Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSTO1-IN-1 是谷胱甘肽 S-转移酶 omega 1 抑制剂,IC50=31 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 327 | 现货 | ||
2 mg | ¥ 469 | 现货 | ||
5 mg | ¥ 775 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
50 mg | ¥ 1,830 | 现货 | ||
100 mg | ¥ 3,160 | 现货 | ||
200 mg | ¥ 4,530 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,370 | 现货 |
产品描述 | GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM). |
靶点活性 | GSTO1:31 nM |
体外活性 | GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to the recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome.?HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. |
体内活性 | GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study. |
分子量 | 311.18 |
分子式 | C10H12Cl2N2O3S |
CAS No. | 568544-03-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 300 mg/mL (964.07 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.2136 mL | 16.0679 mL | 32.1357 mL | 80.3394 mL |
5 mM | 0.6427 mL | 3.2136 mL | 6.4271 mL | 16.0679 mL | |
10 mM | 0.3214 mL | 1.6068 mL | 3.2136 mL | 8.0339 mL | |
20 mM | 0.1607 mL | 0.8034 mL | 1.6068 mL | 4.017 mL | |
50 mM | 0.0643 mL | 0.3214 mL | 0.6427 mL | 1.6068 mL | |
100 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8034 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GSTO1-IN-1 568544-03-6 Metabolism oxidation-reduction Glutathione Peroxidase GST GSTs GSTO1IN1 Glutathione transferases inhibit Inhibitor Gutathione S-transferase GSTO1 IN 1 GSTO-1-IN-1 inhibitor