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63

抑制剂 & 化合物

26

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1765	Erastin	Ferroptosis; VDAC	Apoptosis; Membrane transporter/Ion channel
	Erastin 是一种作用于线粒体 VDAC 的铁死亡激活剂，具有 ROS 和铁依赖性。Erastin 具有抗肿瘤活性，选择性作用于 RAS 致癌突变的肿瘤细胞。该产品在溶液中不稳定，建议现配现用。
T3572	NSC 15364 1,3-Bis(4-aminophenyl)urea,NSC15364	Apoptosis; Others; VDAC	Apoptosis; Membrane transporter/Ion channel; Others
	NSC 15364 (1,3-Bis(4-aminophenyl)urea) 是一种 VDAC1寡聚化和细胞凋亡抑制剂。
T18975	DIDS sodium salt 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂],MDL101114ZA	VDAC; ABC	Membrane transporter/Ion channel
	DIDS sodium salt (MDL101114ZA) 是有效的ABCA1和VDAC1双抑制剂。
T6666	Sevelamer Carbonate	Others	Others
	Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂，能有效降低体内血清磷水平，但对体内血清钙、氯水平影响极小，可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。
T17266	Xipamide 希伯胺,Diurexan,Aquaphor	Others	Others
	Xipamide (Diurexan) 是一种磺胺类利尿剂，具有抗高血压特性。Xipamide 可选择性地抑制阴离子交换器。
T16346	NS1652	Chloride channel	Membrane transporter/Ion channel
	NS1652 是可逆阴离子电导抑制剂，在人和小鼠的红细胞中，可以抑制氯离子通道，IC50值为 1.6 μM。
T30908	Chromotrope 2B C.I. Acid Red 176,Chromotrope2B,Chromotrope-2B,铬变素2B,Chromotrope Red 4B	Others	Others
	Chromotrope 2B (C.I. Acid Red 176) 是一种分析试剂，可用于分析测定硼酸及硼酸盐，还可与Chromotrope 2R 合用于产生高度着色的自由基阴离子。
T15233	Endovion NS3728	Chloride channel	Membrane transporter/Ion channel
	Endovion (NS3728) 是阴离子通道抑制剂和 Anoctamin-1 (ANO 1) 通道抑制剂，也是特异性的 VRAC/VSOAC 阻断剂。
TD0105	Sulfobromophthalein disodium salt	Others	Others
	Sulfobromophthalein disodium salt 是一种有机阴离子染料，能够参与药物和代谢物的运输，可用于研究动物组织中表达的多种膜载体。
T3994	Verinurad RDEA3170,维立诺雷	OAT	Membrane transporter/Ion channel
	Verinurad (RDEA3170) 是一种有效的、特异性的URAT1抑制剂，IC50为 25 nM。
T20736	Cryptating agent 222 Cryptate 222,NSC 264495,NSC-264495,NSC264495	Others	Others
	Cryptating agent 222 (NSC-264495) 是穴状配体，与钾镜一起使用以将受阻二锡烯还原为结晶自由基阴离子并与金属阳离子形成配体。
T7575L1	[Sar1, Ile8]-Angiotensin II acetate	RAAS	Endocrinology/Hormones
	[Sar1, Ile8]-Angiotensin II acetate 可激活 NADPH 和 NADH 氧化酶，并刺激血管平滑肌细胞中超氧阴离子的形成。 [Sar1, Ile8]-Angiotensin II acetate 对血管平滑肌有多种作用，包括正常动脉的收缩和培养细胞或病变血管的肥大或增生。
T19023	Lucigenin NSC-151912,L-6868,光泽精	Others	Others
	Lucigenin (NSC-151912) 是化学发光探针，可用于检测内源性产生的超氧阴离子自由基在细胞的存在。
T10979	DCPIB	Potassium Channel; Chloride channel	Membrane transporter/Ion channel
	DCPIB 是选择性可逆体积调节性阴离子通道抑制剂，抑制肿胀激活氯电流，在 CPAE 细胞中，IC50值为 4.1 μM。它能够电压依赖性激活钾离子通道 TREK1 和 TRAAK，抑制 TRESK、TASK1 和 TASK3的 IC50值分别为 0.14、0.95 和 50.72 μM。
T1098	Denatonium benzoate 苯甲地那铵,THS-839	Others	Others
	Denatonium benzoate (THS-839) 是一种已知的最苦的化合物，可作为厌恶剂(苦味剂)，加入到工业酒精、防冻液、咬指甲癖预防、呼吸器面罩配合测试、动物驱虫剂、液体皂和洗发水中，防止不适当的摄取。
T13287	VBIT-4	VDAC	Membrane transporter/Ion channel
	VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂（Kd：17 μM）。 VBIT-4 可用于治疗凋亡相关疾病（如神经退行性疾病和心血管疾病）。
T40795	BNTA	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BNTA 是一种有效的细胞外基质 (ECM) 调节剂。在大鼠关节炎模型中，BNTA 通过诱导超氧化物歧化酶 3 (SOD3) 促进软骨细胞上软骨结构分子的合成和超氧阴离子消除调节软骨生成从而调节关节炎。
T72054	SLC26A3-IN-1	transporter	Metabolism
	SLC26A3-IN-1 是一种阴离子交换蛋白 SLC26A3 的抑制剂，IC50值为340 nM。SLC26A3 属于溶质载体 (SLC) 蛋白，是 SLC26 家族成员之一。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调，参与氯化物和草酸盐的肠道吸收且与氯离子丢失性腹泻有关。
T11528	H100	Others	Others
	H100 is a Cl- transport inhibitor, no effect against KCl cotransporter. It has partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger.
T34817	Tetrabutylphosphonium cation Tetra-n-butylphosphonium,J279H,Tetrabutylphosphonium ion,Tetrabutylphosphonium,Phosphonium, tetrabutyl-
	Tetrabutylphosphonium cation is a light orange solid and is the salt of the liphilic tetrabutylammonium cation and linear tribromide anion.
T0260L	Meclofenamate sodium hydrate INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668
	Meclofenamate sodium is a potent non-steroidal anti-inflammatory agent, which can specifically inhibit chemokine-induced human polymorphonuclear leukocyte function: chemotaxis, degranulation, and superoxide anion free radical production.
T35977	6α-hydroxy Cholesterol 6α-hydroxy Cholesterol,6α-OHC
	6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.[1]
T40926	Beta-D-Glucopyranosyl nitromethane
	Beta-D-Glucopyranosyl nitromethane is a glycosyl derivative of nitromethane, functioning as a salt of a highly basic anion exchanger in the OH cycle.
T82990	AP-C4
	AP-C4是cGMP依赖性蛋白激酶II（cGKII）的抑制剂，具有pIC50值为5.2，但不影响cGKII依赖性阴离子分泌。
T36597	ISPA-28
	ISPA-28 is a specific antagonist of the plasmodial surface anion channel (PSAC). It exerts its antagonistic effects by direct and reversible binding to CLAG3[1][2].
T83027	Antioxidant agent-17
	Antioxidant agent-17（compound 59）是超氧阴离子生成活性的有效抑制剂，表现出低至9.06 nM的IC50值。
T27013	CHS-111 CHS 111
	CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homol
T39205	HKSOX-1
	HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical.
T82550	DIOA
	DIOA是一种高效的酸敏感外向整流(ASOR)阴离子通道的拮抗剂。
T40331	Ftase inhibitor III
	Ftase Inhibitor III, derived from a phenotypic screen, functions as an anion-dependent inhibitor of Farnesyltransferase.
T25140	BCH 2763 BCH2763,BCH-2763
	BCH 2763 is an effective, selective bifunctional thrombin inhibitor that blocks both the anion binding exosite and the active catalytic site.
T20694	DIDS
	DIDS, an anion exchange inhibitor, acts by blocking reversibly and later irreversibly, exchangers such as chloride-bicarbonate exchanger. It is also a RAD51 inhibitor.
T82695	Colestilan MCI-196,Colestimide
	Colestilan (MCI-196)，一种口服活性的非吸收、非钙基磷酸盐粘合剂，同时为非金属阴离子交换树脂，主要应用于高胆固醇血症的研究。
T82988	AP-C7
	AP-C7是一种特异性的cGMP依赖性蛋白激酶II (cGKII) 抑制剂，pIC50值为5.0。该化合物对cGKII依赖的阴离子分泌仅表现出弱抑制作用。
T82992	AP-C1
	AP-C1是一种针对cGMP依赖性蛋白激酶II (cGKII) 的有效抑制剂，具有pIC50值为6.5。此化合物对cGKII所介导的阴离子分泌仅表现出微弱的抑制作用。
T37004	Estradiol 3-sulfate 17β-Glucuronide (potassium salt)
	Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases. Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most com...
T36005	1-Oleoyl-2-Palmitoyl-rac-glycerol
	1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 μM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.
T82991	AP-C3
	AP-C3为cGMP依赖性蛋白激酶II (cGKII) 的有效抑制剂，其pIC50值为6.3。该化合物仅对cGKII依赖性阴离子分泌表现出微弱的抑制作用。
T14150	AKOS-22	Others	Others
	AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis.
T21079	Decafluorobenzophenone Perfluorobenzophenone
	Decafluorobenzophenone is used in the synthesis of fluorinated acridones and acridines. Decafluorobenzophenone alcoholic solution generates radical anion and ketyl which can be studied by electron spin resonance spectra. It undergoes photolysis to form ke
T38645	Acetyl-Hirudin (54-65) (sulfated)
	Acetyl-Hirudin (54-65) (sulfated) directly binds to thrombin-rHCII(L444R) and hinders the interaction between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin, which stabilizes the complex.
T13286	VBIT-3	Others	Others
	VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
T35721	4’-hydroxy Trazodone
	4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is selective for OAT3 over OAT1 (Ki= >200 μM).2 1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites poten...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...
T73936	HKSOX-1 (5/6-mixture)
	HKSOX-1 是一种荧光探针，用于成像和检测活细胞以及体内的内源性超氧化物。 HKSOX-1 对超氧阴离子自由基具有极好的选择性和敏感性。储存方式：避光。
T30694	Calcium phosphate, dibasic Calcium hydrogen phosphate,Calcium hydrogenorthophosphate
	Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. It is al
T36516	RC574 RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor ...
T27275	Epaminurad
	Epaminurad (UR-1102) 是一种口服有效的和选择性的URAT1(尿酸转运体 1) 抑制剂，其Ki 为 0.057 μM。Epaminurad 适度地抑制OAT1和OAT3(有机阴离子转运体)。Epaminurad 是一种促尿酸排泄剂。Epaminurad 可用于痛风和高尿酸血症的研究。
T36746	Leoidin
	Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM...
T74815	SLC26A3-IN-2
	SLC26A3-IN-2 是一种口服有效的阴离子交换蛋白 SLC26A3的抑制剂 (IC50=360 nM)。SLC26A3 属于溶质载体 (SLC) 蛋白，属于 SLC26 家族。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调，参与氯化物和草酸盐的肠道吸收。SLC26A3 功能突变的丧失与氯离子丢失性腹泻有关。

化合物

Cat.No: T1765

Target: Ferroptosis, VDAC

Cat.No: T3572

Synonym: 1,3-Bis(4-aminophenyl)urea,NSC15364

Target: Apoptosis, Others, VDAC

DIDS sodium salt

Cat.No: T18975

Synonym: 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂],MDL101114ZA

Target: VDAC, ABC

Sevelamer Carbonate

Cat.No: T6666

Target: Others

Cat.No: T17266

Synonym: 希伯胺,Diurexan,Aquaphor

Target: Others

Cat.No: T16346

Target: Chloride channel

Cat.No: T30908

Synonym: C.I. Acid Red 176,Chromotrope2B,Chromotrope-2B,铬变素2B,Chromotrope Red 4B

Target: Others

Cat.No: T15233

Synonym: NS3728

Target: Chloride channel

Sulfobromophthalein disodium salt

Cat.No: TD0105

Target: Others

Cat.No: T3994

Synonym: RDEA3170,维立诺雷

Target: OAT

Cryptating agent 222

Cat.No: T20736

Synonym: Cryptate 222,NSC 264495,NSC-264495,NSC264495

Target: Others

[Sar1, Ile8]-Angiotensin II acetate

Cat.No: T7575L1

Target: RAAS

Cat.No: T19023

Synonym: NSC-151912,L-6868,光泽精

Target: Others

Cat.No: T10979

Target: Potassium Channel, Chloride channel

Denatonium benzoate

Cat.No: T1098

Synonym: 苯甲地那铵,THS-839

Target: Others

Cat.No: T13287

Target: VDAC

Cat.No: T40795

Target: Reactive Oxygen Species

Cat.No: T72054

Target: transporter

Cat.No: T11528

Target: Others

Tetrabutylphosphonium cation

Cat.No: T34817

Synonym: Tetra-n-butylphosphonium,J279H,Tetrabutylphosphonium ion,Tetrabutylphosphonium,Phosphonium, tetrabutyl-

Meclofenamate sodium hydrate

Cat.No: T0260L

Synonym: INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668

6α-hydroxy Cholesterol

Cat.No: T35977

Synonym: 6α-hydroxy Cholesterol,6α-OHC

Beta-D-Glucopyranosyl nitromethane

Cat.No: T40926

Cat.No: T82990

Cat.No: T36597

Antioxidant agent-17

Cat.No: T83027

Cat.No: T27013

Synonym: CHS 111

Cat.No: T39205

Cat.No: T82550

Ftase inhibitor III

Cat.No: T40331

Cat.No: T25140

Synonym: BCH2763,BCH-2763

Cat.No: T20694

Cat.No: T82695

Synonym: MCI-196,Colestimide

Cat.No: T82988

Cat.No: T82992

Estradiol 3-sulfate 17β-Glucuronide (potassium salt)

Cat.No: T37004

1-Oleoyl-2-Palmitoyl-rac-glycerol

Cat.No: T36005

Cat.No: T82991

Cat.No: T14150

Target: Others

Decafluorobenzophenone

Cat.No: T21079

Synonym: Perfluorobenzophenone

Acetyl-Hirudin (54-65) (sulfated)

Cat.No: T38645

Cat.No: T13286

Target: Others

4’-hydroxy Trazodone

Cat.No: T35721

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

HKSOX-1 (5/6-mixture)

Cat.No: T73936

Calcium phosphate, dibasic

Cat.No: T30694

Synonym: Calcium hydrogen phosphate,Calcium hydrogenorthophosphate

Cat.No: T36516

Synonym: RC574

Cat.No: T27275

Cat.No: T36746

Cat.No: T74815

Cat. No.	Product Name	Target	Signaling Pathways
T19866	Indican NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside	OAT; MRP	Immunology/Inflammation; Membrane transporter/Ion channel
	Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷，染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中 IS 是尿毒症毒素，是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。
T8033	Sodium Thiocyanate	Others; Reactive Oxygen Species; Interleukin	Immunology/Inflammation; Metabolism; NF-κB; Others
	Sodium thiocyanate 能够减少促炎细胞因子 IL-6水平，并增强抗炎细胞因子 IL-10水平，并显著减少 ROS 形成。
T5567	Tetradecanedioic acid 十四烷二酸,Tetradecanedicarboxylate	Others; Endogenous Metabolite	Metabolism; Others
	Tetradecanedioic acid (Tetradecanedicarboxylate) 是一种长链脂肪酸，属于内源性代谢物的一种。它能够作为有机阴离子转运多肽介导的药物-药物相互作用的候选生物标志物。
T19081	1,3-Dithiane 1,3-Dithian,M-DITHIANE,1,3-Dithiacyclohexane,1,3-二噻烷	Anti-infection; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	1,3-Dithiane (1,3-Dithian) 是一种受保护的甲醛阴离子等价物，可用作有用的标记合成子。它是在煮熟的牛肉提取物中发现的含硫美拉德反应产物。
TN1035	Irisolidone 尼泊尔鸢尾异黄酮,葛花苷元	IL Receptor; NF-κB; Chloride channel	Immunology/Inflammation; Membrane transporter/Ion channel; NF-κB
	Irisolidone 是葛根花中的一种异黄酮，具有较强的保肝活性。它是一种有效的体积调节阴离子通道 (VRAC) 电流抑制剂，有高效阻断作用，IC50 为 5-13 μM。
T2911	Stevioside 甜菊苷,蛇菊苷	TLR	Immunology/Inflammation
	Stevioside 是一种天然甜味剂，从甜叶菊叶中提取的获得，具有抗癌作用。
T5S1897	Linderalactone	Apoptosis; Others; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯，通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。
T20113	D-(+)-Malic acid (R)-Malic acid,Malic acid, D-,D-(+)-苹果酸,D-Malic acid	Others	Others
	D-(+)-Malic acid ((R)-Malic acid) 一种是Malic acid 活性异构体，是竞争性的 L(--)malic acid 转运的抑制剂。
TN2286	Tsugaric acid A	NO Synthase	Immunology/Inflammation
	Tsugaric acid A 能够显著抑制超氧阴离子的形成，还可以保护人类角质形成细胞，使其免受紫外线 B 诱导的损害。
T36857	Estrone sulfate sodium 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate	Endogenous Metabolite	Metabolism
	Estrone sulfate sodium (17β-Estrone 3-sulfate) 是一种主要的循环血浆雌激素，无生物活性，通过类固醇硫酸酯酶(STS) 转化为生物活性雌激素雌酮。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T5S0281	Tubuloside A	NOS	Immunology/Inflammation
	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
TJS0315	4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。
TN3069	4beta-Carboxy-19-nortotarol	NADPH-oxidase	Immunology/Inflammation
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.
T38805	Euphol acetate
	Euphol acetate, a triterpene found in Euphorbia broteri, has demonstrated inhibitory effects on the hepatic transport proteins known as organic anion-transporting polypeptide 1/3 (OATP1B1/3).
TN4214	Hispanone
	Hispanone possesses anti-inflammatory activity, it shows inhibition of superoxide anion generation and elastase release.
TN2888	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid	Others	Others
	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.
TN5156	Totaradiol	NADPH-oxidase	Immunology/Inflammation
	Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line.
TN1503	Cistanoside F 肉苁蓉苷F,肉苁蓉苷 F	NADPH-oxidase	Immunology/Inflammation
	Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).
T79946	Isorabaichromone	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Isorabaichromone 为强效抗氧化剂，能有效清除 DPPH 自由基及超氧阴离子。
TN3744	Cyclomorusin	NOS; AChR	Immunology/Inflammation; Neuroscience
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin , neocyclomorusin
TN4437	Licorisoflavan A	MMP; IL Receptor; NF-κB; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; NF-κB; Proteases/Proteasome
	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.L
T75619	Aristololactam IIIa
	Aristololactam IIIa 对超氧阴离子生成和弹性蛋白酶的释放有显著抑制作用，其 IC50值分别为 0.12 和 0.20 μg/mL。
TN2973	3'-O-Methylmurraol
	3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB).
TN2408	Evofolin B	Cannabinoid Receptor	GPCR/G Protein
	Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B（fMLP/CB）产生的超氧阴离子有抑制作用。
T82724	Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside
	Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside为一种从Rheum undulatum L. 分离得到的蒽醌类葡萄糖苷，具备显著的DPPH自由基与?O2-清除作用。

天然产物

Cat.No: T19866

Synonym: NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside

Target: OAT, MRP

Sodium Thiocyanate

Cat.No: T8033

Target: Others, Reactive Oxygen Species, Interleukin

Tetradecanedioic acid

Cat.No: T5567

Synonym: 十四烷二酸,Tetradecanedicarboxylate

Target: Others, Endogenous Metabolite

Cat.No: T19081

Synonym: 1,3-Dithian,M-DITHIANE,1,3-Dithiacyclohexane,1,3-二噻烷

Target: Anti-infection, Endogenous Metabolite, Antibacterial

Cat.No: TN1035

Synonym: 尼泊尔鸢尾异黄酮,葛花苷元

Target: IL Receptor, NF-κB, Chloride channel

Cat.No: T2911

Synonym: 甜菊苷,蛇菊苷

Target: TLR

Cat.No: T5S1897

Target: Apoptosis, Others, JAK

D-(+)-Malic acid

Cat.No: T20113

Synonym: (R)-Malic acid,Malic acid, D-,D-(+)-苹果酸,D-Malic acid

Target: Others

Tsugaric acid A

Cat.No: TN2286

Target: NO Synthase

Estrone sulfate sodium

Cat.No: T36857

Synonym: 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate

Target: Endogenous Metabolite

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T5S0281

Target: NOS

4-Methyldaphnetin

Cat.No: TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素

Target: Apoptosis, Lipoxygenase

4beta-Carboxy-19-nortotarol

Cat.No: TN3069

Target: NADPH-oxidase

Cat.No: T38805

Cat.No: TN4214

3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid

Cat.No: TN2888

Target: Others

Cat.No: TN5156

Target: NADPH-oxidase

Cat.No: TN1503

Synonym: 肉苁蓉苷F,肉苁蓉苷 F

Target: NADPH-oxidase

Isorabaichromone

Cat.No: T79946

Target: Reactive Oxygen Species

Cat.No: TN3744

Target: NOS, AChR

Licorisoflavan A

Cat.No: TN4437

Target: MMP, IL Receptor, NF-κB, DNA/RNA Synthesis

Aristololactam IIIa

Cat.No: T75619

3'-O-Methylmurraol

Cat.No: TN2973

Cat.No: TN2408

Target: Cannabinoid Receptor

Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside

Cat.No: T82724

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