72
9
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22605 |
Bifemelane hydrochloride
|
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Bifemelane hydrochloride 是一种选择性的,有效的,和竞争性的单胺氧化酶A (MAO-A)抑制剂,Ki=4.20 μM,它也非竞争性地抑制MAO-B,Ki=46.0 μM。它具有显著的抗抑郁作用,可用于研究与脑血管疾病有关的认知和情绪障碍。 | |||
T0084 |
Moclobemide
吗氯贝胺,Ro111163 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Moclobemide (Ro111163) 是可逆的、可透过血脑屏障的单胺氧化酶 (MAO-A) 抑制剂,能够抑制 hMAO-A (IC50=6.061 μM)。它上调慢性应激小鼠海马祖细胞的增殖。 | |||
T6073 |
OG-L002
|
Histone Demethylase; Monoamine Oxidase; HSV | Chromatin/Epigenetic; Microbiology/Virology; Neuroscience |
OG-L002 是一种高度选择性的 LSD1有效抑制剂,IC50为 0.02 μM。它抑制HSV IE 基因的表达,还是单胺氧化酶抑制剂,对 MAO-A 和 MAO-B 的IC50分别为 1.38 μM 和 0.72 μM。 | |||
T7048 |
1,4-Naphthoquinone
α-Naphthoquinone,Naphthalene-1,4-Dione,P-Naphthoquinone,1,4-萘醌,para-naphthoquinone |
Others; MAO; Topoisomerase | DNA Damage/DNA Repair; Metabolism; Neuroscience; Others |
1,4-Naphthoquinone (P-Naphthoquinone) 被用作单胺氧化酶和 DNA 拓扑异构酶活性的潜在抑制剂,还用于抑制乙酰转移酶活性。 | |||
T0006 |
Methylene Blue trihydrate
碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue |
Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase | Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶,单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药,在医疗中通常用作染料。它具有抗伤害感受,抗疟疾,抗抑郁和抗焦虑作用,可用于高铁血红蛋白血症,神经退行性疾病和异环磷酰胺引起的脑病的研究。 | |||
T10079 |
MAO-IN-1
|
MAO | Metabolism; Neuroscience |
MAO-IN-1是一种高效的单胺氧化酶B (MAO B)抑制剂(IC50:20 nM),可用于研究神经系统相关疾病。 | |||
T77564 |
Coumarin102
Exciton 480 |
||
Coumarin102 (Exciton 480)是一种荧光染料。Coumarin102对Monoamine oxidase B、MAO-B和MAO-A具有较弱的抑制活性,可用来研究神经系统疾病。 | |||
T15023 |
CX-157
KP 157 |
MAO | Metabolism; Neuroscience |
CX-157 (KP 157) 是一种新型单胺氧化酶-A(MAO-A)抑制剂,可用于研究抑郁症类的神经系统疾病和癌症。 | |||
T16803 |
RS 8359
|
MAO | Metabolism; Neuroscience |
RS 8359 是单胺氧化酶 A (MAO-A) 的可逆抑制剂,对 A:B 酶类型的特异性比约为 2200。 RS 8359 具有抗抑郁活性。 | |||
T1578 |
Pargyline hydrochloride
优降宁盐酸盐,Pargylamine hydrochloride |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Pargyline hydrochloride (Pargylamine hydrochloride) 是不可逆的单胺氧化酶抑制剂,可作用于 MAO-A (Ki=13 μM) 和 MAO-B (Ki=0.5 μM) ,具有降压和抗癌作用。 | |||
T60712 |
MAO-B-IN-17
|
MAO | Metabolism; Neuroscience |
MAO-B-IN-17 是一种具有选择性和有效性的单胺氧化酶 B (MAO-B) 抑制剂(IC50:5.08 μM),可用于研究像帕金森类的中枢神经系统疾病。 | |||
T24680 |
PSB-1491
|
MAO | Metabolism; Neuroscience |
PSB-1491 是一种选择性和竞争性的单胺氧化酶 B 抑制剂,IC50 为 0.386 nM,是 MAO-A 的 25000 倍以上。 | |||
T0235 |
Modaline sulfate
|
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Modaline sulfate 是一种 MAO 抑制剂,用于研究抑郁症。 | |||
T5053 |
Eprobemide
LIS 630,依普贝胺 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Eprobemide (LIS 630) 是一种非竞争性的、可逆的单胺氧化酶 A 抑制剂。 | |||
T0300 |
Pargyline
Pargylamine,Paragyline,优降宁 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Pargyline (Pargylamine) 是不可逆的单胺氧化酶抑制剂,对MAO-A 和MAO-B 的Ki 分别为 13 μM 和 0.5 μM,具有降压和抗癌作用。 | |||
T24679 |
PSB-1434
PSB 1434,PSB1434 |
MAO | Metabolism; Neuroscience |
PSB-1434 是一种选择性和竞争性的单胺氧化酶 B 抑制剂,IC50 为 1.59 nM,相对于 MAO-A 的选择性>6000 倍。 | |||
T7942 |
Tranylcypromine hemisulfate
Tranylcypromine Sulfate,Tranylcypromine (hemisulfate),反苯环丙胺半硫酸盐 |
Histone Demethylase; MAO; Monoamine Oxidase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) 是单胺氧化酶(MAO) 和赖氨酸特异性去甲基化酶 1 (LSD1) 的抑制剂,可用于研究抑郁症和子宫内膜异位症。 | |||
T60932 |
MAO-B-IN-8
|
MAO | Metabolism; Neuroscience |
MAO-B-IN-8是一种高效且可逆的单胺氧化酶-B(MAO-B)抑制剂,同时也能抑制微胶质细胞产生的神经炎症介质。该化合物专为神经退行性疾病相关研究而设计[1]。 | |||
T1119 |
Rasagiline
雷沙吉兰,AGN1135,TVP1012 |
BCL; MAO; Monoamine Oxidase | Apoptosis; Metabolism; Neuroscience |
Rasagiline (AGN1135) 是不可逆的、高效的、选择性的线粒体单胺氧化酶 (MAO) 抑制剂,抑制大鼠脑 MAO B 和 MAO A 的 IC50分别为 4.43 nM 和 412 nM。 | |||
T38034 |
MAO-IN-M30 dihydrochloride
M 30 dihydrochloride |
Monoamine Oxidase | Neuroscience |
MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性,可通过血脑屏障的,脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。 | |||
T60671 |
MAO-B-IN-9
|
Beta Amyloid; Serotonin Transporter; Monoamine Oxidase | Neuroscience |
MAO-B-IN-9是一种可穿过血脑屏障的单胺氧化酶B MAO-B 抑制剂(IC50:0.18μM),具有有效性、选择性和时间依赖性。MAO-B-IN-9具有神经保护作用,可以防止Aβ1-42诱导的神经元细胞死亡,这可能与Aβ1-42的抗聚集作用有关。 | |||
T8849 |
PF-9601N
|
MAO | Metabolism; Neuroscience |
PF-9601N 是一种单胺氧化酶 B (MAO-B) 抑制剂,在多种体内外模型中表现出抗帕金森病 (PD) 的神经保护作用。它可用于研究兴奋性毒性介导的神经退行性疾病。 | |||
T11587 |
Hydroxyamine hydrochloride
Hydroxylammonium chloride,Hydroxylamine hydrochloride |
MAO | Metabolism; Neuroscience |
Hydroxyamine hydrochloride(Hydroxylammonium chloride) 是一种具有选择性和有效性的单胺氧化酶 (MAO) 抑制剂,对血小板聚集有抑制作用。Hydroxyamine hydrochloride 是有机合成的中间体,可用于合成其他有活性的化合物。 | |||
T80799 |
WAY-620147
|
MAO | Metabolism; Neuroscience |
WAY-620147 为N-(2-morpholinoethyl)nicotinamide的衍生物,能够抑制单胺氧化酶(Monoamine Oxidase)。WAY-620147 对MAO-A及MAO-B的IC50值分别为26 μM和55 μM,可用于研究神经系统疾病。 | |||
T24069 |
Fluoroclorgyline
|
||
Fluoroclorgyline is a specific inhibitor of monoamine oxidase A (MAO-A). | |||
T68593 |
Almoxatone
|
||
Almoxatone, also known as MD 780236, is a monoamine oxidase (MAO) inhibitor. | |||
T28109 |
Contezolid
MRX-I,MRX I,MRXI |
||
MRX-I, a monoamine oxidase-A (MAO-A) Inhibitor, is used potentially for the treatment of acute bacterial skin. | |||
T72892 |
AChE/MAO-IN-1
|
||
AChE/MAO-IN-1 是一种有效的AChE、MAO-A 和MAO-B 抑制剂,对人 AChE、MAO-B 和MAO-A 的IC50分别为 0.0248、0.0409 和 0.1108 μM。 | |||
T68177 | MDL-72394 | ||
MDL-72394 is a selective inhibitor of monoamine oxidase (MAO-A). | |||
T10154 |
MAO-B-IN-1
|
Others | Others |
MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases. | |||
T33268 |
Mebanazine oxalate
Z-87 |
||
Mebanazine oxalate 是一种有效的单胺氧化酶 (MAO) 抑制剂。Mebanazine oxalate 可用于抑郁症的研究。 | |||
T61321 |
MAO-B-IN-12
|
||
MAO-B-IN-12 (Compound 16c) is a highly effective inhibitor of monoamine oxidase B (MAO-B), displaying significant potency with an IC50 value of 1.3 μM. Additionally, MAO-B-IN-12 exhibits notable neuroprotective activity [1]. | |||
T79229 | ETAP | Monoamine Oxidase | Neuroscience |
ETAP为一种既抑制MAO-A也抑制MAO-B的化合物,展现出抗抑郁样活性,可应用于重度抑郁症的研究领域。 | |||
T27523 |
H77-77
H77/77 |
||
H77-77, a monoamine oxidase (MAO) inhibitor, produces a pronounced protection against phenelzine within the serotonergic and noradrenergic neurons in rats. | |||
T61463 | Monoamine oxidase/Aromatase-IN-1 | ||
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a potent dual inhibitor of monoamine oxidase (MAO) and aromatase, with IC50 values of 39 nM and 31 nM for MAO-B and aromatase, respectively. It holds significant potential for research in neurological disorders and breast cancer [1]. | |||
T61131 | MAO-B-IN-11 | ||
MAO-B-IN-11, also known as Compound 8c, is a highly potent inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.3 μM. Additionally, MAO-B-IN-11 exhibits neuroprotective properties [1]. | |||
T61958 |
MAO A/HDAC-IN-1
|
||
MAO A/HDAC-IN-1 是有效的单胺氧化酶 A (MAO A) 和HDAC 双重抑制剂,可用于胶质瘤研究。 | |||
T72689 | Phenoxypropazine | ||
Phenoxypropazine为一有效MAO(单胺氧化酶)抑制剂,主要应用于抑郁症研究。 | |||
T79761 |
MAO-B-IN-25
|
Monoamine Oxidase | Neuroscience |
MAO-B-IN-25(化合物92)作为一种选择性MAO-B抑制剂,IC50值针对MAO-A为0.5 nM,对MAO-B为240 nM。 | |||
T60660 |
MAO-B-IN-14
|
||
MAO-B-IN-14 (Compound 9) 是选择性的单胺氧化酶-B (MAO-B)抑制剂。MAO-B-IN-14 对人 MAO-B 的 IC50值为 0.95 μM,Ki 值为 0.55 μM。 | |||
T28798 |
SL-25.1188
SL25.1188 |
||
SL-25.1188 is a monoamine oxidase B (MAO-B) inhibitor. SL-25.1188 is characterized by reversible binding, high brain uptake, and very slow plasma metabolism in vivo. | |||
T73130 |
Mebanazine
|
||
Mebanazine 是一种有效的单胺氧化酶 (MAO) 抑制剂。Mebanazine 可用于抑郁症的研究。 | |||
T71956 |
Pimprinine
|
||
Pimprinine is an alkaloid. It is a potent inhibitor of MAO (monoamine oxidase). More recently, pimprinine showed promising anticonvulsant activity in electric seizure threshold. | |||
T5470 |
LAZABEMIDE
拉扎贝胺,Ro 19-6327 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Lazabemide (Ro 19-6327) 是一种单胺氧化酶 B 的选择性的可逆抑制剂 ,但对 MAO-A 活性较低。它高浓度时具有抑制单胺摄取的作用,能够抑制去甲肾上腺素、血清素和多巴胺摄取,其IC50值分别为 86 μM、123 μM 和 >500 μM。它可用于研究帕金森和阿尔茨海默病。 | |||
T79914 |
Tranylcypromine
SKF 385 |
Monoamine Oxidase | Neuroscience |
Tranylcypromine (SKF 385)为一种高效的单胺氧化酶抑制剂。 | |||
T12701 |
(rel)-Tranylcypromine D5 hydrochloride
2-Phenylcyclopropylamine D5 hydrochloride |
Histone Demethylase | Chromatin/Epigenetic |
(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine hydrochloride is an irreversible, nonselective inhibitor of monoamine oxidase (MAO) used in the treatment of depression. | |||
T60651 |
MAO-B-IN-16
|
||
MAO-B-IN-16 是单胺氧化酶 B (MAO-B) 的选择性抑制剂 (IC 50 = 1.55 μM),可用于中枢神经疾病研究,例如帕金森病。 | |||
T78859 | MAO-B-IN-23 | Monoamine Oxidase | Neuroscience |
MAO-B-IN-23(Compound 11f)作为一种MAO-B抑制剂,具有可逆性和竞争性,其IC50为1.44 μM,Ki为0.51 μM。 | |||
T72791 |
AChE/MAO-B-IN-3
|
||
AChE/MAO-B-IN-3 是AChE 和MAO-B 的抑制剂,对人AChE 和MAO-B 的IC50分别为 0.0257 μM 和 0.0456 μM。AChE/MAO-B-IN-3 可用于阿尔兹海默症的研究。 | |||
T26930 |
BW-1370U87
1370U 87,1370U-87,1370U87,BW 1370U87 |
||
BW-1370U87 is a monoamine oxidase A (MAO-A) inhibitor. BW-1370U87 elevates neurotransmitter amines in the brain over the same dose range at which it exhibits positive activities in animal models of depressive illness. BW-1370U87's mechanism of action foll |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3885 |
ROSIRIDIN
6'-O-Deacetylrosiridoside C,络塞定,(-)-Rosiridin |
Others; Monoamine Oxidase | Neuroscience; Others |
Rosiridin (6'-O-Deacetylrosiridoside C) 能够抑制 MAO A 和 MAO B,有潜在的抑郁症和老年性痴呆作用。它在 10 μM 时对 MAO B 的抑制率为 83.8% (pIC50=5.38)。 | |||
TN2004 |
Obtusin
1,7-二羟基-2,3,8-三甲氧基-6-甲基蒽-9,10-二酮,决明素 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Obtusin 是来自决明子种子,是一种高度选择性和竞争性的人单胺氧化酶-A 抑制剂,IC50=11.12 μM,Ki=6.15 μM。它在神经退行性疾病,尤其是焦虑和抑郁中起预防作用。 | |||
T3933 |
Jatrorrhizine
Yatrorizine,neprotin,药根碱 |
MAO; 5-HT Receptor; Antibacterial; AChE | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱,具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。 | |||
T3158 |
Harmane
Loturine,Harman,Aribine,哈尔满碱 |
Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor | GPCR/G Protein; Neuroscience |
Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱,是有效的神经毒素,可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂,具有致突变作用,对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。 | |||
T1311 |
4-aminobenzoic acid
PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid,对氨基苯甲酸 |
Endogenous Metabolite | Metabolism |
4-aminobenzoic acid (para-Aminobenzoic acid) 是一种具有紫外线吸收和抗纤维化特性的有机酸。当暴露在光线下时,4-aminobenzoic acid 吸收紫外线并通过光化学反应释放多余的能量,这可能会对DNA造成损害。4-aminobenzoic acid 还可以增加组织水平的摄氧量,并可能增强单胺氧化酶(MAO)活性以促进血清素的降解,过量可能导致纤维化变化。 | |||
T40244 |
Methyl citrate
|
||
Methyl citrate, obtained from Opuntia ficus-indica var. saboten Makino fruits, serves as a potent Monoamine oxidase B (MAO-B) inhibitor with an IC50 value of 0.23 mM. | |||
T79979 |
Methyl piperate
|
Monoamine Oxidase | Neuroscience |
Methylpiperate,一种胡椒碱类生物碱,展现出显著的MAO抑制活性(IC50 3.6 μM)。该化合物对MAO-B的选择性抑制作用(IC50 1.6 μM)优于对MAO-A(IC50 27.1 μM),因此可用于治疗精神障碍。 | |||
T40576 |
(S)-Salsolidine
|
||
(S)-Salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (MAO), exhibiting an inhibition constant (K i ) of 63 μM. R enantiomer demonstrating a greater efficacy than (S)-Salsolidine, boasting a K i value of 26 μM compared to the S form. | |||
TN3726 | Cudraflavone B | IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy | Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling |
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells. |