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341

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0078	CDK-IN-2 CDK inhibitor II	CDK	Cell Cycle/Checkpoint
	CDK-IN-2 (CDK inhibitor II) 是一种有效且特异性的 CDK9 抑制剂，IC50小于8 nM。
T60869	CDK-IN-10	CDK	Cell Cycle/Checkpoint
	CDK-IN-10 是一种细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗癌活性，可用于研究癌症。
T14916	CDK2-IN-4	CDK	Cell Cycle/Checkpoint
	CDK2-IN-4 是选择性的CDK2抑制剂，对 CDK2/cyclin A 的IC50值为 44 nM，选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。
T36741	CDK-IN-6
	CDK-IN-6, a pyrazolo[1,5-a]pyrimidine compound, exhibits potent anticancer activities as a CDK inhibitor[1].
T39957	CDK4/6-IN-6	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-6 是CDK4/CDK6的有效抑制剂，结合CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 为 0.6 nM 和 13.9 nM。
T10742	CDK9-IN-10	CDK	Cell Cycle/Checkpoint
	CDK9-IN-10 是一种有效的 CDK9 抑制剂。CDK9-IN-10 是 PROTAC CDK9 degrader-2 的配体。
T10736	CDK4/6-IN-2	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。
T10740	CDK8-IN-1	CDK	Cell Cycle/Checkpoint
	CDK8-IN-1 是一个有效的、CDK8 的选择性抑制剂，其 IC50 值为 3 nM。
T14914	Cdk1/2 Inhibitor III	CDK	Cell Cycle/Checkpoint
	Cdk1/2 Inhibitor III 是一种具有选择性的 Cdk1/2抑制剂，对 CDK1/cyclin B 的 IC50值为2.1μM。
T10734	CDK ligand for PROTAC	Others	Others
	CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
T14918	CDK9-IN-2 N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺	Others; CDK	Cell Cycle/Checkpoint; Others
	CDK9-IN-2 是一种特异性CDK9抑制剂。它在 A2058 皮肤细胞系（72 小时）和 H929 多发性骨髓瘤细胞系（72小时）的IC50分别为 7 nM 和 5 nM。
T10745	CDK9-IN-7	CDK	Cell Cycle/Checkpoint
	CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的 CDK9/cyclin T 抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。
T37207L	Cdk5 Substrate acetate	CDK	Cell Cycle/Checkpoint
	Cdk5 Substrate acetate 是一种丝氨酸/苏氨酸激酶，主要在神经元组织中具有活性。与 p25 或 p35 一起，Cdk5 磷酸化一系列蛋白质，包括组蛋白 H1 和 tau。它是一种合成肽 (PKTPKKAKKL)，对应于组蛋白 H1 的序列。它被 Cdk5 磷酸化，Km 值为 5 µM。
T10735	CDK4/6/1 Inhibitor Crozbaciclib	CDK	Cell Cycle/Checkpoint
	CDK4/6/1 Inhibitor (Crozbaciclib) 是一种 CDK4/6 抑制剂 (IC50s: 3 and 1 nM). CDK4/6抑制剂是一类用于治疗一些类型的激素受体阳性、her2阴性乳腺癌的化合物，可阻断了乳腺癌细胞分裂和繁殖的过程。
T36933	Cdk2 Inhibitor II Cdk2 Inhibitor II,CDK2-IN-3	CDK	Cell Cycle/Checkpoint
	Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂，50 为 60 nM。
T39752	CDK12-IN-2 CDK12 inhibitor 2,CDK12-IN-2	CDK	Cell Cycle/Checkpoint
	CDK12-IN-2 (CDK12 inhibitor 2) 是一种有效的选择性 CDK12 抑制剂，对 CDK12、CDK2、CDK7 和 CDK9 的 IC50 为 52 nM、>100 μM、>10 μM 和 16 μM。 CDK12-IN-2可用于研究CDK12的功能。
T10734L	CDK ligand for PROTAC hydrochloride	Others	Others
	CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
TP1875L	CDK2 acetate(255064-79-0 free base)	Others	Others
	CDK2 acetate(255064-79-0 free base) 是真核生物 S/T 蛋白激酶家族的成员，其功能是催化 ATP γ-磷酸磷酸基转移到蛋白质底物中的丝氨酸或苏氨酸羟基（表示为 S0/T0）。
T75127	CDK-IN-12
	CDK-IN-12 (Example 20) 是一种CDK 抑制剂。CDK-IN-12 抑制 CDK4/6 的IC50值小于 20 nM。
T62235	CDK-IN-9
	CDK-IN-9 (compound 24) 是一种 CDK 的有效抑制剂。CDK-IN-9 也是一种能够诱导 CDK12 和 DDB1 相互作用的分子胶，能够作用于 CDK2/E (IC50: 4 nM) 。CDK-IN-9 能够导致细胞周期蛋白 K (cyclin K) 的多泛素化及其随后的降解。CDK-IN-9 可以利用去磷酸化视网膜母细胞瘤蛋白和RNA 聚合酶 II，进而诱导细胞凋亡 (apoptosis)。
T61583	CDK/HDAC-IN-1
	CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.
T78906	CDK/HDAC-IN-3	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CDK/HDAC-IN-3 是一种口服活性的 HDAC/CDK 双重抑制剂，对 CDK9、CDK12、CDK13 及 HDAC1、HDAC2、HDAC3 表现出有效且选择性的抑制，IC50 值分别为 98.32 nM、98.85 nM、100 nM、62.12 nM、93.28 nM 和 82.87 nM。该化合物主要用于急性髓性白血病 (AML) 的相关研究。
T63664	CDK/HDAC-IN-2
	CDK/HDAC-IN-2 是有效的 HDAC/CDK 双重抑制剂，能够作用于 HDAC1 (IC50: 6.4 nM)、HDAC2 (IC50: 0.25 nM)、HDAC3 (IC50: 45 nM)、HDAC6,8 (IC50>1000 nM)、CDK1 (IC50: 8.63 nM)、CDK2 (IC50: 0.30 nM)、CDK4,6,7 (IC50>1000 nM)。CDK/HDAC-IN-2 能够将细胞周期停滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。CDK/HDAC-IN-2 具有优异的抗增殖效果，显示出显著的抗肿瘤作用。
T60025	Eciruciclib	CDK	Cell Cycle/Checkpoint
	Eciruciclib 是一种具有抗肿瘤特性的 CDK 抑制剂。
T37207	Cdk5 Substrate Cdk5 Substrate
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 μM.
T10746	CDK9-IN-8	CDK	Cell Cycle/Checkpoint
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).
T7789	DRB	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	DRB 是一种核苷类似物，对几种羧基末端结构域激酶（包括酪蛋白激酶 II 、细胞周期依赖性激酶）有抑制作用。它可诱导人类结肠腺癌细胞的 p53 依赖性凋亡，且不会诱发健康细胞遗传毒性应激。
T5673	Senexin A	CDK	Cell Cycle/Checkpoint
	Senexin A 是一种有效且选择性的 CDK8 抑制剂，它还抑制 CDK19，Kd 值分别为0.83μM 和0.31μM。
T40263	CDK5-IN-1 CDK5-IN-1
	CDK5-IN-1 is a highly potent inhibitor of CDK5, displaying an inhibitory activity of less than 10 nM. This potent compound is specifically employed in scientific investigations relating to kidney diseases.
T40290	CDK12-IN-5 CDK12-IN-5
	CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50 = 173 μM) and CDK9/Cyclin T1 (IC50 = 127 μM) at the same high ATP concentration of 2 mM, as stated in WO2021116178A1.
T40289	CDK12-IN-6 CDK12-IN-6
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not exhibit any inhibitory effect on CDK2/Cyclin E (IC50 >20 μM) and CDK9/Cyclin T1 (IC50 >20 μM) when tested under the same high ATP conditions (2 mM) (WO2021116178A1).
T39247	CDK7-IN-5 CDK7-IN-5
	CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).
T40160	CDK2-IN-7 CDK2-IN-7
	CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).
T39354	CDK9-IN-12 CDK9-IN-12
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T40264	CDK7-IN-7 CDK7-IN-7
	CDK7-IN-7, a highly potent and selective inhibitor of CDK7 kinase, exhibits remarkable activity with an IC50 of less than 50 nM.
T72029	CDK8-IN-13	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	CDK8-IN-13是一种 CDK8抑制剂（IC50：51.9 nM），具有强效性、选择性和口服活性。CDK8-IN-13能诱导细胞凋亡，降低了 p-STAT1 S727和p-STAT5 S726的表达。CDK8-IN-13表现出抗肿瘤活性。
T39943	CDK7-IN-6 CDK7-IN-6
	CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. This compound holds significant potential for cancer research purposes.
T39372	CDK7-IN-1 CDK7-IN-1
	CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215).
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:147.
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T40288	CDK12-IN-4 CDK12-IN-4
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or CDK9/Cyclin T1 (IC50 > 20 μM) under the influence of high ATP (2 mM) levels (WO2021116178A1).
T9632	CDK9-IN-30	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	CDK9-IN-30 是 Tat 肽衍生物之一，可抑制 HIV-1 长末端重复激活转录。
T64373	CDK1-IN-2 cdk1 inhibitor 2	CDK	Cell Cycle/Checkpoint
	CDK1-IN-2 (cdk1 inhibitor 2)是一种CDK1抑制剂，IC50为5.8μM。CDK1-IN-2的激酶谱显示了多种激酶的非选择性抑制。
T72048	CDK8-IN-12	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	CDK8-IN-12 是一种具有选择性、有效性和口服活性的 CDK8 抑制剂（Ki ： 14 nM），是一种抗癌剂。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有抑制作用，Ki 分别为 13 nM、4 nM、109 nM。CDK8-IN-12对 MV4-11 细胞显示出抗增殖活性。
T60619	CDK9-IN-15	CDK	Cell Cycle/Checkpoint
	CDK9-IN-15 是一种有效的小分子CDK9抑制剂，可通过降解、抑制 CDK9 来阻断正性转录延长因子 P-TEFb (positive transcription elongation factor b) 对 RNA Poly-II C末端区域的磷酸化，抑制转录，迅速降低细胞内 mRNA 水平，从而引起肿瘤细胞凋亡。
T2082	CDK4-IN-1	CDK	Cell Cycle/Checkpoint
	CDK4-IN-1 是一种新型的特异性 CDK4/Cyclin D1 抑制剂，IC50 为 10 nM；分别是 CDK1/Cyclin B (IC50>15 uM) 和 CDK2/Cyclin A (IC50=5.265 uM) 的 1500 倍和 500 倍。
T14901	CCT-251921	CDK	Cell Cycle/Checkpoint
	CCT-251921是一种有口服活性的选择性CDK8抑制剂；IC50值为2.3 nM。
T16391	ON-013100	CDK	Cell Cycle/Checkpoint
	ON-013100 是有丝分裂的抑制剂，具有抗肿瘤活性。ON-013100能够抑制细胞周期蛋白 D1 的表达。
T4482	CC-671	Others; CDK	Cell Cycle/Checkpoint; Others
	CC-671 是一种双重 TTK 蛋白激酶/CLK2抑制剂, 对于 TTK 和 CLK2 的IC50值分别为 0.005 和 0.006 μM。
T40047	CDK6/9-IN-1 CDK6/9-IN-1
	CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.

化合物

Cat.No: TQ0078

Synonym: CDK inhibitor II

Target: CDK

Cat.No: T60869

Target: CDK

Cat.No: T14916

Target: CDK

Cat.No: T36741

Cat.No: T39957

Target: CDK

Cat.No: T10742

Target: CDK

Cat.No: T10736

Target: CDK

Cat.No: T10740

Target: CDK

Cdk1/2 Inhibitor III

Cat.No: T14914

Target: CDK

CDK ligand for PROTAC

Cat.No: T10734

Target: Others

Cat.No: T14918

Synonym: N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺

Target: Others, CDK

Cat.No: T10745

Target: CDK

Cdk5 Substrate acetate

Cat.No: T37207L

Target: CDK

CDK4/6/1 Inhibitor

Cat.No: T10735

Synonym: Crozbaciclib

Target: CDK

Cdk2 Inhibitor II

Cat.No: T36933

Synonym: Cdk2 Inhibitor II,CDK2-IN-3

Target: CDK

Cat.No: T39752

Synonym: CDK12 inhibitor 2,CDK12-IN-2

Target: CDK

CDK ligand for PROTAC hydrochloride

Cat.No: T10734L

Target: Others

CDK2 acetate(255064-79-0 free base)

Cat.No: TP1875L

Target: Others

Cat.No: T75127

Cat.No: T62235

CDK/HDAC-IN-1

Cat.No: T61583

CDK/HDAC-IN-3

Cat.No: T78906

Target: HDAC

CDK/HDAC-IN-2

Cat.No: T63664

Cat.No: T60025

Target: CDK

Cdk5 Substrate

Cat.No: T37207

Synonym: Cdk5 Substrate

Cat.No: T10746

Target: CDK

Cat.No: T7789

Target: HIV Protease

Cat.No: T5673

Target: CDK

Cat.No: T40263

Synonym: CDK5-IN-1

Cat.No: T40290

Synonym: CDK12-IN-5

Cat.No: T40289

Synonym: CDK12-IN-6

Cat.No: T39247

Synonym: CDK7-IN-5

Cat.No: T40160

Synonym: CDK2-IN-7

Cat.No: T39354

Synonym: CDK9-IN-12

Cat.No: T40264

Synonym: CDK7-IN-7

Cat.No: T72029

Target: Apoptosis, CDK

Cat.No: T39943

Synonym: CDK7-IN-6

Cat.No: T39372

Synonym: CDK7-IN-1

Cat.No: T36743

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

Cat.No: T40288

Synonym: CDK12-IN-4

Cat.No: T9632

Target: HIV Protease

Cat.No: T64373

Synonym: cdk1 inhibitor 2

Target: CDK

Cat.No: T72048

Target: GSK-3, CDK

Cat.No: T60619

Target: CDK

Cat.No: T2082

Target: CDK

Cat.No: T14901

Target: CDK

Cat.No: T16391

Target: CDK

Cat.No: T4482

Target: Others, CDK

Cat.No: T40047

Synonym: CDK6/9-IN-1

Cat. No.	Product Name	Target	Signaling Pathways
T5S1467	Cucurbitacin E	CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性，具有预防神经变性，具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。
T2933	Wogonin Vogonin,汉黄芩素	Apoptosis; Wnt/beta-catenin; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Wogonin (Vogonin) 是一种具有细胞渗透性的口服类黄酮，具有抗炎和抗癌特性，能够抑制 CDK8和 Wnt 的活性。
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
TN1673	Garcinone C 伽升沃 C,伽升沃C	ATM/ATR; CDK; STAT; AChR; Antifection	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Garcinone C 是一种从 Garcinia oblongifolia Champ 中提取的黄酮衍生物，具有抗炎、收敛和促进肉芽的活性。 Garcinone C 是一种 AChE 抑制剂，对某些癌症具有潜在的细胞毒性作用。
T7444	6-(Dimethylamino)purine N,N-Dimethyladenine,6-二甲基氨基嘌呤	Serine/threonin kinase; CDK	Cell Cycle/Checkpoint; Metabolism
	6-(Dimethylamino)purine (N,N-Dimethyladenine) 是一种丝氨酸苏氨酸蛋白激酶和 CDK 抑制剂。
TN1299	Desmethylglycitein 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone	PI3K; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物，具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
T25192	Butyrolactone I Olomoucin,丁酸内酯I	CDK	Cell Cycle/Checkpoint
	Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。
TN2080	Pinoresinol 松脂酚，松脂素,(+)-Pinoresinol	Apoptosis; NF-κB; CDK; p53	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素，具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调，抑制 NF-kappaB 和激活蛋白 1 。
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].

天然产物

Cat.No: T5S1467

Target: CDK, Autophagy

Cat.No: T2933

Synonym: Vogonin,汉黄芩素

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Cat.No: TN1673

Synonym: 伽升沃 C,伽升沃C

Target: ATM/ATR, CDK, STAT, AChR, Antifection

6-(Dimethylamino)purine

Cat.No: T7444

Synonym: N,N-Dimethyladenine,6-二甲基氨基嘌呤

Target: Serine/threonin kinase, CDK

Desmethylglycitein

Cat.No: TN1299

Synonym: 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

Butyrolactone I

Cat.No: T25192

Synonym: Olomoucin,丁酸内酯I

Target: CDK

Cat.No: TN2080

Synonym: 松脂酚，松脂素,(+)-Pinoresinol

Target: Apoptosis, NF-κB, CDK, p53

Manzamine A hydrochloride

Cat.No: T38441

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