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41

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15391	Glufosinate ammonium	Others	Others
	Glufosinate ammonium 是谷氨酸的一种膦酸类似物，是一种除草剂，在植物细胞中转化为 PT (L-phosphinothricin) 。Glufosinate ammonium 显示出神经毒性作用。
T0432	Diclofenac diethylamine	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Diclofenac diethylamine 是非选择性抗炎剂，通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂，在 CHO 细胞中，对人COX-1和COX-2的IC50值分别为 4 和 1.3 nM。它对绵羊COX-1和COX-2的IC50值分别为 5.1 μM 和0.84 μM。
T9820	GPI-1485 GM1485	Others	Others
	GPI-1485 (GM1485) 是一种免疫抑制的特异性亲免蛋白配体，可促进中风后的神经功能改善和神经再生。
T0196	Diclofenac 双氯芬酸,奥尔芬,Diclofenacum,Voltaren	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物，是 COX 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM，0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。
T6470	Diclofenac Potassium 双氯芬酸钾,CGP-45840B,Cataflam,Voltfast	Apoptosis; Others; COX	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Diclofenac Potassium (CGP-45840B) 是一种非甾体抗炎药，用于减轻炎症并在某些情况下作为镇痛剂减轻疼痛。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM 和0.84 μM。
T1555	Diclofenac sodium GP 45840,双氯芬酸钠	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Diclofenac sodium (GP 45840) 是一种非选择性抗炎剂，是 COX 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM，0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。
T19913	CKI-7 CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK; SGK; Casein Kinase; CDK; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 抑制剂，IC50为 6 μM，Ki 为 8.5 μM。它选择性抑制 Cdc7激酶，还抑制 SGK，S6K1以及 MSK1。
T16275	NB001 HTS 09836	Adenylyl cyclase	Neuroscience
	NB001 (HTS 09836) 是腺苷酸环化酶 1 的抑制剂，对神经和非神经疼痛有作用。
T16288	Neuropathiazol	Others	Others
	Neuropathiazol 引起成年海马神经祖细胞的神经元分化。
T16287	Neurodazine	DNA Methyltransferase	Chromatin/Epigenetic
	Neurodazine 是一种神经性诱导剂，可促进多能细胞分化为神经元细胞。Neurodazine 通过激活 Wnt 和 Shh 信号传导促进分化。
T68154	TC-2216	AChR	Neuroscience
	TC-2216 是神经烟碱乙酰胆碱受体的部分激动剂，可用于治疗焦虑症和抑郁症。
T38287	C3a Receptor Agonist C3a receptor agonist 1,C3a受体激动剂,Complement 3a Receptor Agonist	Complement System	Immunology/Inflammation
	C3a Receptor Agonist (C3a receptor agonist 1) 结合免疫系统补体途径中的G 蛋白偶联C3a 受体(C3aRs)。在肠缺血再灌注损伤模型中，C3aR 的激活可防止中性粒细胞动员。C3aRs 在成年小鼠的神经祖细胞和未成熟神经元上表达。C3a 在体外刺激神经祖细胞的分化。
T64394	GW 833972A	Cannabinoid Receptor	GPCR/G Protein
	GW 833972A 是一种选择性的 CB2 受体激动剂。GW 833972A 对诱导神经去极化具有抑制作用，且在动物模型中对柠檬酸引起的咳嗽具有抑制作用。
T67913	(-)-GSK598809 hydrochloride
	(-)-GSK598809 hydrochloride 是 GSK598809 的异构体。GSK598809 是多巴胺 D3 受体 (DRD3) 的选择性拮抗剂，是一种选择性增强货币政策期间的神经反应药物和酒精依赖中的奖励预期，可能修复物质依赖中的奖励缺陷。
T3980	Su1498 Tyrphostin SU 1498,AG 1498	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Su1498 (Tyrphostin SU 1498) 是一种选择性的 VEGFR2 抑制剂，能够抑制 Flk-1 (IC50:700 nM)。
T76863	Elezanumab AE12-1Y-QL,ABT-555	TGF-beta/Smad	Stem Cells
	Elezanumab(ABT-555) 是一种有效的人抗 RGMa 单克隆抗体。Elezanumab 通过 SMAD1/5/8 通路发挥对 RGMa 介导的 BMP 信号传导的抑制作用，IC50 约为 97 pM。在神经元损伤和脱髓鞘模型中，Elezanumab 促进神经再生、神经保护和神经恢复。Elezanumab 促进皮质脊髓轴突生长为脊髓灰质，并增强腹角的血清素能神经支配，形成颈部病变尾部的突触连接。
T30808	CG500354 CG-500354,CG 500354
	CG500354 plays a tumor suppressive role through the cAMP/CREB signaling pathway and is a novel inducer of neural differentiation and growth arrest in primary HUMAN GBM derived cells.
T28736	SCR-4026
	SCR-4026 is an inhibitor of the nNOS-PSD-95 interaction with neuroprotective activities. SCR-4026 also promotes neural stem cells to differentiate into neurons-like cells.
TP2407	Small cardioactive peptide A SCPA
	Small cardioactive peptide A, as a neuropeptide that modulates neuromuscular synapsis in Aplysia, can also function as a neural cotransmitter in molluscs and exert a role in both the central and peripheral modulation of the control of feeding behavior.
T72390	Estradiol hemihydrate 17β-Oestradiol hemihydrate,β-Estradiol hemihydrate ; 17β-Estradiol hemihydrate ; 17β-Oestradiol hemihydrate,17β-Estradiol hemihydrate,β-Estradiol hemihydrate
	Estradiol (β-Estradiol) hemihydrate 是主要女性性激素的类固醇激素。它能上调人类子宫内膜干细胞 (hEnSCs) 的神经标志物表达，促进神经分化，适用于癌症、神经退行性疾病和神经组织工程研究。
T25496	Hexaglutamate folate Pteglu6
	Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube
T70420	PHA 543613 hydrochloride
	PHA-543613 hydrochloride acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.
T35546	Yhhu 3792
	Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes5. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice. Increases the spatial and episodic memory in mice.
T62219	NN-390
	NN-390 是一种选择性的、有效的、能够透过血脑屏障的 HDAC6 抑制剂 (IC50: 9.8 μM)。NN-390 具有潜力进行转移性第 3 组成神经管细胞瘤的研究。
TP1977	187-1, N-WASP inhibitor
	Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization
T82778	Cardioexcitatory peptide 1
	Cardioexcitatory peptide 1为从非洲大蜗牛(Achatina)心房分离的心兴奋性神经肽。该化合物对心脏具有显著的兴奋效应，并能影响肌肉组织的运动及神经活动。
T78092	UCL-TRO-1938	PI3K	PI3K/Akt/mTOR signaling
	UCL-TRO-1938为一种有效的PI3Kα变构激活剂，EC50约60 μM。该化合物能够诱导细胞增殖，并具备心脏保护及神经再生功能。
T74130	Epiboxidine
	Epiboxidine 是一种有效的选择性神经nAChR 激动剂，对大鼠和人α4β2nAChR 的Ki 分别为 0.46 nM 和 1.2 nM。Epiboxidine 是生物碱 Epibatidine 的甲基异恶唑类似物，也是另一种烟碱样受体激动剂 ABT 418 的类似物。
T37532	Docosahexaenoyl Glycine
	The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. It can be synthesized from other dietary ω-3 PUFAs or taken as a nutritional supplement. Docosahexaenoyl glycine consists of DHA with glycine attached at its carboxy terminus.
T32706	Levomefolate calcium pentahydrate
	Levomefolate calcium pentahydrate is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12. Levomefolate is included in formulations of certain oral contraceptives to ens
T75831	NTR 368 TFA
	NTR 368 TFA, 衍生自p75神经营养蛋白受体(p75NTR)，对应人类受体残基368-381，胶束脂质存在促使其倾向形成螺旋结构。该肽为神经细胞凋亡(apoptosis)的有效诱导剂。
T74131	Epiboxidine hydrochloride
	Epiboxidine hydrochloride 是一种有效的选择性神经nAChR 激动剂，对大鼠和人α4β2nAChR 的Ki 分别为 0.46 nM 和 1.2 nM。Epiboxidine hydrochloride 是生物碱 Epibatidine 的甲基异恶唑类似物，也是另一种烟碱样受体激动剂 ABT 418 的类似物。
T70174	Pirlindole-d4 HCl
	Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru...
T35552	Ganglioside GD3 Mixture (sodium salt)
	Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increa...
TP1749	IRBP (1-20), human
	IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the inter
T78596	CAD031
	CAD031，一种针对阿尔茨海默病 (AD) 的J147衍生物，展现了神经保护和记忆增强的特性。它能增强小鼠的记忆力，优化树突结构，并促进老年小鼠大脑生发区细胞的分裂。相较于J147，CAD031在人类神经干细胞测定中显示出更高的活性。
T72776	NR2F1 agonist 1
	NR2F1 agonist 1 是一种核受体 NR2F1激动剂，可特异性激活恶性细胞的休眠程序。NR2F1 agonist 1 上调 NR2F1 和调节休眠的下游靶基因。NR2F1 agonist 1 通过 NR2F1 激活在头颈部鳞状细胞癌 (HNSCC) 中诱导神经嵴样生长抑制。NR2F1 agonist 1 在小鼠原发肿瘤模型中抑制肿瘤生长。
T35497	(±)7(8)-EpDPA
	Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting ...
T61930	Yhhu-3792
	Yhhu-3792 激活 Notch 信号通路并促进 Hes3 和 Hes5 的表达。Yhhu-3792 增强神经干细胞 (NSC) 的自我更新能力，扩大了 NSC 池并促进了小鼠海马齿状回部分 (DG) 的内源性神经形成。Yhhu-3792 可提高小鼠的情景和空间记忆能力。 Yhhu-3792 在记忆障碍相关 DG 功能障碍中具有研究潜力。
T75777	187-1, N-WASP inhibitor TFA
	187-1, N-WASP inhibitor TFA，一种14-aa 环肽及N-WASP 抑制剂，能有效阻止由磷脂酰肌醇 4,5-二磷酸酯 (PIP2) 触发的肌动蛋白装配，IC50 值达 2 μM。该化合物通过维持蛋白质自身的抑制状态，进而抑制N-WASP 激活Arp2/3 复合体。
T37391	PSEM 308 hydrochloride
	PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels. Recommended concentration for use in mice is 5 mg/kg or lower. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. Lovett-Barron et al (2012) Regulation of neu...

化合物

Glufosinate ammonium

Cat.No: T15391

Target: Others

Diclofenac diethylamine

Cat.No: T0432

Target: Apoptosis, COX

Cat.No: T9820

Synonym: GM1485

Target: Others

Cat.No: T0196

Synonym: 双氯芬酸,奥尔芬,Diclofenacum,Voltaren

Target: Apoptosis, COX

Diclofenac Potassium

Cat.No: T6470

Synonym: 双氯芬酸钾,CGP-45840B,Cataflam,Voltfast

Target: Apoptosis, Others, COX

Diclofenac sodium

Cat.No: T1555

Synonym: GP 45840,双氯芬酸钠

Target: Apoptosis, COX

Cat.No: T19913

Synonym: CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl

Target: ROCK, SGK, Casein Kinase, CDK, S6 Kinase

Cat.No: T16275

Synonym: HTS 09836

Target: Adenylyl cyclase

Cat.No: T16288

Target: Others

Cat.No: T16287

Target: DNA Methyltransferase

Cat.No: T68154

Target: AChR

C3a Receptor Agonist

Cat.No: T38287

Synonym: C3a receptor agonist 1,C3a受体激动剂,Complement 3a Receptor Agonist

Target: Complement System

Cat.No: T64394

Target: Cannabinoid Receptor

(-)-GSK598809 hydrochloride

Cat.No: T67913

Cat.No: T3980

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR

Cat.No: T76863

Synonym: AE12-1Y-QL,ABT-555

Target: TGF-beta/Smad

Cat.No: T30808

Synonym: CG-500354,CG 500354

Cat.No: T28736

Small cardioactive peptide A

Cat.No: TP2407

Synonym: SCPA

Estradiol hemihydrate

Cat.No: T72390

Synonym: 17β-Oestradiol hemihydrate,β-Estradiol hemihydrate ; 17β-Estradiol hemihydrate ; 17β-Oestradiol hemihydrate,17β-Estradiol hemihydrate,β-Estradiol hemihydrate

Hexaglutamate folate

Cat.No: T25496

Synonym: Pteglu6

PHA 543613 hydrochloride

Cat.No: T70420

Cat.No: T35546

Cat.No: T62219

187-1, N-WASP inhibitor

Cat.No: TP1977

Cardioexcitatory peptide 1

Cat.No: T82778

Cat.No: T78092

Target: PI3K

Cat.No: T74130

Docosahexaenoyl Glycine

Cat.No: T37532

Levomefolate calcium pentahydrate

Cat.No: T32706

Cat.No: T75831

Epiboxidine hydrochloride

Cat.No: T74131

Pirlindole-d4 HCl

Cat.No: T70174

Ganglioside GD3 Mixture (sodium salt)

Cat.No: T35552

IRBP (1-20), human

Cat.No: TP1749

Cat.No: T78596

NR2F1 agonist 1

Cat.No: T72776

Cat.No: T35497

Cat.No: T61930

187-1, N-WASP inhibitor TFA

Cat.No: T75777

PSEM 308 hydrochloride

Cat.No: T37391

Cat. No.	Product Name	Target	Signaling Pathways
T5661	Methyl isoeugenol	Others	Others
	Methyl isoeugenol 是一种天然的食用香精，占石竹叶香精油的 93.7%。该物种的叶子提取物用作镇静剂。作为一种无处不在的食品添加剂，MIE 在治疗情绪障碍方面的应用。
T0062	Folic acid Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Folic acid (Vitamin B9) 是维生素B9，是合成DNA/RNA，新细胞产生和维持的必要成分。
T1048	Estradiol 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estradiol (E2) 是一种天然的类固醇性激素，对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。
TN5131	Tetrahydrocannabivarin THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin	Cannabinoid Receptor	GPCR/G Protein
	Tetrahydrocannabivarin (CRM) 是 cannabinoid type 1 receptor 的中性拮抗剂，对 2 型糖尿病有潜在治疗价值。
TMS2180	Zeaxanthin Anchovyxanthin,All-Trans-Zeaxanthin,玉米	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	Zeaxanthin (All-Trans-Zeaxanthin) 是食物获得类胡萝卜素，存在于眼睛的黄斑部，具有抗氧化活性。
TN1600	Eclalbasaponin I	Others	Others
	Eclalbasaponin I 分离自鳢肠中，具有抗肿瘤作用，能够抑制肝癌细胞 smmc-7721 的增殖(IC50:111.1703 μg/ml)。
T1040	Vitamin B12 Cyanocobalamin,Cobalamin,维生素B12	Endogenous Metabolite	Metabolism
	Vitamin B12 (Cobalamin) 是一种维生素，在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。
T5004	Hyaluronic acid sodium 透明质酸钠,Sodium Hyaluronate	Others	Others
	Hyaluronic acid sodium (Sodium Hyaluronate) 是一种生物聚合物，由二糖的重复单元组成，应用领域广泛。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
T38429	(+)-Intermedine
	(+)-Intermedine, a pyrrolizidine alkaloid (PA), shows remarkable cytotoxic activity against neural progenitor cells (NPCs).
T83582	(±)-Pantothenic acid (±)-Vitamin B5,(±)-Pantothenate
	(±)-Pantothenic acid ((±)-Pantothenate) 作为 B 组维生素的一员，对于哺乳动物细胞中辅酶 A (CoA) 的生物合成是不可或缺的。此外，该化合物能防护丙戊酸 (VPA) 在 CD-1 小鼠中引起的神经管缺陷 (NTD)。

天然产物

Methyl isoeugenol

Cat.No: T5661

Target: Others

Cat.No: T0062

Synonym: Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T1048

Synonym: 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Tetrahydrocannabivarin

Cat.No: TN5131

Synonym: THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin

Target: Cannabinoid Receptor

Cat.No: TMS2180

Synonym: Anchovyxanthin,All-Trans-Zeaxanthin,玉米

Target: Antioxidant, Endogenous Metabolite

Eclalbasaponin I

Cat.No: TN1600

Target: Others

Cat.No: T1040

Synonym: Cyanocobalamin,Cobalamin,维生素B12

Target: Endogenous Metabolite

Hyaluronic acid sodium

Cat.No: T5004

Synonym: 透明质酸钠,Sodium Hyaluronate

Target: Others

Cat.No: T4877

Target: Endogenous Metabolite

(+)-Intermedine

Cat.No: T38429

(±)-Pantothenic acid

Cat.No: T83582

Synonym: (±)-Vitamin B5,(±)-Pantothenate

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