195
169
Cat. No. | Product Name | Target | Signaling Pathways |
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T37739 |
N-decanoyl-L-Homoserine lactone
C10-HSL,N-decanoyl-L-Homoserine lactone |
Reactive Oxygen Species; Antibacterial | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
N-decanoyl-L-Homoserine lactone (C10-HSL) 是一种由克雷莫里色假单胞菌菌株 ND07产生的 N-acyl-homoserine lactone (AHL)。N-decanoyl-L-homoserine lactone 可抑制拟南芥的主根生长。N-decanoyl-L-homoserine lactone 处理可引起拟南芥根胞质游离 Ca2+ 和活性氧 (ROS) 浓度短暂和和立即升高,增加丝裂原激活蛋白激酶 6 (MPK6) 的活性,并促使一氧化氮 (NO) 的产生。 | |||
T37744 |
N-octanoyl-L-Homoserine lactone
C8-HSL,N-octanoyl-L-Homoserine lactone,OHL |
Antibacterial | Microbiology/Virology |
N-octanoyl-L-Homoserine lactone (C8-HSL) 是一种具有扩散性的外源性鼠疫耶尔森菌群体感应分子,可调节LcrV毒力因子,通过参与群体感应控制基因表达,影响细胞代谢。N-octanoyl-L-Homoserine lactone 是用于研究囊性纤维的感染。 | |||
T22374 |
N-(beta-Ketocaproyl)-L-hoMoserine lactone
N-3-氧-己酰高丝氨酸内酯,N-(β-Ketocaproyl)-L-hoMoserine lactone,N-(Ketocaproyl)-L-homoserine lactone,N-(β-Ketocaproyl)-L-hoMoserine lactone |
Others | Others |
N-(beta-Ketocaproyl)-L-hoMoserine lactone (N-(Ketocaproyl)-L-homoserine lactone) 是群体调节感应的成分之一。 | |||
T37746 |
N-phenylacetyl-L-Homoserine lactone
|
Others | Others |
N-phenylacetyl-L-Homoserine lactone 可衰减病原体鲍曼不动杆菌的群体感应,可用于研究细菌感染。 | |||
T14342 |
Atorvastatin lactone
|
HMG-CoA Reductase | Metabolism |
Atorvastatin lactone 是一种 Atorvastatin 的前药。其中 Atorvastatin 是口服具有活力的 3- 羟基 -3- 甲基戊二酰辅酶 A 还原酶抑制剂。 | |||
T16226 |
N-(Ketocaproyl)-DL-homoserine lactone
N-(Ketocaproyl)-D,L-homoserine lactone,N-(3-氧代己酰)-DL-高丝氨酸内酯 |
Antibacterial | Microbiology/Virology |
N-(Ketocaproyl)-DL-homoserine lactone 是群体感应自动诱导剂。它是 LuxR 的天然配体。 | |||
T12490 |
Pitavastatin lactone
|
Others | Others |
Pitavastatin lactone 是 Pitavastatin 在人体中的主要代谢产物。Pitavastatin 是 HMG-CoA 还原酶竞争性抑制剂。 | |||
T18408 |
N-Butanoyl-L-homoserine lactone
N-丁酰基-L-高丝氨酸内酯,N-Butyryl-L-homoserine lactone,C4-HSL |
Antibacterial | Microbiology/Virology |
N-Butanoyl-L-homoserine lactone (C4-HSL) 是一种可降解的 ADClinker,用于抗体偶联药物的合成。它可用于抗菌生物膜,具有抗菌活性。它的适配体抑制铜绿假单胞菌生物膜的形成,可用于阻止群体感应。 | |||
T37742 |
N-hexanoyl-DL-Homoserine lactone
C6-HSL |
Antibiotic | Microbiology/Virology |
N-hexanoyl-DL-Homoserine lactone (C6-HSL) 是从双壳类幼虫培养物中分离出来的,可降解细菌,可抑制植物病原真菌 B. cinerea 诱导的病变。N-hexanoyl-DL-Homoserine lactone 参与细菌间的N-酰基-高丝氨酸内酯 (AHL) 群体感应 (QS) 系统。 | |||
T22375 |
N-hexanoyl-L-Homoserine lactone
己酰-L-高丝氨酸内酯,C6-HSL |
Others; Antibacterial | Microbiology/Virology; Others |
N-hexanoyl-L-Homoserine lactone (C6-HSL) 是一种可扩散信号分子,参与控制基因表达、影响细胞代谢和群体感应。 | |||
T13789 |
N-dodecanoyl-L-Homoserine lactone
C12-HSL,十二烷酰-L-高丝氨酸内酯 |
Others | Others |
N-dodecanoyl-L-Homoserine lactone (C12-HSL) 是群体感应 (QS) 信号分子的一种。它适配体可用于阻止群体感应,并能够阻碍铜绿假单胞菌 (Pseudomonas aeruginosa) 生物膜的形成。 | |||
T41287 |
N-3-Oxo-octanoyl-L-homoserine lactone
|
Others | Others |
N-3-Oxo-octanoyl-L-homoserine lactone 是一种群体感应信号分子,是农杆菌自诱导剂。 | |||
T14829 |
Bromoenol lactone
(6E)-Bromoenol lactone |
Phospholipase | Metabolism |
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. | |||
T41319 |
D-Saccharic acid 1,4-lactone hydrate
|
Others | Others |
D-Saccharic acid 1,4-lactone hydrate 是β-葡萄糖醛酸酶的有效抑制剂(IC50=48.4 μM),可用作标准药物。D-Saccharic acid 1,4-lactone hydrate 显示出抗癌、解毒和抗氧化的活性性。 | |||
T37326 |
Prostaglandin F2α 1,11-lactone
Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) 是前列腺素 F2α 的脂溶性前药,可用于治疗青光眼的研究。 Prostaglandin F2α 1,11-lactone 作为抗生育剂具有活性,可大大降低血管活性。 | |||
T32732 |
L-Glucono-gamma-lactone
L-Glucono-1,4-lactone,L-Gluconic acid,gamma-lactone,Glucono-gamma-lactone, L- |
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L-Glucono-gamma-lactone is a food additive that can be used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. | |||
T37327 |
Prostaglandin F2α 1,15-lactone
Prostaglandin F2α 1,15-lactone |
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PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective. | |||
T37747 |
N-tetradecanoyl-L-Homoserine lactone
C14-HSL,tDHL,N-tetradecanoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-tetradecanoyl-L-Homoserine lactone (C14-HSL) is a small diffu... | |||
T69178 |
Rosuvastatin lactone
|
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Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin. It is found in vivo following rosuvastatin administration. Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 8.52 and 4.1 µM, respectively). | |||
T37642 |
Pravastatin lactone
|
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Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration. | |||
T36838 |
(R)-Bromoenol lactone
|
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The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β exce... | |||
T37339 |
N-3-oxo-tetradecanoyl-L-Homoserine lactone
3-oxo-C14-HSL,N-3-oxo-myristoyl-L-Homoserine lactone,N-3-oxo-tetradecanoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is ... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... | |||
T37240 |
(±)4(5)-DiHDPA lactone
|
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(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5 double bond. (±)4(5)-DiHDPA lactone is a derivative of docosahexaenoic acid that is analogous to (±)5(6)-DiHET lactone. It is the 1,4 cyclic ester derived from (±)4(5)-DiHDPA, which is produced by epoxidation of DHA at the α-4 double bond. Its biological activity is unknown. | |||
T38249 |
2-Hydroxy atorvastatin lactone
|
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2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2]. | |||
T37654 |
5(S)-HETE lactone
|
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5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. The ability of (±)5-HETE lactone to inhibit rat basophilic leukemia cell 5-lipoxygenase (IC50 = 27 μM) may be entirely due to the 5(S) isomer, but the enantiomers have not been tested separately. | |||
T40941 |
Olmesartan lactone impurity
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Olmesartan lactone impurity is a cyclic ester impurity derived from Olmesartan, which is an angiotensin II receptor (AT1R) antagonist with potential applications in the study of high blood pressure. | |||
T36396 |
D-Homoserine lactone
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D-homoserine lactone is an enantiomer of L-homoserine lactone and an inhibitor of serine hydroxymethyltransferase (SHMT; Ki= 11 mM for the rabbit enzyme).1 1.Wang, E.A., Kallen, R., and Walsh, C.Mechanism-based inactivation of serine transhydroxymethylases by D-fluoroalanine and related amino acidsJ. Biol. Chem.256(13)6917-6926(1981) | |||
T70419 | Cerivastatin lactone | ||
Cerivastatin lactone is a metabolite of a competitive inhibitor of HMG-CoA reductase, Cerivastatin. Cerivastatin lactone shows inhibitory effects on CYP3A4/5 activity. | |||
T36556 |
(±)5(6)-DiHET lactone
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5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be b... | |||
T38313 |
L-Homoserine lactone (hydrochloride)
|
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L-Homoserine lactone is a synthetic intermediate.1,2It has been used in the synthesis of organoselenium chemistry intermediates and analogs of bacterial quorum-sensing signaling molecules. 1.Koch, T., and Buchardt, O.Synthesis of L-(+)-selenomethionineSynthesis1065-1067(1993) 2.Chhabra, S.R., Harty, C., Hooi, D.S.W., et al.Synthetic analogues of the bacterial signal (quorum seensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulatorsJ. Med. Chem.46(1)97-104(2003) | |||
T12138 |
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone
N-(3-oxodecanoyl)-homoserine lactone |
Others | Others |
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone has antibacterial activity. | |||
T68376 | Indinavir lactone | ||
Indinavir lactone is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. | |||
T37745 |
N-pentadecanoyl-L-Homoserine lactone
|
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37243 |
(±)5(6)-DiHETE lactone
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Eicosapentaenoic acid is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. (±)5(6)-DiHETE lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHETE. While its biological activity is unknown, the selective capacity of (±)5(6)-DiHETE to form this lactone can be utilized to specifically quantify (±)5(6)-DiHETE in... | |||
T38300 |
Acetyl-L-Homoserine lactone
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Acetyl-L-homoserine lactone belongs to the family of N-acylated homoserine lactones (HSLs) and has an acyl chain length of two carbons. HSLs perform a role in quorum sensing; however, unlike other HSLs, acetyl-L-homoserine lactone does not elicit a response in bacteria. In an assay of carbapenem antibiotic biosynthesis, acetyl-L-homoserine lactone does not induce a response in E. carotovora. In a fluorescence assay using E. coli containing a reporter plasmid of GFP expression in response to exog... | |||
T12092 |
Monacolin J
Antibiotic MB 530A,Lovastatin diol lactone,辛伐他汀内酯二醇 |
HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂,抑制 HMG-CoA 还原酶的活性。 | |||
T37878 |
N-tridecanoyl-L-Homoserine lactone
|
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37879 |
N-undecanoyl-L-Homoserine lactone
|
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37743 |
N-octadecanoyl-L-Homoserine lactone
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37736 |
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic... | |||
T41282 |
N-Heptanoyl-L-homoserine lactone
|
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N-Heptanoyl-L-homoserine lactone 在生命科学相关研究中具有广泛的应用。 | |||
T37335 |
N-3-hydroxybutyryl-L-Homoserine lactone
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N-3-hydroxybutyryl-L-Homoserine lactone is an N-acyl-homoserine lactone produced by the bacterium V. splendidus and has been found in sequencing batch biofilm reactors used in wastewater treatment.1,2 It is the racemic version of the V. harveyi autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone.3 |1. Purohit, A.A., Johansen, J.A., Hansen, H., et al. Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. J. Appl. Microbiol. 115(3), 835-847 (2013).|2. Feng, Z., Sun,... | |||
T11821 |
Latanoprost lactone diol
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Others | Others |
Latanoprost lactone diol is an important intermediate compound in the synthesis of Latanoprost. Latanoprost, classified as a prostaglandin F2α analogue, functions as an agonist for the FP prostanoid receptor, resulting in a reduction in intraocular pressure (IOP). | |||
T36989 |
N-3-hydroxydecanoyl-DL-Homoserine lactone
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N-3-hydroxydecanoyl-DL-Homoserine lactone is a bacterial quorum-sensing molecule.1It activates SdiA (EC50= 0.6 μM), a transcription factor that detects N-acyl homoserine lactones (AHLs), in the 14028/pJNS25 strain ofS. enterica.2 1.Fekete, A., Frommberger, M., Rothballer, M., et al.Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensorsAnal. Bioanal. Chem.387... | |||
T31472 |
Dihydrojasmone lactone
gamma-Methyldecalactone,gamma-Methyl decalactone,4-Methyldecanolide |
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Dihydrojasmone lactone is a biochemical. | |||
T14030 |
3-Desacetyl Cefotaxime lactone
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Others | Others |
3-Desacetyl Cefotaxime lactone, the active metabolite of Cefotaxime, is derived from its sodium salt form, which is recognized as a third-generation cephalosporin antibiotic. | |||
T38154 |
N-3-hydroxydecanoyl-L-Homoserine lactone
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Different quorum sensing molecules are produced at different times in bacterial population growth and have distinct cellular effects mediated through changes in gene expression. N-3-hydroxydecanoyl-L-Homoserine lactone is a small diffusible signaling molecule secreted by various bacteria. This lactone is produced via lactonolysis from 3-oxodecanoyl-homoserine lactone, al... | |||
T19132 |
(3R,5R)-Rosuvastatin Lactone
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Others | Others |
(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone. | |||
T32266 |
Jasmine lactone
Jasmolactone, delta-,EINECS 247-074-2,FEMA No. 3745 |
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Jasmine lactone is a lactone and aroma compound. Its chemical formula is C10H16O2. It exists in some natural product in jasmine oil, tuberose, gardenia, mimosa, honeysuckle, lily, tea, peach, and ginger. It can be mainly used for the preparation of apri |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7995 |
α-Angelica lactone
α-当归内酯,当归内酯,Alpha-Angelica Lactone |
Others; GST | Others; oxidation-reduction |
α-Angelica lactone 是一种乙烯基亲核试剂,也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ,γ-二取代丁烯醇内酯羰基衍生物,并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。 | |||
T12045 |
(-)-Hydroxycitric acid lactone
藤黄内酯,Garcinia lactone |
ATP Citrate Lyase | Metabolism |
(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂,能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A,限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药,是一种广受欢迎的减肥食品补充剂。 | |||
T8085 |
(-)-Corey lactone diol
科立内脂二醇,Corey Lactone Diol |
Others | Others |
(-)-Corey lactone diol 是 corey aldehyde 的还原形式,也是化学合成中的砌块。 | |||
T2833 |
Dehydrocostus Lactone
Epiligulyl oxide,去氢木香内酯,(-)-Dehydrocostus lactone,去氢木香烃内酯 |
IκB/IKK | NF-κB |
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) 是一种倍半萜内酯,从云木香中分离得到。 | |||
T0933 |
D-(+)-Glucono-1,5-lactone
Gluconic acid lactone,Delta-Gluconolactone,Gluconolactone,葡萄糖酸内酯 |
Others; Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB; Others |
D-(+)-Glucono-1,5-lactone (Gluconolactone) 是聚羟基酸,可螯合金属离子,具有保湿、抗氧化特性。 | |||
TN6744 |
Undecanoic gamma-lactone
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Others | Others |
Undecanoic gamma-lactone 是一种天然产物。 | |||
T5578 |
L-Gulono-1,4-lactone
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Others; Endogenous Metabolite | Metabolism; Others |
L-Gulono-1,4-lactone 是一种 L-古洛糖酸-γ-内酯氧化还原酶的作用底物,该酶能促进维生素 C 合成的末步。它是动物、植物和一些原生生物中维生素 C 的直接前体。 | |||
T0434 |
D-Glucuronic acid lactone
Glucuronolactone,D-Glucurone,Dicurone,葡醛内酯 |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucuronic acid lactone (Dicurone) 是内源性代谢产物的一种。 | |||
T40583 |
N-(3-Oxotetradecanoyl)-DL-homoserine lactone
3-Oxo-C14-AHL,N-(3-Oxotetradecanoyl)-DL-homoserine lactone |
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N-(3-Oxotetradecanoyl)-DL-homoserine lactone, part of the N-Acyl homoserine lactone (AHL) family derived from gram-negative bacteria, serves as a quorum sensing (QS) signaling molecule. | |||
T4719 |
1,4-D-Gulonolactone
D-Gulonic acid γ-lactone,D-(-)-古洛糖酸-1,4-内酯 |
Others; Endogenous Metabolite | Metabolism; Others |
1,4-D-Gulonolactone (D-Gulonic acid γ-lactone) (也称为还原性抗坏血酸,RAA) 是 L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8)的底物,催化植物和动物中l -抗坏血酸(维生素C)生物合成的最后一步。enzyme L-Gulono-1,4-lactone oxidase 在容易患坏血病、缺乏维生素c的动物(如人类)中缺失。1,4-D-Gulonolactone 存在于人体血液中,并被用作比较运动引起的氧化应激变化的标志物之一。 | |||
T3151 |
Brassinolide
Brassin lactone,24-Epibrassinolide,芸苔素内酯 |
Apoptosis; Others | Apoptosis; Others |
Brassinolide (Brassin lactone) 是一种植物生长调节剂,可调节植物细胞伸长。 | |||
T2S0605 |
Liquidambaric lactone
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Liquidambaric lactone 是一种分离自Euonymus grandiflorusWall 中的化合物。 | |||
TN4508 |
Matsukaze-lactone
|
Others | Others |
Matsukaze-lactone is a natural product from Boenninghausenia albiflora. | |||
TN5132 |
Tetrahydrolachnophyllum lactone
|
Others | Others |
Tetrahydrolachnophyllum lactone 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5132,CAS号为 56407-87-5。 | |||
TN5803 | (Z)-Lachnophyllum lactone | ||
(Z)-Lachnophyllum lactone 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5803,CAS号为 81122-95-4。 | |||
T2902 |
Costunolide
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯 |
Apoptosis; Endogenous Metabolite; Telomerase | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。 | |||
TN4082 |
Friedelin 3,4-lactone
|
Others | Others |
Friedelin-3,4-lactone has a promotion effect on the inducing proliferation of rat mesenchymal stem cells(rMSCs). | |||
T13501 |
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone
3-oxo-21-alpha-methoxy-24-25-26-27-tetranortirucall-7-ene-23-21-lactone |
Others | Others |
The compound 3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid that has been extracted from the stem barks of Aphanamixis grandifolia. | |||
T19440 |
N-(3-Oxooctanoyl)-DL-homoserine lactone
(Rac)-3-oxo-C8-HSL |
Others | Others |
N-(3-Oxooctanoyl)-DL-homoserine lactone with stereochemistry-dependent growth regulatory activity for roots . | |||
TN2750 |
2-C-Methyl-D-erythrono-1,4-lactone
|
Others | Others |
(-)-2-C-Methyl-D-erythrono-1,4-lactone is inactive alone, but elicits oviposition behavior when mixes with other fractions. | |||
TN1268 |
3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone
3Β,7Β,15Β-三羟基-11-羰基-羊毛甾烷-8-烯-24→20内酯,3beta,7beta,15beta-trihydroxy-11-oxo-lanosta-8-en-24->20 lactone |
Others | Others |
3beta,7beta,15beta-trihydroxy-11-oxo-lanosta-8-en-24->20 lactone is a natural product | |||
T9144 |
Telekin
|
Others | Others |
Telekin 是一种从中草药 Carpesium divaricatum 中分离出来的 eudesmane 型倍半萜内酯化合物,据报道可强烈抑制癌细胞的增殖。 | |||
T9135 |
Epirosmanol
|
Others | Others |
Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性(基本中性)的化合物(基于其 pKa)。 | |||
TN2409 | 6-Deoxy-3-O-methyl-β-allopyranosyl (1→4)-β-cymaronic acid δ-lactone | Others | Others |
6-Deoxy-3-O-methyl-β-allopyranosyl (1→4)-β-cymaronic acid δ-lactone is a natural product from Marsdenia tenacissima | |||
TN7031 |
4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Caramel Furanone,Fenugreck Lactone,Sotolone,葫芦巴内酯 |
Others | Others |
4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one (Fenugreck Lactone) 是一种食品香料,主要用于焦糖、红糖、威士忌、棉花糖、咖啡、太妃糖等香精。 | |||
T81722 |
N-(3-Oxodecanoyl)-L-homoserine lactone
3-Oxo-C10-HSL |
||
N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) 作为一种信号分子,在细菌群体感应中充当自诱导分子的角色。 | |||
T8898 |
Granilin
大叶土木香内酯,Graniline |
Others; Antibacterial; Antifungal | Microbiology/Virology; Others |
Granilin (Graniline) 是存在于Carpesium triste 的花蕾中的一种倍半萜内酯,可作杀菌和杀真菌剂。 | |||
T10941 |
D-Ribonolactone
D-(+)-核糖酸-1,4-内酯,D-核糖内酯 |
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
D-Ribonolactone 是一种大肠杆菌 β-半乳糖苷酶的抑制剂,Ki 为 26 mM。它也一种糖内酯。 | |||
T1353 |
DL-Mevalonolactone
甲瓦龙酸内酯,Mevalonolactone |
Others; Endogenous Metabolite | Metabolism; Others |
DL-Mevalonolactone (Mevalonolactone),一种人内源性代谢物,是甲羟戊酸的 δ-lactone 形式,甲羟戊酸途径的一个前体。它能够降低大脑中线粒体膜电位(∆Ψm),Ca2+的保留能力和 NAD (P) H 的含量 , 而且还诱导线粒体肿胀。 | |||
T9327 |
ω-Pentadecalactone
Cyclopentadecanolide,ω-十五内酯,Oxacyclohexadecan-2-one,Exaltolide,Pentadecanolide |
Others | Others |
ω-Pentadecalactone (Exaltolide) 是香料成分,是一种香味结构组大环内酯和丙交酯衍生物的成员。 | |||
T2896 |
Alantolactone
土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor |
Apoptosis; STAT; TGF-beta/Smad | Apoptosis; JAK/STAT signaling; Stem Cells |
Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 | |||
T8098 |
γ-Hexalactone
γ-caprolactone,gamma-己内酯,γ-己内酯 |
Others | Others |
γ-Hexalactone (γ-caprolactone) 是一种存在成熟水果中的 gamma 内酯。它会导致 DNA 损伤,可用作对氧磷酶 1 的底物 (PON1)。 | |||
T5742 |
Isodemethylwedelolactone
异去甲蟛蜞菊内酯,Isodemethylwedelolacton |
Others | Others |
Isodemethylwedelolactone (Isodemethylwedelolacton) 是一种促凝剂,也是溶血性成分,分离自 Eclipta alba。 | |||
T3384 |
Wedelolactone
蟛蜞菊内酯,IKK Inhibitor II |
Apoptosis; NF-κB; Lipoxygenase; Caspase | Apoptosis; Metabolism; NF-κB; Proteases/Proteasome |
Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物,通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录,具有抗癌,抗炎和抗氧化活性。 | |||
T4S0592 |
Toddalolactone
(+)-Toddalolactone,飞龙掌血内酯,毛两面针素 |
PAI-1 | Metabolism |
Toddalolactone ((+)-Toddalolactone) 是一种Toddalia asiatica 的主要成分,能够抑制重组人纤溶酶原激活物抑制物-1(PAI-1)的活性, IC50=37.31 μM。 | |||
T8078 |
Gamma-decalactone
Decan-4-olide,γ-Decalactone,丙位癸内酯 |
Others | Others |
Gamma-decalactone (Decan-4-olide) 是一种具有果味桃子味的食品添加剂。蓖麻油酸 (12-羟基-十八烷基-9-烯酸) 常作为 γ-Decalactone 的生产过程中的底物。 | |||
TN7021 |
Ent-toddalolactone
|
Others | Others |
Ent-toddalolactone 是一种天然化合物,属于香豆素类,来源于两面针,具有抗炎、抗癌活性。 | |||
TN6700 |
gamma-Nonanolactone
|
Others | Others |
gamma-Nonanolactone 是蒸小麦的香气成分。 | |||
T25192 |
Butyrolactone I
Olomoucin,丁酸内酯I |
CDK | Cell Cycle/Checkpoint |
Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。 | |||
T5S1897 |
Linderalactone
|
Apoptosis; Others; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯,通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。 | |||
TQ0118 |
Britannilactone
Desacetylinulicin |
Others | Others |
Britannilactone (Desacetylinulicin) 是来自 Inula britannica 的倍半萜烯,具有抗炎抗肿瘤活性。Britannilactone 与这种抗黑色素活性有关,可用于研究皮肤美白。 | |||
TN1143 |
1-O-Acetyl britannilactone
|
Apoptosis; Antibiotic | Apoptosis; Microbiology/Virology |
1-O-Acetyl britannilactone 是一种农用杀菌剂,可诱导细胞凋亡,可用于研究肝损伤和癌症。 | |||
TN1637 |
Eurycomalactone
|
Anti-infection; NF-κB | Microbiology/Virology; NF-κB |
Eurycomalactone 是一种NF-κB 抑制剂,IC50=0.5 μM,是一种天然产物。它可抑制蛋白合成,降低 cyclin D1 蛋白水平,但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。 | |||
T40815 |
δ-Decalactone
|
Others | Others |
δ-Decalactone 存在于脱脂奶粉和水果中,具有甜味。 | |||
T2829 |
Isoalantolactone
(+)-Isoalantolactone,Isohelenin,异土木香内酯 |
Apoptosis; Endogenous Metabolite; Antibacterial; Autophagy | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Isoalantolactone (Isohelenin) 是一种可用作细胞凋亡诱导剂的烷化剂。 | |||
T5968 |
DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐 |
Endogenous Metabolite | Metabolism |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。 | |||
TN2539 |
1beta-Hydroxyalantolactone
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
1beta-Hydroxyalantolactone 是从药用植物大英花的花头中分离出的小分子化合物,可抑制细胞中TNF-α、IL-17、IFN-γ的表达,促进TNF-α、IFN-γ、IL-17的分泌,可防治类风湿性关节炎。 | |||
T5S0689 |
Demethylwedelolactone
去甲蟛蜞菊内酯,去甲基蟛蜞内酯 |
Serine Protease | Proteases/Proteasome |
Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭,是一种有效的trypsin 抑制剂(IC50:3.0 μM)。 | |||
T8213 |
Isolinderalactone
|
NOS; STAT | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Isolinderalactone 具有抗炎和抗癌能力,具有中等的 iNOS 抑制活性,IC50 值为 0.30 uM。 | |||
TN6718 |
Dehydrocostuslactone
|
Others | Others |
Dehydrocostuslactone 是一种从奥克兰提取的天然产物。它具有广泛的生物作用,包括抗炎、抗癌、抗病毒、抗菌、抗真菌、抗氧化、抗糖尿病、抗溃疡和驱虫活性。 | |||
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