首页工具

登录

搜索结果

Search Results for " decarboxylase "

47

抑制剂 & 化合物

17

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T73614	Tyrosine decarboxylase
	Tyrosine decarboxylase (TDC; TyrDC)，即酪氨酸脱羧酶，广泛存在于植物、昆虫和不同微生物中，常用于生化研究。Tyrosine decarboxylase 是一种5'-磷酸吡哆醛 (PLP) 依赖性脱羧酶，可以催化酪氨酸中羧基的去除，产生酪胺和二氧化碳。
T60613	Mab Aspartate Decarboxylase-IN-1
	Mab Aspartate Decarboxylase-IN-1 是天冬氨酸脱羧酶 (PanD)的有效抑制剂(IC50 = 56.3 μM)，具有抗菌活性。
T7454	4-Bromo-3-hydroxybenzoic acid	Decarboxylase; Endogenous Metabolite	Metabolism; Others
	4-Bromo-3-hydroxybenzoic acid 是一种组氨酸脱羧酶抑制剂，是一种 Brocresine 的代谢产物，对大鼠胎儿和大鼠胃HDC 的IC50均为 1 mM。它还能够在体外抑制猪肾脏和大鼠胃粘膜中的芳香族 L-氨基酸脱羧酶，两种酶的IC50均为 1 mM。
T5884	Chelidamic acid 4-氧代-1,4-二氢-2,6-吡啶二甲酸,白屈氨酸	GluR	Neuroscience
	Chelidamic acid 是一种有效的谷氨酸脱羧酶抑制剂(Ki:33 μM)，也是含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。
T1517	Benserazide hydrochloride Benserazide HCl,盐酸苄丝肼,Serazide,Ro 4-4602	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Benserazide hydrochloride (Ro 4-4602) 是一种芳香族 L-氨基酸脱羧酶（AADC）的抑制剂，常用于帕金森病。
T2593	Eflornithine hydrochloride hydrate Difluoromethylornithine hydrochloride hydrate,α-difluoromethylornithine hydrochloride hydrate,依氟鸟氨酸盐酸盐一水合物,Eflornithine hydrochloride,MDL-71782 hydrochloride hydrate,DFMO hydrochloride hydrate,RMI-71782 hydrochloride hydrate,Eflornithine hydrochloride Monohydrate	Decarboxylase	Metabolism; Others
	Eflornithine hydrochloride hydrate (RMI-71782 hydrochloride hydrate) 是一种特异性的、不可逆的酶鸟氨酸脱羧酶抑制剂。它可用于研究非洲锥虫病和女性面部毛发过度生长。
T17042	TES-1025	Others	Others
	TES-1025 是一种有效且特异性的人 α-氨基-β-羧基粘康酸-ε-半醛脱羧酶 (ACMSD, IC50 = 13 nM) 抑制剂。
T4676	Sardomozide dihydrochloride CGP 48664 dihydrochloride,Sardomozide dihydrochloride	Others	Others
	Sardomozide dihydrochloride (CGP 48664 dihydrochloride) 是 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 的抑制剂 (IC50 = 5 nM)。
T40811	Eflornithine RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782
	Eflornithine is an irreversible inhibitor that specifically targets the enzyme ornithine decarboxylase. It serves as a therapeutic medication for two conditions: the treatment of African trypanosomiasis and the management of excessive facial hair growth in women.
T37190	L-Allylglycine	Dehydrogenase; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Allylglycine 是 GABA 合成酶（谷氨酸脱羧酶）的有效抑制剂。
T3937	Methyl L-histidinate dihydrochloride L-Histidine methyl ester dihydrochloride,L-组氨酸甲酯二盐酸盐	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) 在Sprague-Dawley 大鼠胃中组氨酸脱羧酶的抑制作用被评估为 14CO2 产生减少，活性值为 1.8 μM。
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T5954	Methyldopa hydrate L-甲基多巴,Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate	Dopamine Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methyldopa hydrate (MK-351 hydrate) 是一种前药，在中枢神经系统中被代谢成 α-Methylepinephrine。它是一种 α-肾上腺素能激动剂，对α2-adrenergic receptors 有选择性。
T35617	Mitoguazone MGBG,Methyl-GAG	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Mitoguazone (Methyl-GAG) 是一种可透过血脑屏障的选择性的 S-腺苷-蛋氨酸脱羧酶 (S-adenosyl-methionine decarboxylase) 抑制剂，可破坏多胺的生物合成。Mitoguazone 是一种具有抗肿瘤活性的合成多羰基衍生物，可抑制 HIV DNA 整合到单核细胞和巨噬细胞中的细胞 DNA 中，诱导细胞凋亡 (apoptosis)。Mitoguazone 具可用于预防急性白血病，霍奇金淋巴瘤和非霍奇金淋巴瘤。
T35449	α-(difluoromethyl)-DL-Arginine DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine	Others	Others
	α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时，它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时，能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长，并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。
T22831	Protein kinase inhibitor H-7 dihydrochloride H-7 dihydrochloride	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C（PKC）抑制剂。Protein kinase inhibitor H-7 dihydrochloride（100 μM）显著抑制 TPA (皮肤肿瘤启动子，12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶)，抑制 PMA 诱导的混杂细胞溶解活性。
T11812	L-Eflornithine L-依氟鸟氨酸,L-α-difluoromethylornithine,L-RMI71782,L-DFMO	Others	Others
	L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine is an enantiomer of Eflornithine.
T11812L	L-Eflornithine monohydrochloride L-α-difluoromethylornithine monohydrochloride,L-RMI71782 monohydrochloride,L-DFMO monohydrochloride	Others	Others
	L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.
T17166	Tritoqualine Hypostamine,酞茂异喹,Inhibostamin	Decarboxylase	Metabolism; Others
	Tritoqualine is used as an inhibitor of histidine decarboxylase.
T26374	(S)-alpha-Fluoromethylhistidine 2 HCl
	(S)-alpha-Fluoromethylhistidine 2 HCl is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase.
T12833	Sardomozide CGP 48664,SAM-486A	Others	Others
	Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).
T23822	Brocresine
	Brocresine is an aromatic L-amino acid decarboxylase inhibitor. It has both a peripheral and central action.
T68410	CBM 301940
	CBM 301940 is a potent malonyl-CoA decarboxylase inhibitor that is orally bioavailable.
T25052	Allylglycine
	Allylglycine is a glutamate decarboxylase inhibitor and a GAMMA-AMINOBUTYRIC ACID antagonist. It is used to induce convulsions in experimental animals.
T13132	TES-991	Others	Others
	TES-991 is a potent and selective inhibitor of human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)(IC50 of 3 nM).
T7622L	Gabazine free base Chebi:34968,SR95531,C13796,J331.170H,SR 95531
	Gabazine free base is a specific antagonist of the GABA receptor. It does not affect GABA-transaminase or glutamate-decarboxylase activities.
T26177	S-Aristeromycinylhomocysteine S-Aristeromycinyl-L-homocysteine
	S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.
T71495	Monofluoromethylagmatine
	Monofluoromethylagmatine is an arginine decarboxylase inhibitor.
T68771	2-Fluoromethylornithine
	2-Fluoromethylornithine is an ornithine decarboxylase antagonist.
T69101	NSD-1034
	NSD-1034 is an amino acid decarboxylase inhibitor.
T72531	6-Fluoromevalonate Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one
	6-Fluoromevalonate 是甲羟戊酸-焦磷酸脱羧酶抑制剂。
T40789	Eflornithine hydrochloride MDL71782hydrochloride,RMI71782hydrochloride,盐酸依氟乌氨酸,DFMO hydrochloride,α-difluoromethylornithinehydrochloride
	Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.
T36206	Methyldopate
	Methyldopate is an ethyl ester prodrug form of methyldopa , a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo., Formulations containing methyldopate have been used in the treatment of hypertension.
T69891	CGP 40215
	CGP 40215 is a specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor that was found to inhibit the growth of Leishmania donovani promastigotes
T20396	Levadopa Related Compound A 6-Hydroxydopa, L-,L-Hydroxydopa
	Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent and catecholamine-selective neurot
T17274	YM022	CCR	Immunology/Inflammation; Microbiology/Virology
	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively.
T33440	MK785 MK-785,MK 785
	MK785 is part of the association between inhibition of aortic histamine formation, aortic albumin permeability, and atherosclerosis. Aortic histamine synthesis was inhibited by partial inhibition of aortic histidine decarboxylase (HD) by application of MK
T36300	Uridine-5’-monophosphate (sodium salt hydrate)
	Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements. 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002)
T15701	Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride,MK-351 hydrochloride	Others	Others
	L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist psychoactive drug. It is used as a sympatholytic or antihypertensive. Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts
T1517L	Benserazide Ro-44602,Ro44602,Ro 44602,Serazide
	Benserazide is an inhibitor of dopa decarboxylase. It is often given with levodopa in the treatment of Parkinson's to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system an
T22509	3-Methyl-GABA	Others	Others
	3-Methyl-GABA 是一种有效的GABA 氨基转移酶激活剂。3-Methyl-GABA 能与 GABAA 受体 (GABAaR) 结合。3-Methyl-GABA 能够激活 L-谷氨酸脱羧酶 (GAD)，表现出抗惊厥作用。
T40115	GAD65 (206-220) GAD65 (206-220)
	GAD65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 180-188. It is known that GAD65 interacts with I-Ag7 MHC class II molecules and is a significant pancreatic antigen that self-reactive T cells target in type I diabetes mellitus.
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. \|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate...
T7626L	Budipine Hydrochloride BY-701,BY 701,BY701,Parkinsan
	Budipine is a non-dopaminergic antiparkinsonian drug. The primary action of budipine is an indirect dopaminergic effect as shown by facilitation of dopamine (DA) release, inhibition of monoamine oxidase type B (MAO-B) and of DA (re) up-take and stimulatio
T80218	GAD65(247-266) epitope TFA	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	GAD65(247-266) epitope TFA 为T细胞表位，与I-Ag7（I型糖尿病相关分子）竞争性结合，亲和力较低。该表位源自胰岛抗原，GAD65 是谷氨酸脱羧酶 65，涉及将谷氨酸转换为γ-氨基丁酸（GABA）。
T35578	Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre...
T82354	GAD65 (524-543)
	GAD65 (524-543) 是具有生物活性的肽，属于谷氨酸脱羧酶 65 (GAD65) 氨基酸片段 524-543。作为胰岛抗原的关键片段之一，该肽在自发性自身免疫性糖尿病非肥胖糖尿病 (NOD) 小鼠模型中，可诱导增殖性 T 细胞反应。GAD65 (524-543) 对T细胞克隆BDC2.5具有特异性刺激作用，但可能存在亲和力较低的问题。此外，p524-543免疫可增强NOD小鼠对通过BDC2.5 T细胞过继转移诱导的1型糖尿病的敏感性。

化合物

Tyrosine decarboxylase

Cat.No: T73614

Mab Aspartate Decarboxylase-IN-1

Cat.No: T60613

4-Bromo-3-hydroxybenzoic acid

Cat.No: T7454

Target: Decarboxylase, Endogenous Metabolite

Chelidamic acid

Cat.No: T5884

Synonym: 4-氧代-1,4-二氢-2,6-吡啶二甲酸,白屈氨酸

Target: GluR

Benserazide hydrochloride

Cat.No: T1517

Synonym: Benserazide HCl,盐酸苄丝肼,Serazide,Ro 4-4602

Target: Dopamine Receptor

Eflornithine hydrochloride hydrate

Cat.No: T2593

Synonym: Difluoromethylornithine hydrochloride hydrate,α-difluoromethylornithine hydrochloride hydrate,依氟鸟氨酸盐酸盐一水合物,Eflornithine hydrochloride,MDL-71782 hydrochloride hydrate,DFMO hydrochloride hydrate,RMI-71782 hydrochloride hydrate,Eflornithine hydrochloride Monohydrate

Target: Decarboxylase

Cat.No: T17042

Target: Others

Sardomozide dihydrochloride

Cat.No: T4676

Synonym: CGP 48664 dihydrochloride,Sardomozide dihydrochloride

Target: Others

Cat.No: T40811

Synonym: RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782

Cat.No: T37190

Target: Dehydrogenase, GABA Receptor

Methyl L-histidinate dihydrochloride

Cat.No: T3937

Synonym: L-Histidine methyl ester dihydrochloride,L-组氨酸甲酯二盐酸盐

Target: HDAC

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Methyldopa hydrate

Cat.No: T5954

Synonym: L-甲基多巴,Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate

Target: Dopamine Receptor, Adrenergic Receptor

Cat.No: T35617

Synonym: MGBG,Methyl-GAG

Target: Apoptosis, HIV Protease

α-(difluoromethyl)-DL-Arginine

Cat.No: T35449

Synonym: DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine

Target: Others

Protein kinase inhibitor H-7 dihydrochloride

Cat.No: T22831

Synonym: H-7 dihydrochloride

Target: PKC

Cat.No: T11812

Synonym: L-依氟鸟氨酸,L-α-difluoromethylornithine,L-RMI71782,L-DFMO

Target: Others

L-Eflornithine monohydrochloride

Cat.No: T11812L

Synonym: L-α-difluoromethylornithine monohydrochloride,L-RMI71782 monohydrochloride,L-DFMO monohydrochloride

Target: Others

Cat.No: T17166

Synonym: Hypostamine,酞茂异喹,Inhibostamin

Target: Decarboxylase

(S)-alpha-Fluoromethylhistidine 2 HCl

Cat.No: T26374

Cat.No: T12833

Synonym: CGP 48664,SAM-486A

Target: Others

Cat.No: T23822

Cat.No: T68410

Cat.No: T25052

Cat.No: T13132

Target: Others

Gabazine free base

Cat.No: T7622L

Synonym: Chebi:34968,SR95531,C13796,J331.170H,SR 95531

S-Aristeromycinylhomocysteine

Cat.No: T26177

Synonym: S-Aristeromycinyl-L-homocysteine

Monofluoromethylagmatine

Cat.No: T71495

2-Fluoromethylornithine

Cat.No: T68771

Cat.No: T69101

6-Fluoromevalonate

Cat.No: T72531

Synonym: Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one

Eflornithine hydrochloride

Cat.No: T40789

Synonym: MDL71782hydrochloride,RMI71782hydrochloride,盐酸依氟乌氨酸,DFMO hydrochloride,α-difluoromethylornithinehydrochloride

Cat.No: T36206

Cat.No: T69891

Levadopa Related Compound A

Cat.No: T20396

Synonym: 6-Hydroxydopa, L-,L-Hydroxydopa

Cat.No: T17274

Target: CCR

Cat.No: T33440

Synonym: MK-785,MK 785

Uridine-5’-monophosphate (sodium salt hydrate)

Cat.No: T36300

Methyldopa hydrochloride

Cat.No: T15701

Synonym: L-(-)-α-Methyldopa hydrochloride,MK-351 hydrochloride

Target: Others

Cat.No: T1517L

Synonym: Ro-44602,Ro44602,Ro 44602,Serazide

Cat.No: T22509

Target: Others

GAD65 (206-220)

Cat.No: T40115

Synonym: GAD65 (206-220)

Methylspinazarin

Cat.No: T36207

Budipine Hydrochloride

Cat.No: T7626L

Synonym: BY-701,BY 701,BY701,Parkinsan

GAD65(247-266) epitope TFA

Cat.No: T80218

Target: GABA Receptor

Phosphatidylserines (sodium salt)

Cat.No: T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

GAD65 (524-543)

Cat.No: T82354

Cat. No.	Product Name	Target	Signaling Pathways
T4891	Sodium phenylpyruvate 苯丙酮酸钠,Phenylpyruvic acid, sodium salt	Others	Others
	Sodium phenylpyruvate (Phenylpyruvic acid, sodium salt) 是phenylpyruvate decarboxylase 和phenylpyruvate tautomerase 互变异构酶的底物。
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T4913	Maleic acid	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	Maleic Acid 是大肠杆菌和单核细胞增生李斯特菌的谷氨酸脱羧酶抑制剂。
TN1774	Isobavachromene	Others; Antibacterial	Microbiology/Virology; Others
	Isobavachromene 是一种抗菌剂。
T3S0507	Homovanillic acid Homovaniuic acid,Vanilacetic acid,高香草酸,Vanillacetic acid	Others; Endogenous Metabolite	Metabolism; Others
	Homovanillic acid (Vanillacetic acid) 是一种多巴胺代谢物，它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。
TN7221	6-Bromovanillin
	6-Bromovanillin 是一种生化试剂，可用于用于合成caridopa。Caridopa 一种芳香氨基酸脱羧酶抑制剂。
T0848	L-DOPA 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine	Dopamine Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	L-DOPA (Levodopa) 是的神经递质多巴胺的代谢前体，具有口服活性。Levodopa 能够透过血脑屏障，并在大脑中转化为多巴胺。Levodopa 具有抗痛觉过敏作用。Levodopa 还具有帕金森氏病的研究潜力。
T5291	Malonic acid Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid	Others	Others
	Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子：它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关，这是一种先天性代谢错误。
T4734	Suberic acid Octanedioic acid,1,8-Octanedioic acid,辛二酸	Others; Endogenous Metabolite	Metabolism; Others
	Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。
T5279	Ethylmalonic acid alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸	Others; Endogenous Metabolite	Metabolism; Others
	Ethylmalonic acid (alpha-Carboxybutyrate) 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。
T1611	Isotretinoin 13-cis-Retinoic acid,异维A酸	Retinoid Receptor; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。它结合并激活核视黄酸受体 (RAR)，活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
T5S1331	Herbacetin	c-Met/HGFR; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Herbacetin 是一种亚麻籽中的天然类黄酮，具有多种药理活性，如抗氧化、抗炎、抗癌作用。它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂，能够直接与 ODC 上的 Asp44，Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。
T5558	Chelidonic acid Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质，用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂，Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。
T73775	Dopamine 3-O-sulfate
	Dopamine 3-O-sulfate，一种主要存在于血浆中的化合物，可作为芳香族氨基酸脱羧酶(AADC)缺乏症的生物标志物。
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by
T39626	Orotidine 5′-monophosphate Orotidine monophosphate,Orotidylicacid,Orotidine 5′-monophosphate
	Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase.
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...

天然产物

Sodium phenylpyruvate

Cat.No: T4891

Synonym: 苯丙酮酸钠,Phenylpyruvic acid, sodium salt

Target: Others

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T4913

Target: Endogenous Metabolite, Antibacterial

Isobavachromene

Cat.No: TN1774

Target: Others, Antibacterial

Homovanillic acid

Cat.No: T3S0507

Synonym: Homovaniuic acid,Vanilacetic acid,高香草酸,Vanillacetic acid

Target: Others, Endogenous Metabolite

6-Bromovanillin

Cat.No: TN7221

Cat.No: T0848

Synonym: 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine

Target: Dopamine Receptor, Endogenous Metabolite

Cat.No: T5291

Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid

Target: Others

Cat.No: T4734

Synonym: Octanedioic acid,1,8-Octanedioic acid,辛二酸

Target: Others, Endogenous Metabolite

Ethylmalonic acid

Cat.No: T5279

Synonym: alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸

Target: Others, Endogenous Metabolite

Cat.No: T1611

Synonym: 13-cis-Retinoic acid,异维A酸

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Cat.No: T5S1331

Target: c-Met/HGFR, Akt

Chelidonic acid

Cat.No: T5558

Synonym: Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid

Target: NF-κB, Caspase

Dopamine 3-O-sulfate

Cat.No: T73775

Cat.No: TN3607

Target: cAMP

Orotidine 5′-monophosphate

Cat.No: T39626

Synonym: Orotidine monophosphate,Orotidylicacid,Orotidine 5′-monophosphate

Phosphatidylserines (bovine)

Cat.No: T35577

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼