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Search Results for " anti-inflammatory agents "

12

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T50012	4-(3-chlorophenyl)-2,3-dihydro-1,3-thiazol-2-one	Others	Others
	4-(3-chlorophenyl)-2,3-dihydro-1,3-thiazol-2-one 已被用作合成多种生物活性化合物的起始材料，包括抗真菌剂、抗病毒剂和抗炎剂。
T50102	3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one	Others	Others
	3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one 是一种化合物，已被广泛研究用于治疗各种疾病，包括肿瘤、阿尔茨海默症和帕金森病、抗炎药和镇痛剂。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T50020	1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride 1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride	Others	Others
	1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride (1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride) 是一种哌嗪的化学衍生物，已被用作合成其他化合物的起始材料，如抗炎剂。它通过与酶和蛋白质的活性位点结合来调节其活性，已被用于酶抑制和蛋白质结构的研究，以及药物代谢的研究。
T27908	LY 269415 LY269415,LY-269415
	LY 269415 is an anti-inflammatory agent with antioxidant properties in vitro and could be beneficial as therapeutic agents in inflammatory arthritis.
T25283	Cytochrome P450 2C9 Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase
	Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, anticoagulants, hypoglycemic agents, a
T25542	Isamfazone Isamfazona,Isamfazonum
	Isamfazone is utilized in the chemical and pharmacological studies on substituted pyridazones, the discovery of novel anti-inflammatory agents by aligning screening.
T71176	Atiprimod (free base)
	Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, ind...
T77851	INX-SM-6
	INX-SM-6适用于靶向输送抗炎药物。它能在PBMCS细胞中抑制LPS引发的IL-1β产生。
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major ...
T37644	Bengamide B
	Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor. Hu et al (2007) Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 14 764 PMID:17656313 \|Johnson et al (2012) Myxobacteria versus sponge-derived alkaloids: the be...

化合物

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

4-(3-chlorophenyl)-2,3-dihydro-1,3-thiazol-2-one

Cat.No: T50012

Target: Others

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one

Cat.No: T50102

Target: Others

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride

Cat.No: T50020

Synonym: 1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride

Target: Others

Cat.No: T27908

Synonym: LY269415,LY-269415

Cytochrome P450 2C9

Cat.No: T25283

Synonym: Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase

Cat.No: T25542

Synonym: Isamfazona,Isamfazonum

Atiprimod (free base)

Cat.No: T71176

Cat.No: T77851

DL-Sulforaphane N-acetyl-L-cysteine

Cat.No: T36614

Cat.No: T37644

Cat. No.	Product Name	Target	Signaling Pathways
T3834	8-Epideoxyloganic acid 8-表去氧马钱酸	ROS; Immunology/Inflammation related	Immunology/Inflammation
	8-Epideoxyloganic acid 是从 Incarvillea delavayi 中分离得到的一种环烯醚萜苷。它具有微弱的缓解疼痛活性。
T5687	WITHAFERIN A 醉茄素 A,醉茄素A	Ferroptosis; NF-κB	Apoptosis; NF-κB
	Withaferin A 是从南非醉茄中分离到的一种甾体内酯，是内皮蛋白 C 受体脱落抑制剂，可以抑制NF-kB 的活性，具有抗炎，抗肿瘤等作用。它是一种新型 NFkappaB 抑制剂，有望成为治疗各种炎症性疾病和癌症的新型抗炎药。
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T3411	Curdione 莪术二酮,(+)-Curdione	P450	Metabolism
	Curdione ((+)-Curdione) 是一种具有高生物活性的倍半萜类物质，从莪术中分离获得，具有抑制血小板聚集、抵抗血栓形成的作用。
T7918	2-Amino-2-dichlorobenzophenone	Others	Others
	2-Amino-2-dichlorobenzophenone 是一种芳香族天然化合物，已被用于研究各种化合物对细胞代谢、蛋白质合成和酶活性的影响，还被用于药物的合成，如抗肿瘤药物和抗炎药。
T3851	Vicenin 2 Vicenin -2,维采宁 2,新西兰牡荆苷	RAAS	Endocrinology/Hormones
	Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
T4900	(±)-Methyl Jasmonate (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate	Others; Endogenous Metabolite	Metabolism; Others
	Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T3417	Amentoflavone Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin	Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal	Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物，有抗炎、抗氧化和神经保护等作用。
TN4164	Grandifloroside	TNF	Apoptosis
	Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory ag
TN4877	Quercetin 3,4'-dimethyl ether	ERK; BCL; MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ether could be useful in the development of novel anticancer agents, it has high cytotoxic aga

天然产物

8-Epideoxyloganic acid

Cat.No: T3834

Synonym: 8-表去氧马钱酸

Target: ROS, Immunology/Inflammation related

Cat.No: T5687

Synonym: 醉茄素 A,醉茄素A

Target: Ferroptosis, NF-κB

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Cat.No: T3411

Synonym: 莪术二酮,(+)-Curdione

Target: P450

2-Amino-2-dichlorobenzophenone

Cat.No: T7918

Target: Others

Cat.No: T3851

Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷

Target: RAAS

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

(±)-Methyl Jasmonate

Cat.No: T4900

Synonym: (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

Target: Others, Endogenous Metabolite

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: T3417

Synonym: Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin

Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal

Grandifloroside

Cat.No: TN4164

Target: TNF

Quercetin 3,4'-dimethyl ether

Cat.No: TN4877

Target: ERK, BCL, MAPK, Caspase, JNK

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