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Search Results for " angina "

49

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T21454	Nicardipine Cardene,Dagan,尼卡地平,Antagonil,Flusemide	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Nicardipine (Cardene) 是一种二氢吡啶类钙通道阻滞剂，可阻断心脏钙通道，IC50为 1 μM，可用于治疗心绞痛和高血压。
T6551	Isosorbide Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide	Others	Others
	Isosorbide (Devicoran) 是一种血管舒张剂，也是一种高渗利尿剂，口服具有活性。可用于研究心力衰竭和心绞痛(胸痛)。
T20656	Verapamil NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil (CP-16533-1) 是一种钙通道阻滞剂，是一种口服有效的 P-gp 抑制剂。Verapamil 抑制 CYP3A4，可用于治疗高血压、心律失常和心绞痛的研究。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T1010	Verapamil hydrochloride Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
T11148	Ecastolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ecastolol 是一种 beta adrenergic receptor 拮抗剂，具有防心绞痛的作用。
T35161	Xemilofiban SC-54684A,SC54684A,SC 54684A	Others	Others
	Xemilofiban (SC 54684A) 可中断血小板聚集，可促进血栓形成，可用于研究不稳定型心绞痛。
T27808	Lefradafiban BIBU 104,BIBU104,BIBU-104	Others	Others
	Lefradafiban（BIBU-104）是一种口服血小板糖蛋白 IIb/IIIa 受体拮抗剂，可用于研究心绞痛和急性冠状动脉综合症。
T34648	Sinitrodil ITF296,ITF-296,ITF 296	Guanylate cyclase	GPCR/G Protein
	Sinitrodil (ITF-296) 是一种鸟苷酸环化酶兴奋剂，可用于治疗心肌缺血和心绞痛。
T1479	Isosorbide dinitrate 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others; NO Synthase	Immunology/Inflammation; Others
	Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。
T13154	Tiapamil hydrochloride Ro 11-1781 hydrochloride,ORE 5002 hydrochloride	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Tiapamil hydrochloride (Ro 11-1781 hydrochloride) 是一种钙通道阻滞剂，具有抗高血压活性，可用于研究心绞痛和心血管疾病。
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T68060	Elgodipine
	Elgodipine 显著降低了运动诱导的心绞痛系统的发生率和严重程度，能够通过独立于转录因子c-fos 和c-jun 表达的机制抑制血管平滑肌增殖。 Elgodipine 诱导的抑制是电压依赖性的。Elgodipine 是治疗心绞痛的潜在化合物。
T8143	Bevantolol hydrochloride 贝凡洛尔盐酸盐,NC-1400 hydrochloride,盐酸贝凡洛尔	Calcium Channel; Adrenergic Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Bevantolol hydrochloride (NC-1400 hydrochloride) 是一种 β1-肾上腺素受体拮抗剂，可治疗心绞痛和高血压，在大鼠大脑皮层中的pKi 值分别为 7.83、6.9。
T30586L	Brefonalol HCl Brefonalol HCl(103880-26-8 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brefonalol HCl 是一种 ADRA 拮抗剂，可用于治疗神经系统疾病和心血管疾病，可用于研究心绞痛、心律失常和高血压。
T68073	Flosatidil	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Flosatidil是一种小分子电压门控性钙通道复合体(VDCCs)阻滞剂，可用于治疗神经系统疾病和心血管疾病，可用于研究心绞痛。
T6633	Ranolazine 雷诺嗪,CVT 303,Ranexa,RS 43285-003	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ranolazine (RS 43285-003) 具有抗心绞痛和抗缺血的功效，通过抑制内向钠电流的后期作用 (对INa 和IKr 的IC50值分别为 6 μM 和 12 μM) 发挥作用，而不会影响心率或血压。Ranolazine 还是脂肪酸氧化 (FAO) 的部分抑制剂。
T0988	Trimetazidine dihydrochloride 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F	Autophagy; Fatty Acid Synthase	Autophagy; Metabolism
	Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂，也用作缺血性心脏病或心绞痛的血管扩张剂，具有抗氧化，抗炎，抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
T0230	Prasugrel LY640315,CS-747,普拉格雷,PCR 4099	P2Y Receptor	GPCR/G Protein; Neuroscience
	Prasugrel (CS-747) 是一种噻吩吡啶和前药，是一种可口服的 P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。
T1282	Carteolol hydrochloride Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。
T50077	m-Nisoldipine 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	Others	Others
	m-Nisoldipine (3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) 是一种二氢吡啶类钙通道阻滞剂，尼索地平的衍生物，阻断心脏和平滑肌细胞中的 L-型钙通道，用于治疗高血压和心绞痛。
T36665	Dehydro Nifedipine BAY-b 4759
	Dehydro Nifedipine (BAY-b 4759) 是人血浆中硝苯地平的主要代谢物。Dehydro Nifedipine 抑制PC-12细胞葡萄糖摄取，IC50值为130 μM，硝苯地平是一种钙通道阻滞剂，用于治疗高血压和心绞痛。当硝苯地平被细胞色素P450 (CYP)异构体CYP3A4和CYP3A5代谢时形成脱氢硝苯地平。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T24873	TGX-115 TGX 115	PI3K	PI3K/Akt/mTOR signaling
	TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM），是一种调节血小板粘附过程的酶，可抑制磷酸肌苷（PI）3-激酶，可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病。
T28191	NP-252 NP252
	NP-252 is a calcium channel antagonist potentially for the treatment of angina pectoris and congestive heart failure.
T28800	SL-870495 SL870495
	SL-870495, a calcium channel antagonist, is used potentially for the treatment of angina pectoris.
T25575	KF 14124 KF14124,Dptpp-2-ismn,KF-14124
	KF 14124 exhibits potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats).
T28457	Proxodolol hydrochloride
	Proxodolol, a β-adrenergic receptor antagonist, is used potentially for the treatment of glaucoma, hypertension and angina.
T68213	Palonidipine HCl
	Palonidipine HCl is a calcium channel antagonist potentially for the treatment of angina pectoris and hypertension.
T8663L	Nifenalol
	Nifenalol is an adrenergic beta-blocker with good antiarrhythmic properties. It tends to lower blood pressure and provide protection against angina.
T69494	Toliprolol
	Toliprolol is an adrenergic receptor antagonist with some stimulant action; it has been proposed for angina pectoris.
T21010	Diacetolol Acetylacebutolol,(+-)-Diacetolol,M and B 16942
	Diacetolol is the major metabolite of acebutolol, a selective beta blockers used to treat hypertension, angina pectoris and arrhythmia.
T27197	Dopropidil hydrochloride ORG-30701,CERM-4205,CERM4205,ORG30701
	Dopropidil, a calcium channel antagonist, is used potentially for the treatment of arrhymia and angina pectoris.
T12358	Palonidipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Palonidipine is an antagonist of calcium, is potential for the therapy of angina-pectoris and hypertension.
T24659	Prenylamine lactate Agozol,Angormin
	Prenylamine lactate is a drug formerly used in the treatment of angina pectoris. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity.
T11080	Dopropidil	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models.
T32770	Linsidomine CV 664
	Lincydomine is a smooth muscle relaxant, beneficial to the treatment of unstable angina pectoris, but also can open the respiratory tract of humans and guinea pigs.
T33673	Niludipine Niludipina,BAY-a 7168,Bay a 7168,Niludipinum
	Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug
T61138	Bevantolol
	Bevantolol, a selective β-1 adrenoceptor antagonist, is utilized for the investigation of angina pectoris and hypertension [1].
T24631	Pheniprazine hydrochloride Pheniprazine HCl,NSC 17766,CCRIS 1417,NSC-17766,NSC17766
	Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor of the hydrazine chemical class. It was also used in the treatment of angina pectoris and schizophrenia.
T24863	Tedisamil Tedisamilum,Pulzium
	Tedisamil is a blocker of K+ currents in cardiac tissues, exerts bradycardic effects. It is an antiarrhythmic drug with predominantly class III activity. It has shown clinical efficacy in angina pectoris.
T71583	Amlodipine hydrochloride, (R)-
	Amlodipine hydrochloride, (R)-, is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina.
T68367	Amlodipine orotate
	Amlodipine orotate is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina.
T0112L	Diltiazem Diltiazem free base,Dilticard,地尔硫卓,CRD-401,CRD401,Dilzen,CRD 401
	Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is used to treat hypertension, angina pec
T10229	Acebutolol D7	Others	Others
	Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, hypertension, and cardiac arrhythmias.
T62909	SGC agonist 2
	SGC agonist 2 是一种有效的可溶性鸟苷酸环化酶 (SGC) 激动剂。其中可溶性鸟苷酸环化酶是 NO-sGC-cGMP 信号通路中的关键信号转导酶。SGC agonist 2 具有潜力进行心血管疾病 (心力衰竭、心绞痛、肺动脉高压、心肌梗塞) 和纤维化疾病 (肾纤维化、系统性硬化症) 的研究。
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...

化合物

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T21454

Synonym: Cardene,Dagan,尼卡地平,Antagonil,Flusemide

Target: Calcium Channel

Cat.No: T6551

Synonym: Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide

Target: Others

Cat.No: T20656

Synonym: NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Verapamil hydrochloride

Cat.No: T1010

Synonym: Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Cat.No: T11148

Target: Adrenergic Receptor

Cat.No: T35161

Synonym: SC-54684A,SC54684A,SC 54684A

Target: Others

Cat.No: T27808

Synonym: BIBU 104,BIBU104,BIBU-104

Target: Others

Cat.No: T34648

Synonym: ITF296,ITF-296,ITF 296

Target: Guanylate cyclase

Isosorbide dinitrate

Cat.No: T1479

Synonym: 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

Tiapamil hydrochloride

Cat.No: T13154

Synonym: Ro 11-1781 hydrochloride,ORE 5002 hydrochloride

Target: Calcium Channel

Cat.No: T8580

Target: Adrenergic Receptor

Cat.No: T68060

Bevantolol hydrochloride

Cat.No: T8143

Synonym: 贝凡洛尔盐酸盐,NC-1400 hydrochloride,盐酸贝凡洛尔

Target: Calcium Channel, Adrenergic Receptor

Cat.No: T30586L

Synonym: Brefonalol HCl(103880-26-8 Free base)

Target: Adrenergic Receptor

Cat.No: T68073

Target: Calcium Channel

Cat.No: T6633

Synonym: 雷诺嗪,CVT 303,Ranexa,RS 43285-003

Target: Calcium Channel, Sodium Channel

Trimetazidine dihydrochloride

Cat.No: T0988

Synonym: 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F

Target: Autophagy, Fatty Acid Synthase

Cat.No: T0230

Synonym: LY640315,CS-747,普拉格雷,PCR 4099

Target: P2Y Receptor

Carteolol hydrochloride

Cat.No: T1282

Synonym: Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan

Target: Adrenergic Receptor

Cat.No: T50077

Synonym: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Target: Others

Dehydro Nifedipine

Cat.No: T36665

Synonym: BAY-b 4759

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Cat.No: T24873

Synonym: TGX 115

Target: PI3K

Cat.No: T28191

Synonym: NP252

Cat.No: T28800

Synonym: SL870495

Cat.No: T25575

Synonym: KF14124,Dptpp-2-ismn,KF-14124

Proxodolol hydrochloride

Cat.No: T28457

Palonidipine HCl

Cat.No: T68213

Cat.No: T8663L

Cat.No: T69494

Cat.No: T21010

Synonym: Acetylacebutolol,(+-)-Diacetolol,M and B 16942

Dopropidil hydrochloride

Cat.No: T27197

Synonym: ORG-30701,CERM-4205,CERM4205,ORG30701

Cat.No: T12358

Target: Calcium Channel

Prenylamine lactate

Cat.No: T24659

Synonym: Agozol,Angormin

Cat.No: T11080

Target: Calcium Channel

Cat.No: T32770

Synonym: CV 664

Cat.No: T33673

Synonym: Niludipina,BAY-a 7168,Bay a 7168,Niludipinum

Cat.No: T61138

Pheniprazine hydrochloride

Cat.No: T24631

Synonym: Pheniprazine HCl,NSC 17766,CCRIS 1417,NSC-17766,NSC17766

Cat.No: T24863

Synonym: Tedisamilum,Pulzium

Amlodipine hydrochloride, (R)-

Cat.No: T71583

Amlodipine orotate

Cat.No: T68367

Cat.No: T0112L

Synonym: Diltiazem free base,Dilticard,地尔硫卓,CRD-401,CRD401,Dilzen,CRD 401

Cat.No: T10229

Target: Others

Cat.No: T62909

Cat.No: T71402

Cat. No.	Product Name	Target	Signaling Pathways
T3S0128	Hydroprotopine 氢化原阿片碱,氢化物碱	Others	Others
	Hydroprotopine 是一种来自Hypecoum leptocarpumand 的生物碱，能够有效的治疗冠心病及心绞痛。
TN2303	Viscumneoside III 槲寄生新甙III,槲寄生新苷III	Tyrosinase	Proteases/Proteasome
	Viscumneoside III 是一种二氢黄酮 O-糖苷，抑制酪氨酸酶 (tyrosinase)，IC50 为 0.5 mM。Viscumneoside III 具有抗心绞痛作用。
TN4323	Isorauhimbine	Antibiotic	Microbiology/Virology
	Isorauhimbine 是一种从萝芙藤 (R. serpentina) 中提取得到生物碱，具有抗癌、抗炎和抗菌活性，可用于治疗高血压、心律失常和心绞痛等心血管疾病。

天然产物

Cat.No: T3S0128

Synonym: 氢化原阿片碱,氢化物碱

Target: Others

Viscumneoside III

Cat.No: TN2303

Synonym: 槲寄生新甙III,槲寄生新苷III

Target: Tyrosinase

Cat.No: TN4323

Target: Antibiotic

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