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45

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25180	Bromodiphenhydramine hydrochloride	Others	Others
	Bromodiphenhydramine hydrochloride 是一种控制皮肤的新型抗组胺药。
T39113L	Povorcitinib phosphate	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Povorcitinib phosphate 是一种选择性 JAK1 抑制剂，可用于治疗皮肤红斑狼疮和扁平苔藓的研究。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T6410	Bexarotene Ro 26-4455,Targretin,蓓萨罗丁,贝沙罗汀,LGD1069	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Bexarotene (LGD1069) 是一种高亲和力的选择性类视黄醇 X 受体 (RXR) 激动剂，对 RXRα、RXRβ和 RXRγ的 EC50分别为 33、24和25 nM。它是一种类视黄醇类似物，用于治疗皮肤 T 细胞淋巴瘤的皮肤表现。
T20444	Hexyl nicotinate AI3 15769,AI3-15769,烟酸己酯,AI315769	Others	Others
	Hexyl nicotinate (AI3 15769) 是一种皮肤血管扩张剂，可用于研究头皮、面部和背部的非免疫性接触性荨麻疹。
T90596	Sivifene	Others	Others
	Sivifene 是一种抗肿瘤化合物。Sivifene 可用于治疗癌症皮肤转移的研究。
T25982	Pramiconazole R-126638,R126638,R 126638,Azoline	Antifungal	Microbiology/Virology
	Pramiconazole (R126638) 是一种可口服的抗真菌化合物。Pramiconazole 是治疗皮肤癣菌和皮肤酵母菌感染的候选化合物，可用于治疗脂溢性皮炎。
T39733	Hu7691 free base
	Hu7691 free base is an orally active, selective Akt inhibitor. It exhibits IC50 values of 4.0 nM, 97.5 nM, and 28 nM for Akt1, Akt2, and Akt3, respectively. Furthermore, it effectively inhibits tumor growth and facilitates a reduction in cutaneous toxicity in mice.
T20802	Flumethasone pivalate Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten	Others	Others
	Flumethasone pivalate (Locorten) 具有止痒、抗炎和血管收缩的特性，可用于肾上腺皮质抑制、皮肤萎缩、血浆转皮质素结合和毛细血管扩张的研究。
T0033	Miltefosine HePC,米替福新,Hexadecyl phosphocholine	Akt; HIV Protease; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Miltefosine (HePC) 是一种广谱抗微生物剂，是治疗内脏和皮肤利什曼病的药物。它是 CTP 磷酸胆碱胞苷基转移酶的抑制剂。
T6665	Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑	Antibiotic; Antifungal	Microbiology/Virology
	Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药，可用于治疗浅表皮肤和粘膜感染。
T16729	Remetinostat SHP-141	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Remetinostat (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶抑制剂，可用于治疗皮肤 T 细胞淋巴瘤的研究。
T77455	Burosumab KRN23	Others	Others
	Burosumab(KRN23) 是一种靶向成纤维细胞生长因子 23 （FGF23）的人单克隆抗体，用于治疗皮肤骨骼低磷血症综合征（CSHS）和肿瘤诱导的骨软化症。
T10295	Amantanium bromide 金刚溴铵,Amantanil bromidum	Others	Others
	Amantanium bromide (Amantanil bromidum) 是一种季铵抗菌/抗真菌剂，可用作手术防腐剂以及粘液和皮肤感染的局部治疗。
T11581	HSR6071	Others	Others
	HSR6071 是一种新型具有口服活性和有效性的抗过敏制剂，能抑制被动皮肤过敏反应 (PCA)。HSR6071 在大鼠实验性哮喘模型中显示出抗哮喘活性。
T17315	(±)-CPSI-1306 cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one	Others	Others
	(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂，可用于关于非胰岛素依赖型糖尿病 (NIDDM) 的研究以及预防急性和慢性 UVB 暴露对皮肤的有害影响。
T12399	Peldesine BCX 34	Nucleoside Antimetabolite/Analog; HIV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖，IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。
T6006	Romidepsin FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Romidepsin (FR 901228) 是一种 HDAC 抑制剂，抑制 HDAC1/2/4/6 (IC50=36/47/510/1400 nM)。Romidepsin 具有抗肿瘤活性，可以用于治疗外周 T 细胞淋巴瘤和皮肤 T 细胞淋巴瘤。
T77491	Prezalumab AMG 557	Others	Others
	Prezalumab (AMG 557) 是一种针对 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 可用于研究干燥综合征皮肤红斑狼疮、银屑病、系统性红斑狼疮关节炎和系统性红斑狼疮 (SLE)。
T76782	Mogamulizumab KW-0761	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的单克隆抗体。Mogamulizumab 具有抗癌活性，通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞，可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。
T67385	Neratinib maleate HKI-272 maleate	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Neratinib maleate (HKI-272 maleate) 是一种不可逆且具有口服活性和高选择性的 HER2 和 EGFR 抑制剂，IC50 值分别为 59 nM 和 92 nM。Neratinib maleate具有抗肿瘤活性，可用于治疗消化系统疾病、呼吸系统疾病、泌尿生殖系统疾病和皮肤和肌肉骨骼疾病，可用于研究乳腺癌和前列腺癌。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T28777	Silicon Phthalocyanine 4 Pc-4,Pc 4,Pc4
	Silicon Phthalocyanine 4 is a drug with anti-cutaneous neoplasms activity.
T29990	Aminoquinol diphosphate
	Aminoquinol diphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.
T29991	Aminoquinol triphosphate Aminochinol triphosphate
	Aminoquinol triphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.
T21035	Rufloxacin MF 934
	Rufloxacin is a drug that belongs to the class of fluoroquinolones, which act mainly as specific inhibitors of bacterial Topoisomerase II. These drugs involve in various diseases including cutaneous reactions, aging, etc.
T13172	TMP780	ROR	Metabolism
	TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T23783	Benzoxonium chloride Bradophen,Bialcol,D 301,D301,Cohortan
	Benzoxonium chloride, The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy.
T39113	Povorcitinib
	Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).
T10528	Bexarotene D4 LGD1069 D4	Others	Others
	Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma.
T40270	MrgprX2 antagonist-1 MrgprX2 antagonist-1
	MrgprX2 antagonist-1, is a novel MrgprX2 antagonist compound. It exhibits potential for exploration in studying cutaneous inflammatory disorders.
T70930	GSK SYK inhibitor
	The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double-blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of the selective SYK inhibitor GSK2646264 in active CLE lesions
T39295	Remlarsen MRG-201
	Remlarsen (MRG-201), a miR-29b mimic, functions as a miR-29b agonist with the potential to prevent the formation of fibrotic scars or cutaneous fibrosis.
T78209	Nedometinib	MEK	MAPK
	Nedometinib是MEK1酪氨酸激酶的抑制剂，具备抗肿瘤活性，适用于皮肤病、皮肤纤维神经瘤和神经纤维瘤病研究。
T38127	pNPS-DHA
	pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019)
T78329	Litifilimab BIIB059
	Litifilimab为一种靶向C型凝集素结构域家族4成员C（CLEC4C）的人源化IgG1-κ抗体，主要用于皮肤红斑狼疮（CLE）研究。
T61013	Bromodiphenhydramine
	Bromodiphenhydramine 具有抗菌活性，可用于皮肤过敏研究。它是一种有效的抗组胺剂，并且可以抑制大量的革兰氏阴性和革兰氏阳性细菌。
T63284	PAD-IN-2
	PAD-IN-2 是 pad4 的有效抑制剂，IC50 值 <1 μM，能够用于研究自身免疫性疾病和癌症，如类风湿性关节炎、血管炎、系统性红斑狼疮、皮肤红斑狼疮、囊性纤维化、溃疡性结肠炎、哮喘、多发性硬化和牛皮癣。
T80744	Zanolimumab Anti-Human CD4 Recombinant Antibody
	Zanolimumab（Anti-HumanCD4Recombinant Antibody）是靶向CD4的人源单克隆抗体，能有效地抑制T细胞受体（TCR）的信号转导。它在类风湿性关节炎、银屑病、黑色素瘤、皮肤及周围T细胞淋巴瘤的研究中有应用。
T70377	BAY 61-3606 HCl
	BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used i...
T35552	Ganglioside GD3 Mixture (sodium salt)
	Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increa...
T72865	Sofnobrutinib AS-0871
	Sofnobrutinib (AS-0871) 是口服有效、选择性的 BTK 抑制剂，抑制激活和未激活BTK 的IC50分别为 4.2 nM 和 0.39 nM。Sofnobrutinib 也抑制hERG，IC50为 24 μM。Sofnobrutinib 具有良好的代谢稳定性和生物利用度。Sofnobrutinib 的被动皮肤过敏反应低，在胶原诱导的小鼠关节炎模型中具有抗炎作用。
T60836	PT4
	PT4 可治疗皮肤利什曼病 (CL) ，它通过降低线粒体膜电位并增加活性氧的产生，从而寄生虫死亡。PT4 对两种利什曼原虫均产生效果，其对L. amazonensis 和L. braziliensis 的 IC50值分别为 125.18 和 233.18 μM。PT4 同时在体内具有有效的抗炎活性。
T60799	Peldesine dihydrochloride
	Peldesine (BCX 34) dihydrochloride 是一种有效的，竞争性，可逆和口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂，对人，大鼠和小鼠红细胞 (RBC)PNP 的 IC50分别为 36 nM，5 nM 和 32 nM。Peldesine dihydrochloride 还是一种 T 细胞 (T-cell) 增殖抑制剂，IC50为 800 nM。Peldesine dihydrochloride 可用于皮肤 T 细胞淋巴瘤，牛皮癣和 HIV 感染的研究。
T80234	SFNGGP-NH2
	SFNGGP-NH2是一种具有生物活性的肽。PAR-3是一种与凝血酶高亲和力结合的受体，其mRNA在人类皮肤肥大细胞中得到表达。研究指出，蛋白酶激活受体（PAR）在瘙痒反应中的作用涉及组胺依赖性及独立途径。虽然PAR-3本身不直接诱发瘙痒，却可能与PAR-4共同促发此症状。它们的共同表达可增强凝血酶的效应，这表明PAR-3单独时不进行跨膜信号传导，而是作为激活PAR-4的协同因子。

化合物

Bromodiphenhydramine hydrochloride

Cat.No: T25180

Target: Others

Povorcitinib phosphate

Cat.No: T39113L

Target: JAK

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T6410

Synonym: Ro 26-4455,Targretin,蓓萨罗丁,贝沙罗汀,LGD1069

Target: Retinoid Receptor, Autophagy

Hexyl nicotinate

Cat.No: T20444

Synonym: AI3 15769,AI3-15769,烟酸己酯,AI315769

Target: Others

Cat.No: T90596

Target: Others

Cat.No: T25982

Synonym: R-126638,R126638,R 126638,Azoline

Target: Antifungal

Hu7691 free base

Cat.No: T39733

Flumethasone pivalate

Cat.No: T20802

Synonym: Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten

Target: Others

Cat.No: T0033

Synonym: HePC,米替福新,Hexadecyl phosphocholine

Target: Akt, HIV Protease, PKC

Sertaconazole nitrate

Cat.No: T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑

Target: Antibiotic, Antifungal

Cat.No: T16729

Synonym: SHP-141

Target: HDAC

Cat.No: T77455

Synonym: KRN23

Target: Others

Amantanium bromide

Cat.No: T10295

Synonym: 金刚溴铵,Amantanil bromidum

Target: Others

Cat.No: T11581

Target: Others

Cat.No: T17315

Synonym: cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

Target: Others

Cat.No: T12399

Synonym: BCX 34

Target: Nucleoside Antimetabolite/Analog, HIV Protease

Cat.No: T6006

Synonym: FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176

Target: Apoptosis, HDAC

Cat.No: T77491

Synonym: AMG 557

Target: Others

Cat.No: T76782

Synonym: KW-0761

Target: CXCR

Neratinib maleate

Cat.No: T67385

Synonym: HKI-272 maleate

Target: EGFR, HER

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Silicon Phthalocyanine 4

Cat.No: T28777

Synonym: Pc-4,Pc 4,Pc4

Aminoquinol diphosphate

Cat.No: T29990

Aminoquinol triphosphate

Cat.No: T29991

Synonym: Aminochinol triphosphate

Cat.No: T21035

Synonym: MF 934

Cat.No: T13172

Target: ROR

Benzoxonium chloride

Cat.No: T23783

Synonym: Bradophen,Bialcol,D 301,D301,Cohortan

Cat.No: T39113

Cat.No: T10528

Synonym: LGD1069 D4

Target: Others

MrgprX2 antagonist-1

Cat.No: T40270

Synonym: MrgprX2 antagonist-1

GSK SYK inhibitor

Cat.No: T70930

Cat.No: T39295

Synonym: MRG-201

Cat.No: T78209

Target: MEK

Cat.No: T38127

Cat.No: T78329

Synonym: BIIB059

Bromodiphenhydramine

Cat.No: T61013

Cat.No: T63284

Cat.No: T80744

Synonym: Anti-Human CD4 Recombinant Antibody

BAY 61-3606 HCl

Cat.No: T70377

Ganglioside GD3 Mixture (sodium salt)

Cat.No: T35552

Cat.No: T72865

Synonym: AS-0871

Cat.No: T60836

Peldesine dihydrochloride

Cat.No: T60799

Cat.No: T80234

Cat. No.	Product Name	Target	Signaling Pathways
T4S0290	Araloside A Chikusetsusaponin IV,竹节参皂苷IV	RAAS; Fas/FasL	Apoptosis; Endocrinology/Hormones
	Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分，对肾素renin 具有低抑制活性(IC50:77.4 μM)。
T0744	10-Undecenoic acid zinc salt Zinc diundec-10-enoate,Zinc 10-undecenoate,Zinc undecylenate,十一烯酸锌	Antibiotic; Antifungal	Microbiology/Virology
	10-Undecenoic acid zinc salt (Zinc undecylenate) 是一种天然的或合成的抗真菌脂肪酸, 在乳膏中可局部用于治疗湿疹、真菌感染、癣和其他皮肤病。锌具有收敛作用。
T82250	Gymconopin C
	Gymconopin C 在小鼠耳部被动皮肤过敏模型中显示出抗过敏活性。
T8001	Aloe vera	Others	Others
	Aloe vera 是一种天然产品，对伤口特别是皮肤伤口的愈合有很好的作用。
T40859	5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen
	5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight.
T82248	Gymnoside I
	Gymnoside I（化合物1）是糖苷氧基苄基2-异丁基苹果酸，其在小鼠被动皮肤过敏反应（PCA）实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。
TN5164	trans-Hinokiresinol	IL Receptor; TNF; NOS; LTR	Apoptosis; Immunology/Inflammation
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen

天然产物

Cat.No: T4S0290

Synonym: Chikusetsusaponin IV,竹节参皂苷IV

Target: RAAS, Fas/FasL

10-Undecenoic acid zinc salt

Cat.No: T0744

Synonym: Zinc diundec-10-enoate,Zinc 10-undecenoate,Zinc undecylenate,十一烯酸锌

Target: Antibiotic, Antifungal

Cat.No: T82250

Cat.No: T8001

Target: Others

5-Hydroxy-8-methoxypsoralen

Cat.No: T40859

Synonym: 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen

Cat.No: T82248

trans-Hinokiresinol

Cat.No: TN5164

Target: IL Receptor, TNF, NOS, LTR

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地址：

上海市静安区江场三路238号8楼