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34

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T69709	GST-HG131
	GST-HG131 是一种特异性的乙肝病毒 (HBV) 表面抗原抑制剂，属于二氢苯并吡哆醛 (DBP) 类化合物。GST-HG131 抑制 HBsAg 和 HBeAg 的特异性和效力很强 (EC50=28.2 nM, 16.0 nM)。GST-HG131 还具有良好的动物安全性。
T8461	SKI V	Apoptosis; PI3K; S1P Receptor	Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling
	SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂，对 GST-hSK 的IC50为 2 μM。它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成，可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K，对 hPI3k 的IC50为 6 μM。
T1052	Proglumide 二丙谷酰胺	cholecystokinin	GPCR/G Protein
	Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌，具有保护胃十二指肠粘膜的能力，并表现出抗癫痫和抗氧化活性。
T78800	GST-IN-1
	GST-IN-1 (compound 16) 为一种谷胱甘肽 S-转移酶 (GST) 抑制剂，其半抑制浓度 (IC50s) 分别针对sjGST为1.55 μM，针对hGSTM2为2.02 μM。
T69708	Azilsartan mopivabil
	Azilsartan mopivabil 是血管紧张素 II 受体 (angiotensin II receptor) 的强效拮抗剂。
T26629	Angstrom6 A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide	PAI-1	Metabolism
	Angstrom6 (A-6 peptide) 是一种从单链尿激酶纤溶酶原激活剂(scuPA)中提取的 8 肽，它能干扰 uPA/uPAR 级联反应并抑制下游效应。Angstrom6 具有抗肿瘤活性，能通过与 CD44 结合并调节 CD44 介导的细胞信号传导，抑制肿瘤细胞的迁移、侵袭和转移。
T11505	GSTO1-IN-1	Glutathione Peroxidase; GST	Metabolism; oxidation-reduction
	GSTO1-IN-1 是谷胱甘肽 S-转移酶 omega 1 抑制剂，IC50=31 nM。
T12519	Sodium metatungstate POM-1,聚钨酸钠,Sodium polyoxotungstate	Phosphatase	Metabolism
	Sodium metatungstate (Sodium polyoxotungstate) 是一种外核苷三磷酸二磷酸水解酶抑制剂，能够抑制 ATP 的分解，并阻断中枢突触传递，这是独立于抑制 NTPDase 而发挥作用的。
T71081	Nagstatin
	Nagstatin is an inhibitor of N-acetyl-beta-D-glucosaminidase and is produced by Streptomyces amakusaensis MG846-fF3.
T64775	Sodium tungstate(VI)
	Sodium tungstate(VI) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64775。
T15379	GGsTop Nahlsgen	Others	Others
	GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively.
T11504	GSTO-IN-2	Others	Others
	GSTO-IN-2 is a glutathione S-transferase inhibitor (IC50s: 1.4, 16.3, and 3.6 μM for GSTP1-1, GSTM1, and GSTA2).
T64830	Tetrapotassium decatungstate
	Tetrapotassium decatungstate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64830。
T64579	Tetrabutylammonium decatungstate
	Tetrabutylammonium decatungstate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64579。
T64838	Tetrabutylphonium decatungstate
	Tetrabutylphonium decatungstate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64838。
TQ0003L1	740 Y-P acetate PDGFR 740Y-P Acetate,740YPDGFR acetate,740 Y-P acetate(1236188-16-1 Free base)	PI3K	PI3K/Akt/mTOR signaling
	740 Y-P acetate (740YPDGFR acetate) 是一个有效的且具有细胞渗透性的 PI3K 激活剂。740 Y-P acetate 倾向和含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白结合，但不能单独结合 GST。
T5862	Ezatiostat TFA TER199(free base),Ezatiostat TFA (free base),Ezatiostat,TLK199	GST	oxidation-reduction
	Ezatiostat TFA (TLK199) 是一种具有造血刺激活性的谷胱甘肽 S-转移酶 (GST) P1-1 的脂质体小分子谷胱甘肽类似物抑制剂。
TQ0003	740 Y-P 740YPDGFR,PDGFR 740Y-P	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	740 Y-P (740YPDGFR) 是一个细胞渗透性PI3K 激活剂。它能结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白。
T0153	Oltipraz 吡噻硫酮,NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活，IC50为 10 μM，浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。
T12189	NBDHEX	Apoptosis; Glutathione Peroxidase; Autophagy	Apoptosis; Autophagy; Metabolism
	NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂，也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡，通过抑制 GST 的催化活性，避免抑制剂被特异性泵从细胞中排出，以及破坏 GSTP1-1和关键信号传导因子之间的相互作用，从而起到抗癌的作用。
T75723	740 Y-P TFA
	740 Y-P TFA (740YPDGFR;PDGFR740Y-P) 是一个有效的，具有细胞渗透性的PI3K 激活剂。740 Y-P TFA 很容易结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白，但不能单独结合 GST。
T81136	S-Octylglutathione
	S-Octylglutathione 是一种针对谷胱甘肽硫转移酶 (GST) 的竞争性抑制剂。
T75929	Caffeic acid-pYEEIE TFA
	Caffeic acid-pYEEIE TFA 是一种非磷酸肽抑制剂，对 GST-Lck-SH2 结构域具有强大的结合亲和力。
T33957	PF-Alkyne PF Alkyne
	PF-Alkyne is a fluorophosphonate-based probe which specifically and covalently reacts with the tyrosine-111 residue of the Schistosoma japonicum GST (sjGST) tag. PF-Alkyne rapidly and site-selectively immobilizes sjGST fusion proteins.
T40349	DS45500853
	DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM), exhibiting an IC50 of 0.80 μM. This compound holds potential for research pertaining to metabolic disorders, particularly type 2 diabetes mellitus (T2DM).
T60759	DS20362725
	DS20362725 是可用于代谢紊乱研究，如二型糖尿病的雌激素相关受体 α (ERRα) 激动剂。DS20362725 抑制受体相互作用蛋白 140 (RIP140) 辅助抑制肽 (10 nM) 和 GST-ERRα 配体结合结构域 (LBD; 1.2 μM) 之间的结合的 IC50值为 0.6 μM。
T83931	JQ1-FITC
	JQ1-FITC是一种荧光BET溴结构域探针。它与BRD4(BD1)和BRD4(BD2)具有高亲和力绑定（KD,app值分别为6.5 nM和5.8 nM，使用GST标签的BRD4蛋白，通过CoraFluorTR-FRET实验测定；在荧光偏振实验中，对于BRD4(BD1)的值为58.7 nM）。激发和发射峰（λ）分别为495 nm和525 nm。
T35979	Benastatin C
	Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul...
T70798	Benastatin B
	Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S....
T35978	Benastatin A
	Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benastatin A is active against several bacteria, including methicillin-resistantS. aureus(MRSA; MIC = 3.12 μg/ml). It induces apoptosis and cell cycle arrest at the G1/G0phase in Colon 26 mouse colon cancer cells when used at concentrations of 20 and 16 μM, respectively.3 1.Xu, Z., Sch...
T69978	Brostallicin HCl
	Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent ...
T19580	Thrombin (MW 37kDa) 凝血酶,Thrombin	Thrombin	Proteases/Proteasome
	Thrombin (MW 37kDa) 是一种 Na+激活的胰蛋白酶样别构丝氨酸蛋白酶。它能够利用凝血酶识别序列对融合蛋白进行位点特异性切割，并可用于消化 GST 标记的蛋白。
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells. Biochemical assays with purified glutathione S transferase (GST)-Abl kinase domain confirmed that AP23464 directly inhibits Abl activity. Importantly, the lo...
T36057	Diallyl Tetrasulfide ICD-1585
	Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind...

化合物

Cat.No: T69709

Cat.No: T8461

Target: Apoptosis, PI3K, S1P Receptor

Cat.No: T1052

Synonym: 二丙谷酰胺

Target: cholecystokinin

Cat.No: T78800

Azilsartan mopivabil

Cat.No: T69708

Cat.No: T26629

Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide

Target: PAI-1

Cat.No: T11505

Target: Glutathione Peroxidase, GST

Sodium metatungstate

Cat.No: T12519

Synonym: POM-1,聚钨酸钠,Sodium polyoxotungstate

Target: Phosphatase

Cat.No: T71081

Sodium tungstate(VI)

Cat.No: T64775

Cat.No: T15379

Synonym: Nahlsgen

Target: Others

Cat.No: T11504

Target: Others

Tetrapotassium decatungstate

Cat.No: T64830

Tetrabutylammonium decatungstate

Cat.No: T64579

Tetrabutylphonium decatungstate

Cat.No: T64838

740 Y-P acetate

Cat.No: TQ0003L1

Synonym: PDGFR 740Y-P Acetate,740YPDGFR acetate,740 Y-P acetate(1236188-16-1 Free base)

Target: PI3K

Cat.No: T5862

Synonym: TER199(free base),Ezatiostat TFA (free base),Ezatiostat,TLK199

Target: GST

Cat.No: TQ0003

Synonym: 740YPDGFR,PDGFR 740Y-P

Target: PI3K, Autophagy

Cat.No: T0153

Synonym: 吡噻硫酮,NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Cat.No: T12189

Target: Apoptosis, Glutathione Peroxidase, Autophagy

Cat.No: T75723

S-Octylglutathione

Cat.No: T81136

Caffeic acid-pYEEIE TFA

Cat.No: T75929

Cat.No: T33957

Synonym: PF Alkyne

Cat.No: T40349

Cat.No: T60759

Cat.No: T83931

Cat.No: T35979

Cat.No: T70798

Cat.No: T35978

Brostallicin HCl

Cat.No: T69978

Thrombin (MW 37kDa)

Cat.No: T19580

Synonym: 凝血酶,Thrombin

Target: Thrombin

Cat.No: T68581

Diallyl Tetrasulfide

Cat.No: T36057

Synonym: ICD-1585

Cat. No.	Product Name	Target	Signaling Pathways
T39668	Methyl propyl disulfide	Others	Others
	Methyl propyl disulfide 是在大蒜和洋葱中产生的挥发性含硫化合物，具有抗癌活性。
T7995	α-Angelica lactone α-当归内酯,当归内酯,Alpha-Angelica Lactone	Others; GST	Others; oxidation-reduction
	α-Angelica lactone 是一种乙烯基亲核试剂，也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ，γ-二取代丁烯醇内酯羰基衍生物，并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。
TN5562	10-Hydroxyligstroside 10-Hydroxyligustroside
	10-Hydroxyligstroside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5562，CAS号为 35897-94-0。
T3S0012	coniferyl ferulate	P-gp; GST	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Coniferyl ferulate 是从川芎中提取的一种天然产物，是强效的谷胱甘肽 S-转移酶抑制剂，强抑制人胎盘型谷胱甘肽 S-转移酶，IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。
TN1376	α-Solanine alpha-Solanine,A-茄碱	MMP; Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
TN2849	3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid	Antifection	Microbiology/Virology
	2-O-beta-d-Glucosyloxy-4-methoxybenzenepropanoic acid[3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid] exhibits glutathione S-transferase (GST) inhibitory and antifungal activities.

天然产物

Methyl propyl disulfide

Cat.No: T39668

Target: Others

α-Angelica lactone

Cat.No: T7995

Synonym: α-当归内酯,当归内酯,Alpha-Angelica Lactone

Target: Others, GST

10-Hydroxyligstroside

Cat.No: TN5562

Synonym: 10-Hydroxyligustroside

coniferyl ferulate

Cat.No: T3S0012

Target: P-gp, GST

Cat.No: TN1376

Synonym: alpha-Solanine,A-茄碱

Target: MMP, Akt, PI3K

3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid

Cat.No: TN2849

Target: Antifection

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