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69

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T74282	HIV-IN-2
	HIV-IN-2 (Compound 100) 是一种有效的HIV 抑制剂。HIV-IN-2 具有研究HIV 感染的潜力。
T63949	HIV-1 protease-IN-2
	HIV-1 protease-IN-2 是 HIV-1 protease 的有效抑制剂 (IC50: 2.53 nM)。HIV-1 protease-IN-2 对 DRV (达芦那韦)敏感或耐药性 HIV-1 突变体均表现出抗病毒效果。
T6420	BMS-707035 N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	BMS707035是一种 HIV-1 整合酶抑制剂，IC50为15 nM。
T7779	Nelfinavir AG1341,甲磺酸萘非那韦	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Nelfinavir (AG1341) 是一种口服活性的 HIV-1 蛋白酶抑制剂，用于抑制 HIV 感染,是一种广谱抗癌剂。
T67797	DDG-39 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine	Antiviral; HBV; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。
T28946	Tenofovir exalidex Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157	Antiviral	Immunology/Inflammation
	Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物，对野生型和抗逆转录病毒耐药的 HIV 毒株，包括多药核苷/核苷酸类似物耐药病毒，都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性，EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性，无明显毒性。Tenofovir exalidex 对 HBV 也有活性。
T14313	Apricitabine AVX754,SPD754	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM)，是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用，Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果，具有良好的耐受性和较低的选择性抗性。
T23910	Cosalane NSC 658586,NSC-658586,NSC 640067	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cosalane (NSC 658586) 是一种 HIV 复制抑制剂，是人和小鼠趋化因子受体 7 （CCR7）信号传导的抑制剂，具有抗病毒活性，可阻断 CCR7 与其天然配体 CCL19 和 CCL21 结合。Cosalane 对多种 HIV-1 株系和 HIV-2 具有活性。
T0682	Lamivudine GR109714X,BCH-189,拉米夫定	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂，可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
T0781	Dimercaprol Dicaptol,二巯丙醇,Dithiopropanol,二巯基丙醇	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Dimercaprol (Dicaptol) 是一种具有抗HIV 活性的重金属中毒解毒剂。
TQ0297	Cenicriviroc TAK-652,TBR-652	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Cenicriviroc (TAK-652) 是一种可口服的CCR2/CCR5拮抗剂，可抑制 HIV-1 和 HIV-2，具有抗炎、抗感染作用。
T7208	AMD 3465 hexahydrobromide GENZ-644494 (hexahydrobromide)	HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂，具有潜在的抗癌和抗 HIV 活性。
T3614	Inosine pranobex Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun	IL Receptor; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Inosine pranobex (Delimmun) 是一种免疫增强剂，它是一种广谱抗病毒剂，用于 HIV 感染。
T15776	Loviride R 89439	Others	Others
	Loviride is a non-nucleoside reverse transcriptase inhibitor (IC50: 0.3 µM). Loviride inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. It is used for reverse transcriptase from HIV-1.
T76537	GP120, HIV-1 MN
	GP120，HIV-1MN 是一种肽。GP120,HIV-1MN 可用于 HIV 感染的研究。
T29393	3'-Deoxy-4-thiothymidine Thymidine, 3'-deoxy-4-thio-,Ddthds
	3'-Deoxy-4-thiothymidine can moderately active in protecting HIV-induced cytopathogenicity of MT-2 and CEM cells.
T60714	gp120-IN-2
	gp120-IN-2 (compound 4i) 显示出抗 HIV-1 活性。它是 HIV-1 gp120的有效抑制剂，IC50值为 7.5 μM，CC50值为 112.93 μM。gp120-IN-2 在癌细胞 SUP-T1 中表现出剂量依赖性的细胞毒性。
T10141	4'-Ethynyl-2'-deoxyadenosine	Others	Others
	4'-Ethynyl-2'-deoxyadenosine (4'-E-dA) is a nucleoside reverse transcriptase (RT) inhibitor. It is potent against drug-resistant HIV variants (EC50: 98 nM in MT-4 cells for anti-HIV-1 activity).
T74487	AL-470
	AL-470 是一个有效的抗病毒剂，对HIV-1、HIV-2、EV-A71的EC50值分别为0.27、0.63 和 0.35 µM。
T69582	AMD-3451 free base
	AMD-3451 free base is a dual CCR5/CXCR4 antagonist which may be useful in the treatment of a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2. AMD3451 is the first low-molecular-weight anti-HIV agent with selective HIV coreceptor, CCR5 and CXCR4, interaction.
T60342	HIV-1 inhibitor-47
	HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3].
T78551	Glycolithocholic acid 3-sulfate disodium Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium
	Glycolithocholic acid 3-sulfate (disodium) 是抑制HIV-1复制的化合物，同时它也被用于HIV感染和胆囊疾病的研究。
T72162	HIV-1 integrase inhibitor 10
	HIV-1integrase inhibitor 10 是一种 HIV-1变构整合酶抑制剂 (ALLINI)，具有口服活性。HIV-1integrase inhibitor 10 可抑制 NLRepRluc 病毒在 MT-2 细胞中的生长，其 EC50值为 3-5 nM。HIV-1integrase inhibitor 10 可用于人类免疫缺陷病毒-1 (HIV-1) 的研究。
T77141	Pegaldesleukin
	Pegaldesleukin 是一种聚乙二醇与白细胞介素-2 的偶联物 (PEG-IL2)。Pegaldesleukin 具有抗病毒活性，在 HIV 中有潜在应用，可能通过保留免疫组库来延缓 HIV 感染的进展。
T70260	AMD-3329 hydrobromide
	AMD-3329 hydrobromide is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses.
T79493	HIV-1 protease-IN-10	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	HIV-1protease-IN-10（化合物2）显示出对HIV-1潜伏期的逆转活性，IC50值为0.22 μM。该化合物通过与PKCδC1b结构域结合展现活性，IC50值为0.69 μM。此外，HIV-1protease-IN-10对于酯酶介导的水解表现出稳定性。
T61797	HIV-1 inhibitor-15
	HIV-1 inhibitor-15 (compound 9d) is a potent and broad-spectrum inhibitor targeting HIV-1. It exhibits inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, and E138K with respective EC50 values of 1.7 nM, 4 nM, 2 nM, 6 nM, and 9 nM. In addition to its high efficacy, HIV-1 inhibitor-15 possesses favorable solubility, safety profiles, and oral bioavailability [1].
T70259	AMD-3329 free base
	AMD-3329 free base is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses.
T76991	Suvizumab
	Suvizumab (KD-247) 是一种抗HIV-1的中和抗体。Suvizumab 有效中和了HIV-1MN、HIV-1SF2和HIV-189.6，IC50值分别为 0.1 µg/mL、1.0 µg/mL 和 0.2 µg/mL。Suvizumab 减少了HIV 的病毒载量。Suvizumab 具有良好的耐受性，可用于预防HIV 感染。
T74990	ICeD-2
	ICeD-2 是一种细胞死亡诱导剂，可诱导HIV-1感染的细胞死亡。 ICeD-2 介导的HIV-1感染细胞杀伤依赖于HIV-1蛋白酶活性。ICeD-2 可有效阻断二肽基肽酶DPP8和DPP9对 Gly-Pro-AMC 的水解。ICeD-2 显示 PBMC 中 DPP9 的强稳定性。
T70859	ent-Abacavir
	ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni...
T40238	Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
	Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties.
T83707	F9170 TFA
	F9170是一种抗病毒肽，对应HIV-1包膜糖蛋白的789-803氨基酸。它与HIV-1包膜蛋白胞浆尾部的LLP1域结合，并抑制HIV-1 IIIB对MT-2细胞的感染(EC50 = 0.19 µM)。在恒河猴模型的类人猿免疫缺陷病毒(SHIV)感染中，F9170 (3 mg/kg)能降低血浆病毒负荷。
T37344	5,6-dimethyl-2-Thiouracil
	5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 \|1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).\|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chroma...
T80621	Semzuvolimab UB421
	Semzuvolimab是靶向T细胞表面抗原T4/Leu-3，即p55 (CD4)的鼠IgG1κ类抗体。该CD4抗体具备中和HIV感染的能力，潜在用于抑制HAART稳定型HIV感染。
T28494	R-82913 NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib
	R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold
T62430	HIV-1 inhibitor-24
	HIV-1 inhibitor-24 (compound S-12a) 是一种 HIV-1 逆转录 (HIV-1 RT) 的高效抑制剂 (IC50: 9.5 nM)。HIV-1 inhibitor-24 对野生型 HIV-1 表现出较高的抗病毒效果，其 EC50 值为 1.6 nM，且细胞毒性较低 (对 MT-4 细胞的 CC50 值为 9.07 μM)。HIV-1 inhibitor-24 在小鼠中 2 g/kg 剂量下具有良好的耐受性，并具有明显的心血管安全性。
T73321	CLK1-IN-2
	CLK1-IN-2 是代谢稳定的Clk1抑制剂。CLK1-IN-2 对 Clk1 具有选择性，IC50值为 1.7 nM。CLK1-IN-2 可用于肿瘤、杜氏肌营养不良症和病毒感染如HIV-1和流感的研究。
T75783	Apelin-36(human) TFA
	Apelin-36(human) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂，EC50为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) TFA 与两种主要的生物活性有关：心血管和代谢。Apelin-36(human) TFA 抑制 HIV-1和 HIV-2进入表达 APJ 的 NP2/CD4细胞。
T37065	6-Chloro-2-fluoropurine
	6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV)in vitro.2 1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2....
TP2093	Apelin-36(human) Apelin-36 (human)
	Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Bloc
T75330	Lysozyme chloride
	Lysozyme chloride 是一种杀菌酶，它能裂解革兰氏阳性细菌 (bacteria)。Lysozyme chloride 还可用于HIV 感染和肺气肿的研究。
TP2094	Apelin-36(rat, mouse) Apelin-36 (rat, mouse)
	Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis
T61679	Abacavir monosulfate
	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
T61193	DDX3-IN-2
	DDX3-IN-2, a potent inhibitor of DEADbox polypeptide 3 (DDX3), demonstrates remarkable activity against the target with an IC50 value of 0.3 μM. Notably, this compound exhibits a wide range of antiviral effects, showcasing its efficacy against various viral strains. Importantly, DDX3-IN-2 exhibits the potential to overcome resistance observed in the context of HIV [1].
T35703	2-hydroxy Stearic Acid methyl ester
	2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.
T73904	Ditiocarb
	Ditiocarb (Diethyldithiocarbamic acid) 是一种铜试剂，与 Cu2+溶液反应，生成络合物，提高了铜置换沉淀速率。Sodium diethyldithiocarbamate 可降低HIV 感染，并应用于高危乳腺癌的辅助免疫研究。
T36659	Boromycin
	Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromyc...
T73696	Peginterferon alfa-2b
	Peginterferon alfa-2b 是一种免疫调节剂。Peginterferon alfa-2b 是一种共价连接 PEG 的重组 alfa-2b 干扰素。Peginterferon alfa-2b 减少HIV 中的病毒 DNA。Peginterferon alfa-2b 可用于黑色素瘤的研究。
T76512	Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
	Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 是 HIV-1蛋白酶的肽底物。Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 在肽水解测定法作为可变底物，用于量化蛋白酶的抑制作用。

化合物

Cat.No: T74282

HIV-1 protease-IN-2

Cat.No: T63949

Cat.No: T6420

Synonym: N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺

Target: HIV Protease

Cat.No: T7779

Synonym: AG1341,甲磺酸萘非那韦

Target: HIV Protease

Cat.No: T67797

Synonym: 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

Target: Antiviral, HBV, HIV Protease

Tenofovir exalidex

Cat.No: T28946

Synonym: Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157

Target: Antiviral

Cat.No: T14313

Synonym: AVX754,SPD754

Target: HIV Protease, DNA/RNA Synthesis

Cat.No: T23910

Synonym: NSC 658586,NSC-658586,NSC 640067

Target: HIV Protease

Cat.No: T0682

Synonym: GR109714X,BCH-189,拉米夫定

Target: HIV Protease, Reverse Transcriptase

Cat.No: T0781

Synonym: Dicaptol,二巯丙醇,Dithiopropanol,二巯基丙醇

Target: Others, HIV Protease

Cat.No: TQ0297

Synonym: TAK-652,TBR-652

Target: HIV Protease, CCR

AMD 3465 hexahydrobromide

Cat.No: T7208

Synonym: GENZ-644494 (hexahydrobromide)

Target: HIV Protease, CXCR

Inosine pranobex

Cat.No: T3614

Synonym: Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Cat.No: T15776

Synonym: R 89439

Target: Others

GP120, HIV-1 MN

Cat.No: T76537

3'-Deoxy-4-thiothymidine

Cat.No: T29393

Synonym: Thymidine, 3'-deoxy-4-thio-,Ddthds

Cat.No: T60714

4'-Ethynyl-2'-deoxyadenosine

Cat.No: T10141

Target: Others

Cat.No: T74487

AMD-3451 free base

Cat.No: T69582

HIV-1 inhibitor-47

Cat.No: T60342

Glycolithocholic acid 3-sulfate disodium

Cat.No: T78551

Synonym: Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium

HIV-1 integrase inhibitor 10

Cat.No: T72162

Cat.No: T77141

AMD-3329 hydrobromide

Cat.No: T70260

HIV-1 protease-IN-10

Cat.No: T79493

Target: PKC

HIV-1 inhibitor-15

Cat.No: T61797

AMD-3329 free base

Cat.No: T70259

Cat.No: T76991

Cat.No: T74990

Cat.No: T70859

Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

Cat.No: T40238

Synonym: Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

Cat.No: T83707

5,6-dimethyl-2-Thiouracil

Cat.No: T37344

Cat.No: T80621

Synonym: UB421

Cat.No: T28494

Synonym: NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib

HIV-1 inhibitor-24

Cat.No: T62430

Cat.No: T73321

Apelin-36(human) TFA

Cat.No: T75783

6-Chloro-2-fluoropurine

Cat.No: T37065

Apelin-36(human)

Cat.No: TP2093

Synonym: Apelin-36 (human)

Lysozyme chloride

Cat.No: T75330

Apelin-36(rat, mouse)

Cat.No: TP2094

Synonym: Apelin-36 (rat, mouse)

Abacavir monosulfate

Cat.No: T61679

Cat.No: T61193

2-hydroxy Stearic Acid methyl ester

Cat.No: T35703

Cat.No: T73904

Cat.No: T36659

Peginterferon alfa-2b

Cat.No: T73696

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2

Cat.No: T76512

Cat. No.	Product Name	Target	Signaling Pathways
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T8689	Chloroquine CQ,氯喹	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine 是一种 Toll 样受体抑制剂，可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性，广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。
TN1622	Ermanin 堪非醇3,4'-二-O-甲醚	NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集，具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达，从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>
T73758	Glycolithocholic acid 3-sulfate
	Glycolithocholic acid 3-sulfate (SLCG) 为一种胆汁酸衍生物及甘胆酸的代谢产物，具有抑制HIV-1复制的作用。该化合物在HIV感染和胆囊疾病的研究中有潜在应用价值。
T75477	Epicoccone B
	Epicoccone B 首次报道于C.globosum，具有清除 DPPH 自由基的能力，IC50值为10.8 μM，并具有有效的 α-葡萄糖苷酶抑制作用，IC50值为 27.3 μM。具有抗HIV 活性。
T37451	Stachybotrysin B
	Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 \|1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).\|2. Ma, X.-h., Zhen...
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul
T72429	α-Lipoic Acid sodium Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium
	α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制NF-κB 依赖性的HIV-1LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与CPUL1 合成自组装的纳米聚合体 CPUL1-LA NA，其抗肿瘤效果优于 CPUL1。
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Cat.No: T8689

Synonym: CQ,氯喹

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Cat.No: TN1622

Synonym: 堪非醇3,4'-二-O-甲醚

Target: NOS, Influenza Virus, COX, HIV Protease, Antibacterial, Antibiotic

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: TN5012

Target: HIV Protease, Antifection

Glycolithocholic acid 3-sulfate

Cat.No: T73758

Cat.No: T75477

Stachybotrysin B

Cat.No: T37451

Cat.No: TN5011

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

α-Lipoic Acid sodium

Cat.No: T72429

Synonym: Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium

Cat.No: T36438

3-Hydroxyterphenyllin

Cat.No: T36000

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

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