Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models. |
体外活性 | In the calcium-free medium (IC50 = 30.0 uM), dopredil can inhibit caffeine-induced contraction of rabbit renal arteries. Dopredil inhibits norepinephrine (NE)-induced responses with IC50 of 2.7 and 29.8 uM, respectively. At 3 μM and 10 μM, dopredil significantly reduced the maximum increase in diastolic pressure caused by veratrine (IC50 = 2.8 μM). |
体内活性 | Dopamine (1 and 2.5 mg/kg) dose-dependently reduced electrical (ST segment elevation), biochemical (lactate production and potassium release) and mechanical (myocardial segment contractility loss) disturbances caused by ischemia in anesthetized dogs. Intraduodenal administration of dopredil (50 mg/kg) can significantly reduce tachycardia caused by isoproterenol. This effect is evident between 15 and 120 minutes after application of the compound, indicating rapid absorption and long duration of action. In awake dogs, doprodil (12-14 mg/kg p.o.) can reduce the resting heart rate by about 10 beats/minute. |
分子量 | 321.5 |
分子式 | C20H35NO2 |
CAS No. | 79700-61-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dopropidil 79700-61-1 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor inhibitor inhibit