189
48
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22269 |
Benzyldodecyldimethylammonium Chloride Dihydrate
|
Antibacterial | Microbiology/Virology |
Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂,可以靶向耐药性细菌,如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等,且具有浓度依赖性。 | |||
T36683 |
Vedaprofen
Quadrisol,PM 150,维达洛芬,CERM 10202 |
COX; Antibacterial; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Vedaprofen (PM 150) 抑制 COX-1 并通过抗炎活性减少前列腺素 H2 的合成。 Vedaprofen 是一种大肠杆菌滑动钳抑制剂,IC50 为 222 μM,Ki 为 131 μM。 | |||
T19794 |
Temafloxacin
替马沙星,Omniflox |
Antibiotic | Microbiology/Virology |
Temafloxacin (Omniflox) 是一种喹诺酮类广谱抗菌剂,对革兰氏阳性菌、革兰氏阴性菌和厌氧菌均有效。 | |||
T9508 |
MONOCAPRYLIN
Sefsol 318,Glyceryl monocaprylate,辛酸甘油酯 |
Antibacterial | Microbiology/Virology |
Monocaprylin (Sefsol 318) 是一种辛酸甘油单辛酸酯,有出色的抗菌活性,可抑制多种食源性致病和腐败微生物,有用于替代食品防腐剂的研究潜力。 | |||
T1389 |
Dyclonine hydrochloride
盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl |
Sodium Channel; Antibacterial; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分,具有显著的杀菌和杀真菌作用。 | |||
T82462 |
Enterotoxin STp (E. coli)
|
||
Enterotoxin STp (E. coli), 热稳定肠毒素,适用于疫苗研究领域。 | |||
T1293 |
Gatifloxacin
BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml)。在动物模型中,它有抗细菌性结膜炎作用。 | |||
T39912 |
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
5'-O-DMT-dU,保护-2'-脱氧尿苷 |
Others | Others |
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) 是大肠杆菌 dUTP 核苷酸水解酶的竞争性抑制剂,Ki 高于 1000 μM。它通过合成核苷亚磷酰胺嵌段用于机器辅助的 DNA 合成。 | |||
T13477 |
β-Glucuronidase-IN-1
|
Antibacterial | Microbiology/Virology |
β-Glucuronidase-IN-1 是一种 E. coli β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂,对 E. coli β-葡萄糖醛酸酶的 IC50 和 Ki 值分别为 283 nM 和 164 nM,具有强效性,选择性,非竞争性和具有口服活性。 | |||
T12126 |
MUT056399
Fab-001 |
Antibacterial | Microbiology/Virology |
MUT056399 (Fab-001) 是一种金黄色葡萄球菌和大肠杆菌的 FabI 酶的高效抑制剂,IC50值分别为 12 nM 和 58 nM。 | |||
TP1496L |
p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) |
HSP | Cytoskeletal Signaling; Metabolism |
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) 是一种九肽。它是 DnaK(大肠杆菌 Hsp70)和 DnaJ(大肠杆菌 Hsp40)的高亲和力配体。 | |||
T77798 |
Sodium Nitrite
Nitrous acid, sodium salt |
Others | Others |
Sodium Nitrite (Nitrous acid, sodium salt) 是一种不易保存的化合物,放置在空气中会被氧化成硝酸。Sodium Nitrite 具有多种功能,既具有氧化性又具有还原性,作用颇多。 | |||
T33828 |
O-Succinylhomoserine
O-琥珀酰-L-高丝氨酸,O-Succinyl-L-homoserine |
Others | Others |
O-Succinylhomoserine (O-Succinyl-L-homoserine) 是大肠杆菌合成胱硫醚的中间体。 | |||
TQ0018 |
6-Amino-5-azacytidine
|
Antibacterial | Microbiology/Virology |
6-Amino-5-azacytidine 对大肠杆菌的生长有抑制作用。 | |||
T22387 |
NSC 55655
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione |
Others | Others |
NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性,抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ,A. niger 和 C. albicans 的增殖,可用于糖尿病。 | |||
T32490 |
L-161240
L-161,240 |
Antibacterial | Microbiology/Virology |
L-161240 是一种与脂质A生物合成有关的抗菌剂,在DEACET测定IC50值为 30 nM,并且对野生型大肠杆菌的MIC值为1-3μg/ mL。 | |||
T6638 |
Retapamulin
瑞他莫林,SB-275833 |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Retapamulin (SB-275833) 是一种能结合金黄色葡萄球菌和大肠杆菌核糖体的局部抗生素,Kd 为3 nM。 | |||
T20936 |
Lauramine oxide
LDAO,Dimethylaurylamine oxide,十二烷基二甲基氧化胺,Refan,Lauryldimethylamine oxide |
Antibacterial | Microbiology/Virology |
Lauramine oxide (Refan) 对大肠杆菌和金黄色葡萄球菌等常见细菌有效,但它是非变性的,可用于溶解蛋白质。 | |||
T10347L |
Apidaecin IB acetate
Apidaecin IB acetate (123276-94-8 Free base) |
Others | Others |
Apidaecin IB acetate 是一种昆虫抗菌肽。 apidaecin IB acetate 对大肠杆菌(大肠杆菌 ML35、o18k1h7 和 ATCC 25922)的有效浓度为 8 μM。 | |||
T11227L |
Eravacycline dihydrochloride
TP-434-046,TP-434 dihydrochloride |
Antibacterial | Microbiology/Virology |
Eravacycline dihydrochloride (TP-434-046) 是一种有效的广谱抗菌剂,可对抗六种大肠杆菌(MIC:0.125-0.25 mg/L)。 | |||
T10337 |
Antimicrobial Compound 1
|
Antibacterial | Microbiology/Virology |
Antimicrobial Compound 1 是一种烷基吡啶鎓化合物,尾部为 12C,头部为 4-羧基。 Antimicrobial Compound 1 对枯草芽孢杆菌和大肠杆菌具有抗菌活性。 | |||
TP1663L |
CysHHC10 acetate
CysHHC10 acetate(1408311-03-4 free base) |
Antibacterial | Microbiology/Virology |
CysHHC10 acetate 对革兰氏阳性菌和革兰氏阴性菌均具有抗菌活性,对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌和表皮葡萄球菌的 MIC 分别为 10.1、20.2、2.5 和 1.3 mM。 | |||
T11348 |
G907
|
Antibiotic | Microbiology/Virology |
G907 是一种具有选择性和有效性的小分子ATP 结合盒 (ABC) 转运蛋白 MsbA 的拮抗剂,具有杀菌活性,可将 MsbA 捕获在朝内的脂多糖中。 G907 对大肠杆菌 MsbA 有抑制作用, IC50 值为 18 nM。 | |||
T9727 |
2'-Fluoro-2'-Deoxyadenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2′-Deoxy-2′-fluoroadenosine 可用于合成2 ' -脱氧-2 ' -氟修饰的寡核苷酸。它能被大肠杆菌嘌呤核苷磷酸化酶(PNP)有效地分解成毒性物 2-氟腺嘌呤,对表达大肠杆菌 PNP 的肿瘤表现出良好的体内活性。 | |||
T1569 |
Tigecycline
替加环素,GAR-936 |
ribosome; Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Tigecycline (GAR-936) 是甘氨酰环素抗生素,对 Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对 E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。 | |||
T5413 |
ML216
CID-49852229 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
ML216 (CID-49852229) 是一种选择性、细胞渗透性的BLM 解旋酶抑制剂,具有抗肿瘤活性。它对BLMfull-length 和BLM636-1298的IC50分别为 2.98 μM 和 0.97 μM。 | |||
T77615 |
ND-011992
ND011992 |
Mitochondrial Metabolism; Antibacterial | Metabolism; Microbiology/Virology |
ND-011992 是一种靶向醌还原酶 (quinone reductases) 和醌氧化酶 (quinol oxidases)的喹唑啉类抑制剂,具有可逆性和选择性。ND-011992 对大肠杆菌 BL21*Δcyo 呼吸复合体I (respiratory complex I) 、 bo3 氧化酶(bo3 oxidase)、 bd-I 氧化酶 (bd-I oxidases) 和 bd-II 氧化酶 (bd-II oxidases)具有抑制作用,IC50 分别为 0.12、2.47、0.63 和 1.3 μM。ND-011992 可以用于研究肺结核。 | |||
T60247 |
Diethylamine NONOate diethylammonium salt
NOC-18 Diethylamine,DEA NONOate diethylamine |
Antibiotic | Microbiology/Virology |
Diethylamine NONOate diethylammonium salt (DEA NONOate diethylamine) 是一种一氧化氮供体,具有抗菌活性,是铜绿假单胞菌生物膜预形成生物膜的分散剂,可抑制大肠杆菌的生长。Diethylamine NONOate diethylammonium salt 可用于离体大鼠心脏的保存。 | |||
T21831 |
UCM05
G28UCM |
Fatty Acid Synthase | Metabolism |
UCM05 (G28UCM) (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂,对 HER2+ 乳腺癌异种移植物具有作用活性,且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂,可抑制革兰氏阳性菌B. subtilis 生长,MIC 值为 100 μM,但对革兰氏阴性菌E. coli 缺乏活性。 | |||
T36352 |
Suc-Leu-Tyr-AMC
|
||
Suc-Leu-Tyr-AMC 是钙蛋白酶 I 和 II 以及木瓜蛋白酶(另一种半胱氨酸蛋白酶)的荧光底物,用于测量 20S 蛋白酶体的糜蛋白酶样肽酶活性(Ex-max:360 nm;Em-max:460 nm)。Suc-Leu-Tyr-AMC 也能被大肠杆菌的 Ti 蛋白酶裂解。 | |||
T77675 |
TNKS-2-IN-1
|
PARP; Wnt/beta-catenin; Antibiotic | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; Stem Cells |
TNKS-2-IN-1 是一种 TNKS-2 抑制剂。TNKS-2-IN-1 对 TNKS-1 和 TNKS-2有抑制作用,IC50 分别为 259 nM 和 1100 nM。TNKS-2-IN-1 具有抗菌活性,对大肠杆菌和金黄色葡萄球菌具有抑制作用。TNKS-2-IN-1 抑制 NLRP3 炎症小体 (IC505μM)通过抑制ATP刺激的J1A.774细胞释放IL-1β。 | |||
T11876 |
LpxH-IN-AZ1
|
Antibacterial | Microbiology/Virology |
LpxH-IN-AZ1 是一种有效的 UDP-2,3-二酰基葡糖胺焦磷酸水解酶LpxH 抑制剂,也是磺酰基哌嗪化合物。LpxH-IN-AZ1 具有抗菌活性,对肺炎克雷伯菌具有抑制作用,IC50 为 0.36 μM。 | |||
T41275 |
PF-04753299
|
Others | Others |
PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用,对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg/ml、4 μg/ml 和 16 μg/ml。PF-04753299 用于革兰氏阴性菌感染的研究。 | |||
T3097 |
Mycophenolic Acid Impurity
马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide |
Others | Others |
Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) 是一种免疫抑制药物和有效的抗增殖剂,可用于代替旧的抗增殖剂 azathioprine。它通常用作三联疗法的一部分,包括钙调神经磷酸酶抑制剂(ciclosporin 或 tacrolimus)和prednisolone。它还可用于研究选择表达编码 XGPRT(黄嘌呤鸟嘌呤磷酸核糖基转移酶)的大肠杆菌基因的动物细胞。 | |||
TP1773L |
PGLa acetate
|
Antibacterial; Antibiotic | Microbiology/Virology |
PGLa acetate 是 magainin 抗生素肽家族的 21 个残基成员。 | |||
T38164 |
MnTBAP chloride
Mn(III)TBAP |
||
MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂,能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物,具有抗氧化性能,具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。 | |||
T35449 |
α-(difluoromethyl)-DL-Arginine
DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine |
Others | Others |
α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时,它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时,能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长,并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。 | |||
T14043 |
4-(tert-Butyl)-benzhydroxamic Acid
|
Others | Others |
4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1]. | |||
T26790 |
Bharangin
|
||
Bharangin is a inhibitor of penicillinase enzyme in E coli. | |||
T31854 |
Formylmethionyl-alanyl-leucine
Fmet-ala-leu |
||
Formylmethionyl-alanyl-leucine is formed by E coli ribosomal protein L10 gene. | |||
T27972 |
MAC173979
MAC-173979,MAC 173979 |
||
MAC173979 inhibits E. coli de novo PABA biosynthesis and growth. | |||
T36594 |
4-Chloroguaiacol
|
||
4-Chloroguaiaco (4-Chloro-2-methoxyphenol) is a phenol derivative, with antimicrobial activity. 4-Chloroguaiaco shows inhibition against S. aureus and E. coli with MICs of both 110 μg/mL[1]. [1]. Patrícia Fontes Pinheiro, et al. Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties. J Agric Food Chem. 2018 Jan 10;66(1):323-330. | |||
T29677 |
Aerobactin
|
||
Aerobactin, as a bacterial iron chelating agent (siderophore), can be found in E. coli. It is a virulence factor that can enable E. coli to sequester iron in iron-poor environments. | |||
T32778 | Lipid X | ||
Lipid X is a monosaccharide precursor of E coli lipid A. | |||
T24527 |
Netzahualcoyone
|
||
Netzahualcoyone inhibited the respiration of intact cells of B. subtilis but had no effect on the respiration of E. coli. | |||
T79132 |
Du011
|
||
Du011为针对MprA的大肠杆菌多糖胶囊生物发生抑制剂,用于探讨抗大肠杆菌感染的潜能。 | |||
TP2336 |
Tripalmitoyl pentapeptide
P3C-Ssna,Bpppcssaa,Bppp cssaa,Bppp-cssaa,P3C Ssna P3CSsna |
||
Tripalmitoyl pentapeptide is a Mitogen from E Coli lipoprotein. It also is a potent macrophage B lymphocyte activator. | |||
T32779 |
Lipid Y
|
||
Lipid Y is a monosaccharide precursor of E coli lipid A. | |||
T80293 |
RP-1
|
||
RP-1为一抗菌肽,具备针对S. aureus、S. typhimurium、E. coli及C. albicans的抗菌活性。 | |||
T37873 | CAP 3 | ||
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infecte... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T41078 |
Lipopolysaccharides, Escherichiacoli (11C)
LPS E. coli O55:B5,Lipopolysaccharide, E. coli O111:B4 |
Others | Others |
Lipopolysaccharides, Escherichiacoli (11C) (LPS E. coli O55:B5)是革兰阴性菌外膜的大分子成分,由脂质a、寡糖核心和o -特异性多糖(O-antigen) 3个区域组成。 | |||
T1313 |
Nitrofurantoin
Furadantine,呋喃妥因,Macrodantin,Furadonine |
Antibacterial; Antibiotic | Microbiology/Virology |
Nitrofurantoin (Furadantine) 是一种具有口服活性的广谱内酰胺酶抗菌剂。它是一种抗生素,可研究尿路感染。 | |||
T1100 |
Polymyxin B Sulfate
Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX |
Antibacterial; Antibiotic | Microbiology/Virology |
Polymyxin B Sulfate (Poly-RX) 是一个阳离子型表面活性剂抗生素剂,能够提高细胞膜的渗透性。 | |||
T8384 |
Gatifloxacin hydrochloride
AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素,有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml) 。它在动物模型中,可研究细菌性结膜炎。 | |||
T13708 |
Glycol chitosan
羟乙基脱乙酰壳多糖,乙二醇壳聚糖 |
Antibacterial | Microbiology/Virology |
Glycol chitosan 是具有亲水性乙二醇支链的壳聚糖衍生物。它抑制大肠杆菌,金黄色葡萄球菌和肠炎链球菌的生长,MIC 值分别为 4 μg/mL,32 μg/m L 和 <0.5 μg/mL。它可增强 Glycine max Harosoy 63W 细胞的膜通透性和渗漏。 | |||
T4913 |
Maleic acid
|
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
Maleic Acid 是大肠杆菌和单核细胞增生李斯特菌的谷氨酸脱羧酶抑制剂。 | |||
TN2281 |
Sinapaldehyde
trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛 |
Antibacterial | Microbiology/Virology |
Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用,MIC 值都为 128 μg/mL。 | |||
T19146 |
5,6-Dihydrouridine
|
Endogenous Metabolite | Metabolism |
5,6-Dihydrouridine 是一种修饰碱基,存在于真核生物、细菌和某些古细菌tRNA D 环的保守位置。 | |||
TN2898 |
Kaempferol-7,4'-dimethyl ether
3,5-Dihydroxy-4',7-dimethoxyflavone |
Antioxidant; Antifection | Microbiology/Virology; oxidation-reduction |
Kaempferol-7,4'-dimethyl ether 是从 Zingiber phillipseae 的根茎中分离得到的,对金黄色葡萄球菌和大肠杆菌具有抗氧化活性,MIC 分别为 200 和 225 μg/ml。 | |||
T37267 |
Pachybasin
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Antibacterial | Microbiology/Virology |
Pachybasin 是一种蒽醌真菌代谢物。 Pachybasin 对大肠杆菌、枯草芽孢杆菌、M. luteus、S. cerevisiae、C. albicans、A. niger 和 A. flavus 具有抗菌活性,MIC 值为 64.0 μg/mL,对金黄色葡萄球菌具有抗菌活性 和尖孢镰刀菌,MIC 值分别为 32.0 和 16.0 μg/mL。 | |||
T0710 |
L-Cycloserine
Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,环丝氨酸,(S)-4-Amino-3-isoxazolidone |
HIV Protease; GABA Receptor | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
L-Cycloserine ((-)-Cycloserine) 不可逆地抑制大肠杆菌以及各种动物大脑中的 GABA 吡哆醛 5'-磷酸依赖性转氨酶,导致体内抑制性神经递质 γ-氨基丁酸水平升高。 | |||
T4010 |
Juglone
5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin |
DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料,有抗菌作用。 | |||
T36473 |
trans-Nerolidol
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trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re... | |||
T10933 |
D-Cysteine
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Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
D-Cysteine 是一种大肠杆菌生长的有力抑制剂,是半胱氨酸的 D 型异构体。它由 D-氨基酸氧化酶介导产生 H2S,是一种对抗小脑共济失调的神经保护剂。 D-半胱氨酸可以抑制由变形链球菌和链球菌血红蛋白形成的两种生物膜的生长和致龋性。 | |||
T4788 |
L-Norvaline
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Others; Endogenous Metabolite | Metabolism; Others |
L-Norvaline 是一种精氨酸酶抑制剂,也是一种非蛋白支链氨基酸。 L-Norvaline 先前已被报道为枯草芽孢杆菌抗真菌肽的天然成分。 L-Norvaline 和其他修饰的支链氨基酸在研究中受到了关注,因为它们似乎被掺入到大肠杆菌中发现的一些重组蛋白中。 | |||
TN4927 |
Rupesin E
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Antifection | Microbiology/Virology |
Rupesin E shows significant antibacterial activities against Escherichia coli. | |||
T10455 |
Bafilomycin B1
巴佛洛霉素 B1 |
Others | Others |
Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi. | |||
T72250 |
4aα,7α,7aα-Nepetalactone
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4aα,7α,7aα-Nepetalactone 具有抗菌 (antibacterial) 活性,抑制Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus,Salmonella typhi 和Enterococcus faecalis。 | |||
TN1538 |
Curzerenone
莪术呋喃烯酮,莪术酮 |
Caspase; Antifection | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52). | |||
TN2809 |
22-Dehydroclerosterol
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Antifection | Microbiology/Virology |
22-Dehydroclerosterol has antibacterial activity against against E. coli, S. aureus, and H. pylori. | |||
T80001 |
Majoranaquinone
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Antibiotic | Microbiology/Virology |
Majoranaquinone对4种Staphylococcus菌株、1种Moraxella菌株和1种Enterococcus菌株显示出良好的抑菌作用。此外,Majoranaquinone在E.coli ATCC 25922菌株中表现出显著的外排泵抑制活性,并能有效抑制E.coli ATCC 25922和E.coli K-12 AG100的生物膜形成。 | |||
T75685 | UDP-3-O-acyl-GlcNAc | ||
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) 是一种E. coli 代谢产物,参与 3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。 | |||
T40436 |
N,N'-Diacetylchitobiose
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N,N'-Diacetylchitobiose, a dimer of β(1,4) linked N-acetyl-D glucosamine, is derived from the hydrolysis of chitin. This compound serves as an alternative carbon source for E. coli. | |||
T38275 |
Kirromycin
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Kirromycin is an antibiotic originally isolated from Streptomyces and an inhibitor of protein biosynthesis. It inhibits isoleucine incorporation, polyphenylalanine synthesis, and growth of B. brevis. Kirromycin inhibits elongation factor Tu-dependent peptidyl transfer activity in E. coli. | |||
T80020 |
UDP-3-O-acyl-GlcNAc diammonium
UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine diammonium |
Endogenous Metabolite | Metabolism |
UDP-3-O-acyl-GlcNAc diammonium 是一种E. coli代谢产物,涉及3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。 | |||
TN5229 | Vibralactone B | Antifection | Microbiology/Virology |
Vibralactone B shows antibacterial activity, it can inhibit significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 ug/mL, respectively. | |||
T83920 |
4-Trehalosamine
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4-Trehalosamine是一种在Streptomyces中发现的微生物代谢产物,具有抗生素活性。在杯碟法测试中,当浓度为0.5、1和2 mg/ml时,对E. coli、K. pneumoniae和B. subtilis展现出活性。 | |||
TN3978 |
Epitaraxerol
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Antifection | Microbiology/Virology |
Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis. | |||
TN3650 |
Chrysothol
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Antifection | Microbiology/Virology |
Chrysothol shows strong antimicrobial activities (MICs=50-100 ug/ml) against enterobacteria E. coli and S. enteritidis. It also shows anti-cancer activity against human breast cancer cells. | |||
T39626 |
Orotidine 5′-monophosphate
Orotidine monophosphate,Orotidylicacid,Orotidine 5′-monophosphate |
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Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase. | |||
T36815 | Chevalone C | ||
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells. | |||
T83918 |
Clazamycin A hydrochloride
NSC 332188 |
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Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性,包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa(MICs分别为100、6.25、100、50和25 µg/ml)。 | |||
T80342 |
XT-4
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XT-4,一种抗菌肽,源自热带爪蟾 (Xenopus tropicalis) 皮肤分泌物,对E.coli表现出高效的抑菌作用,最小抑制浓度 (MIC) 为18 μM。 | |||
T83902 |
Polymyxin E1 sulfate
Colistin A sulfate |
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Polymyxin E1,是一种肽类抗生素,也是原初从B. polymyxa分离得到的阳离子脂肽抗生素colistin的主要成分。对P. aeruginosa和E. coli具有活性(MICs分别为2和0.8 µg/ml)。 | |||
T80331 |
XT-2 peptide
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XT-2 peptide, 源自热带爪蟾(Xenopus tropicalis)皮肤分泌物的抗菌肽,具有强效抗E.coli活性,其最小抑菌浓度(MIC)为8 μM。 | |||
T80330 |
XT-1
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XT-1是一种抗菌肽,源自热带爪蟾Xenopus tropicalis的皮肤分泌物,表现出对S.aureus、E.coli和C.albicans的强烈活性,其最小抑菌浓度(MIC)分别为5μM、6μM和50μM。 | |||
T38258 |
Phanerosporic Acid
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Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytoch... | |||
TN5014 | Shoreic acid | Antifection; HSV | Microbiology/Virology |
Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI | |||
T37442 |
Aspergillin PZ
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Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM). | |||
T83862 |
Bactobolin A hydrochloride
BN-183B |
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Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物,具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内,bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。 | |||
T38086 |
Neohydroxyaspergillic Acid
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Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae ... | |||
T75439 | Angustifoline hydrochloride | ||
Angustifoline hydrochloride是从狭叶狼疮(Lupinus angustifolius L.)的生物碱提取物中分离出的一种生物碱,展现出对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和苏云金芽孢杆菌的抑制作用,证明了其抗菌活性。 | |||
T80343 |
MCF
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MCF为源自蜂毒的抗菌肽,对E.coli W 160-37、S.aureus 8530及B.subtilis展现出抗菌活性,其最小抑菌浓度(MIC)值分别为E.coli W 160-37为35-45 μg/ml,S.aureus 8530为25-35 μg/ml,及B.subtilis为15-25 μg/ml。 | |||
TN4264 |
Isoapetalic acid
胡桐,海棠木 |
HIV Protease; Antifection | Microbiology/Virology; Proteases/Proteasome |
Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a | |||
TN1991 |
Norchelerythrine
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Antifection | Microbiology/Virology |
Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. It exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm. | |||
TN4402 | Labd-13-ene-8,15-diol | Antifection | Microbiology/Virology |
13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer ac | |||
T83693 |
Magainin 2 TFA
MG2 |
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Magainin 2是一种从非洲爪蟾(X. laevis)皮肤中分离出的阳离子肽,具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性(MICs分别为5、10、10、50和80 µg/ml)。Magainin 2(20 µM)能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型(HSV-1)或2型(HSV-2)感染的Vero细胞中,它可减少病毒复制(EC50s分别为22.16和19.8 µM),同时不影响细胞活性,其50%细胞毒性浓度值(CC50)大于100 µM。 | |||
T36417 |
Nargenicin
Antibiotic 47444 |
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Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (... |