; Metabolism |
Allopurinol (Zyloric) 是一种黄嘌呤氧化酶(XO)抑制剂,IC50=7.82±0.12 μM。 | |||
T0318 |
Azacyclonol
氮杂环醇,Ataractan,γ-pipradol,MDL 4829,MER 17 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Azacyclonol (MER 17) 是一种中枢神经系统抑制剂,是 Terfenadine 的代谢产物。它是神经节阻滞剂,可用于减少精神病引起的幻觉。 | |||
T6376 |
Allopurinol Sodium
1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol |
ROS | Immunology/Inflammation |
Allopurinol Sodium 是黄嘌呤氧化酶抑制剂,其IC50= 0.2~50 μM。它能够抗利什曼原虫,也可用于研究痛风以及高尿酸血症。 | |||
T78556 |
Antidepressant agent 5
|
Others | Others |
Antidepressant agent 5 是一种具有抗抑郁活性的 7-取代四氢异喹啉衍生物。Antidepressant agent 5 在研究抑郁症方面和木兰花碱作用效果类似,可用于预防和治疗抑郁症疾病。 | |||
T75003 | Antidepressant agent 4 | ||
Antidepressant agent 4为一种口服活性抗抑郁剂,具备抗抑郁、抗焦虑、性能增强以及促智活性。 | |||
T62495 | Antidepressant agent 2 | ||
Antidepressant agent 2 表现出明显的抗抑郁作用,其 MED 值为 0.1 mg/kg。 | |||
T75002 | Antidepressant agent 3 | ||
Antidepressant agent 3, 一种具有口服活性的抗抑郁剂,具备抗抑郁、抗焦虑、性能增强及促智活性。 | |||
T10332 | Antidepressant agent 1 | Others | Others |
Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. It also can be used to increase body temperature. | |||
T11097 |
Drobuline hydrochloride
|
Others | Others |
Drobuline hydrochloride 是一种抗心律失常剂。 | |||
T15812 |
LY2979165
mGlu2 agonist |
GluR | Neuroscience |
LY2979165 (mGlu2 agonist) 是 mGluR2 的正构激动剂,可用于作为抗抑郁药的研究。 | |||
T2990 |
Phenibut
Phenybut,Fenigam,非尼布特,Fenibut,PhGABA,Aminophenylbutyric acid,β-Phenyl-γ-aminobutyric acid |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Phenibut (Aminophenylbutyric acid) 是GABA-B 激动剂,可作为 GABA 类似物,主要作用于 GABAB 受体,具有抗焦虑和增强认知的作用。 | |||
T0235 |
Modaline sulfate
|
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Modaline sulfate 是一种 MAO 抑制剂,用于研究抑郁症。 | |||
T9846 |
5-HT3 antagonist 5
|
||
5-HT3 antagonist 5 是喹喔啉 -2- 甲酰胺化合物,是一种5-HT3受体拮抗剂。5-HT3 antagonist 5 对5-HT3激动剂和2-甲基-5-HT 也具有拮抗作用,并在小鼠中表现出抗抑郁作用。 | |||
T6649 |
(S)-(+)-Rolipram
(S)-Rolipram,(+)-Rolipram,盐酸环胞苷,S- (+)-Rolipram |
Apoptosis; PDE | Apoptosis; Metabolism |
(S)-(+)-Rolipram ((+)-Rolipram) 是一种 cAMP 依赖性磷酸二酯酶 4 (PDE4) 抑制剂,IC50=1100 nM。它能够抑制人单核细胞产生的肿瘤坏死因子 α (TNFα)。 | |||
T1144 |
Lidocaine hydrochloride
Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin |
Apoptosis; ERK; NF-κB; MEK; Sodium Channel | Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB |
Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。 | |||
T1320 |
Disopyramide
Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平 |
Potassium Channel; Sodium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流,延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合,并具有强大的负性肌力作用。 | |||
T23831 |
Bucainide
|
||
Bucainide is an agent of cardiac depressant. | |||
T25344 | Disobutamide | ||
Disobutamide is used as a Cardiac Depressant (Anti-Arrhythmic). | |||
T25756 |
Lorajmine hydrochloride
WIN 11831 |
||
Lorajmine hydrochloride is used as a Cardiac Depressant (Antiarrhythmic). | |||
T32155L | Indecainide hydrochloride | ||
Indecainide hydrochloride is a cardiac depressant. | |||
T23844 |
Butoprozine HCl
L9394,L 9394,Butoprozine hydrochloride,EINECS 263-427-3,L-9394 |
||
Butoprozine HCl is a cardiac depressant agent. | |||
T73342 |
Prenderol
2,2-Diethyl-1,3-propanediol |
||
Prenderol 是一种有效的中枢神经系统抑制剂。Prenderol 具有抗惊厥活性。 | |||
TP1188 |
Cortistatin 14, human, rat
CST-14, human, rat |
||
Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. | |||
T28850 |
SR57227A
SR 57227A,SR-57227A |
||
SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive beh | |||
T70021 |
Oleanolic acid acrylate
|
||
Oleanolic acid acrylate (OAA) is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A and a derivative of oleanolic acid. It is also a selective inhibitor of MAO-A with anti-depressant-like and anxiolytic activities. | |||
T77724 |
OBHSA
Oxabicycloheptane sulfonamide |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
OBHSA(Oxabicycloheptane sulfonamide) 是一种新型选择性雌激素受体降解剂 (SERD),可用于研究乳腺癌。 | |||
T73273 | SERT-IN-2 | ||
SERT-IN-2 是一种强效 SERT 抑制剂 (IC50=0.58 nM),具有抗抑郁活性。SERT-IN-2 的生物利用度好,在大鼠中 F(%) 为 83.28%。SERT-IN-2 能够透过血脑屏障。 | |||
T82385 |
FMF-06-098-1
|
PROTACs | PROTAC |
FMF-06-098-1是一种多靶点蛋白降解剂。通过专一性降解作用,FMF-06-098-1针对多种激酶,能够有效降解AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1及WEE1等关键蛋白。 | |||
T41156 |
MS 39
|
||
MS 39是突变型表皮生长因子受体(EGFR)的高效、高亲和力和选择性降解剂,具有的高效、高亲和力和选择性。MS 39 由吉非替尼通过连接物偶联至 VHL 配体,能有效地诱导突变型 EGFR 的降解(在 HCC827(外显子19 del)和 H3255 (L858R 突变)肺癌细胞系中的 DC50值分别为5 nM 和3.3 nM),但在浓度高达10 μM 的野生型 EGFR 细胞系中无显著作用。MS 39在体外抑制 H3255肺癌细胞的增殖,并且在给药后在小鼠中具有生物利用性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3858 |
macranthoidin A
灰毡毛忍冬皂苷甲,金银花 |
Others | Others |
Macranthoidin A 是一种具有口服活性的、提取于金银花中的皂苷。它对四氯化碳,对乙酰氨基酚和镉所致的肝损伤具有保护作用,对耳巴豆油的溶胀具有明显的抑制作用。 | |||
T4S1519 |
Pseudoginsenoside RT5
拟人参皂苷RT5 |
Others | Others |
Pseudoginsenoside RT5 分离于 Panax quinquefolium 中。它通过促进神经生长和提高认知能力,具有抗癫痫、抗抑郁活性,还具有抗菌、抗肿瘤、抗疟疾等活性。 | |||
T2S2335 |
Dehydroevodiamine
DHED,去氢吴茱萸碱 |
Others; NF-κB; COX; PGE Synthase; NO Synthase | Immunology/Inflammation; Neuroscience; NF-κB; Others |
Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱,可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达,对豚鼠心室肌细胞具有抗心律失常作用。 | |||
TN4322 |
Isopulegol
|
ATPase; Potassium Channel; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper... | |||
TN2084 |
Piperitol
|
Others | Others |
Piperitol has in vitro antioxidant potential, it also exhibits a stronger CNS depressant effect than that of M. rotundifolia. | |||
T2S2363 |
Corydine
|
IL Receptor; Antifection | Immunology/Inflammation; Microbiology/Virology |
Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant and CNS depressant activities. Injected intravenously in rabbits corydine produced an initial |