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147

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T18064	Lenalidomide-Br	Ligand for E3 Ligase	PROTAC
	Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a protein ligand through a linker to create PROTACs. For instance, Lenalidomide-Br is utilized as a component in the PROTAC STAT3 degrader SD-36.
T21938	AS-041164	PI3K	PI3K/Akt/mTOR signaling
	AS-041164 是选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50=70 nM。它对 PI3Kα (IC50:240 μM)，PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。
T40548	NH-3	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
T28073	MLS1547 MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor	GPCR/G Protein; Neuroscience
	MLS1547 (MLS000051547) 是一种高效的 G 蛋白偏向多巴胺 D2 受体激动剂，Ki 为 1.2 μM。 MLS1547 在钙动员试验中刺激 D2R G 蛋白介导的信号传导，EC50 为 0.37 μM。
T26869	BMS-986122 BMS 986122	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂，可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用，还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。
T8497	SX-682	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂，可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫，具有治疗去势抵抗性前列腺癌的潜力。
T16850	SB-265610 GSK-CXCR2	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SB-265610 (GSK-CXCR2) 是竞争性非肽变构CXCR2选择性拮抗剂，可阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性，IC50分别为 3.7 和 70 nM。
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T14667	BLT-1	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	BLT-1 是一种氨基硫脲铜螯合剂，是一种选择性清除受体 B1 型 (SR-BI) 抑制剂，抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。
T40028	(S,R,S)-AHPC	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC 是一种 VHL 配体，用于募集 VHL 蛋白。
T40503	Thalidomide-5-methyl	Ligand for E3 Ligase	PROTAC
	Thalidomide-5-methyl 是基于 Thalidomide 的 CRBN 配体，可以用于CRBN 的招募。
T18831	Thalidomide-propargyl	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-propargyl 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到含 IMiD 的 PROTAC。
T22021	ACHP IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP(IKK-2 Inhibitor VIII) 是一种新型具有选择性和高效性的 IKK 抑制剂，对IKK-α和IKK-β 具有抑制作用。ACHP 具有抗 HIV-1 活性，通过抑制 NF-κB 激活来抑制 HIV-1 长末端重复序列（LTR）驱动的基因表达，抑制 TNF-α 诱导的 NF-κB （p65）募集到 HIV-1 LTR。
T7329	C-178	STING	Immunology/Inflammation
	C-178 是 STING 选择性共价抑制剂，与 Cys91 结合抑制小鼠中由不同的激活剂引起的 STING 反应。
T9029	STING-IN-3 C-171	STING	Immunology/Inflammation
	STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。它与 STING 结合，抑制其棕榈酰化，并阻止 TBK1 的募集和磷酸化。
TP1922L1	ELA-11 (human) acetate(1784687-32-6 free base)	Apelin receptor; Arrestin	GPCR/G Protein
	ELA-11 (human) acetate(1784687-32-6 free base)是亲和力 apelin 受体激动剂 (Ki = 14 nM)。 ELA-32 的生物活性片段。在体外抑制毛喉素诱导的 cAMP 产生并刺激 β-arrestin 募集。
T18066	Lenalidomide-OH	Ligand for E3 Ligase	PROTAC
	Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. An example of a PROTAC BTK degrader incorporating Lenalidomide-OH is SJF620.
T7753	Thalidomide-O-COOH Cereblon ligand 3,E3 ligase Ligand 3,TCE35031	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T9291	Thalidomide-5-OH 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体，可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T39988	6'-GNTI dihydrochloride	Opioid Receptor; Akt	Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	6'-GNTI dihydrochloride 是一种κ-阿片受体（KOR）激动剂，它偏向于激活 G 蛋白介导的信号传导，而不是β-阿司匹林2的募集。6'-GNTI dihydrochloride 只能激活纹状体神经元中的 Akt 通路。
T77673	7-FluorotryptaMine HCl	GPR; Arrestin	Endocrinology/Hormones; GPCR/G Protein
	7-FluorotryptaMine HCl 是一种有效的芳香单胺 GPRC5A 激动剂，可诱导 GPRC5A 介导的 β-arrestin 募集。7-FluorotryptaMine HCl 可用于研究与免疫和癌症相关的信号通路。
T13671	(S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.
T8412	(S,R,S)-AHPC VH032-NH2,MDK7526,VHL ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC (VH032-NH2) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T76882	Talquetamab JNJ-64407564,JNJ-7564	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Talquetamab (JNJ-64407564）是一种用于多发性骨髓瘤的 T 细胞重定向 GPRC5D 双特异性抗体，具有抗肿瘤活性，通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab 可用于治疗多发性骨髓瘤 (MM）。
T13877	(S,S,S)-AHPC hydrochloride (S,S,S)-VH032-NH2 hydrochloride,(S,S,S)-AHPC盐酸盐	Ligand for E3 Ligase	PROTAC
	(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) 是 von Hippel-Lindau (VHL) 氨基砌块。(S,S,S)-AHPC (Compound 27) 常作为 (S,R,S)-AHPC 的阴性对照。(S,R,S)-AHPC 是基于 VH032 的 VHL 配体，可用于募集 VHL 蛋白。
T7755	Thalidomide 4-fluoride E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮	IRAK; Ligand for E3 Ligase	Immunology/Inflammation; NF-κB; PROTAC
	Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。
T15611	JH-RE-06	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	JH-RE-06是一种REV1-REV7互作抑制剂，IC50为0.78 μM，Kd 为0.42 μM。它靶向与 POLζ 的 REV7 亚基相互作用的 REV1，可改善化疗效果。它通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成。
T17157	TRAF-STOP inhibitor 6877002 CD40-TRAF6 inhibitor	NF-κB	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂，可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化，减少白细胞募集和巨噬细胞的活化，减少动脉粥样硬化斑块中的巨噬细胞增殖。
T17927	(S,R,S)-AHPC TFA VH032-NH2 TFA,VHL ligand 1 TFA	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC TFA (VHL ligand 1 TFA) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，形成 PROTAC 分子。
T7752	(S,R,S)-AHPC-Me VHL ligand 2,E3 ligase Ligand 1A	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白，DC50<1 nM。它可用于合成 ARV-771。
T41231	GP 1a	Cannabinoid Receptor; PERK; Arrestin	Apoptosis; GPCR/G Protein
	GP 1a 是cannabinoid receptor 2（CB2）的强效激动剂（EC50=7.1),是在cAMP、GTPγS 和β-arrestin 招募试验中显示的。GP 1a 对CB2受体的选择性约为CB1受体的30倍，且在体外增加HL-60细胞的P-ERK1/2表达。GP 1a 对皮肤伤口愈合有益。GP 1a 可抑制炎症和纤维生成，同时促进上皮的重新形成。
T41068	P53R3	p53	Apoptosis
	P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合，包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用，其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5（DR5）的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。
T63790	Cbl-b-IN-3	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂（ic50 < 1 nM）。Cbl-b 是一种环型E3泛素蛋白连接酶，与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85，通过其E3泛素连接酶活性，参与了p85向CD28和T 细胞抗原受体ζ的募集，抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T77579	JC2-11	IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2	Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用，通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。
T10926L	CYT-1010 hydrochloride	Others	Others
	CYT-1010 hydrochloride is an mu-opioid receptor agonist. The EC50 for β-arrestin recruitment and cAMP production inhibition were 13.1 nM and 0.0053 nM, respectively.
T10926	CYT-1010	Others	Others
	CYT-1010 is an mu-opioid receptor agonist. The EC50 for the inhibition of β-arrestin recruitment and cAMP production is 13.1 nM and 0.0053 nM, respectively.
T77951	Thalidomide-5-O-C4-NH2 hydrochloride
	Thalidomide-5-O-C4-NH2 hydrochloride为一种Thalidomide衍生的cereblon配体，能够招募CRBN蛋白。它能通过linker与目标蛋白配体结合，进而构建PROTAC分子，如THAL-SNS-032。
T39721	Thalidomide-5-PEG2-Cl Thalidomide-5-PEG2-Cl
	Thalidomide-5-PEG2-Cl, a Thalidomide-derived cereblon ligand, serves as the ligand for the recruitment of CRBN protein. It can be conjugated to the protein ligand via a linker to produce PROTACs.
T40283	Thalidomide-5,6-Cl
	Thalidomide-5,6-Cl, a derivative of Thalidomide, serves as a cereblon ligand for the recruitment of CRBN protein. It can be linked to a ligand for protein using a linker to form PROTACs.
T14777	BRD5529	Others	Others
	BRD5529 is a selective inhibitor of CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction (IC50: 8.6 μM). BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and activation of CARD9.
T70983	Zoledronate disodium
	Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma.
T39032	Pomalidomide-5-O-CH3 Pomalidomide-5-O-CH3
	Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.
T71869	IMB-10
	IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.
T39894	Thalidomide-4-C3-NH2 hydrochloride Thalidomide-4-C3-NH2 hydrochloride
	Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs.
T38457	Lenalidomide-4-OH
	Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC.
T39699	Thalidomide-O-C8-Boc Thalidomide-O-C8-Boc
	Thalidomide-O-C8-Boc is a Cereblon ligand derived from Thalidomide, primarily employed in the recruitment of CRBN protein. This ligand can be linked to a protein ligand via a linker to create PROTACs.
T77960	Thalidomide-5-O-C13-NH2 hydrochloride
	Thalidomide-5-O-C13-NH2 hydrochloride 是一款Thalidomide衍生的cereblon配体，能够招募CRBN蛋白。该化合物能通过linker与特定的靶蛋白配体结合，进而构建PROTAC分子，如THAL-SNS-032。
T40897	Lenalidomide-4-aminomethyl
	Lenalidomide-4-aminomethyl is a CRBN ligand derived from Lenalidomide, which is utilized for the recruitment of CRBN protein. By linking Lenalidomide-4-aminomethyl to the ligand, a PROTAC can be formed.
T39599	Lenalidomide-C5-amido-Boc Lenalidomide-C5-amido-Boc
	Lenalidomide-C5-amido-Boc is a Cereblon ligand derived from Lenalidomide, and serves in the recruitment of CRBN protein. It can be effectively linked to the protein ligand through a linker, resulting in the formation of PROTAC.
T61371	CB1R Allosteric modulator 4
	CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arrestin-2 recruitment [1].

化合物

Lenalidomide-Br

Cat.No: T18064

Target: Ligand for E3 Ligase

Cat.No: T21938

Target: PI3K

Cat.No: T40548

Target: Thyroid hormone receptor(THR)

Cat.No: T28073

Synonym: MLS000051547,MLS 1547,MLS-1547

Target: Dopamine Receptor

Cat.No: T26869

Synonym: BMS 986122

Target: Opioid Receptor

Cat.No: T8497

Target: CXCR

Cat.No: T16850

Synonym: GSK-CXCR2

Target: CXCR

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Cat.No: T14667

Target: Others, HCV Protease

Cat.No: T40028

Target: Ligand for E3 Ligase

Thalidomide-5-methyl

Cat.No: T40503

Target: Ligand for E3 Ligase

Thalidomide-propargyl

Cat.No: T18831

Target: Others, Ligand for E3 Ligase

Cat.No: T22021

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

Cat.No: T7329

Target: STING

Cat.No: T9029

Synonym: C-171

Target: STING

ELA-11 (human) acetate(1784687-32-6 free base)

Cat.No: TP1922L1

Target: Apelin receptor, Arrestin

Lenalidomide-OH

Cat.No: T18066

Target: Ligand for E3 Ligase

Thalidomide-O-COOH

Cat.No: T7753

Synonym: Cereblon ligand 3,E3 ligase Ligand 3,TCE35031

Target: Others, Ligand for E3 Ligase

Thalidomide-5-OH

Cat.No: T9291

Synonym: 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

Target: Others, Ligand for E3 Ligase

6'-GNTI dihydrochloride

Cat.No: T39988

Target: Opioid Receptor, Akt

7-FluorotryptaMine HCl

Cat.No: T77673

Target: GPR, Arrestin

(S,R,S)-AHPC-Me hydrochloride

Cat.No: T13671

Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Target: Others, Ligand for E3 Ligase

Cat.No: T8412

Synonym: VH032-NH2,MDK7526,VHL ligand 1

Target: Others, Ligand for E3 Ligase

Cat.No: T76882

Synonym: JNJ-64407564,JNJ-7564

Target: Dopamine Receptor

(S,S,S)-AHPC hydrochloride

Cat.No: T13877

Synonym: (S,S,S)-VH032-NH2 hydrochloride,(S,S,S)-AHPC盐酸盐

Target: Ligand for E3 Ligase

Thalidomide 4-fluoride

Cat.No: T7755

Synonym: E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮

Target: IRAK, Ligand for E3 Ligase

Cat.No: T15611

Target: DNA/RNA Synthesis

TRAF-STOP inhibitor 6877002

Cat.No: T17157

Synonym: CD40-TRAF6 inhibitor

Target: NF-κB

(S,R,S)-AHPC TFA

Cat.No: T17927

Synonym: VH032-NH2 TFA,VHL ligand 1 TFA

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-Me

Cat.No: T7752

Synonym: VHL ligand 2,E3 ligase Ligand 1A

Target: Ligand for E3 Ligase

Cat.No: T41231

Target: Cannabinoid Receptor, PERK, Arrestin

Cat.No: T41068

Target: p53

Cat.No: T63790

Target: E1/E2/E3 Enzyme

Cat.No: T77579

Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2

CYT-1010 hydrochloride

Cat.No: T10926L

Target: Others

Cat.No: T10926

Target: Others

Thalidomide-5-O-C4-NH2 hydrochloride

Cat.No: T77951

Thalidomide-5-PEG2-Cl

Cat.No: T39721

Synonym: Thalidomide-5-PEG2-Cl

Thalidomide-5,6-Cl

Cat.No: T40283

Cat.No: T14777

Target: Others

Zoledronate disodium

Cat.No: T70983

Pomalidomide-5-O-CH3

Cat.No: T39032

Synonym: Pomalidomide-5-O-CH3

Cat.No: T71869

Thalidomide-4-C3-NH2 hydrochloride

Cat.No: T39894

Synonym: Thalidomide-4-C3-NH2 hydrochloride

Lenalidomide-4-OH

Cat.No: T38457

Thalidomide-O-C8-Boc

Cat.No: T39699

Synonym: Thalidomide-O-C8-Boc

Thalidomide-5-O-C13-NH2 hydrochloride

Cat.No: T77960

Lenalidomide-4-aminomethyl

Cat.No: T40897

Lenalidomide-C5-amido-Boc

Cat.No: T39599

Synonym: Lenalidomide-C5-amido-Boc

CB1R Allosteric modulator 4

Cat.No: T61371

Cat. No.	Product Name	Target	Signaling Pathways
T4953	Neotuberostemonine	NOS	Immunology/Inflammation
	Neotuberostemonine 是一种结核分枝杆菌根中主要的止咳生物碱，能够阻碍巨噬细胞的募集和活化，从而减轻博来霉素 (Bleomycin) 诱导的肺纤维化。
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.

天然产物

Neotuberostemonine

Cat.No: T4953

Target: NOS

Cat.No: TN6458

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