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T22346
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Indomethacin sodium hydrate
Indometacin sodium hydrate
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COX |
Immunology/Inflammation;
Neuroscience |
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Indomethacin sodium hydrate (Indometacin sodium hydrate) 是一种口服活性、竞争性和可逆性的 COX1/2 抑制剂，具有潜在的抗炎活性，可诱发的偏头痛，诱导的胃肠道损伤，可用于研究成人继发于严重创伤性脑损伤的颅内压增高和类风湿性关节。 |
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T0161
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Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)
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Apoptosis;
Potassium Channel;
Proton pump;
Autophagy |
Apoptosis;
Autophagy;
Membrane transporter/Ion channel |
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Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 |
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T1191
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Metamizole sodium hydrate
安乃近水合物,Sulpyrine,Analgin,Dipyron hydrate,安乃近
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COX |
Immunology/Inflammation;
Neuroscience |
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Metamizole sodium hydrate (Analgin) 可抑制环氧合酶(COX)，用于缓解疼痛的研究。 |
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T1720
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Amfenac Sodium Hydrate
一水氨芬酸钠,Amfenac Sodium Monohydrate,氨芬酸钠水合物
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COX |
Immunology/Inflammation;
Neuroscience |
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Amfenac Sodium Hydrate 是一种含有乙酸部分的非甾体镇痛抗炎药，是 COX-2抑制剂。 |
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T9154
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Sodium taurodeoxycholate hydrate
牛磺去氧胆酸钠,Taurodeoxycholic acid sodium salt monohydrate
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Others |
Others |
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Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid sodium salt monohydrate) 已用于一项研究，以评估亚胶束浓度的胆汁盐对脂质双层膜的影响。 |
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T1001
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Dicloxacillin Sodium hydrate
Dicloxacillin sodium salt monohydrate,双氯西林钠,Dicloxacillin sodium monohydrate
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Antibacterial;
Antibiotic |
Microbiology/Virology |
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Dicloxacillin Sodium hydrate 是一种青霉素类窄谱β内酰胺抗生素，可研究革兰氏阳性菌感染。 |
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T36503
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Sodium Hydrogen Sulfide (hydrate)
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Others |
Others |
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Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样，是一种重要的气体介质，对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体，常用于细胞和整个动物实验系统。例如，它被用来证明H2S 促进中性粒细胞迁移，减少气道炎症，保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。 |
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T37986
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D-Mannose-6-Phosphate sodium salt hydrate
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Others |
Others |
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D-Mannose-6-Phosphate sodium salt hydrate 是一种多功能单糖，可用于研究代谢、溶酶体传递和癌症。 |
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T2403
|
Bromfenac sodium hydrate
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠
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COX |
Immunology/Inflammation;
Neuroscience |
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Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) 是一种可口服的 COX 抑制剂，抑制 COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药，有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。 |
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T37985
|
D-Fructose-6-phosphate (sodium salt hydrate)
D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base)
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D-Fructose-6-phosphate (sodium salt hydrate) 是由磷酸葡萄糖异构酶将 6-磷酸葡萄糖异构化产生的糖酵解途径的糖中间体，可用于研究癌症。 |
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T1223
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Ceftriaxone sodium hydrate
Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium
|
Others;
Antibacterial;
Antibiotic |
Microbiology/Virology;
Others |
|
Ceftriaxone sodium hydrate 是一种头孢菌素类抗生素，对革兰氏阳性和革兰氏阴性菌均有活性。它具有抗炎和抗氧化作用。 |
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T6373
|
Alendronate sodium hydrate
G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax
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Transferase |
Metabolism |
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Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。 |
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T4615
|
Balsalazide sodium hydrate
巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium
|
STAT;
Interleukin |
Immunology/Inflammation;
JAK/STAT signaling;
Stem Cells |
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Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。 |
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T37583
|
XTT (sodium salt hydrate)
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XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3
1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas... |
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T38326
|
Cromolyn (sodium salt hydrate)
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Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions. |
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T36600
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Cefsulodin (sodium salt hydrate)
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Cefsulodin is a β-lactam antibiotic that lyses actively-growingE. coliby binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2 |
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T36066
|
NADP+ (sodium salt hydrate)
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NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynth... |
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T78218
|
Ilaprazole sodium hydrate
IY-81149 sodium hydrate
|
Proton pump |
Membrane transporter/Ion channel |
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Ilaprazole (IY-81149) sodium hydrate是一种具有口服活性的质子泵抑制剂，可以量依赖性地不可逆抑制H+/K+-ATPase，并在兔壁细胞制剂中展示出IC50为6μM的效力。该化合物主要用于胃溃疡的研究，并已证实是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。 |
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T69059
|
Cromoglicate sodium hydrate
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Cromoglicic acid , cromolyn (USAN), cromoglycate (former BAN), or cromoglicate, is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma. Cro... |
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T68692
|
Palmoxirate sodium hydrate
|
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Palmoxirate sodium hydrate is a potent inhibitor of long-chain fatty acid oxidation. |
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T35571
|
Adenosine 3’-monophosphate (sodium salt hydrate)
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Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine . |
|
T37789
|
Riboflavin 5'-monophosphate (sodium salt hydrate)
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Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA to alter gene regulation. FMN is a substrate of FMN phosphohydrolases and is used to study their function. |
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T36740
|
Guanosine 5’-diphosphate (sodium salt hydrate)
|
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Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)... |
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T3286
|
Sodium picosulfate monohydrate
Sodium picosulfate hydrate,匹可硫酸钠一水合物,Laxoberal
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Others |
Others |
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Sodium picosulfate monohydrate (Sodium picosulfate hydrate) 增加水和电解质的分泌并抑制它们的吸收。 |
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T38100
|
Betamethasone 21-phosphate (sodium salt hydrate)
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Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top... |
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T36300
|
Uridine-5’-monophosphate (sodium salt hydrate)
|
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Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements.
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) |
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T36916
|
Estrone-3-Glucuronide (sodium salt hydrate)
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Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of fertility in women.
1.Blackwell, L.F., Brown, J.B., and Cooke, D.Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual ... |
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T37900
|
UDP-Glucuronic Acid (sodium salt hydrate)
|
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UDP-Glucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1
1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998) |
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T35718
|
N-desmethyl Rosuvastatin (sodium salt hydrate)
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N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1
1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand... |
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T0087
|
Sulfacetamide sodium monohydrate
磺胺乙酰钠水合物,Sulfacetamide sodium salt hydrate,Sulfacetamide sodium
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Antibacterial;
Antibiotic;
Autophagy |
Autophagy;
Microbiology/Virology |
|
Sulfacetamide sodium monohydrate 是一种磺胺类药物，用于治疗酒渣鼻和花斑糠疹。 |
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T36827
|
Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA
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Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5] |
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T35652
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2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
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2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome. |
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T37902
|
Uridine-5'-diphosphoglucuronic Acid (sodium salt hydrate)
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Uridine-5'-diphosphoglucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1
1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998) |
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T37106
|
2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)
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2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations ... |
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T38357
|
1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)
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1,3,6,8-Pyrenetetrasulfonic acid is an intermediate in the synthesis of the color additive pyranine.1It has been used to stabilize intermolecular interactions for the crystallization ofL. mexicanapyruvate kinase.2
1.Jitian, S., White, S.R., Yang, H.-H.W., et al.Conventional high-performance liquid chromatography versus derivative spectrophotometry for the determination of 1,3,6-pyrenetrisulfonic acid trisodium salt and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt in the color additive D&C G... |
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T4054
|
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene
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Calcium Channel;
Autophagy |
Autophagy;
Membrane transporter/Ion channel;
Metabolism |
|
Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。 |
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T37901
|
UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)
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UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3
1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K.,... |
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T19979
|
Saccharin sodium hydrate
O-benzoic sulfimide sodium salt,糖精钠,Saccharin, sodium salt hydrate
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Saccharin, sodium salt hydrate is used in the food industry and for sweetening diabetes diet. It is also used as a synthetic sweet ignorance agent. Saccharin, sodium salt hydrate is the first generation′ synthetic sugar alternative that has been studied f |
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T37898
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UDP-α-D-Glucose (sodium salt hydrate)
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UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14receptor (EC50= 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.1It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.2
1.Jacobson, K.A., Ivanov, A.A., de Castro, S., et al.Development of selective agonists and antagonists of P2Y receptorsPurin... |
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T5039
|
Aminohippurate sodium
Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt
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Others |
Others |
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Aminohippurate sodium (Sodium p-aminohippurate) 是能够利用肾血浆流量测量肾脏医学测试的诊断剂。 |
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T6226
|
Pemetrexed disodium hemipenta hydrate
培美曲塞二钠一水合物,Pemetrexed Disodium Hydrate,LY-231514 Disodium Hydrate,Pemetrexed sodium hydrate,培美曲塞二钠水合物
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Apoptosis;
DHFR;
DNA/RNA Synthesis;
Antifolate;
Autophagy |
Apoptosis;
Autophagy;
Cell Cycle/Checkpoint;
DNA Damage/DNA Repair;
Metabolism |
|
Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) 是一种叶酸拮抗剂。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki 分别为 1.3 nM，7.2 nM 和 65 nM。 |
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T35416
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α-D-Glucose-1-phosphate (sodium salt hydrate)
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α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-... |
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T70887
|
GSK-1059615 sodium salt hydrate
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GSK-1059615 sodium salt hydrate is a potent inhibitor of PI 3-kinase α (PI3Kα). |
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T36973
|
5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)
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5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase.
N/A |
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T36807
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Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
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Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 ... |
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T2550L
|
Tolmetin (sodium salt hydrate)
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Tolmetin sodium dihydrate, a non-steroidal anti-inflammatory drug (NSAID), is a potent and orally active inhibitor of COX (cyclooxygenase). Its IC 50 values for human COX-1 and COX-2 are 0.35 μM and 0.82 μM, respectively [1] [2]. |
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T20762
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Sivelestat sodium tetrahydrate
ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046
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Serine Protease |
Proteases/Proteasome |
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Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其 IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 |
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T6706
|
Ticarcillin sodium
Ticarpen hydrate,Aerugipen hydrate,替卡西林单钠盐单水合物,BRL 2288,AB 2288,Monapen
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Others;
Antibacterial;
Antibiotic |
Microbiology/Virology;
Others |
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Ticarcillin sodium (Aerugipen hydrate) 主要用于抗革兰氏阴性菌, 也能用于研究嗜麦芽感染。 |
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T5016
|
Tofogliflozin (hydrate)
托格列净,Tofogliflozin hydrate,CSG-452 hydrate
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SGLT;
Reactive Oxygen Species;
ROS |
GPCR/G Protein;
Immunology/Inflammation;
Metabolism;
NF-κB |
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Tofogliflozin hydrate (CSG-452 hydrate) 是一种有效的，选择性的 SGLT2抑制剂，IC50为 2.9 nM，对人、大鼠和小鼠 SGLT2的Ki 分别为 2.9 nM，14.9 nM 和 6.4 nM。Tofogliflozin hydrate 对肾小管细胞中高葡萄糖诱导的ROS 生成具有部分抑制作用。 |
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T9308
|
AzoMethine-H Monosodium salt hydrate
Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate,偶氮甲碱-H 单钠盐 水合物
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Others |
Others |
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AzoMethine-H Monosodium salt hydrate (Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate) 是一种试剂，用于比色测定土壤、植物、堆肥、肥料、水和营养液中的硼。 |
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