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Search Results for " 肝细胞生长因子 "

Targets Recommended: Others

17

抑制剂 & 化合物

4

天然产物

2

化合物库

9

重组蛋白

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Cat. No.	Product Name
L2193	抗肝癌化合物库		1787 compounds
	1787 种与肝癌相关的化合物，可以用于抗肝癌药物研发和药理研究；
L2550	谷氨酰胺代谢化合物库		565 compounds
	565 种谷氨酰胺代谢相关的分子，可以用于高通量和高内涵筛选；

化合物库

抗肝癌化合物库

Cat.No: L2193

Compounds: 1787

谷氨酰胺代谢化合物库

Cat.No: L2550

Compounds: 565

Cat. No.	Product Name	Target	Signaling Pathways
T4508	Glycyl-L-Histidyl-L-Lysine	Others	Others
	Glycyl-L-Histidyl-L-Lysine 是一种肝细胞生长因子和一种合成的肝营养剂，可刺激肝红细胞生成因子的产生。
T39507L	Fosgonimeton acetate Fosgonimeton acetate (2093305-05-4 Free base)	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Fosgonimeton acetate 是一种肝细胞生长因子受体激动剂。
T7376	Dihexa PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) 是肝细胞生长因子/c-Met (HGF/c-Met) 系统的激活剂，它与 HGF (Kd = 65 pM) 结合，是肽血管紧张素 IV 的类似物。
T10904	CWP232228	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T77437	Telisotuzumab ABT-700,Mab-224G11	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Telisotuzumab(ABT-700) 是一种人源化重组抗体，靶向治疗性肝细胞生长因子受体（MET）的抗体，对 c-Met 具有很高的亲和力。Telisotuzumab 对 c-Met 信号传导具有抑制作用且具有抗肿瘤活性。
T5478	SRI 31215 TFA SRI 31215	c-Met/HGFR	Tyrosine Kinase/Adaptors
	SRI 31215 TFA 是 matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为 0.69 μM、0.65 μM、0.3 μM。它能够阻断 pro-HGF 的活化，模拟 HAI-1/2 的活性。
T76758	Rilotumumab AMG 102	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Rilotumumab (AMG 102) 是一种针对肝细胞生长因子的单克隆抗体，对 HGF/MET 驱动的信号传导有抑制作用。Rilotumumab 具有抗肿瘤作用，可用于研究去势抵抗性前列腺癌 (CRPC) 和胃癌。
T78297	Aldafermin NGM282
	Aldafermin (NGM282)，一种成纤维细胞生长因子19的类似物，主要用于非酒精性脂肪性肝炎（NASH）的研究。
T70434	Vabametkib
	Vabametkib为有效的肝细胞生长因子受体(HGFR)抑制剂，以IC50 7 nM抑制Hs746T细胞增殖及c-Met，具有抗肿瘤活性。
T76051	NFF-3 TFA
	NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3和 MMP-10而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA，可在细胞实验中产生荧光，而检测细胞活性。
T76745	Ficlatuzumab
	Ficlatuzumab 是一种靶向人肝细胞生长因子 (HGF) 的单克隆抗体 (McAb)。Ficlatuzumab 能够阻断HGF/c-Met 信号通路的激活，抑制c-Met 受体介导的癌细胞增殖、迁移和侵袭。
T80884	Val-Cit-amide-Ph-Maytansine
	Val-Cit-amide-Ph-Maytansine 是用于肝细胞生长因子受体 c-Met (MET) 或抗体药物偶联物 (ADCs) 的抗体和双特异性抗原结合分子。
T80885	Val-Cit-amide-Cbz-N(Me)-Maytansine
	Val-Cit-amide-Cbz-N(Me)-Maytansine是一种可用于构建抗体和双特异性抗原结合分子，能够特异性结合肝细胞生长因子受体c-Met (MET)以及用于制备抗体药物偶联物(antibody-drug conjugates) (ADCs)的化合物。
T75940	Norleual TFA
	Norleual TFA 是一种血管紧张素 (Ang) IV 类似物，是一种肝细胞生长因子(HGF)/c-Met 抑制剂，IC50为 3 pM。Norleual TFA 还是一种AT4拮抗剂，具有强大的抗血管生成活性。
T62277	PPARδ agonist 8
	Pparδ agonist 8 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族，在体内代谢稳态、炎症、细胞生长和分化的调节中具有关键作用。Pparδ agonist 8 具有潜力进行非酒精性脂肪肝 (NAFLD) 的研究。
T62205	Pparδ agonist 7
	Pparδ agonist 7 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族，在体内代谢稳态、炎症、细胞生长和分化的调节中发挥着关键作用。Pparδ agonist 7 对非酒精性脂肪肝 (NAFLD) 表现出研究潜力。
T83951	TM2 TEAD inhibitor
	TM2 TEAD抑制剂是一种有效并且可逆的TEA领域转录因子抑制剂(IC50为TEAD4自动棕榈酰化和TEAD2棕榈酰化分别为38 nM和156 nM)。它抑制TEAD-YAP的结合和转录活性。TM2 TEAD抑制剂在YAP依赖型癌症细胞中，无论是单独使用还是与MEK抑制剂联合使用，都显示出强大的抗增殖效果。同时抑制体外YAP依赖的肝脏类器官生长。

化合物

Glycyl-L-Histidyl-L-Lysine

Cat.No: T4508

Target: Others

Fosgonimeton acetate

Cat.No: T39507L

Synonym: Fosgonimeton acetate (2093305-05-4 Free base)

Target: c-Met/HGFR

Cat.No: T7376

Synonym: PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide

Target: c-Met/HGFR

Cat.No: T10904

Target: Wnt/beta-catenin

Cat.No: T77437

Synonym: ABT-700,Mab-224G11

Target: c-Met/HGFR

Cat.No: T5478

Synonym: SRI 31215

Target: c-Met/HGFR

Cat.No: T76758

Synonym: AMG 102

Target: c-Met/HGFR

Cat.No: T78297

Synonym: NGM282

Cat.No: T70434

Cat.No: T76051

Cat.No: T76745

Val-Cit-amide-Ph-Maytansine

Cat.No: T80884

Val-Cit-amide-Cbz-N(Me)-Maytansine

Cat.No: T80885

Cat.No: T75940

PPARδ agonist 8

Cat.No: T62277

Pparδ agonist 7

Cat.No: T62205

TM2 TEAD inhibitor

Cat.No: T83951

Cat. No.	Product Name	Target	Signaling Pathways
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
T9113	Myristicin Myristicine,肉豆蔻醚	IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用，还具有抗炎作用，其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡，其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。
TN1831	Macranthoside A Kalopanaxsaponin H	Antioxidant	oxidation-reduction
	Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷，属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性，抑制促炎细胞因子的产生和抑制炎症信号通路的激活，有助于中和有害的自由基，保护细胞免受氧化损伤，可以促进神经元的存活和生长，并防止氧化应激或神经毒性化合物引起的神经元细胞死亡，具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Cat.No: T9113

Synonym: Myristicine,肉豆蔻醚

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Macranthoside A

Cat.No: TN1831

Synonym: Kalopanaxsaponin H

Target: Antioxidant

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00375	HGF Protein, Human, Recombinant (His) Scatter factor,Hepatocyte growth factor,HGF,SF,Hepatopoietin...	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia...
TMPK-00369	HGF Protein, Human, Recombinant (hFc) HGF,F-TCF,HGFB,SF,F-TCFB,肝细胞生长因子,DFNB39,Hepatopoiet...	Human	HEK293 Cells
	Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response.HGF plays a central role in these metabolic disorders,HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pa...
TMPY-03290	HGF Protein, Mouse, Recombinant hepatocyte growth factor (hepapoietin A,NK1,scatter factor),...	Mouse	HEK293 Cells
	HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1.
TMPY-02327	HGF Protein, Human, Recombinant SF,hepatocyte growth factor (hepapoietin A,HGFB,F-TCF,F-TCFB...	Human	CHO Cells
	HGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 79.7 kDa and the accession number is P14210-1.
TMPY-00456	HGF Protein, Canine, Recombinant 肝细胞生长因子,scatter factor),hepatocyte growth factor (h...	Canine	HEK293 Cells
	HGF Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.9 kDa and the accession number is Q867B7.
TMPY-03246	HGF Protein, Rat, Recombinant 肝细胞生长因子,hepatocyte growth factor (hepapoietin A,sca...	Rat	HEK293 Cells
	HGF Protein, Rat, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is A6K5E8.
TMPY-03545	HGF Protein, Cynomolgus, Recombinant 肝细胞生长因子,hepatocyte growth factor (hepapoietin A,sca...	Cynomolgus	HEK293 Cells
	HGF Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.6 kDa and the accession number is C9E9X5.
TMPY-00821	HGFA Protein (pro form), Human, Recombinant (His) MGC138397,HGFA,RP11-529E1.2,肝细胞生长因子,MGC138395	Human	HEK293 Cells
	HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is clea...
TMPY-03237	HGF Protein, Mouse, Recombinant (His) SF/HGF,hepatocyte growth factor (hepapoietin A,肝细胞生长因子	Mouse	HEK293 Cells
	HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1.

重组蛋白

HGF Protein, Human, Recombinant (His)

Cat.No: TMPJ-00375

Species: Human

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00369

Species: Human

Expression System: HEK293 Cells

HGF Protein, Mouse, Recombinant

Cat.No: TMPY-03290

Species: Mouse

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant

Cat.No: TMPY-02327

Species: Human

Expression System: CHO Cells

HGF Protein, Canine, Recombinant

Cat.No: TMPY-00456

Species: Canine

Expression System: HEK293 Cells

HGF Protein, Rat, Recombinant

Cat.No: TMPY-03246

Species: Rat

Expression System: HEK293 Cells

HGF Protein, Cynomolgus, Recombinant

Cat.No: TMPY-03545

Species: Cynomolgus

Expression System: HEK293 Cells

HGFA Protein (pro form), Human, Recombinant (His)

Cat.No: TMPY-00821

Species: Human

Expression System: HEK293 Cells

HGF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03237

Species: Mouse

Expression System: HEK293 Cells

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