Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MUT056399 (Fab-001) 是一种金黄色葡萄球菌和大肠杆菌的 FabI 酶的高效抑制剂,IC50值分别为 12 nM 和 58 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 813 | 现货 | ||
5 mg | ¥ 1,970 | 现货 | ||
10 mg | ¥ 3,310 | 现货 | ||
25 mg | ¥ 5,320 | 现货 | ||
50 mg | ¥ 7,290 | 现货 | ||
100 mg | ¥ 9,820 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,990 | 现货 |
产品描述 | MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli (IC50s of 12 nM and 58 nM, respectively). |
靶点活性 | S. aureus:12 nM , for E. coli:58 nM |
体外活性 | MUT056399 is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli.?In vitro, MUT056399 was very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC(90)s between 0.03 and 0.12 μg/ml.?MUT056399 was also active against coagulase-negative staphylococci, with MIC(90)s between 0.12 and 4 μg/ml.?The antibacterial spectrum is consistent with specific FabI inhibition with no activity against bacteria using FabK but activity against FabI-containing Gram-negative bacilli.?In vitro, resistant clones of S. aureus were obtained at a low frequency.?All of the resistant clones analyzed were found to contain mutations in the fabI gene[1]. |
体内活性 | In vivo, MUT056399, administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day).?In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice[1] |
别名 | Fab-001 |
分子量 | 293.27 |
分子式 | C15H13F2NO3 |
CAS No. | 1269055-85-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (102.29mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4098 mL | 17.0491 mL | 34.0983 mL | 85.2457 mL |
5 mM | 0.682 mL | 3.4098 mL | 6.8197 mL | 17.0491 mL | |
10 mM | 0.341 mL | 1.7049 mL | 3.4098 mL | 8.5246 mL | |
20 mM | 0.1705 mL | 0.8525 mL | 1.7049 mL | 4.2623 mL | |
50 mM | 0.0682 mL | 0.341 mL | 0.682 mL | 1.7049 mL | |
100 mM | 0.0341 mL | 0.1705 mL | 0.341 mL | 0.8525 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MUT056399 1269055-85-7 Microbiology/Virology Antibacterial Inhibitor inhibit Bacterial Fab 001 Fab-001 Fab001 MUT-056399 MUT 056399 inhibitor